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drug dose     
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  药物剂量
     The drug dose of BSO is 5mmol/kg and the radiation dose was 10Gy.
     BSO药物剂量为5mmol/kg,放射剂量为10Gy。
短句来源
     2 in stage D2.The drug dose was CBP 400mg,MMC 20mg,Epirubicin 50mg,VCR 1.0mg and the embolic agent was gelfoam.
     所用药物剂量分别是 :卡铂 40 0mg ,丝裂霉素 2 0mg ,表阿霉素 5 0mg ,长春新碱 1mg。
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     The amount of apoptotic cells was directly proportional to the drug dose.
     ELISA检测结果表明培养细胞中凋亡细胞比例随药物剂量增加而增大。
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     Methods Selected 68 patients with hypertension and hyperuricemia,in which divided two groups by random,one group with losartan 50 mg per day po,other group with captopril 25 mg per day po,the drug dose can be changed according the level of the blood pressure,for 4 weeks,compared the changes of serum uric acid and the blood pressure for two groups.
     方法68例高血压合并高尿酸血症患者随机分成两组,氯沙坦组34例,每天口服氯沙坦50 mg,卡托普利组34例,每天口服卡托普利25 mg,药物剂量根据血压水平调整,治疗4周,测定两组治疗前、后收缩压、舒张压、血清尿酸水平,并对两组进行了比较。
短句来源
     Methods: Selected 60 elderly patients with hypertension and hyperuricemia, in which divided two groups by random, one group with losartan 50 mg per day po, other group with captopril 25 mg per day po, the drug dose can be changed according the level of the blood pressure, for 4 weeks, compared the changes of serum uric acid and the blood pressure for two groups.
     方法:60例老年高血压合并高尿酸血症患者随机分成2组,氯沙坦组30例,每天口服氯沙坦50mg,卡托普利组30例,每天口服卡托普利25mg,药物剂量根据血压水平调整,治疗4周,测定2组治疗前、后收缩压、舒张压、血清尿酸水平,并对2组进行了比较。
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  药物浓度
     Results The average sensitization enhancement ratio of CGEONA was 1.4 using 1/10 LD 50 drug dose.
     结果 CGEONA药物浓度为 1/ 10LD50 时平均放射增敏比为 1 4。
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     ③The cyclosporin A effect in inhibiting contact dermatitis of guinea pigs is dependent on the drug dose .
     ③环孢菌素A对豚鼠接触性皮炎的抑制与药物浓度有关
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     Results Treated with 0.1-2.0μmol/L DNR,the percentage of apoptotic Jurkat cells increased following the drug dose as well as the time extending.
     结果当DNR为0.1~2.0μmol/L浓度范围时,作用一定时间后Jurkat细胞发生的凋亡率随药物浓度的增加与作用时间的延长而升高。
短句来源
     Whereas,the percentage of apoptotic Jurkat cells was decreased and cells died absolutely when the drug dose was over 2.0μmol/L or cells were treated 48h with 2.0μmol/L DNR.
     但药物浓度超过2.0μmol/L,或2.0μmol/L作用48h后Jurkat细胞出现凋亡率下降,细胞大部分死亡。
短句来源
     Effective drug dose and sufficient volume of liquid can improve the effect.
     有效的药物浓度与充足的药液容量可以提高腹腔化疗的疗效 ;
短句来源
  剂量
     The drug dose of BSO is 5mmol/kg and the radiation dose was 10Gy.
     BSO药物剂量为5mmol/kg,放射剂量为10Gy。
短句来源
     The closure of choriocapillaris was seen at drug dose 1.0 mg/kg,power density 300-600 mW/cm2 and energy fluence 14.4-56.0 J/cm2. Conclusions The biological effect is determined by dose of sensitizer,interval between injection of photosensitizer and irradiation,power density and energy fluence.
     HB剂量1.0mg/kg,功率密度300~600mW/cm2,照光时间80~100s,能量密度30~50J/cm2是适宜的治疗参数。
短句来源
     Conclusion Within the dosage of 50~150 IU·kg -1 ,the increase of serum rhEPO level after multiple subcutaneous administrations was correlated with the drug dose administrated.
     结论 剂量在50~150IU·kg-1,多次皮下注射rhEPO,血药浓度水平与给药剂量呈正相关;
短句来源
     The pathological results showed that there were inflammatory cells and hepatocellular necrosis in model group,the protective effects of rhKD/APP on hepatic injury showed linear relation to the drug dose.
     肝脏组织病理切片显示,模型组有炎细胞浸润,肝细胞坏死,与模型组相比,rhKD/APP小、中、大剂量组肝组织损伤程度较轻,且随着rhKD/APP剂量增加肝组织损伤程度逐渐减轻。
短句来源
     Conclusion There is no significant change of motor black time and it is related to drug dose for 0.5%, 0.75% and 1% ropivacaine in continuous spinal anesthesia.
     结论:0.5%,0.75%和1%罗哌卡因用于连续蛛网膜下腔运动神经完全阻滞时间无差异,恢复时间与 剂量有关。
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  药物用量
     Results:There was a significant difference in onset of analgesia and drug dose at12hours between tramadol group and fentanyl group(P<0.05). There was no significant difference in sexual distribution,status of drink,incidence of nausea and vomiting,level of education,analgesia efficacy,sedation,patient satisfaction,recovering time of gut motility,and postoperative hospitalization(P>0.05).
     结果 :两组镇痛起效时间 ,术后12h药物用量及有效按压次数T组多于F组 ,两组比较有显著性差异 (P<0.05或P<0.01) ,术后24 ,36,48h有效按压次数、镇痛满意度无显著性差异(P>0.05)。
短句来源
     The following indexes were recorded at 12,24,36 and 48 hours after the PCA pumps were used: VAS scores of pain,demanded delivery effective delivery,drug dose,sedation score,side effects,and patient satisfaction.
     镇痛开始后12、24、36和48 h记录疼痛VAS评分、PCA需求按压次数和有效按压次数、药物用量、镇静程度评分;
短句来源
     Objective To investigate the significance of T lymphocyte subset determination during antithymocyte globulin (ATG) induction therapy in reducing the total drug dose, incidence of complications and cost of treatment in hand allograft.
     目的探讨异体手移植中使用抗胸腺细胞球蛋白(ATG)治疗时T淋巴细胞亚群监测对于指导药物用量、减少并发症和减少治疗费用的意义。
短句来源
     Results Onset of analgesia in Group Ⅰ was significantly faster than that in Group Ⅱ (P<0.01). There were no significant differences in VAS scores , demanded delivery , drug dose, sedation score, side effects, and patient satisfaction (P>0.05).
     结果Ⅰ组患者镇痛起效时间显著快于Ⅱ组(P<0.01),两组疼痛评分、按压次数、药物用量、镇静评分、术后并发症与不良反应发生率及镇痛满意度的差异均无统计学意义(P>0.05)。
短句来源
     There were no significant difference in VAS scores of pain,demanded delivery effective delivery,drug dose,sedation score,and patient satisfaction(P>0.05). There was significant difference in side effects(P<0.05).
     结果Ⅱ组病人镇痛起效时间显著快于Ⅰ组(P<0.01),两组疼痛评分、按压次数、药物用量、镇静评分、镇痛满意度差别无统计学意义(P>0.05),术后并发症与不良反应发生率有不同(P<0.05)。
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      drug dose
    plantarum 8P-A3 strains makes it possible to decrease the therapeutic drug dose 1000 times as compared to the well-known probiotics based on bacilli and lactobacilli species.
          
    Morning plasma cortisol was determined at baseline, at 12 h following the first study drug dose, and weekly thereafter.
          
    At all drug dose levels administered, supraependymal neuron-like cells appeared atop the ependyma of the third ventricle above the median eminence.
          
    We find that depending on the model and on the drug mechanism function, Tmax may increase, decrease, decrease and then increase, or stay the same, as the drug dose is increased.
          
    The relationship between drug dose and drug effect is often described by pharmacokinetic/pharmacodynamic (PK/PD) models where typically the PK model has a multicompartment form and the PD model is the sigmoidal Emax model.
          
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    This papei reports the effects of aciaci-nomycin B(ACM B) on multiplication and DNA polymerase activities of HSV-2. The experiment was carried out on Vero cell monolayer cultures and the plaque reduction assay was used as a main method evaluating the results. In the presence of ACM B, the plaque forming units of the virus was remarkably reduced.The plaque number was reduced to zero when the drug dose was beyond the level of 0.3 μM.The results showed that ACM B inhibited HSV-2 multiplication. Besides, ACM...

    This papei reports the effects of aciaci-nomycin B(ACM B) on multiplication and DNA polymerase activities of HSV-2. The experiment was carried out on Vero cell monolayer cultures and the plaque reduction assay was used as a main method evaluating the results. In the presence of ACM B, the plaque forming units of the virus was remarkably reduced.The plaque number was reduced to zero when the drug dose was beyond the level of 0.3 μM.The results showed that ACM B inhibited HSV-2 multiplication. Besides, ACM B also inhibited HSV-2 induced DNA poiymerase. It was presumed that the inhibitory action of ACM B to HSV

    本文报道了阿克拉霉素B(ACM-B)对单纯疱疹病毒Ⅱ型(HSV-2)复制及其DNA聚合酶活性的影响。实验采用单层Vero细胞,空斑降低测定用来评价实验结果。加入ACM-B,明显地降低病毒空斑的形成。当ACM-B剂量大于0.3μm时,空斑数降低到零,表明ACM-B抑制HSV-2的复制。另外,ACM-B也抑制HSV-2诱导的DNA聚合酶活性。这提示,药物对HSV-2复制的抑制作用可能是由于对病毒DNA合成的抑制。吸收光谱分析证实,ACM-B能与活化DNA模板相互作用。ACM-B也抑制E.Coli DNA pol.Ⅰ及L1210DNA pol.α,证明ACM-B对HSV-2 DNApol.的抑制是非选择性的.ACM-B对HSV-2复制的抑制效应较ACM-A强,而细胞毒性效应也较后者为高。

    This paper reports the inhibition actions of isoprinosine, cyclocytidine and their combination to HSV-1 and HSV-2 on primary rabbit kidney cell culture and has discussed the experimental results. The minimum toxic doses of isoprinosine and cyclocytidine are 5 mg and 0.5 mg per millilitre, respectively. The combination of the two drugs can slightly reduce the toxity of isoprinosine. When the viral infectivity dose of 10 TCID 50/0.1mi was used to infect cell culture, isoprinosine which doses...

    This paper reports the inhibition actions of isoprinosine, cyclocytidine and their combination to HSV-1 and HSV-2 on primary rabbit kidney cell culture and has discussed the experimental results. The minimum toxic doses of isoprinosine and cyclocytidine are 5 mg and 0.5 mg per millilitre, respectively. The combination of the two drugs can slightly reduce the toxity of isoprinosine. When the viral infectivity dose of 10 TCID 50/0.1mi was used to infect cell culture, isoprinosine which doses are from 125 to 750 ug/ml exhibit antiviral action. Cyclocytidine which doses are 2.5 ug/ml and 5.0 ug/ml or higher can partly and completly reduce the production of HSV, respectively. By combining isoprinosine with cyclocytidine, the two drug doses can be decreased, especially that of latter, and the antlviral actions to HSV-1 and HSV2 exhibit subplusaction and plusaction, respectively. When isoprinosine and cyclocytidine were given within 6 and 24 hours after infecting cell culture using a dose of 10 TCID 50/0.1ml, respectively, they exhibit antiviral actions, otherwise no this action.

    在原代兔肾细胞上研究异丙肌苷、环胞苷及其联合应用对HSV-1、HSV-2的抑制作用,结果表明异丙肌苷抗病毒作用较环胞苷弱,二者联合应用对HSV-1、HSV-2的抑制作用分别为次相加和相加作用。

    The results of observation on experimental photolocalization and photochemotherapy with a new drug photocarcinorin (PsD-007) and argon laser (514.5+ 488nm) for different transplanted animal tumors are reported.The interrelationship among the dose of light irradiation,dose level of the drug and the efficiency of experimental photodiagnosis and photochemotherapy for animal tumors was studied.It has been shown that the degree of photodynamic damage on tumors is proportional to the light dose.The upper and lower...

    The results of observation on experimental photolocalization and photochemotherapy with a new drug photocarcinorin (PsD-007) and argon laser (514.5+ 488nm) for different transplanted animal tumors are reported.The interrelationship among the dose of light irradiation,dose level of the drug and the efficiency of experimental photodiagnosis and photochemotherapy for animal tumors was studied.It has been shown that the degree of photodynamic damage on tumors is proportional to the light dose.The upper and lower thresholds of effective light-dose seem to be about 150 mw/cm2 and 40 mw/cm2 for 30 min respectively.The light dose for curing half of experimental animals ranged from 80 to 100 mw/cm2 for 30 min with a drug dose of 5mg/kg.The photodynamic damage on tumors in closely correlated to drug dose with a given light dose.The photodynamic effects on different tumors are essentially consistent with each other.A bright oranged-red fluorescence appeared on the fumor tissues of S180 sarcoma,Lewis lung carcinoma or U14 cervical carcinoma bearing mice on exposure to argon laser and/or UV light (365nm) 24 and 48 h after the injection of 5mg/kg of PsD-007.But no fluorescence was found on the normal tissues around the tumors under the same conditions.It is suggested that PsD-007 may be specifically uptaken into the malignant tissues.The intensity of fluorecence on tumors is directly proportional to drug dose and inversely proportional to the time interval between drug administration and observation on the fluorescence.The homogeneity of distribution of light energy was improved by using a "lens aperture" placed between the light source and irradiated animal.A model system was thus provided for the evaluation of the efficiency of drugs in the photochemodiagnosis and photochemotherapy for animal tumors.

    本文报道了肿瘤光化学诊治新药癌光啉(PsD-007)对三种动物移植瘤(S_(180)肉瘤、Lewis肺癌、U_(14)宫颈癌)的实验性光化学诊治效果,初步探讨了辐照光能量和药物剂量与肿瘤实验性诊治效果的关系。作者采用“透镜光阑”法改善辐射光斑内功率密度分布的不均匀性。提供了一种能比较客观地评价药物对动物移植瘤的光动力学治疗效价的模型体系。

     
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