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   gene p 53 的翻译结果: 查询用时:0.009秒
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gene p
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  癌基因p53
     Objective To explore the association between the polymorphism of metabolic genes(GSTT1、GSTM1、CYP1A1) and tumor suppression gene p53 coden 72 and human longevity.
     目的:探讨代谢相关基因GSTT1、GSTM1、CYP1A1及抑癌基因p53第4外显子第72位密码子(codon72)与人类长寿的关系。
短句来源
     This paper reviews advance s of tumor suppressor gene p53,DCC,nm23,TIMP,p21,p16,bcl X etc al in tumor su ppressor gene therapy for malignant tumors.
     就抑癌基因p53,DCC,nm23,TIMP,p21,p16,bcl X等在恶性肿瘤基因治疗方面的研究进展作一综述。
短句来源
     Interaction of suppressor gene p53 and oncogene   mdm2 in human glandular lung cancer cell line GLC82
     抑癌基因p53与癌基因mdm2在肺腺癌细胞系GLC-82中的相互作用
短句来源
     Methods Expression of tumor supressor gene P53 and oncogene ras,c-erbB-2 were detected by immunohistochemical Sp methods in 62 cases of gastric cancer.
     方法 :应用免疫组化Sp法检测 62例胃癌中抑癌基因P5 3、癌基因ras和c -erbB -2的蛋白表达。
短句来源
     THE RELATIONSHIP BETWEEN SALIVARY GLAND TUMOUR AND OVEREXPRESSION OF ONCOGENE C-MYC,TUMOUR SUPPRESSOR GENE P53,INFECTION OF HUMAN PAPILLOVIRUS.
     涎腺肿瘤与癌基因c-myc、抑癌基因P53和人类乳头状病毒感染的关系
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  基因p53
     Apoptosis in supratentorial astrocytomas and expression of apoptosis related gene p53 and bcl-2
     幕上星形细胞瘤的凋亡及相关基因p53、bcl-2的表达
短句来源
     Expression of protein encoded by apoptosis-associated gene p53, Bcl-2,and Bax in adaptive response of thymocyte apoptosis in miceinduced by low dose radiation with X-rays
     低剂量X线照射诱导小鼠胸腺细胞凋亡适应性反应的相关凋亡基因p53、Bcl-2和Bax蛋白表达
短句来源
     3. The level of related Gene p53 mRNA、 bax mRNA、 bcl-2 mRNA was evaluated by RT-PCR methods.
     4.Bcap-37细胞经不同浓度MSZ处理48小时后,RT-PCR法检测相关基因p53 mRNA、bax mRNA、bcl-2 mRNA的表达。
短句来源
     Purpose To explore the expression of apoptosis-related gene p53 and bcl-2 in gastrointestinal stromal tumors(GISTs)and their relation to the prognosis.
     目的探讨细胞凋亡相关基因p53和bc l-2在胃肠道间质瘤(gastrointestinal strom al tumors,G ISTs)中的表达与预后关系。
短句来源
     Apoptotic rate and expression of tumor suppressor gene p53 and Bcl-2 were detected by flow cytometry(FCM).
     通过流式细胞仪(FCM)观察KLE细胞的凋亡率及凋亡基因p53和Bcl-2在诱导细胞凋亡中的作用。
短句来源
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  p53基因
     The Expression and Significance of Gene p53, CCK-B and SSTR-2 Receptor in Pancreatic Carcinomas
     P53基因、CCK-B和SSTR-2受体在胰腺癌中的表达及临床意义
短句来源
     Both p33ING1 and wild-type p53 are tumor suppressor genes. Gene p33ING1 is the molecular chaperon of gene p53.
     p33ING1和野生型p53基因都是抑癌基因,p33ING1是p53的分子伴侣。
短句来源
     Methods PCR-SSCP and Immunohistochemistry techniques were used to detect for LOH of p53 gene, p53 gene mutation and protein accumulation in 56 ESCC.
     方法采用聚合酶链反应—单链构象多态性分析(PCR-SSCP)和免疫组织化学方法(SP)检测56例ESCC中p53基因LOH和p53基因蛋白的表达情况。
短句来源
     Conclusions The (combining) polymorphism of metabolic gens GSTT1, GSTM1,CYP1A1 and tumor suppression gene p53 codon 72 might involve in the human longevity in Bama area which mechanism needs further studies.
     结论:GSTT1、GSTM1、CYP1A1及p53基因的多态性与人类长寿有着较为密切的联系,其具体作用机制有待进一步研究。
短句来源
     Gene p53 point mutation and protein expression in human malignant mesothelioma
     恶性间皮瘤p53基因点突变和蛋白表达
短句来源
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  “gene p 53”译为未确定词的双语例句
     The relationship of cancer suppressor gene p53 with HBV in hepatocellular carcinoma
     The relationship of cancer suppressor gene p53 with HBV in hepatocellular carcinoma
短句来源
     Expression of P21,P53 protein and mutation of k-ras gene, P53 gene in colorectal carcinoma
     大肠癌P21、P53蛋白表达和k-ras基因、P53基因突变研究
短句来源
     Expression of P21, P53 Protein and Mutation of K -ras Gene, p53 Gene in Colo rectal Carcinoma
     大肠癌P21、P53蛋白表达和K-ras基因、p53基因突变研究
短句来源
     THE EXPRESSIONS OF TELOMERASE PROTEIN hTRT GENE,P53,N-ras,nm23H1, PCNA AND THEIR RELATIONSHIP IN SMALL HEPATOCELLULAR CARCINOMA(SHC)
     小肝癌中端粒酶蛋白hTRT基因检测与P53、N-ras、nm23H1、PCNA表达及其相关性研究
短句来源
     Expression regularity and its clinical significance of gene p53V and p16 in tumor tissue of patients with lung cancer
     肺癌组织中p53V和p16基因的表达及临床意义
短句来源
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  gene p
Further, the renal taurine transporter gene is down-regulated by the tumor suppressor gene p53, and up-regulated by the Wilms tumor (WT-1) and early growth response-1 (EGR-1) genes.
      
To elucidate the involvement of murine-double-minute (mdm)2 gene amplifications and mutations of the tumor suppressor gene p53 in the tumorigenesis of malignant gliomas we analyzed a series of 75 glioblastomas.
      
Taken together, oxidative stress and oxidative tissue damage, and a cascade of cellular events including modulation of apoptotic regulatory gene p53 are involved in chromium (VI)‐induced toxicity and carcinogenesis.
      
CK2 cooperates in transforming cells with other lymphoid oncogenes such as myc and tal-1, and here we show cooperativity with loss of the tumor suppressor gene p53.
      
The tumor suppressor gene p53 has been identified as the most frequent target of genetic alterations in human cancers.
      
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This is the first report of cytogenetic study of flag leaf position in common wheat, Triti-cum aestivum L. F1 and F2 analyses by monosomics and telocentrics indicated that 2D chromosome of Chinese Spring carried at least two genes for pendulous flag leaves, ie. P1 on 2DL and P3 on 2DS; gene (s) E for erect flag leaves on the same chromosome of Xiaoyan No. 6. Gene P1 expressed fully, and P2 partially. Relativizing gene E, P1 and P2 were dominant and recessive...

This is the first report of cytogenetic study of flag leaf position in common wheat, Triti-cum aestivum L. F1 and F2 analyses by monosomics and telocentrics indicated that 2D chromosome of Chinese Spring carried at least two genes for pendulous flag leaves, ie. P1 on 2DL and P3 on 2DS; gene (s) E for erect flag leaves on the same chromosome of Xiaoyan No. 6. Gene P1 expressed fully, and P2 partially. Relativizing gene E, P1 and P2 were dominant and recessive respectively, and vice versa. The chromosome manipulation of these genes was also discussed.

本文首次对小麦旗叶姿态进行了比较系统的细胞遗传学研究。单体、端体的F_1及F_2分析表明:中国春2D染色体上至少有两个旗叶下披基因,即位于2DL上的P_1和2DS上的P_2,前者表达能力很强,后者则较弱,与小偃6号旗叶直立基因共存时分别表现为显性和隐性;小偃6号的旗叶直立基因E也位于2D染色体上,同(P_1+P_2)共存时表现为隐性,仅与P_2共存时则表现为显性。文章还就这些基因的染色体操作等进行了讨论。

Allelotype and point mutation of p53 exon 7 were detected in 45 pairs of primary hepatocellular carcinoma (PHC) by restriction fragment length polymorphism (RFLP) and polymerase chain reaction (PCR). Thirty -one gene markers covered 14 chromosomes were used including suppressor genes p53 and RB1. The results showed 19 gene markers covered 8 chromosomes revealed loss of heterozygosity. Six of 28 informative cases showed loss on 6q21 using probe pJCZ30, which had not been reported before....

Allelotype and point mutation of p53 exon 7 were detected in 45 pairs of primary hepatocellular carcinoma (PHC) by restriction fragment length polymorphism (RFLP) and polymerase chain reaction (PCR). Thirty -one gene markers covered 14 chromosomes were used including suppressor genes p53 and RB1. The results showed 19 gene markers covered 8 chromosomes revealed loss of heterozygosity. Six of 28 informative cases showed loss on 6q21 using probe pJCZ30, which had not been reported before. The allele loss was low frequent on the other chromosomes including p53 and RBI.Fourty-five cases of PHC from areas of low aflatoxin Bl (AFB1) exposure but high risk to HBV were examined for identifying point mutation of p53 exon 7 by PCR and restriction enzyme analysis using Rsa Ⅰ, Msp Ⅰ, Hae Ⅲ site at codon 229, 247 and 249, respectively. Two of 45 cases showed point mutation at codon 247 and 249, respectively. Our results indicated that changes of molecular genetics on PHC is a complex event, and there are multiple steps, and multiple genes are involved in hepatocarcinogenesis. Meanwhile, the results supported the postulated role of AFB1 together with HBV in the generation of specific mutation of the p53 gene provide evidence to suggest that HBV infection alone-or exposure to AFB1 alone do not contribute to these base changes.

作者应用Southern杂交和PCR扩增技术,分析了45例配对的原发性肝癌及其癌旁肝组织的等位基因型和p53第七外显子的突变状况.共应用了位于14对染色体的31个基因标志,结果在8对染色体的19个基因位点出现不同程度的杂合型丢失(LOH),丢失频率3.2%~23.5%.其中第6对染色体的pJCZ30位点的LOH为首次报告.应用PCR扩增后限制性酶切,分析了p53第七外显子的229,247和249三个密码子,结果仅2例癌组织分别在247和249密码子出现点突变.本实验结果表明,原发性肝癌的分子遗传学变化是复杂的,不同原因(HBV,黄曲霉毒素)相关的原发性肝癌,其等位基因的变化和LOH的频率存在差异,特别是p53基因第249密码子的特征性点突变差别显著,说明原发性肝癌的发生是一多基因变化,多步骤的过程.

24 female Goats were superovulated with Gonadotrophins. About 48h after first mating,total 155 ova were recovered from 16 stimulated donors. The ova recovery rate was 79.08%(155/196).The average number of ova produced by per donor was about 12.25%(196/16). Pronuclei or nuclei in atotal of 65 one-celled zygotes and 29 two-four cell stage embryos were visualized under Normarski IC microscope, and microinjected with Human Growth Hormone Gene(p~(SMGHI)/BamHI) respectively. 91 injected zygotes and embryos...

24 female Goats were superovulated with Gonadotrophins. About 48h after first mating,total 155 ova were recovered from 16 stimulated donors. The ova recovery rate was 79.08%(155/196).The average number of ova produced by per donor was about 12.25%(196/16). Pronuclei or nuclei in atotal of 65 one-celled zygotes and 29 two-four cell stage embryos were visualized under Normarski IC microscope, and microinjected with Human Growth Hormone Gene(p~(SMGHI)/BamHI) respectively. 91 injected zygotes and embryos were transferred surgically into 14 synchronized recipients. After embryotransfer, 7 recipients became pregnant, and total 12 lambs were born, 11 alive and one dead at parturition.The frequency of hGH integration was examinated by using DNA probes labeled with NonradioactiveDigoxigenin. Results showed that 4 in 12 tested lambs carried the foreign genes, the integration frequencywas 33.33%(4/12). Gene expression in 4 living lambs (2 hGH gene integration positive, 2 negative) wasdetected by ELISA, and no one exprcsscd humane Growth Hormone in plasma.

对24头供体山羊进行超数排卵处理,16头超排有效。在第1次配种后48h左右取卵,共收集到卵155个。回收率79.08%(155/16)。平均每头供体排卵12.25个(196/16)。在Normarski干涉相差显微镜下观察65个单细胞受精卵及29个2~4细胞期胚胎的原核及细胞核,并分别注射人生长激素基因(p~(SMGHI)/BamHI),其中91枚移植到经同期发情处理的14头受体中。结果7头妊娠,共产活羔11头,死胎1头。经用Digoxigcnin标记核酸探针对转移基因羊检测,4头整合了外源基因。整合频率为33.33%(4/12)。采用酶联免疫吸附法(ELISA)对仍存活的2头未整合、2头整合羊检测是否表达外源基因,全为阴性。

 
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