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   myc genes 的翻译结果: 查询用时:0.158秒
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myc genes     
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  myc基因
     Objective: To investigate the effects of interferon α(IFN α) and IFN α combined with granulocytic macrophage colony stimulating factor(GM CSF) on expression of bcr abl, bcl 2 and c myc genes in the mononuclear cells(MNCs) from bone marrow(BM) of the patients with chronic myelogenous leukemia at chronic phase(CML CP).
     目的 :探讨IFN α及IFN α联合GM CSF调节慢性期慢性粒细胞白血病 (CML CP)患者骨髓单个核细胞(MNCs) bcr abl,bcl 2 和 c myc基因表达的影响。
短句来源
     Immunohistochemistry was used to detect expression of P53,Cmyc genes in mice.
     免疫组化法检测HSV 2、C型病毒致瘤后P53、C myc基因表达的变化.
短句来源
     Objective:To study the expression of CD44V6,RB and C myc genes and determine whether the three genes were related to pancreas carcinogenesis and prognosis.
     目的 :通过CD44V6 ,RB ,C myc基因表达 ,探讨三种基因蛋白对胰腺肿瘤的发生及预后的影响。
短句来源
     The expression of ced\|3,ced\|4,ced\|9,p53, bc1\|2,c\|myc genes plays a crucial role in apoptosis process.
     介绍 ced- 3,ced- 4 ,ced- 9,p53,bc1- 2 ,c- myc基因在细胞凋亡中的调控作用 .
短句来源
     Alterations of N ras、c myc genes and the expression of their proteins in human osteosarcoma
     骨肉瘤N-ras、c-myc基因异常及其蛋白产物的表达
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  myc基因的
     EXPRESSION AND SIGNIFICANCE OF BCL 2 AND C MYC GENES IN COLORECTAL TUMORS
     大肠肿瘤bcl-2和C-MYC基因的表达及其意义
短句来源
     Methods:Expression of bcl 2,bax and c myc genes in hepatocarcinomas were detected with immunohistochemical ABC method.
     方法 :利用免疫组化法 ,检测肝癌中bcl 2、bax和c myc基因的表达 ;
短句来源
     HSV2,type C virus can induce development of leukemia in mice by modifying expressions of P53,Cmyc genes. 
     HSV 2、C型病毒可以通过调节P53、C myc基因的表达从而诱导小鼠白血病的发生.
短句来源
  myc癌基因
     The cells were continuously cultivated in vitro and the dynamic characteristics of Haras, Kiras and cmyc genes expression in the oval cells were detected using RNADNA slot blot hybridization.
     在培养过程中,通过RNADNAslotblot杂交方法,动态观察Haras、Kiras和cmyc癌基因的表达变化。
短句来源
     (2) There was significant enhanced expression of ras and myc genes in penile cancer and cervical cancinomas compared with genital warts.
     ②C-Ha-ras及C-myc癌基因在阴茎癌及宫颈癌中表达较生殖器疣中均显著增强(P<0.001);
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  “myc genes”译为未确定词的双语例句
     Objective\ To investigate the expression of bcl 2 and C MYC genes in colorectal carcinoma and adenoma and their clinical significance.
     目的探讨大肠癌和大肠腺瘤中细胞凋亡相关基因bcl-2和C-MYC的表达及临床意义。
短句来源
     The c myc genes expression in control group [(2.73±0.51)]was obviously higher than that of normal artery [(0.82±0.09), P <0.05],and the c myc genes expression in active group [(1.44±0.25), P < 0.05] was reduced but still higher than that of normal artery( P <0.05).
     对照组c mycmRNA相对表达强度为 (2 .73± 0 .5 1) ,明显高于正常动脉 [(0 .82± 0 .0 9) ,P <0 .0 5 ],普罗布考组c mycmRNA相对表达强度为 (1.44± 0 .2 5 ) ,较对照组减弱 (P <0 .0 5 ) ,但仍高于正常动脉 (P <0 .0 5 )。
短句来源
     Analysis of transgene copies and tumor development in mice bearing myc genes
     分析myc小鼠的转基因复本和肿瘤发生
短句来源
     Analysis of transgenic copies and tumor development in mice bearing myc genes
     分析myc小鼠的转基因复本和肿瘤发生
     Objective: To study the effect of compound Chinese drug Bailong on the transcription of Cyclin Dependent Kinase Inhibitor (CKI) p16 INK4a , p21 and Rb, c myc genes, and the relationship between gene expression and cAMP PKA pathway.
     目的 :探讨复方中药白龙 (简称白龙 )对人胃癌BGC82 3G1期细胞周期蛋白激酶抑制因子(CKI) p16INK4a、p2 1以及Rb、c myc等基因转录的影响和cAMP PKA信号通路的调节关系。
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  myc genes
We found that the expression of the c-fos and c-jun genes, but not of thelyn and c-myc genes, was augmented 2- to 20-fold in histologically normal skin and muscle of these mice.
      
In one cell line, KHC287, amplified c-myc genes were localized in two chromosomes and Ki-ras in three chromosomes.
      
Thus, the TG and c-myc genes map to the same chromosome band in normal human cells.
      
Proximity of thyroglobulin and c-myc genes on human chromosome 8
      
A v-myc probe, containing sequences from the 3' domain of the gene, hybridized to single human HindIII and mouse EcoRI genomic DNA fragments of the cellular myc genes whose segregation could be followed in interspecies somatic cell hybrids.
      
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A recently devised protocol was used to obtain macrophage (M) lines with a variety of derived DNA to see if different oncogenes would lead to generation of M lines with different phenotypes. SV 40 DNA, cellular myc genes, U 937 DNA and Insulin gene have been used and 7 cell lines obtained. All these lines show heterogeneity in the cell phenotype and in each case there are Macrophage-like cells. They all secrete collagenase and lysozyme. 30-40% of these lines have Fc receptor and Fc receptor mediated...

A recently devised protocol was used to obtain macrophage (M) lines with a variety of derived DNA to see if different oncogenes would lead to generation of M lines with different phenotypes. SV 40 DNA, cellular myc genes, U 937 DNA and Insulin gene have been used and 7 cell lines obtained. All these lines show heterogeneity in the cell phenotype and in each case there are Macrophage-like cells. They all secrete collagenase and lysozyme. 30-40% of these lines have Fc receptor and Fc receptor mediated phagocytosis and also complement receptor and phagocytosis. Heterogeneity within the lines is probably due to the fact that the lines are not cloned yet, It is supposed that this protocol can be used not only to derive M lines but also T and B cell lines.

本文报告应用转染技术建立巨噬细胞传代株,探讨应用不同来源的DNA获得具有不同功能特性的巨噬细胞株,应用SV40DNA、C-myc基因,U937DNA和胰岛素基因已获得7株细胞,经鉴定它们均有巨噬细胞的特性,即可分泌胶元酶、溶菌酶,其中有30—40%的细胞带有Fc受体,并有经Fc受体介导的吞噬功能。细胞株内细胞功能各异是因为细胞株尚未克隆化。从本试验结果看不仅经转染方法可获得巨噬细胞株,而且有可能经此法获得B或T淋巴细胞传代株。

Expression of seven oncogenes and their cha nges after induced differentiation in a HGPRT- human promyelocytic leukemia cell mutant (HL-60-AR) were studied by Northern blot and dot blot techniques. Results indicated that in HL-60-AR cells, the c-myc gene was highly expressed, while oncogenes of H-ras, fos, sis, abl and erb-B although expressed actively, yet lower than that of c-myc. The expression of K-ras gene, however, was weak or undetectable. When HL-60-AR cells were chemically induced...

Expression of seven oncogenes and their cha nges after induced differentiation in a HGPRT- human promyelocytic leukemia cell mutant (HL-60-AR) were studied by Northern blot and dot blot techniques. Results indicated that in HL-60-AR cells, the c-myc gene was highly expressed, while oncogenes of H-ras, fos, sis, abl and erb-B although expressed actively, yet lower than that of c-myc. The expression of K-ras gene, however, was weak or undetectable. When HL-60-AR cells were chemically induced to differentiate, the expression of c-myc was significantly decreased. Decrease in expression of H-ras, fos, sis, abl and erb-B oncogenes could also be observed, but without change of K-ras during cell differentiation. Our data also indicated that the decrease in c-myc gene expression after induced differentiation was not due to the decrease of number of c-myc gene copy, but mainly a transcriptional regulation pf c-myc.

用Northern杂交和斑点杂交方法分别探测HL-60-AR细胞中七种癌基因的表达及其在诱导分化后的变化。结果表明,在HL-60-AR细胞中c-myc基因高度活跃表达,H-ras基因次之,fos、sis、abl和erb-B基因表达微弱,而K-ras基因表达极微弱或检测不出。当HL-60-AR细胞被药物诱导成熟分化后,c-myc基因表达大为下降,H-ras、fos、sis、abl和erb-B基因表达亦相应降低,而K-ras的表达则无变化。对诱导分化前后c-myc基因拷贝数的比较分析表明,c-myc基因表达下降可能主要发生在基因的转录或/和转录后调节水平。

Expression of c-myc oncogene of myeloma cells and their changes after hybridization in homo-and hetero-cellular cybrid and hybrid were studied with Northern-blot and dot-blot techniques, using cloned c-myc gene as a probe. Results indicated that c-myc oncogene transcripts could not be detected in cybrids of mouse X mouse (BW-RM), mouse X rabbit (BW-RR) and human X mouse (HMy-RM) hybridization. However, weak transcription of this oncogene was shown to be active in cybrids after 15th passages...

Expression of c-myc oncogene of myeloma cells and their changes after hybridization in homo-and hetero-cellular cybrid and hybrid were studied with Northern-blot and dot-blot techniques, using cloned c-myc gene as a probe. Results indicated that c-myc oncogene transcripts could not be detected in cybrids of mouse X mouse (BW-RM), mouse X rabbit (BW-RR) and human X mouse (HMy-RM) hybridization. However, weak transcription of this oncogene was shown to be active in cybrids after 15th passages with a tendency of increasing expression activity noted during later subcultures. Similarly, no detectable c-myc gene transcript was seen in 4th and 7th subcultures of hetero-cellular hybrids (mouse plasmocytoma Sp 2/0 X rat erythroblasts, SP-ER), suggesting that "cy-toplasmic factor" of erythroid cells could inhibit or reduce expression of originally active c-myc, the inhibition being nonspecific in both cybrid and hybrid and reduction of expression of oncogene closely related to decrease or reversion of malignancy of tumor cells. Mechanisms of regulatory effects of erythroid cell cytoplasmic factors and molecular basis for oncogene repression in tumor cells were discussed.

本实验用Northern杂交方法,以c-myc癌基因为探针,对人和小鼠骨髓瘤细胞以及杂交后的同种和异种胞质体杂交细胞和异种杂交细胞进行了癌基因表达的核酸分子杂交分析。结果表明,在小鼠-小鼠,小鼠-兔及人-小鼠的胞质体杂交细胞(BW-RM,BW-RR,HMy-RM)中均未检测到myc癌基因的表达产物。但自15代以后开始出现微弱或可测的表达活性,并随传代而有上升的趋向。同样,在小鼠浆细胞瘤(Sp2/o)与大鼠有核红细胞(ER)的异种杂交中,杂交细胞(SpER)的第4代和第7代细胞中亦未检查到myc基因转录物。表明细胞杂交后,myc基因受到了抑制。这种抑制作用似无种属特异性。这一结果提示红系细胞内“胞质因子”对肿瘤细胞原来活化的myc基因具有抑制作用,并与杂交细胞的恶性下降有关。论文对胞质因子对癌基因表达的调控作用及其分子生物学机理进行了讨论。

 
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