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urge incontinence
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  急迫性尿失禁
     Results The overall prevalence of UI was 38.5 %(2008 / 5221), among theses women, 22.9%(1197/ 5221)、had stress incontinence, 2.8%(147/ 5221)urge incontinence and 12.4% (649/ 5221)mixed incontinence. In multiple logistic models, age, delivery mode, smoking,hypertension, constipation, body mass index, chronic pelvic pain (CPP) were relation factors for stress incontinence.
     被调查的对象年龄22~99,平均年龄(46±17)岁。 北京地区成年女性尿失禁的患病率为38·5%(2008/5221),压力性尿失禁、急迫性尿失禁和混合性尿失禁的患病率分别为22·9%(1197/5221)、2·8%(147/5221)和12·4%(649/5221)。
短句来源
     Backgrounds and AimsOveractive bladder (OAB) is defined as urgency, with or without urge incontinence usually with frequency and nocturia.
     膀胱过度活动症(overactive bladder,OAB)是一种以尿急症状为特征的征候群,常伴有尿频和夜尿症状,可伴或不伴有急迫性尿失禁
短句来源
     Trospium chloride is a new available marketing anticholinergic drug to treat the overactive bladder with urge incontinence,which directly and competitively blocks the contractile effect of acetylcholine on the smooth musculature of human urinary bladder through binding linkage to the muscarinic M_1,M_2,and M_3 re- ceptor subtypes.
     曲司氯铵为新近上市的用于治疗伴有急迫性尿失禁症状的膀胱过度活动症的抗胆碱药物,具有抗胆碱能神经末梢M_1,M_2,M_3受体的作用,从而拮抗乙酰胆碱对人膀胱平滑肌的收缩效应。
短句来源
     Methods:Thirty-six patients with detrusor hyperreflexia had urodyuamic study,their detrusor leak point pressure(DLPP)was all more higher 40cm H2O,the average DLPP was 82.4 cmH2O. All cases had serious urge incontinence.
     方法36例脊髓损伤的患者经尿动力检查证实存在明确的逼尿肌反射亢进,逼尿肌漏尿点压力均大于40cmH2O,平均82.4cmH2O,并伴有严重的急迫性尿失禁
短句来源
     Clinical situation is urinary frequency,urgency of urination and urge incontinence.
     膀胱逼尿肌活动亢进是下尿路症状的常见原因,临床上表现为尿频、尿急和急迫性尿失禁,是膀胱储尿功能障碍的表现。
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  尿失禁
     The incidence rates of urge incontinence and stress incontinence were 19.8% (with 3.1% often) and 14.5% (with 1.9% often), respectively.
     紧迫型尿失禁和压力型尿失禁的发病率分别为19 8%(3 1%为经常发生 )和 14 5 %(1 9%为经常发生 )。
短句来源
     Results The overall prevalence of UI was 38.5 %(2008 / 5221), among theses women, 22.9%(1197/ 5221)、had stress incontinence, 2.8%(147/ 5221)urge incontinence and 12.4% (649/ 5221)mixed incontinence. In multiple logistic models, age, delivery mode, smoking,hypertension, constipation, body mass index, chronic pelvic pain (CPP) were relation factors for stress incontinence.
     被调查的对象年龄22~99,平均年龄(46±17)岁。 北京地区成年女性尿失禁的患病率为38·5%(2008/5221),压力性尿失禁、急迫性尿失禁和混合性尿失禁的患病率分别为22·9%(1197/5221)、2·8%(147/5221)和12·4%(649/5221)。
短句来源
     Results Urge incontinence had a higher prevalence rate, with 36.6% to 41.6% of the elderly having at least an occasional problem (with 7.5% to 9.6% having problems often), compared to 23.4% to 28.8% having at least an occasional problem with stress incontinence (with 3.3% to 5.0% having problems often).
     结果 紧迫型尿失禁的患病率较高 ,36 6 %- 4 1 6 %的老年人曾经发生过紧迫型尿失禁 ,7 5 %- 9 6 %的老年人经常发生紧迫型尿失禁。 压力型尿失禁的患病率为 2 3 4 %- 2 8 8%,3 3%- 5 %的老年人经常发生压力型尿失禁
短句来源
     Backgrounds and AimsOveractive bladder (OAB) is defined as urgency, with or without urge incontinence usually with frequency and nocturia.
     膀胱过度活动症(overactive bladder,OAB)是一种以尿急症状为特征的征候群,常伴有尿频和夜尿症状,可伴或不伴有急迫性尿失禁
短句来源
     Result:Thirty-two patients had improvement 4~8 weeks after tolterodine,their maximum residue bladder volume were more than 300ml,comparing with that they would have urge incontinence when the bladder capacity averaged 160ml.
     结果4~8周后32例患者最大导尿容量均大于300ml,与治疗前首次无抑制收缩并发生尿失禁时的平均膀胱容量160ml相比明显增加,其中20例完全无尿失禁发生,获得满意效果,12例患者偶发尿失禁治疗有效,4例患者最大导尿容量小于200ml,治疗无效。
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  urge incontinence
In two patients cholinesterase inhibition treatment caused urge incontinence, indicating detrusor denervation supersensitivity.
      
Each new modality needs to prove its efficacy in common indications for voiding dysfunction such as refractory urgency-frequency, urge incontinence, and perhaps urinary retention, as well as in select patient populations and subgroups.
      
Lasting symptomatic improvement of more than 50% was achieved in 16 of 21 patients with motor urge incontinence (76.2%) and in 22 of the 28 patients with urinary retention (78.6%).
      
Chronic neuromodulation should be considered predominantly in patients with urinary retention and in patients with motor urge incontinence who refuse temporary techniques or who require too much effort to achieve a sustained clinical effect.
      
S3 nerve root neuromodulation is becoming an accepted therapy for individuals afflicted with lower urinary tract symptoms, such as idiopathic urinary urge incontinence, frequency, urgency, and urinary retention, who fail current standard therapies.
      
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Toevaluate the two interventions by the urodynamic method postoperatively, urodynamic investigations were performed in 61 cases with clinical BPH after prostatectomy for 2 weeks and 4~6 months, respectively 26 of these were carried out with Madigan prostatectomy (Group 1), 35 of these were carried out with suprapubic transvesical prostatectomy (Group 2), which were randomized Results: Results of first investigation revealed that bladder capacity required evoke a first desire to void (FD), incidence of detrusor...

Toevaluate the two interventions by the urodynamic method postoperatively, urodynamic investigations were performed in 61 cases with clinical BPH after prostatectomy for 2 weeks and 4~6 months, respectively 26 of these were carried out with Madigan prostatectomy (Group 1), 35 of these were carried out with suprapubic transvesical prostatectomy (Group 2), which were randomized Results: Results of first investigation revealed that bladder capacity required evoke a first desire to void (FD), incidence of detrusor instability( DI ) and urge incontinence(UI) were significant different between two groups Group 2 FD was significantly decreased than group 1(P<0 01) Group 2 DI and UI were significantly increased than group 1(P<0 01) The second investigative results revealed that there were no significant difference between two groups(P>0 05) Conclusions: It was suggested that DI could be a role that caused clinical symptoms after prostatectomy The advantages of Madigan prostatectomy were the preservation of bladder neck and prostatic urethra, therefore, DI was decreased, It was beneficial to improve postoperative symptom

为比较两种术式术后尿动力学改善的差异 ,将 2 6例Madigan手术与随机抽取的同期 35例经膀胱前列腺切除术术后进行尿动力学比较 ,术后拔尿管后 1周进行第 1次尿动力学检查 ,术后 4~ 6个月进行第 2次检查 .结果 :(1)初次尿意容量 (FD) :第 1次检查两组间有显著性差异 ,Madigan组大于经膀胱组 (P <0 0 1) ;第 2次检查两组间无显著性差异 (P >0 0 5) .(2 )逼尿肌不稳定 (DI)发生率 :第 1次检查两组间有显著性差异 ,Madigan组低于经膀胱组 (P <0 0 1) ;第 2次检查两组无显著性差异(P >0 0 5) .(3)急迫性尿失禁发生率 :第 1次检查两组间有显著性差异 (P <0 0 5) ,第 2次检查无显著性差异 (P >0 0 5) .结果表明 :逼尿肌不稳定是引起BPH术后患者临床症状的主要因素之一 ,Madi gan手术由于保持了膀胱颈及后尿道的完整性 ,其逼尿肌不稳定发生率低 ,有利于患者术后临床症状迅速改善 .

To describe the surgical methodology, effects and complications of sacral nerve stimulation (SNS), and discuss the mechanism and result of SNS for the treatment of voiding dysfunction. There were 4 patients suffering respectively from urge incontinence, frequency urgency syndromes, urinary retention and neurogenic bladder due to sacrococcygeal defect When good responses were obtained in test stimulation of the sacral nerve in all patients, the implantation of InterStim device was performed After test...

To describe the surgical methodology, effects and complications of sacral nerve stimulation (SNS), and discuss the mechanism and result of SNS for the treatment of voiding dysfunction. There were 4 patients suffering respectively from urge incontinence, frequency urgency syndromes, urinary retention and neurogenic bladder due to sacrococcygeal defect When good responses were obtained in test stimulation of the sacral nerve in all patients, the implantation of InterStim device was performed After test stimulation, all of the parameters (such as voiding frequency, voiding volume, urge incontinence, pad test, retention volume) were improved by over 75%.They were also significantly improved after the implantation ( P <0 05) It suggested that SNS is a clinically efficacious new technique, and it offers an alternative treatment for the patients with refractory voiding dysfunction

对 4例临床确诊为急迫性尿失禁、尿频尿急症、尿潴留、骶柱裂排尿障碍的患者先进行试验性刺激 ,得到满意的症状改善后施行骶神经刺激InterStim装置永久性植入术 ,以探讨骶神经刺激术治疗排尿功能障碍的手术方法、疗效评估、并发症及其机制。结果表明 ,试验刺激后患者排尿次数、尿量、尿失禁次数和数量、残余尿量均获得 75 %以上的改善 ,永久性植入术后上述各客观指标也获得了显著性改善 (P <0 0 5 ) ,无明显手术并发症。提示骶神经刺激是一项疗效确切、临床可行的新技术 ,它为那些对常规治疗无效的难治性排尿功能障碍者提供了一条新的治疗途径

Objective To evaluate the efficacy and tolerability of tolterodine in patients with an overactive bladder. Methods A randomized,double-blind,double-simulant,parallel-controlled,multicentric study was carried out in 207 patients with bladder overactivity,patients received either tolterodine (2 mg twice daily)or oxybutynin (5 mg twice daily). Results After 8 weeks of treatment,the mean frequency of micturition decreased 3.0±3.4 times and 4.6±6.4 times in those receiving tolterodine (n=103) and oxybutynin(n=104),respectively.Among...

Objective To evaluate the efficacy and tolerability of tolterodine in patients with an overactive bladder. Methods A randomized,double-blind,double-simulant,parallel-controlled,multicentric study was carried out in 207 patients with bladder overactivity,patients received either tolterodine (2 mg twice daily)or oxybutynin (5 mg twice daily). Results After 8 weeks of treatment,the mean frequency of micturition decreased 3.0±3.4 times and 4.6±6.4 times in those receiving tolterodine (n=103) and oxybutynin(n=104),respectively.Among those with urge incontinence,the mean number of incontinence episodes decreased 1.5±1.8 times and 2.4±2.1 times,respectively,in those receiving tolterodine and oxybutynin.The effect of tolterodine and oxybutynin on these two micturition variables was statistically equivalent.In the tolterodine group,the total incidence of adverse event was 66.9% and the incidence of dry mouth,the most common adverse,was 55.3%.While in the oxybutynin group,the incidences were 87.5% and 76.9% respectively.The incidences of adverse events and dryness were significantly lower in those on tolterodine than in those on oxybutynin. Conclusions Tolterodine 2 mg twice daily had the equivalent efficacy on patients with overactive bladder as compared to oxybutynin 5 mg twice daily,and the adverse events of tolterodine were lower than oxybutynin.

目的 评价新型抗胆碱药物托特罗定治疗膀胱过度活动症的有效性和安全性。 方法 采用随机、双盲、双模拟、平行对照的方法对 2 0 7例膀胱过度活动症患者进行托特罗定与奥昔布宁的对比研究 ,服药方法每日 2次 ,每次托特罗定 2mg或奥昔布宁 5mg。  结果 治疗 6周后 ,托特罗定组 (10 3例 ) 2 4h平均排尿次数减少 (3.0± 3.4)次 ,其中尿失禁患者的平均尿失禁次数减少 (1.5± 1.8)次 ;奥昔布宁组 (10 4例 )治疗后 2 4h平均排尿次数减少 (4 .6± 6 .4)次 ,平均尿失禁次数减少(2 .4± 2 .1)次 ,两组间差别无显著性意义 (P >0 .0 5 )。托特罗定组患者副作用发生率 6 6 .9% ,其中口干为 5 5 .3% ;而奥昔布宁组发生率为 87.5 % ,口干为 76 .9% ,两组间差别有显著性意义 (P <0 .0 5 )。 结论 托特罗定是治疗膀胱过度活动症的有效药物 ,疗效与奥昔布宁相同 ,但不良反应明显低于奥昔布宁。

 
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