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bupivacaine hydrochloride
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  盐酸布比卡因
     A comparison of 0.625%bupivacaine hydrochloride(pH5.7) and alkalinized bupivacaine hydrochloride (0.1ml of 0.5% NaHCO_3per 20ml bupivacaine, pH6.75) in epidural anesthesia was performed in 40 patients.
     本文报道用0.625%盐酸布比卡因(pH5.70)和碱化盐酸布比卡因(每20ml布比卡因中加入0.1ml 5%NaHCO_3,pH6.75)硬膜外麻醉40例的观察。
短句来源
     All patients accepted spinal-epiduaral anesthesia by single lumbar puncture at L2-3.Hyperbaric solution of 0.596% Ropivacaine mesylate 14.3 mg,0.5% Ropivacaine hydrochloride 12.0 mg and 0.5% Bupivacaine hydrochloride 8.0 mg were injected intrathecaly respectively in three groups.
     3组均采用腰-硬联合麻醉,分别注入0.596%甲磺酸罗哌卡因14.3mg、0.5%盐酸罗哌卡因12.0mg和0.5%盐酸布比卡因8.0mg重比重液。
短句来源
     Study of sustained release microspheres of human serum albumin containing bupivacaine hydrochloride
     缓释盐酸布比卡因人血清白蛋白微球的研究
短句来源
     Objective: To prepare sustained release microspheres of human serum albumin containing bupivacaine hydrochloride (Bupi-HSA-MS ) and evaluate the physical and chemical characteristics, release function in vitro, pharmacokinetics and pharmacodynamics in vivo of Bupi-HSA-MS. Methods: The high voltage method was used to prepare Bupi-HSA-MS.
     目的:制备缓释盐酸布比卡因人血清白蛋白微球(bupivacaine human serum albumin microspheres,Bupi-HSA-MS),并对其理化特性、体外释放、体内药动学、药效学进行评价。
短句来源
     【Methods】 90 cases of patients who accepted renal transplantation were allocated into group Ropivacaine mesylate(Ⅰ),group Ropivacaine hydrochloride(Ⅱ) and group Bupivacaine hydrochloride(Ⅲ).
     方法90例肾移植患者被随机分为甲磺酸罗哌卡因组(Ⅰ)、盐酸罗哌卡因组(Ⅱ)和盐酸布比卡因组(Ⅲ)。
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  布比卡因
     A comparison of 0.625%bupivacaine hydrochloride(pH5.7) and alkalinized bupivacaine hydrochloride (0.1ml of 0.5% NaHCO_3per 20ml bupivacaine, pH6.75) in epidural anesthesia was performed in 40 patients.
     本文报道用0.625%盐酸布比卡因(pH5.70)和碱化盐酸布比卡因(每20ml布比卡因中加入0.1ml 5%NaHCO_3,pH6.75)硬膜外麻醉40例的观察。
短句来源
     All patients accepted spinal-epiduaral anesthesia by single lumbar puncture at L2-3.Hyperbaric solution of 0.596% Ropivacaine mesylate 14.3 mg,0.5% Ropivacaine hydrochloride 12.0 mg and 0.5% Bupivacaine hydrochloride 8.0 mg were injected intrathecaly respectively in three groups.
     3组均采用腰-硬联合麻醉,分别注入0.596%甲磺酸罗哌卡因14.3mg、0.5%盐酸罗哌卡因12.0mg和0.5%盐酸布比卡因8.0mg重比重液。
短句来源
     Epidural Block with 0.25% Bupivacaine Hydrochloride for Abdomi- nal Surgery:Report of 300 Cases
     0.25%布比卡因硬膜外阻滞应用于腹部手术(附300例报告)
短句来源
     Conclusion: Epidural anesthesia for analgesia with bupivacaine hydrochloride (0. 125%) and Fentanyl citrate (2 .5μg/ml) is a safe, effective and painless labour.
     结论:0.125%布比卡因加芬太尼2.5μg/ml用于硬膜外阻滞镇痛是一种安全、有效无痛分娩术。
短句来源
     Study of sustained release microspheres of human serum albumin containing bupivacaine hydrochloride
     缓释盐酸布比卡因人血清白蛋白微球的研究
短句来源
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  “bupivacaine hydrochloride”译为未确定词的双语例句
     immunized with pCIS after treatment of bupivacaine hydrochloride,38.9%(23/54) of rats were detected in positive antibody against inhibin after twice immunizations,55.6%(20/36) of rats were detected in positive antibody against inhibin after three times immunizations,and rats immunized with 100 μg produced the highest level of antibody against inhibin.
     抑制素融合表达质粒pCIS免疫经盐酸普鲁卡因处理的大鼠,2次免疫获得了38.9%(23/54)的抗体阳性率,3次免疫获得55.6%(20/36)的抗体阳性率,100μg组产生的抗体水平最高;
短句来源
     Regional Block with Bupivacaine Hydrochloride: Report of 1164 Cases
     应用布比卡因于部位麻醉1164例临床分析
短句来源
     Influence of Bupivacaine Hydrochloride and Fentanyl Citrate for Lumbar Epidural Anesthesia on Women in Labour
     布比卡因加芬太尼硬膜外阻滞对分娩的影响
短句来源
     (2) Preparing for Bupivacaine Hydrochloride:①2-pipecolic acid was reacted with 1-butyl bromide to give 1-butyl-N-butyl-pipecolate, the latter amidated with 2,6-dimethylaniline that used NaH to form bupivacaine, bupivacaine was reacted with HCl aqueous to give Bupivacaine Hydrochloride.
     单纯形优化法寻找最佳反应条件,丁基化反应收率92%,酰胺化反应收率55%,总收率50%。 ②在罗哌卡因合成方法基础上,以中间体1-N-(2,6-二甲苯基)-2-哌啶甲酰胺为原料,与溴丁烷发生丁基化,反应收率93.5%;
短句来源
     The recovery of bupivacaine hydrochloride was 99.77%. Gentamicin,sulfate and sodium sulfite did not interfere with the determination.
     回收率达99.77%,硫酸庆大霉素及辅料亚硫酸钠对测定均无干扰。
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  bupivacaine hydrochloride
We induced acute skeletal muscle necrosis in rats using bupivacaine hydrochloride and found that both 2,5- and 2,3-dihydroxybenzoic acid significantly increased in skeletal muscle.
      
Bupivacaine Hydrochloride Induces Muscle Fiber Necrosis and Hydroxyl Radical Formation-Dimethyl Sulphoxide Reduces Hydroxyl Radi
      
A forced degradation study and a shelf‐life study at room temperature (20‐25 °C) were started on morphine hydrochloride 0.2 mg/ml and bupivacaine hydrochloride 7.5 mg/ml in 50 ml sterilized glass bottles type II.
      
No bupivacaine hydrochloride degradation was detectable during the study.
      
The stability of diamorphine (0.02 mg/ml as the hydrochloride) in 250 ml bupivacaine hydrochloride (0.15% wt/vol infusion) was studied by high pressure liquid chromatography at temperatures in the range 7 to 45°C.
      
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This study reported 1164 operative cases receiving bupivacaine hydrochloride as anes-thesia in different concentrations, with or without adrenaline, for epidural, spinal andperipheral nerve regional blocks, as compared at random with lidocaine-tetracaine mixtureor tetracaine alone. The data confirmed that the latency and the duration of complete block with bupiva-caine was the same as that with the above mentioned mixture solutions; but the durationof the action and the postoperative analgesia were significantly...

This study reported 1164 operative cases receiving bupivacaine hydrochloride as anes-thesia in different concentrations, with or without adrenaline, for epidural, spinal andperipheral nerve regional blocks, as compared at random with lidocaine-tetracaine mixtureor tetracaine alone. The data confirmed that the latency and the duration of complete block with bupiva-caine was the same as that with the above mentioned mixture solutions; but the durationof the action and the postoperative analgesia were significantly longer than that with themixture solutions. The duration of action was bowever affected by the sites of block. Bupivacaine in concentration of either 0.25% or 0.5% only resulted in slight hemodyna-mic change and there was no respiratory depression observed. This study revealed thatregional block with bupivacaine was more adequate for cervical-upper thoracic epiduralanesthesia, orthopedic surgery and cesarean section. The dosage of bupivacaine used in this study was 2.2~3.2mg/kg; and no toxic reactionhad ever happened, since the plasma concentration of bupivacaine was much lower than itsconvulsive level. In conclusion, bupivacaine was an effective, safe and long action anesthe-tic.

报告应用不同浓度的国产布比卡因加/不加肾上腺素于硬膜外、脊麻、神经阻滞等部位麻醉1164例。并与同期内随机抽样用地卡因和利多卡因混合液、地卡因、普普卡因作阻滞的病例作了对比。布比卡因的作用、潜伏期、达到完全阻滞的时间均与混合液或地卡因相同,而维持时间及术后镇痛时间则较后者明显延长。其维持时间的长短随阻滞部位而异。应用布比卡因0.25%、0.5%浓度,血液动力学改变轻微,对呼吸无抑制。因而尤其适用于颈上、胸部、硬膜外、剖腹产及骨科矫形手术的麻醉。本组用药量为2.2~3.2mg/kg,远低于血浆致痉水平,故认为布比卡因为一有效安全的长效麻醉剂。

This paper reports a clinical trial of 0.25% bupivacaine hydrochloride for epidural block in 300 patients undergoing lower abdominal and upper abdominal surgery. The initial dose was 8-25 ml with a mean 19 ml. Excellent clinical results were obtained in 291 patients (97%). Hypotension after local anesthetic injection occurred in 12.7% of the patients, less than those with 0.75% bupivacaine or 2% lidocaine. The results show that 0.25% bupivacaine is satisfactory and effective for epidural block...

This paper reports a clinical trial of 0.25% bupivacaine hydrochloride for epidural block in 300 patients undergoing lower abdominal and upper abdominal surgery. The initial dose was 8-25 ml with a mean 19 ml. Excellent clinical results were obtained in 291 patients (97%). Hypotension after local anesthetic injection occurred in 12.7% of the patients, less than those with 0.75% bupivacaine or 2% lidocaine. The results show that 0.25% bupivacaine is satisfactory and effective for epidural block in abdominal surgery.

本文总结国产低浓度(0.25%)盐酸布比卡因硬膜外阻滞应用于腹部手术300例,并与30例同类手术采用0.75%布比卡因进行比较,结果0.25%组首回剂量平均18.61±3.5ml,比0.75%组多约1/3;有效麻醉持续时间平均123.4±33.84分钟,短于0.75%组,但无统计学意义;0.25%组肌松一般相当于1.5%利多卡因,部分病人与2%相似;麻醉后血压下降者占29.7%,低血压发生率比0.75%布比卡因或2%利多卡因明显减少。0.25%布比卡因适当增加容量,可满足一般腹部手术要求,尤其适用于老年、体弱病人及剖腹产手术。

Since the beginning of November, 1982. Domestic bupivacaine has been applied in our hospital to a series of 333 cases operated on the middle and lower abdomen, the cavitas pelvis, the perineum and the lower extermities. During the operation, bupivacaine hydrochloride solution (in a conecentration of 0.75%) was injected into the cavitas subarachnoidealis at a rate of 1/3 ml or second (0.4mg/kg for adults, 0.3mg/kg for childrn). In order to get a very effective anesthesia, the patient's position was adjusted...

Since the beginning of November, 1982. Domestic bupivacaine has been applied in our hospital to a series of 333 cases operated on the middle and lower abdomen, the cavitas pelvis, the perineum and the lower extermities. During the operation, bupivacaine hydrochloride solution (in a conecentration of 0.75%) was injected into the cavitas subarachnoidealis at a rate of 1/3 ml or second (0.4mg/kg for adults, 0.3mg/kg for childrn). In order to get a very effective anesthesia, the patient's position was adjusted according to the principle of the hyperbaric solution. The results were as follow: 1. The primary anesthetic effect appeared 3 minutes aed 25 seconds (after bapivacaine had been injected) (±1 miuute and 23 seeonds); 2. The perfect anesthetic effect came 6 minutes and 53 seconds (±1 minute and 26 seconds) after the injection; 3. The aesnthetic effect lasted at 4 hours and 50 minutes (±1 hour and 35 minutes). so far on accident has happened. The results mentioned above show that the method is simple and safe, If can be used with less dosage and little side effect, especially on the cireulatory and the respitatory systems, We are of opinion that it is worth popularizing.

我院于1982年11月始,用0.75%布比卡因,以成人0.4mg/kg体重、小儿0.3mg/kg,每3秒钟1ml的速度注入蛛网膜下腔。按重比重液原则调节体位。施行中、下腹、盆腔、会阴部及下肢各种手术333例。经临床观察,麻醉出现时间一般为3分25秒±1分23秒,完善时间为6分53秒±1分26秒,麻醉持续时间为4小时50分±1小时35分,布比卡因对呼吸、循环系统影响小,副反应少。方法简便,用药量小,安全可取。

 
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