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   mutational p 53 的翻译结果: 查询用时:0.158秒
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mutational p
相关语句
  突变p53
     Objects Our aim is to clone and expresse the human decorin extron gene, to evaluate the anti-proliferation on BGC-823 gastric cancer cell line and influence on mutational P53 and VEGF expression using decorin.
     目的通过克隆hDCN 基因,构建原核表达体系并表达DCN 蛋白,进一步研究其对胃癌细胞株BGC-823 的抗增殖作用以及对细胞突变P53、血管内皮细胞生长因子(VEGF)表达的影响。
短句来源
     ABC immunohistochemical studies of protein expression were performed on bone marrow samples of 36 cases with different types of acute or chronic leukemias using anti - p53 monoclonal antibody pAB1801. The positive rate of mutational p53 protein expression was 55.56% in 36 leukemia cases.
     采用人类特异的p53单克隆抗体pAB1801,用ABC免疫组化法即生物素-抗生物素法对36例白血病骨髓细胞进行了免疫组化检测,结果突变p53蛋白表达阳性率为55.56%。
短句来源
     The positive expression of mutational P53 and VEGF was determined by immunocytochemistry(ICC).
     利用免疫细胞化学染色法检测胃癌细胞中突变P53、VEGF 在处理前后的变化。
短句来源
     Our study indicated that decorin can induce the anti-proliferation of BGC-823 gastric cancer cell line and the molecular biological mechanism may be related to the suppressing the expression of mutational P53 and VEGF.
     DCN 有诱导胃癌细胞凋亡和抗增殖的作用,并能下调胃癌细胞中突变P53 和VEGF 的表达,这种作用可能与其抗增殖、抑制肿瘤细胞浸润有关。
短句来源
  突变型p53
     Objective To detect the expression of mutational p53 and inducible nitric oxide synthase(iNOS) in ovarian neoplasm,and study the correlation between them.
     目的检测卵巢肿瘤组织中突变型p53表达及诱导型一氧化氮合酶(iNOS)活性并与正常卵巢相比,同时探讨二者在卵巢恶性肿瘤组织中的相关性。
短句来源
     Objective To detect the expression of mutational p53 and inducible nitric oxide synthase in ovarian neoplasm and study the correlation between them.
     目的检测卵巢肿瘤组织中突变型p53表达及诱导型一氧化氮合酶(iNOS)活性并与正常卵巢相比,同时探讨二者在卵巢恶性肿瘤组织中的相关性。
短句来源
     Expression of iNOS and Mutational p53 Protein and Correlation between Them in Ovarian Neoplasm
     卵巢肿瘤组织中突变型p53表达与iNOS活性及二者相关性的研究
短句来源
     In addition,the expression of P53 in bladder carcinoma cells was detected through immunohistochemistry method. The result indicated that mutational P53 was positively expressed in drug-resistant BIU-87/ADM cells,but the expression of mutational P53 was poorly positive in BIU-87 cells.
     另外还利用兔疫组化方法对膀肌癌细胞中P53表达进行了检测,结果表明在耐药的mU{7/ADM细胞中突变型P53表达阳性,而在 BIU{ 细胞中表达较弱。
短句来源
     The bcl 2 oncoprotein can inhibit apoptosis in adenoma and adenocarcinoma. However,mutational p53 oncoprotein may likely block apoptosis in adenocarcinoma
     bcl-2蛋白在腺瘤和腺癌中均可抑制细胞凋亡,而突变型p53蛋白可能仅在腺癌中起抑制细胞凋亡的作用。
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  “mutational p 53”译为未确定词的双语例句
     The characteristics of distribution of mutational p53 gene exons during multistage human oral carcinogenesis
     口腔粘膜鳞状细胞癌发生发展过程中p53基因突变的外显子分布特征
短句来源
     Expression of GST-TAT-P53c fusion protein and its promotive action on apoptosis of tumor cells with mutational p53 gene
     GST-TAT-P53c融合蛋白的表达及对p53基因突变型肿瘤细胞的促凋亡作用
短句来源
     The expression of mutational p53 gene and the inducible nitric wxide synthase and correlation of them in ovarian malignant neoplasms
     卵巢肿瘤中p53、iNOS表达及二者相关性研究
短句来源
     The Expression of Mutational p53 Gene and the Inducible Nitric Oxide Synthase and Correlation of them in Ovarian Malignant Neoplasms
     卵巢肿瘤中p53、iNOS表达及二者相关性研究
短句来源
     Objective To explore relationship between apoptosis and expression of mutational p53 protein and predict possibilities of p53 protein as a prognostic factor.
     目的 探讨细胞凋亡在子宫内膜癌发生发展中的作用 ,细胞凋亡与抑癌基因p53表达产物的关系 ,以及p53蛋白表达与预后相关性。
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ABC immunohistochemical studies of protein expression were performed on bone marrow samples of 36 cases with different types of acute or chronic leukemias using anti - p53 monoclonal antibody pAB1801. The positive rate of mutational p53 protein expression was 55.56% in 36 leukemia cases. There was a close relationship between p53 positive rate and the type of leukemias. There was higher p53 protein expression in ANLL while lower expression in ALL. During the chronic phase of CML, the expression...

ABC immunohistochemical studies of protein expression were performed on bone marrow samples of 36 cases with different types of acute or chronic leukemias using anti - p53 monoclonal antibody pAB1801. The positive rate of mutational p53 protein expression was 55.56% in 36 leukemia cases. There was a close relationship between p53 positive rate and the type of leukemias. There was higher p53 protein expression in ANLL while lower expression in ALL. During the chronic phase of CML, the expression of p53 protein was very low, but once a patient got into the blast crisis phase, the p53 protein expression became very high. This finding demonstrated that expression of p53 protein could be one of the early diagnostic indications of the blast crisis of CML.

采用人类特异的p53单克隆抗体pAB1801,用ABC免疫组化法即生物素-抗生物素法对36例白血病骨髓细胞进行了免疫组化检测,结果突变p53蛋白表达阳性率为55.56%。p53突变与白血病的类型有重要关系:在急性粒细胞白血病中p53有较高表达,在急性淋巴细胞白血病中p53表达较低,在慢性粒细胞白血病的慢性期突变p53的表达很低,而急变期可出现类似急性粒细胞白血病的突变p53基因表达。研究结果提示p53蛋白表达有可能作为慢性粒细胞白血病急变期的早期诊断指标之一。

Objective To investigate the effects of apoptosis and its regulating genes in different stages of malignant transformation of large instestine epithelium in colorectal adenoma and adenocarinoma.Methods The density and distribution of the apoptotic cells and the positive expression of p53 and bcl 2 oncoprotein were observed in situ in 32 villous adenomas and 33 papillary adenocarinomas of the large intestine,using DNA nick end labelling technique and immunohistochemical staining for p53 and bcl 2 oncoprotein.15...

Objective To investigate the effects of apoptosis and its regulating genes in different stages of malignant transformation of large instestine epithelium in colorectal adenoma and adenocarinoma.Methods The density and distribution of the apoptotic cells and the positive expression of p53 and bcl 2 oncoprotein were observed in situ in 32 villous adenomas and 33 papillary adenocarinomas of the large intestine,using DNA nick end labelling technique and immunohistochemical staining for p53 and bcl 2 oncoprotein.15 nontumor mucosa were used as controls.Results The density of apoptotic cells in adenoma and adenocarcinoma was significantly higher than that in nontumor mucosa( P <0 01),and their density in adenoma was higher than in adenocarcinoma( P <0.01).The positive rate and staining intensity of p53 and bcl 2 oncoprotein in adenoma and adenocarcinoma were significantly higher than in non tumor mucosa( P <0.01),their staining intensity in adenocarcinoma was higher than that in adenoma( P <0.01).In adenoma,the density of apoptotic cells in the bcl 2 oncoprotein positive group was higher than that in the bcl 2 oncoprotein negative group( P <0.01).Conclusion The abnormal regulation of apoptosis may play an important role in the pathogenesis of large intestine carcinoma.The bcl 2 oncoprotein can inhibit apoptosis in adenoma and adenocarcinoma.However,mutational p53 oncoprotein may likely block apoptosis in adenocarcinoma

目的通过观察结、直肠腺癌和腺瘤中的细胞凋亡及其调控基因p53、bcl-2的表达状态,探讨细胞凋亡及其调控基因在大肠上皮恶性转化进程的不同阶段中的作用。方法利用DNA缺口末端标记技术和p53、bcl-2蛋白免疫组化染色,原位观察32例大肠绒毛状腺瘤和33例大肠乳头状腺癌中的凋亡细胞和p53、bcl-2蛋白阳性表达细胞的密度与分布,以15例非肿瘤大肠粘膜做为对照。结果腺瘤和腺癌中的凋亡细胞密度均显著高于非肿瘤粘膜(P<0.01);腺瘤高于腺癌(P<0.01)。p53和bcl-2蛋白的表达率和表达强度,腺癌和腺瘤高于非肿瘤粘膜(P<0.01),腺癌的表达强度也高于腺瘤(P<0.05)。腺瘤中bcl-2蛋白表达阳性组的凋亡细胞密度显著低于bcl-2阴性组(P<0.01)。结论细胞凋亡调控异常在大肠癌发病中可能起重要作用。bcl-2蛋白在腺瘤和腺癌中均可抑制细胞凋亡,而突变型p53蛋白可能仅在腺癌中起抑制细胞凋亡的作用。

Objective: To investigate the expression of P53,P16 and P21 proteins in esophagus in duodenoesophageal reflux and gastroesophageal reflux. Methods: Four kinds of model: gastroesophageal reflux(G group), duodenoesophageal reflux(D group) and duodenogastroesophageal reflux(DG group), and control group (C group) were obtained by operations.All rats were given carcinogen (methyl n amyl nitrosamine,MANA).Then their esophagi were taken 26 weeks after operation. The expression of P53,P16...

Objective: To investigate the expression of P53,P16 and P21 proteins in esophagus in duodenoesophageal reflux and gastroesophageal reflux. Methods: Four kinds of model: gastroesophageal reflux(G group), duodenoesophageal reflux(D group) and duodenogastroesophageal reflux(DG group), and control group (C group) were obtained by operations.All rats were given carcinogen (methyl n amyl nitrosamine,MANA).Then their esophagi were taken 26 weeks after operation. The expression of P53,P16 and P21 proteins were measured by immunohistochemical study. Results: The expression of mutational P53 protein increased in all reflux groups and were significantly stronger than that in C group.There was no difference between 3 kinds of reflux groups. The expression of P16 and P21 proteins in all reflux groups(except P16 protein in G group) were significantly lower than those in C group,and those in D and DG groups were significantly lower than those in G group. Conclusion: Both gastric juice and duodenal content reflux can promote tumourgenesis of MANA in rats esophagi by changing the expression of neoplasm inhibiting genes.The effect of duodenal content is stronger than gastric juice.It may play an important role in tumourgenesis of gastroesophageal reflux disease. [

目的 :研究胃及十二指肠内容物反流对食管组织内抑癌基因表达蛋白的影响 ,从而探讨不同反流状态下食管肿瘤发生的机制。 方法 :通过不同手术方式制作单纯胃食管反流 (G组 )、单纯十二指肠食管反流 (D组 )、十二指肠胃混合食管反流(DG组 )及无反流对照组 (C组 )动物模型。术后均注射致癌剂甲基戊基亚硝胺 (MANA) ,于 2 6周取出食管 ,用免疫组化法检测组织中 P5 3,P16 ,P2 1等基因的蛋白表达。 结果 :各反流组大鼠食管上皮细胞中突变型 P5 3蛋白的表达均较对照组显著增强 ,反流组间相比无显著差异 ;各反流组 P16 ,P2 1蛋白的表达较对照组减弱 (G组 P16蛋白表达与 C组相比无显著差别 ) ,其中 D组、DG组的表达较 G组更弱 ,D组与 DG组结果相似。突变型 P5 3蛋白的表达与 P16 ,P2 1蛋白的表达均呈负相关 (r分别为 - 0 .6 2及 - 0 .75 ) ,P16蛋白的表达与 P2 1蛋白的表达呈正相关 (r=0 .5 4)。结论 :胃液及十二指肠内容物反流可通过改变抑癌基因的蛋白表达而影响致癌剂甲基戊基亚硝胺诱发大鼠食管肿瘤的作用 ,其中十二指肠内容物的作...

目的 :研究胃及十二指肠内容物反流对食管组织内抑癌基因表达蛋白的影响 ,从而探讨不同反流状态下食管肿瘤发生的机制。 方法 :通过不同手术方式制作单纯胃食管反流 (G组 )、单纯十二指肠食管反流 (D组 )、十二指肠胃混合食管反流(DG组 )及无反流对照组 (C组 )动物模型。术后均注射致癌剂甲基戊基亚硝胺 (MANA) ,于 2 6周取出食管 ,用免疫组化法检测组织中 P5 3,P16 ,P2 1等基因的蛋白表达。 结果 :各反流组大鼠食管上皮细胞中突变型 P5 3蛋白的表达均较对照组显著增强 ,反流组间相比无显著差异 ;各反流组 P16 ,P2 1蛋白的表达较对照组减弱 (G组 P16蛋白表达与 C组相比无显著差别 ) ,其中 D组、DG组的表达较 G组更弱 ,D组与 DG组结果相似。突变型 P5 3蛋白的表达与 P16 ,P2 1蛋白的表达均呈负相关 (r分别为 - 0 .6 2及 - 0 .75 ) ,P16蛋白的表达与 P2 1蛋白的表达呈正相关 (r=0 .5 4)。结论 :胃液及十二指肠内容物反流可通过改变抑癌基因的蛋白表达而影响致癌剂甲基戊基亚硝胺诱发大鼠食管肿瘤的作用 ,其中十二指肠内容物的作用较胃液更强。

 
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