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breast cancer risk     
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  乳腺癌风险
     Relation between single nucleotide polymorphism in estrogen-metabolizing genes COMT,CYP17 and breast cancer risk among Chinese women
     雌激素代谢基因COMT和CYP17单核苷酸多态与女性乳腺癌风险的关系
短句来源
     Mission methodology: Menopause, breast cancer risk, morbidity and prevalence (Fren)
     Mission方法学:绝经、乳腺癌风险、发病及流行状况
短句来源
     No associations were found between oral contraceptives (OCs), soybean foods and breast cancer risk.
     ER XbaI多态可能与月经初潮年龄(≤12岁)、乳腺癌家族史、良性乳腺疾病史对乳腺癌风险有危险联合作用,OR为3~4左右。
短句来源
  乳腺癌危险性
     Conclusion: The variant genotype (Met/Met) is associated with breast cancer risk.
     结论:Met/Met变异基因型与乳腺癌危险性相关;
短句来源
     epidemioligic studies concerning with dietary fat and breast cancer risk are analyzed by the method of Meta analysis, The results showed that the dietary fat is positively associated with the breast cancer risk synthesizing all 24 studies.
     应用META分析方法综合24篇有关乳腺癌的流行病学研究结果,对饮食脂肪及与乳腺癌危险性的关系进行分析。
短句来源
     Analyses stratified by menopausal status were conducted to check the associations of the XbaⅠ and PvuⅡ gene polymorphisms of ERα gene and breast cancer risk.
     分析XbaⅠ和PvuⅡ基因多态性与罹患乳腺癌危险性的关系。
短句来源
  乳腺癌易感性
     Conclusion This study indicated that the polymorphism of CYP1A1 MspI is not associated with the breast cancer risk.
     结论CYP1A1 Msp I基因多态性与乳腺癌易感性无关。
短句来源
  乳腺癌发生
     Conclusion Genetic factor is significantly related to enhanced breast cancer risk.
     结论 遗传因素与乳腺癌发生危险显著相关 ,并可能加强其它危险因素的致癌作用。
短句来源
     Results: After adjusting for potential confounding factors, the resuits showed evidence that exercise in adolescence and adulthood could reduce breast cancer risk, with odds ratio (OR) and 95% confidence interval (CI) as 0.83 (0.66~1.03) and 0.64 (0.46~0.87) respectively, and with p value for trend as 0.040 and 0.002 respectively.
     结果:对可能的混杂因素校正后,发现青春期和成年期体育锻炼活动均能降低乳腺癌发生,每周运动量在75%分位数以上的妇女OR值分别为0.83(0.66~1.03)和0.64(0.46~0.87),趋势性检验的P值分别为0.040和0.002。
短句来源
     Relationship between Physical Activity and Breast Cancer Risk in China
     体力活动与乳腺癌发生的关系
短句来源
     Neither household activity, cycling in the two age periods, and walking in adulthood, nor occupational physical activity was found related with breast cancer risk.
     两个年龄段做家务、骑自行车和成年期步行均与乳腺癌无关,但青春期较多步行可减少乳腺癌发生
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      breast cancer risk
    Association of SULT1A1 and UGT1A1 polymorphisms with breast cancer risk and phenotypes in Russian women
          
    No association was observed between any of the SULT1A1 genotypes and breast cancer risk or phenotypes.
          
    Our data suggest that UGT1A1, but not SULT1A1, genotypes are important for breast cancer risk and phenotype in Russian women.
          
    Recently, convincing epidemiological data establishing a positive effect of folate status on breast cancer risk were published.
          
    An incident case-referent study on plasma enterolactone and breast cancer risk
          
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    A classification of the risks in the development of breast cancer has been devised based solely on the appearance of the breast parenchyma on mammograms. Four paterns (Denseness, Transparency, Strip and Mix) of patients were defined. Each pattern can be subdivided into two or three sub-types. Therefore, ten types could be identified totally. A case-control study of 1000 breast cancers, each with two matching controls, was conducted to assess the role of this classification of breast parenchymal patterns as...

    A classification of the risks in the development of breast cancer has been devised based solely on the appearance of the breast parenchyma on mammograms. Four paterns (Denseness, Transparency, Strip and Mix) of patients were defined. Each pattern can be subdivided into two or three sub-types. Therefore, ten types could be identified totally. A case-control study of 1000 breast cancers, each with two matching controls, was conducted to assess the role of this classification of breast parenchymal patterns as a breast cancer risk factor. Relative risks of 29.64 for type Ⅳc, 16.39 for type Ⅲc and 7.08 for type Ⅱb to lowest risk group were determined,

    乳腺二级预防已被公认为是降低乳腺癌死亡率的有效途径。乳腺X线摄影是进行乳腺癌普查的主要手段,该方法不但有助于发现无临床体征的早期乳腺癌,而且可以藉其对乳腺实质的不同分型,判断其发生乳腺癌的不同潜在危险性,从而有助于明确须重点予以监视的普查对象,以提高普查效益。

    epidemioligic studies concerning with dietary fat and breast cancer risk are analyzed by the method of Meta analysis, The results showed that the dietary fat is positively associated with the breast cancer risk synthesizing all 24 studies. The general odds ratio (OR) is 1.49 (95 % confidence interval (CI): 1.32,1. 68). However, the OR of cohort studies is 1.01 (95 % CI: 0.77, 1. 33) and that of thecase - control studies is 1.67 (95% CI: 1. 47,1.89 ). The difference of results between two kinds of...

    epidemioligic studies concerning with dietary fat and breast cancer risk are analyzed by the method of Meta analysis, The results showed that the dietary fat is positively associated with the breast cancer risk synthesizing all 24 studies. The general odds ratio (OR) is 1.49 (95 % confidence interval (CI): 1.32,1. 68). However, the OR of cohort studies is 1.01 (95 % CI: 0.77, 1. 33) and that of thecase - control studies is 1.67 (95% CI: 1. 47,1.89 ). The difference of results between two kinds of epidemiologic studies is statistically significant. The results suggest the relationship between dietary fat and breast cancer risk need to be further supported by the results from the cohort studies of general population since the subjects of most cohort studies in this analysis are special populatioll and the results may be biased.

    应用META分析方法综合24篇有关乳腺癌的流行病学研究结果,对饮食脂肪及与乳腺癌危险性的关系进行分析。结果显示最高饮食脂脂摄入量组与最低组相比.总比数比值为1.49,95%可信区间为1.32~1.68,说明高饮食脂肪是乳腺癌危险因素。队列研究组高饮食脂肪摄入的乳腺癌危险性为1.01(95%可信区间:0.77~1.33),而在病例对照组则为1.67(95%可信区间:1.47~1.89),两类设计研究结果差异有统计学意义。本次分析中队列研究的对象多为特殊人群,存在影响研究结果的干扰因素,提示目前需要一般人群的队例研究结果支持高饮食脂肪摄入与乳腺癌的关系。

    Objective To investigate the relationship between exogenous estrogen and breast cancer risk. Methods Female rats were randomly divided into three groups, namely diethylstilbestrol (DES), norethindrone compositae (CoNET) and control group. The histological structure and ultrastructural changes of mammae were observed. The levels of sexual hormones in serum were determined and the AgNOR counts, DNA contents and steroid receptor contents in mammary epithelium were also detected. Results In DES group,...

    Objective To investigate the relationship between exogenous estrogen and breast cancer risk. Methods Female rats were randomly divided into three groups, namely diethylstilbestrol (DES), norethindrone compositae (CoNET) and control group. The histological structure and ultrastructural changes of mammae were observed. The levels of sexual hormones in serum were determined and the AgNOR counts, DNA contents and steroid receptor contents in mammary epithelium were also detected. Results In DES group, the level of progesterone (10.38 ng/ml) was obviously lower than that in the control group (13.37 ng/ml); the incidence of hyperplasia of mammary gland (73.33%) was significantly higher than that in the control group (7.69%); and the degree of hyperplasia was obviously more serious than that in the control group. Moreover, there were 13.33% of rats with atypical hyperplasia in DES group. The DNA contents, AgNOR counts and estrogen receptor (ER) positive rate were markedly higher in DES group (95.60, 2.43 and 71.71% respectively) than in the control group (83.07, 1.88 and 40% respectively). However, in CoNET group, there were no obvious influences on ER, AgNOR and DNA in mammary epithelium. Conclusions Exogenous estrogen (DES) could affect the levels of sexual hormones in serum, accelerate the DNA duplication, increase the AgNOR counts and ER contents, and induce atypical hyperplasia and ultrastructural changes of mammary gland, hence becoming a latent risk factor of breast cancer. However, the results failed to suggest that the contraceptive, CoNET, could increase the risk of breast cancer.

    ExperimentalstudyonrelationshipbetwenexogenousestrogenandbreastcancerriskZengXizhi曾希志andYaoZhengxiang姚榛祥ObjectiveToinvestigat...

     
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