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nimodipine tablets     
相关语句
  尼莫地平片
     Determination of Content and Content Uniformity in Nimodipine Tablets by RP-HPLC
     RP-HPLC法测定尼莫地平片含量及含量均匀度
短句来源
     DISSOLUTION STUDY OF NIMODIPINE TABLETS
     尼莫地平片溶出度的研究
短句来源
     Determination of the dissolution of nimodipine tablets and capsules
     尼莫地平片/胶囊的溶出度测定
短句来源
     A HPLC method was established for the determination of Nimodipine Tablets and related substances.
     建立高效液相色谱法测定尼莫地平片的含量及有关物质的方法。
短句来源
     Determination of Nimodipine Tablets and Related Substances by HPLC
     HPLC法测定尼莫地平片的含量及有关物质
短句来源
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  尼莫地平片剂
     The pharmacokinetics of nimodipine was determined by this GC ECD method following a single oral dose of 100 mg of two kinds of domestic nimodipine tablets given to each of 10 volunteers in an open randomized two way crossover design.
     10名志愿者随机交叉口服单剂量100mg二种国产尼莫地平片剂后,以本法测定其体内过程符合一室模型。
短句来源
     The article determined the bioavailability and pharmacokinetic parameters of two kinds of nimodipine tablets produced by Tianjin Center Pharmaceutical Factory in 6 healthy volunteers using HPLC method.
     用高效液相色谱法测定了6名健康志愿者口服二种尼莫地平片剂的相对生物利用度和药代动力学参数。
短句来源
     RELATIVE BIOAVAILABILITY OF THREE DOMESTIC NIMODIPINE TABLETS IN HEALTHY VOLUNTEERS
     三种国产尼莫地平片剂的相对生物利用度研究
短句来源
     OBJECTIVE To evaluate the bioequivalence of two domestic nimodipine tablets.
     目的:评价两种国产尼莫地平片剂人体生物等效性。
短句来源
     Comparison of Dissolubility Among Six Kinds of Nimodipine Tablets
     6种尼莫地平片剂的溶出度比较
短句来源
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  尼莫地平片体
     Study on correlation between dissolution in vitro and absorption in vivo of nimodipine tablets
     尼莫地平片体外溶出度与体内吸收的相关性研究
短句来源
     RESULTS The linear regressive equation established between the absorption percentage in vivo and the dissolution percentage in vitro of nimodipine tablets were Y= 2.230 4X -60.72,r = 0.9983(P<0.01)and Y= 3.708 5X - 107.41, r = 0.895 1( P < 0.05) ,respectively.
     结果两种尼莫地平片体内吸收对体外溶出度回归方程分别为:Y=2.2304X-60.72,r=0.9983(P<0.01)和Y=3.7085X-107.41,r=0.8951(P<0.05)。
短句来源
     Comparison of dissolution rates of domestically-made and imported nimodipine tablets
     国内外尼莫地平片体外溶出度考察
短句来源
     OBJECTIVE To study the correlation between the dissolution in vitro and the absorption in vivo of nimodipine tablets.
     目的 考察两种尼莫地平片体外溶出度与体内吸收的相关性。
短句来源
     CONCLUSION The results suggested that there was a significant correlation between the absorption in vivo and the dissolution in vitro of nimodipine tablets.
     结论两种尼莫地平片体外溶出度与体内吸收有显著的相关性。
短句来源
  种尼莫地平片体
     RESULTS The linear regressive equation established between the absorption percentage in vivo and the dissolution percentage in vitro of nimodipine tablets were Y= 2.230 4X -60.72,r = 0.9983(P<0.01)and Y= 3.708 5X - 107.41, r = 0.895 1( P < 0.05) ,respectively.
     结果两种尼莫地平片体内吸收对体外溶出度回归方程分别为:Y=2.2304X-60.72,r=0.9983(P<0.01)和Y=3.7085X-107.41,r=0.8951(P<0.05)。
短句来源
     OBJECTIVE To study the correlation between the dissolution in vitro and the absorption in vivo of nimodipine tablets.
     目的 考察两种尼莫地平片体外溶出度与体内吸收的相关性。
短句来源
     CONCLUSION The results suggested that there was a significant correlation between the absorption in vivo and the dissolution in vitro of nimodipine tablets.
     结论两种尼莫地平片体外溶出度与体内吸收有显著的相关性。
短句来源

 

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    We assessed the effects of Nimodipine on LV diastolic functions in 26 patients with CHD (unstable angina pectoris) treated with nimodipine tablet therapy for two weeks. The diastolic filling velocity, filling time and filling fraction across the mitral valve were measured by pulsed Doppler e-chocardiography. The results showed that nimodipine significantly improved the PFVE, PFVA/PFVE, AEF, DEF, DT, RFF, 1/3FF, 1/2FF. especially the diastolic functional parameters of the active filling of LV....

    We assessed the effects of Nimodipine on LV diastolic functions in 26 patients with CHD (unstable angina pectoris) treated with nimodipine tablet therapy for two weeks. The diastolic filling velocity, filling time and filling fraction across the mitral valve were measured by pulsed Doppler e-chocardiography. The results showed that nimodipine significantly improved the PFVE, PFVA/PFVE, AEF, DEF, DT, RFF, 1/3FF, 1/2FF. especially the diastolic functional parameters of the active filling of LV.

    本文利用脉冲式多普勒超声心动图技术(PDE)通过测定二尖瓣血流评价钙拮抗剂尼莫地平对26例冠心病(不稳定型心绞痛)患者左室舒张功能的影响。初步结果显示尼莫地平对舒张期二尖瓣血流充盈速度(PFVE、PFVA/PFVE、AEP、DEP),充盈时间DT及充盈分数RFF、1/3FF、1/2FF等左室主动充盈过程的舒张功能参数有良好的改善作用。

    The article determined the bioavailability and pharmacokinetic parameters of two kinds of nimodipine tablets produced by Tianjin Center Pharmaceutical Factory in 6 healthy volunteers using HPLC method. The commercially available conventional tablet A and the tablet formulation B were compared with the reference solution C in vivo. The pharmacokinetic parameters of nimodipine in vivo were estimated by using PKBP--N1 program on the basis of one compartment open model. After administration...

    The article determined the bioavailability and pharmacokinetic parameters of two kinds of nimodipine tablets produced by Tianjin Center Pharmaceutical Factory in 6 healthy volunteers using HPLC method. The commercially available conventional tablet A and the tablet formulation B were compared with the reference solution C in vivo. The pharmacokinetic parameters of nimodipine in vivo were estimated by using PKBP--N1 program on the basis of one compartment open model. After administration of 120 mg dose of B, the pharmacokinetic parameters were as follows: Tp=0.977 h, C_(max)=44.28ng/ml, ka=2.02 h~(-1), t 1/2=1.63 h, Vd=26. 25 L/ kg, AUC=130.56 ng·h~(-1)·ml~(-1). The result imply that nimodipine is absorbed rapidly, distributed widely in the body, and also eliminated at a fairly rapid rate.

    用高效液相色谱法测定了6名健康志愿者口服二种尼莫地平片剂的相对生物利用度和药代动力学参数。结果表明:尼莫地平在人体内的浓度—时间数据可用一室开放模型拟合,主要动力学参数与国外文献报道一致。新片剂和普通片的人体相对生物利用度分别为82.39%和16.01%。

    A HPLC method for the determination of nimodipine in human plasma was described.Under alkaline condition,nimodipine and internal standards nitrendipine and methyltestosterone are extracted with mixed solvent of ether and n-hexane(1:1).Then the separation is performed in an ODS column with a mobile phase of methanol-water-n-butylamine(65: 35 :0.001)and detected at 238nm.The linear concentration range of this method is 5~100 ng/ml and the detectable lowest concentration is 2ng/ml (S/N=3).This method has been applied...

    A HPLC method for the determination of nimodipine in human plasma was described.Under alkaline condition,nimodipine and internal standards nitrendipine and methyltestosterone are extracted with mixed solvent of ether and n-hexane(1:1).Then the separation is performed in an ODS column with a mobile phase of methanol-water-n-butylamine(65: 35 :0.001)and detected at 238nm.The linear concentration range of this method is 5~100 ng/ml and the detectable lowest concentration is 2ng/ml (S/N=3).This method has been applied to the determination of pharmacokinetic parameters of six normal volunteers after single dose administration of nimodipine tablets. Results show that the pharmacokinetic parameters fit with one compartment model.

    本文以反相高效液相色谱法测定人血浆中尼莫地平的浓度。以尼群地平和甲基睾丸素为内标物,碱性条件下用乙醚-正已烷(1:1)萃取,流动相为甲醇-水-正丁胺(65:35:0,001),流速1.2ml/min,紫外检测波长238nm,线性范围5~100ng/ml,最低检测浓度2ng/ml,日内差异小于5%,日间差异约为5%。6名健康受试者口服-种国产尼莫地平片剂后,以本方法测定其体内药代动力学符合一室模型。

     
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