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new antiepileptic
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  抗癫痫新药
     Rufinamide is a new antiepileptic developed by Novartis Company of Switzerland and has finished Phase Ⅲ clinical trial.
     Rufinamide为瑞士诺华公司新研制的抗癫痫新药,已完成三期临床。
短句来源
     PHARMACOLOGY AND CLINICAL USE OF FELBAMATE, A NEW ANTIEPILEPTIC
     抗癫痫新药非氨酯的药理与临床
短句来源
     Conclusion:Data obtain shows that topiramate is a new antiepileptic agent with multiple mechanism of action,the total effective rate in the add on therapy is 56.3%(9/16)without severe side effect,with good tolerability in treatment of refratory partial epilepsy.
     结论 :托吡酯作为具有多重作用机制的抗癫痫新药 ,加用治疗难治性癫痫部分性发作的总有效率为 5 6 .3% (9/ 16 ) ,无明显的必须停药的不良反应 ,耐受性良好
短句来源
     Advances of pharmacokinetic studies of topiramate,a new antiepileptic agent
     抗癫痫新药托吡酯药代动力学研究现状
短句来源
     SC1001 is a new antiepileptic drug syn-thesized by professor Li Zhenghua in ourcollege. It is an organic acid. The capsulesof SC1001Na and SC1001amine are nowgiven to the epileptic patients.
     本文报道抗癫痫新药SC1001Na静注、肌注后在家兔体内的药代动力学。
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  “new antiepileptic”译为未确定词的双语例句
     Interactions and combination rationale of new antiepileptic drugs with traditional antiepileptic drugs
     新型抗癫痫药之间及其与传统抗癫痫药的相互作用和机制
短句来源
     New antiepileptic drugs have good effects on obstinateepilepsy, even on the epilepsy treated very diffcult nowa-days, such as infant spasm, Lennox - Gastaut syndrome,etc.
     新抗癫痫药对难治性癫痫有很好的疗效,甚至对目前治疗非常困难的癫痫如婴儿痉挛、Lennox-Gas-taut综合征(一种小儿癫痫性脑病)也有一定疗效。
短句来源
     Objective: Although new antiepileptic drugs are recently used for therapy of epilepsy in clinics, epileptic seizures remains uncontrolled in about 30% of patients who eventually developed refractory epilepsy. The most important characteristics of many patients resistant to antiepileptic drugs (AEDs) treatment are simultaneously resistant to almost all of the AEDs with different structure and proposed mechanisms of actions, which is called multidrug resistance (MDR), indicating that nonspecific mechanisms are responsible for drug resistance in epilepsy.
     目的:尽管不断有新的抗癫痫药物(antiepileptic drugs, AEDs)用于临床,但是仍有近30%的癫痫患者不能控制发作而成为难治性癫痫,其主要的临床特征是同时对多种结构和作用机制完全不同的AEDs均产生耐药,即多药耐药(multiple drug resistance, MDR),表明难治性癫痫的耐药机制是一种非特异性机制。
短句来源
     AIMPresent study made use of advanced experimental method to observe the change of CX32 and CX43 in epilepsy on molecular level so that which kind of connexin in formting GJ play important role in epilepsy was clarified. The finding can define the target that new antiepileptic will act on.
     目 的本研究采用先进的实验手段,从分子水平探讨CX32和CX43在癫痫中变化,阐明何种CX形成的GJ在癫痫活动中起主要作用,为针对GJ发展新的抗癫痫药物确定靶点。
短句来源
     Evaluation of new antiepileptic drugs safety
     新型抗癫痫药的安全性评价
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  相似匹配句对
     New
     新 编辑手记
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     NEW
     新品撷英
短句来源
     Evaluation of new antiepileptic drugs safety
     新型抗癫痫药的安全性评价
短句来源
     A new antiepileptic drug——levetiracetam
     抗癫痫新药左乙拉西坦
短句来源
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  new antiepileptic
New antiepileptic preparations of methindione for the therapy of status epilepticus
      
Although new antiepileptic drugs have been developed during recent years, still more than one third of patients with epilepsy are refractory to treatment.
      
Levetiracetam (LEV) is a new antiepileptic agent with broad-spectrum effects on seizures and animal models of epilepsy.
      
The main benefit of new antiepileptic drugs may be in reducing the incidence and severity of adverse reactions compared to older drugs and in doing so they may prove to be more effective.
      
Such comparative monotherapy studies may form a part of phase III drug development programmes for a new antiepileptic drug.
      
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SC1001 is a new antiepileptic drug syn-thesized by professor Li Zhenghua in ourcollege. It is an organic acid.The capsulesof SC1001Na and SC1001amine are nowgiven to the epileptic patients. The pharmacokinetics of SC1001Na wasinvestigated in 9 healthy rabbits given in-travenous bolus and intramuscular injectionsin single dose crossover study. A UV-spec-trophotometry was used in the assay deter-mination of the injection and plasma sample.Plasma data were fitted to curves employingNONLIN program. The weight...

SC1001 is a new antiepileptic drug syn-thesized by professor Li Zhenghua in ourcollege. It is an organic acid.The capsulesof SC1001Na and SC1001amine are nowgiven to the epileptic patients. The pharmacokinetics of SC1001Na wasinvestigated in 9 healthy rabbits given in-travenous bolus and intramuscular injectionsin single dose crossover study. A UV-spec-trophotometry was used in the assay deter-mination of the injection and plasma sample.Plasma data were fitted to curves employingNONLIN program. The weight is 1/C~2 whereC means the plasma level of SC1001Na.According to the value of F, the da afitted the two-compartmental open model.When administered intramuscularly, SC1001Na was absorbed well from the site of in-jection giving maximum plasma level of SC1001Na varying from 145.32 to 168.07μg/ml.The half-life seen after intravenous andintramuscular administration was 6-7 h.

本文报道抗癫痫新药SC1001Na静注、肌注后在家兔体内的药代动力学。作者首先对该药的体内外含量测定方法及制剂进行了研究,然后对血药时间数据进行了曲线拟合。F 值检验及理论计算值与实测值的契合程度比较均表明:该药静注与肌注给药在家兔体内的转运均符合二室开模型动力学方程。

EPA (enpiperate) is developing for new antiepileptic,antitremous drug. On requirements of clinical pharamacological andtoxicological studies on new drugs. We have done some physical depen-dence-producing tests in mice and monkeys. The experiment in mice: i.p EPA, phenobarbital sodium (PBS) anddiazepam (DZP), twice a day or drinking water containing EPA or PBSat equal effective dosage for 4 weeks. After abrupt withdrawal of thedrug, 24 hours later, the mouse was put into audiogenic box to induceaudiogenic...

EPA (enpiperate) is developing for new antiepileptic,antitremous drug. On requirements of clinical pharamacological andtoxicological studies on new drugs. We have done some physical depen-dence-producing tests in mice and monkeys. The experiment in mice: i.p EPA, phenobarbital sodium (PBS) anddiazepam (DZP), twice a day or drinking water containing EPA or PBSat equal effective dosage for 4 weeks. After abrupt withdrawal of thedrug, 24 hours later, the mouse was put into audiogenic box to induceaudiogenic seizure (AS) individually, or ip. Pentylenetetrazole(PTZ) toinduce PTZ(+). The AS(+) or PTZ(+) rate of PBS and DZP are verysignificant from EPA or control group (P<0 .01). There 's no differentbetween EPA and control group. Experiment in monkeys: i.g EPA 5mg/kg, and phenobarbital (PB)35mg/kg, or i .m EPA 2mg/kg, PBS 25mg/kg, twice a day, at first week.Then gradually increased dosage every week for 6-8 weeks. After with-drawal of drug, EPA-monkeys show no abstinent syndrome during two we-eks observational period. While PB, PBS-monkeys have mild, intermediateand severe degrees of withdrawal symptoms. Such as: apprehension, hyper-irritability, restlessness: anorexia, piloerection, tremor, muscle rigidity,impaired moter activity, nausea, boby weight lost, covulsion, dyspnea,failure. Large dosage of EPA cannot substitute for PB in monkegs.

桥哌酯具有较好的抗癫痫、抗震颤作用。用小白鼠、猴实验观察桥哌酯有无身体依赖性表现,并与苯巴比妥(钠)、安定平行比较。小白鼠腹腔注射或饮用药液各4周,用铃声诱发听源性惊厥或成四唑诱发阵挛惊厥,苯巴比妥钠、安定组小白鼠惊厥率明显高于桥哌酯组。猴肌注或灌胃给药6~8周,停药后苯巴比妥(钠)猴表现轻、中、重度自然戒断症状;桥哌酯猴无明显异常。桥哌酯也不能替代苯巴比妥.两组实验均提示桥哌酯无身体依赖性特性。

Antiepilepsirine is a kind of new antiepileptic drug. In this paper, a new method, adsorptive voltammetry(ADV) has been established for the determination of antiepilepsirine. In 0. 20 mol/L H_2SO_4 solution, a sensitive reduction wave of antiepilepsirine was obtained by ADV after preconcentration on the surface of hanging mercury drop electrode (HMDE) (Ei= 0.7V, v =100 mV/s), the peak potential was--0.94V(vs Ag/AgCl). The linear range between the peak current and the concentration of antiepilepsirine...

Antiepilepsirine is a kind of new antiepileptic drug. In this paper, a new method, adsorptive voltammetry(ADV) has been established for the determination of antiepilepsirine. In 0. 20 mol/L H_2SO_4 solution, a sensitive reduction wave of antiepilepsirine was obtained by ADV after preconcentration on the surface of hanging mercury drop electrode (HMDE) (Ei= 0.7V, v =100 mV/s), the peak potential was--0.94V(vs Ag/AgCl). The linear range between the peak current and the concentration of antiepilepsirine was 3. 0×10~(-9)~3. 0×10~(-6)mol/L with a detection limit of 1.0×10~(-9)mol/L. Antiepilepsirine in tablet and urine samples was determined by using this method. The electrochemical behaviour of the system and its electrode reaction mechanism were studied by means of linear sweep and cyclic voltammetry, constant potential coulometry, normal pulse polarography (NPP), etc. The diffusion coefficient D was 7.7×10~(-6)cm~2/s. The electrode reaction rate constant was 1.5×10~(-3)cm/s. The number of reduction electron n was 2. The electron transfer coefficient was 0.52. The electrode reduction process was shown to be irreversible with the adsorptive characteristics.

抗痫灵在0.20 mol/L H_2SO_4底液、富集电位-0.70 V(vs Ag/AgCl)、扫速100 mV/s等条件下,用吸附伏安法得一灵敏的还原峰,峰电位-0.94 V,峰电流与抗痫灵浓度在3.0×10~(-9)~1.0×10~(-8)mol/L(富集时间t_(ac)=120 s),1.0×10~(-8)~7.0×10~(-8)mol/L(t_(ac)=90 s),7.0×10~(-8)~7.0×10~(-7)mol/L(t_(ac)=60 s),7.0×10~(-7)~3.0×10~(-6)mol/L(t_(ac)=45 s)范围内成线性关系,检测限可达1.0×10~(-9)mol/L,并用于片剂及病人尿样的测定,得到满意的结果。以多种电化学手段研究抗痫灵的电化学行为及反应机理。实验表明属不可逆吸附波。测得扩散系数D为7.7×10~(-6)cm~2/s,电极反应速率常数k_1为1.5×10~(-3)cm/s,电极反应电子数n为2,电子转移系数α=0.52。抗痫灵的还原基团为分子中碳碳双键。

 
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