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   population stratification 的翻译结果: 查询用时:0.159秒
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population stratification
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  人群分层
     Population stratification is one of the major causes of confounding in association studies.
     人群分层是关联研究混杂的主要来源之一。
短句来源
     Conclusion Case-sibling control design might avoid population stratification by using siblings as controls thus might be used to test association and linkage between genes and disease.
     结论病例同胞对照设计使用患者同胞作为对照,避免了人群分层现象,可以用来检测基因与疾病之间的关联或连锁。
短句来源
  “population stratification”译为未确定词的双语例句
     2^Population stratification, total-family association, andrwithin-family association were performed between BMDs at the spine and hip and the (GT)n marker in the intron 1 of the COL1A& gene and the (AAAG)n marker in the P3 promoter of PTHR1 gene in 388 nuclear families composed of both parents and at least one healthy daughter with a total of 1, 220 individuals.
     2)在388个核心家庭(包括双亲和至少一个健康的女性子代,总共1220个体)中,同时分析了腰椎和髋部骨密度与COL1A2基因内含子1的(GT)n多态位点、PTHR1基因P3启动子的(AAAG)n多态位点之间的群体混层、总的家庭关联、家庭内关联。
短句来源
     To test if the association of CHGB with schizophrenia is caused by population stratification, we performed TDT study for CHGB 277T>A, CHGB 433G>A, CHGB 533A>G in family samples from shanghai.
     为了验证CHGB基因同精神分裂症的关联是否是人群层化引起的假阳性,我们又利用上海地区来源的三口之家样品对CHGB 277T>A,CHGB 433G>A,CHGB 533A>G进行了传递不平衡检验。
短句来源
     Method To avoid the confounding effects of population stratification, the independence of transmission of each parental alleles about HLA-DQA1 was tested with the HHRR methtod for 40 neuclear families.
     方法 采用HHRR方法对 40个SLE核心家系进行了HLA -DQA1等位基因独立传递检验。
短句来源
     Use of unlinked genetic markers to detect population stratification: a case-control multicenter study
     利用多个微卫星位点判断病例对照关联研究中的人群层化
短句来源
     Detection and controlling for population stratification in association studies of human complex disease
     人类复杂疾病关联研究中群体分层的检出和校正
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  相似匹配句对
     Population Census
     中国人口普查研究
短句来源
     Population culture stratification contains household, community, country and world.
     可分为家庭、社区、国家和世界四个层次。
短句来源
     Population 436
     绝命人口436
短句来源
     On Social Stratification
     社会分层论
短句来源
     Reshaping of Urban Communities and the Social Stratification in Communities of Migrant Population
     城市社区格局重组与流动人口聚集地的社会分层——北京等五城市流动人口社区调查
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  population stratification
A family-based association design was chosen to prevent population stratification.
      
Reduced selection pressure was present at baseline and persisted through treatment and follow-up, suggesting population stratification of host factors that influence selection pressure on hepatitis C virus.
      
However, an increased mortality was still present when controlling for these differences by population stratification (eg, mortality in patients ≥60 years old: COPD=36%, controls=13%, odds ratio=4.6,P>amp;lt;0.05).
      
Great attention has been focused upon the specific threat of confounding due to population stratification.
      
A number of large twin cohorts have already been collected and provide a valuable resource for carrying out studies that are robust to the effect of population stratification.
      
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Objective To study the familial relevance of syetemic lupus erythematosus (SLE).Method To avoid the confounding effects of population stratification, the independence of transmission of each parental alleles about HLA-DQA1 was tested with the HHRR methtod for 40 neuclear families.Results The findings revealed significant association between DQA1*0102 andDQA1*0501, of which DQA1*0102 may be a risk factor and DQA1*0501 a protective one ( χ\+2=10.40,P <0.001).Conclusion As SLE is a complex disease,...

Objective To study the familial relevance of syetemic lupus erythematosus (SLE).Method To avoid the confounding effects of population stratification, the independence of transmission of each parental alleles about HLA-DQA1 was tested with the HHRR methtod for 40 neuclear families.Results The findings revealed significant association between DQA1*0102 andDQA1*0501, of which DQA1*0102 may be a risk factor and DQA1*0501 a protective one ( χ\+2=10.40,P <0.001).Conclusion As SLE is a complex disease, the relationship of other loci including non-MHC chromsomes to SLE should be noted according to recent reports.

目的 探讨系统性红斑狼疮的可能易感基因。方法 采用HHRR方法对 40个SLE核心家系进行了HLA -DQA1等位基因独立传递检验。结果 DQA1 0 5 0 1和DQA1 0 10 2在统计学上具有显著关联 ,其中 ,DQA1 0 5 0 1具有保护作用 ,而DQA1 0 10 2可能是一个危险因素 (χ2 =10 40 ,P <0 0 0 1)。结论 由于SLE是一种复杂疾病 ,根据最近报道 ,其它位点 (包括非MHC染色体 )与SLE的关系也应引起关注。

Association study is widely used in elucidating genetic basis of complex diseases such as cardiovascular diseases,type 2 diabetes,essential hypertension and obesity.Some issues were discussed in the review,which include defining and controlling of confounding effects,selection of candidate genes and single nucleotide polymorphisms (SNPs),application of intermediate phenotype and haplotype analyses as well as judgement of the result in association studies.Population stratification is one of the major causes...

Association study is widely used in elucidating genetic basis of complex diseases such as cardiovascular diseases,type 2 diabetes,essential hypertension and obesity.Some issues were discussed in the review,which include defining and controlling of confounding effects,selection of candidate genes and single nucleotide polymorphisms (SNPs),application of intermediate phenotype and haplotype analyses as well as judgement of the result in association studies.Population stratification is one of the major causes of confounding in association studies.It could be reduced by selecting relatives of affected patients as control,genome control and by using isolated populations which have higher homogeneity in genetic background.A candidate gene could be selected because of its’biological association with some disease or being congenerous to a known gene related to the disease.Appropriate application of intermediate phenotype of diseases and haplotype analyses may increase the opportunity to obtain meaningful findings in association studies.An optimal study design,sufficient sample size and proper controls,in conjunction of modern statistic analyses,association analyses would exert its effect on studies on susceptibility of human common diseases.

关联研究广泛应用于阐述心血管疾病、2型糖尿病、原发性高血压和肥胖等人类复杂疾病的遗传学基础。文中就关联研究中混杂的识别与控制、候选基因的选择、中间表型的应用、单体型分析方法的应用 ,以及结果的判定等问题进行了讨论。人群分层是关联研究混杂的主要来源之一。选择患者亲属做对照、基因组对照和选择遗传背景较为一致的隔离人群都可以减少混杂。候选基因的选择可以基于与疾病间的生物学联系或是该基因与疾病某已知相关基因的同源性。适当的应用中间表型和单体型分析方法可以增加关联研究有意义发现的机会。本文认为 ,优化研究设计、足够的样本含量、正确选择对照 ,结合先进的数据分析方法 ,关联研究必将为困扰人类的常见疾病的易感性研究发挥更大的作用。

Objective To evaluate whether population stratification exists in microsatellite polymorphic sites. Methods Eight microsatellite markers not related to stroke, D11S1361、D19S927、D7S483、D14S990、D15S993、D1S2622、D1S2876和D3S3560 located in different chromosomes were selected based on the GenBank database (http://www.gdb.org/). PCR assay was used to detect the alleles of these microsatellite in 294 patients of cerebral apoplexy, aged 58, and 325 sex, age and geographically-match controls in 7 cities in China....

Objective To evaluate whether population stratification exists in microsatellite polymorphic sites. Methods Eight microsatellite markers not related to stroke, D11S1361、D19S927、D7S483、D14S990、D15S993、D1S2622、D1S2876和D3S3560 located in different chromosomes were selected based on the GenBank database (http://www.gdb.org/). PCR assay was used to detect the alleles of these microsatellite in 294 patients of cerebral apoplexy, aged 58, and 325 sex, age and geographically-match controls in 7 cities in China. The PCR products were subjected to electrophoresis on the ABI 377 DNA sequencer and analyzed with Genescana and Genotypera software. The frequencies of these markers in these stroke patients and controls were compared by c2 test. Total 294 patients with stroke and 325 age, sex, and geographically matched controls were randomly selected from 973 case-control population. Eight loci including D11S1361, D19S927, D7S483, D14S990, D15S993, D1S2622, D1S2876 and D3S3560 were detected by fluorescence-based genotyping approach. Results Except for the alleles of D11S1361, the size, frequency, heterozygosity, and polymorphism information in the alleles of the other 7 microsatellite sites were in the range of 0.63-0.81 and their distribution varies in different races and populations. between Chinese and Caucasians. There were no differences in the frequencies of main alleles between the case group and control group (all P≥0.05). Conclusion The selected seven markers are highly polymorphic and variable between human populations, and the genomic control data indicate that there is no unequal genetic admixture and stratification in the case-control cohort.

目的利用多个与脑卒中无关的基因微卫星DNA多态性判断脑卒中病例对照人群的遗传背景。方法多中心病例对照研究,从7个临床中心随机选取294例脑卒中病例和325例对照,采用微卫星荧光标记、半自动基因分型技术,检测8个位于不同染色体上的微卫星多态性位点D11S1361、D19S927、D7S483、D14S990、D15S993、D1S2622、D1S2876和D3S3560,比较各等位基因片段在病例组和对照组的频率分布。结果D11S1361观察到3种等位基因;其余位点的多态性信息含量为0.63~0.81,各等位基因的片段大小、频率分布与白种人(法国人类多态研究中心提供)存在一定差异。7个微卫星多态的各主要等位基因频率在脑卒中病例组和对照组的分布,差异无统计学意义(P>0.05)。结论所选用的微卫星位点具有高度多态性和种族差异性,脑卒中病例对照人群的遗传背景有较好的一致性。

 
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