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acute asthma exacerbation
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  “acute asthma exacerbation”译为未确定词的双语例句
     1. Totally 10 patients with acute asthma exacerbation, 10 children with asthma remission and 8 normal controls were recruited in this study.
     方法1、病例收集:10 例哮喘急性发作期患儿,10 例缓解期患儿,8例正常儿童作为对照;
短句来源
     Conclusion:The results indicate that infant asthma exacerbation is related closely to RSV and CP infections,but in children acute asthma exacerbation is related closely to MP infection.
     结论 :RSV及CP感染与婴幼儿哮喘急性发作关系密切 ,而MP感染与儿童期哮喘急性发作关系密切。
短句来源
     The reverse transcription polymerase chain reaction is a routine diagnostic assay for the detection of hMPV.hMPV also plays a direct etiologic role in acute asthma exacerbation and acute exacerbation of chronic obstructive pulmonary disease.
     RT-PCR技术是hMPV主要的检测手段,hMPV感染也是哮喘急性发作和慢性阻塞性肺病急性加重的诱因。
短句来源
  相似匹配句对
     ASTHMA
     哮喘
短句来源
     TREATMENT OF SEVERE ACUTE ASTHMA
     急性严重哮喘发作36例治疗
短句来源
     Relationship between Acute Exacerbation of Asthma and Respiratory Tract Infections in Children
     哮喘急性发作与呼吸道感染的关系
短句来源
     METABOLIC ACIDOSIS IN ACUTE ASTHMA
     支气管哮喘代谢性酸中毒的探讨
短句来源
     Effect of inhaled furosemide on lung function in patients with acute exacerbation of asthma
     吸入呋塞米对急性发作期支气管哮喘患者肺通气功能的影响
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  acute asthma exacerbation
A single dose of intravenous magnesium sulfate given to patients with acute asthma exacerbation has been shown to be safe, but its efficiency is still under discussion.
      
A double blind, randomized trial of two regimens of nebulized metaproterenol was conducted in patients presenting to an Emergency Department with an acute asthma exacerbation.
      
Short-acting β-agonists, oxygen, and corticosteroids are fundamental to early intervention in acute asthma exacerbation.
      
The present study failed to show any significant role of inhaled furosemide in acute asthma exacerbation.
      
The authors conclude that routine administration of magnesium to moderate and severe children with an acute asthma exacerbation is not efficacious.
      
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Objective:To explore the relationship between viral respiratory tract,mycoplasmal pneumonia,Chlamydia pneumonia infection and actue attack of asthma in children.Methods:7 viruses including respiratory syncytial virus(RSV),adenovirus(Adv),influenza virus A(InfA),influenza virusB(InfB),and parainfluenza virus 1.2.3(PInfl.2.3) from the nasopharyngeal aspirate of the patients were rapidly diagnosed by immunofluorescence method and MP.CP-IgM in serum were detected with ELISA.Results:18 cases could reach the definite...

Objective:To explore the relationship between viral respiratory tract,mycoplasmal pneumonia,Chlamydia pneumonia infection and actue attack of asthma in children.Methods:7 viruses including respiratory syncytial virus(RSV),adenovirus(Adv),influenza virus A(InfA),influenza virusB(InfB),and parainfluenza virus 1.2.3(PInfl.2.3) from the nasopharyngeal aspirate of the patients were rapidly diagnosed by immunofluorescence method and MP.CP-IgM in serum were detected with ELISA.Results:18 cases could reach the definite etiological diagnosis among 45 infant asthmatic patients (40%).Of them RSV was discovered in 13 cases (accounting for 28.9%),ranking the first,second CP in 3 cases (6.7%),MP in 1 case (2.2%) and Plnf3 in 1 case (2.2%).13 cases (35.1%) were detected positively in 37 asthmatic patients of children.Of them MP was discovered in 9 cases (24.3%),ranking the first,second RSV in 4 cases (10.8%).Conclusion:The results indicate that infant asthma exacerbation is related closely to RSV and CP infections,but in children acute asthma exacerbation is related closely to MP infection.

目的 :探讨重庆地区小儿哮喘急性发作与呼吸道病毒及肺炎支原体 (MP)、肺炎衣原体 (CP)感染的相关性。方法 :采取患儿鼻咽分泌物用免疫荧光快速诊断方法检测包括呼吸道合胞病毒 (RSV)、腺病毒 (Adv)、流感病毒A、B(InfA、B)型、副流感病毒 1、2、3(PInf1、2、3)型在内的 7种病毒抗原及血清ELISA法检测CP、MPIgM抗体。结果 :4 5例婴幼儿哮喘患儿阳性检出有 18例 (40 % )其中感染RSV有 13例 (2 8.9% )居首位 ,其次为CP有 3例 (6 .7% ) ,MP有 1例 (2 .2 % ) ,PInf3有 1例 (2 .2 % )。 37例儿童哮喘阳性检出有 13例 (35 .1% )其中感染MP有 9例 (2 4 .3% )居首位 ,其次为RSV有 4例 (10 .8% ) ,其余均阴性。结论 :RSV及CP感染与婴幼儿哮喘急性发作关系密切 ,而MP感染与儿童期哮喘急性发作关系密切。

Objective To explore the impact of Foxp3 expression and CD+4CD+ 25 regulatory T cells on pathogenesis of childhood asthma.Methods Totally 15 patients with acute asthma exacerbation, 15 children with asthma remission and 10 children who were hospitalized for skeleton deformity without atopic disorders or history of allergic diseases or respiratory infections within a month as controls were recruited in this study from Sep. 2004 to Mar. 2005. The percentage of CD+4CD+ 25 T cells were detected by...

Objective To explore the impact of Foxp3 expression and CD+4CD+ 25 regulatory T cells on pathogenesis of childhood asthma.Methods Totally 15 patients with acute asthma exacerbation, 15 children with asthma remission and 10 children who were hospitalized for skeleton deformity without atopic disorders or history of allergic diseases or respiratory infections within a month as controls were recruited in this study from Sep. 2004 to Mar. 2005. The percentage of CD+4CD+ 25 T cells were detected by 2-color flow cytometry. The levels of interleukin (IL)-4, IL-10, interferon (IFN)-γ, transforming growth factor (TGF)-β in plasma and supernatant were assayed by ELISA. Both the asthmatic children and the control children were selected to induce sputum by hypertonic saline.Sputum was processed for detecting the expression of Foxp3-mRNA.The expression of Foxp3-mRNA in both sputum and PBMC was detected by semi-quantitative RT-PCR with β-actin as internal control.Results The percentage of CD+4CD+ 25 regulatory T cells in exacerbation and remission asthmatic children was significantly lower than that of the control children both prestimulation[(10.1±2.1) % vs. (15.5±2.7) %, (11.7±2.5) % vs. (15.5±2.7)%, P<0.05] and poststimulation with PHA[(12.4±2.3)% vs.(26.9±3.8)%, (17.3±3.2)% vs.(26.9±3.8)%,P<0.05]. The percentage of CD+4CD+ 25 regulatory T cells was significantly higher after PHA stimulation in normal children [(15.5±2.7) % vs. (26.9±3.8 )%, P<0.01]. The expression of Foxp3-mRNA(Foxp3/β-actin) in asthmatic children was significantly lower than that in the control children in both PBMC and induced sputum.The expression of Foxp3-mRNA in PBMC was significantly higher after PHA stimulation in the control children (0.77±0.22 vs. 1.07±0.21, P<0.05). However, there was no significant difference in Foxp3-mRNA expression in asthmatic children pre and post PHA stimulation. A significant positive correlation between the Foxp3-mRNA expression and the percentage of CD+4CD+ 25 regulatory T cells was detected. The levels of IFN-γ and TGF-β were significantly lower in asthmatic children than those in the control children, and the levels of IFN-γ and TGF-β correlated positively with Foxp3-mRNA expression and the percentage of CD+4CD+ 25 regulatory T cells. The level of IL-4 both in plasma and supernatant was higher in asthmatic children. The levels of IL-10 was higher only in exacerbation than in control children, the levels of IL-4 and IL-10 had no correlation with Foxp3-mRNA expression and the percentage of CD+4CD+ 25 regulatory T cells.Conclusion Insufficient secretion of TGF-β, decreased Foxp3 expression, insufficient number of CD+4CD+ 25 regulatory T cells and the defective ability of converting CD+4CD- 25 T cells to CD+4CD+ 25 regulatory T cells might play an important role in pathogenesis of asthma.

目的研究Foxp3基因表达与CD4+CD2+5调节性T细胞在哮喘发病中的作用。方法以确诊哮喘的患儿为研究对象,急性发作期15例、缓解期15例,同期选10例正常儿童作对照,提取外周血单个核细胞(PBMC)进行CD4、CD25表面标志及血浆、培养上清液IL-4、IFN-γ、IL-10和TGF-β等细胞因子的ELISA检测,同时收集哮喘患儿和正常儿童的诱导痰,用RT-PCR方法检测PBMC及诱导痰中转录因子Foxp3-mRNA的表达。结果PBMCCD4+CD2+5T细胞百分率在哮喘急性发作期、缓解期分别为(10·1±2·1)%、(11·7±2·5)%,低于对照组的(15·5±2·7)%(P分别<0·01、<0·05);对照组PBMC在体外培养后CD4+CD2+5细胞百分率显著升高,同培养前比较差异有统计学意义(P<0·01)。PBMCFoxp3-mRNA表达水平(Foxp3/β-actin)在哮喘急性发作期、缓解期分别为0·46±0·14、0·50±0·19,低于对照组0·77±0·22,诱导痰Foxp3-mRNA表达水平哮喘患儿也低于对照组;PBMC在体外培养后对照组Foxp3-mRNA表达水平较培养前升高(P<...

目的研究Foxp3基因表达与CD4+CD2+5调节性T细胞在哮喘发病中的作用。方法以确诊哮喘的患儿为研究对象,急性发作期15例、缓解期15例,同期选10例正常儿童作对照,提取外周血单个核细胞(PBMC)进行CD4、CD25表面标志及血浆、培养上清液IL-4、IFN-γ、IL-10和TGF-β等细胞因子的ELISA检测,同时收集哮喘患儿和正常儿童的诱导痰,用RT-PCR方法检测PBMC及诱导痰中转录因子Foxp3-mRNA的表达。结果PBMCCD4+CD2+5T细胞百分率在哮喘急性发作期、缓解期分别为(10·1±2·1)%、(11·7±2·5)%,低于对照组的(15·5±2·7)%(P分别<0·01、<0·05);对照组PBMC在体外培养后CD4+CD2+5细胞百分率显著升高,同培养前比较差异有统计学意义(P<0·01)。PBMCFoxp3-mRNA表达水平(Foxp3/β-actin)在哮喘急性发作期、缓解期分别为0·46±0·14、0·50±0·19,低于对照组0·77±0·22,诱导痰Foxp3-mRNA表达水平哮喘患儿也低于对照组;PBMC在体外培养后对照组Foxp3-mRNA表达水平较培养前升高(P<0·05),而哮喘患儿培养前后Foxp3-mRNA表达水平无显著变化。血浆及培养上清液IFN-γ、TGF-β在哮喘急性发作期、缓解期低于对照组(P<0·05),且IFN-γ、TGF-β与PBMCFoxp3-mRNA水平、CD4+CD2+5细胞百分率呈正相关。哮喘患儿血浆及培养上清液IL-4显著高于对照组,急性发作期血浆IL-10显著高于对照组,而缓解期与正常组无显著性差异;IL-4、IL-10与PBMCFoxp3-mRNA水平、CD4+CD2+5细胞百分率无相关性。结论哮喘患儿的TGF-β分泌不足、Foxp3基因表达降低、CD4+CD2+5调节性T细胞数量减少及分化发育障碍可能在儿童哮喘的发病中起重要作用。

Human metapneumovirus(hMPV) is a recently described paramyxovirus associated with respiratory tract infection.Most infections with hMPV are detected during winter and spring,and can occur over a wide age range,mainly young children,elderly subjects and immunosuppressed hosts.The prevalences of hMPV infections vary from country to country,and the consequences range from mild upper respiratory tract infection to severe bronchiolitis or pneumonia.The reverse transcription polymerase chain reaction is a routine...

Human metapneumovirus(hMPV) is a recently described paramyxovirus associated with respiratory tract infection.Most infections with hMPV are detected during winter and spring,and can occur over a wide age range,mainly young children,elderly subjects and immunosuppressed hosts.The prevalences of hMPV infections vary from country to country,and the consequences range from mild upper respiratory tract infection to severe bronchiolitis or pneumonia.The reverse transcription polymerase chain reaction is a routine diagnostic assay for the detection of hMPV.hMPV also plays a direct etiologic role in acute asthma exacerbation and acute exacerbation of chronic obstructive pulmonary disease.

人偏肺病毒(hMPV)是一种新近发现的呼吸道致病病毒。hMPV感染主要发生在冬春季,各年龄阶段的人群都可受到感染,尤其是儿童、老年人和免疫缺陷患者。世界各国报道其感染率不径相同,感染症状可从轻微的上呼吸道病变到严重的细支气管炎和肺炎。RT-PCR技术是hMPV主要的检测手段,hMPV感染也是哮喘急性发作和慢性阻塞性肺病急性加重的诱因。

 
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