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aromatase inhibitor
相关语句
  芳香化酶抑制剂
     Cultured cells were challenged with testosterone(10 -8 ,10 -7 ,10 -6 mol/L) and an aromatase inhibitor letrozole(10 -9 ,10 -8 ,10 -7 mol/L) for 48 h and then the germ cell proliferation was determined.
     培养的鸡胚卵巢细胞用睾酮(T,10-8、10-7、10-6mol/L)和/或芳香化酶抑制剂letrozole(Let,10-9、10-8、10-7mol/L)处理,48h后测定生殖细胞增殖的变化。
短句来源
     The aromatase inhibitor AMIN and 5×10 -7 mol/L TAM could inhibit the growth of A549 cells and block them in G 0/G 1 phase ( P <0.01 or P <0.001).
     芳香化酶抑制剂AMIN和 5× 10 - 7mol L的TAM可抑制A5 49细胞的生长 ,使之阻滞于G0 G1 期 (P <0 0 1和P <0 0 0 1)。
短句来源
     Objective To determine the aromatase protein expression in A549 cell and to investigate the effects of 17β estrogen (E 2), testosterone (T), estrogen receptor antagonist tamoxifen (TAM), and aromatase inhibitor DL aminoglutethimide (AMIN) on the growth and proliferation of A549 cells.
     目的 检测肺腺癌细胞株A5 49芳香化酶蛋白表达 ,并探讨 17β 雌二醇 (estrogen ,E2 )、睾酮 (testosterone ,T)、雌激素受体拮抗剂三苯氧胺 (tamoxifen ,TAM)和芳香化酶抑制剂氨鲁米特 (DL Aminoglutethimide ,AMIN)对A5 49细胞生长增殖的影响。
短句来源
     [Methods] Synthesis of estrogen was blocked by injection of aromatase inhibitor arimidex 100 μg/mouse to 3, 4 weeks old C57B6 F1 female mice each day, the control group were given the same amount saline.
     方法采用3、4周C57B6杂交1代小鼠,实验组小鼠每日腹腔注射芳香化酶抑制剂arimidex100μg,对照组注射等体积的生理盐水。
短句来源
     The effect and significance of aromatase inhibitor exemestane on the expression of NO/ET in ectopic uterine endometrial stromal cells
     芳香化酶抑制剂对异位子宫内膜间质细胞NO/ET表达的影响和意义
短句来源
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  芳香酶抑制剂
     Synthesis of aromatase inhibitor exemestane
     芳香酶抑制剂依西美坦(Exemestane)的合成
短句来源
     Anastrozole is a new, highly selective nonsteroidal aromatase inhibitor indicated for the endocrine treatment of postmenopausal women with advanced breast cancer.
     阿那曲唑是-种新型高选择性的非甾体类芳香酶抑制剂,临床用于绝经后妇女晚期乳腺癌的治疗。
短句来源
     Studies on the Synthesis of Aromatase Inhibitor Fadrozole
     芳香酶抑制剂法倔唑的合成工艺研究
短句来源
     The aromatase inhibitor letrozole increases the concentration of intraovarian androgens and improves in vitro fertilization outcome in low responder patients: A pilot study
     芳香酶抑制剂来曲唑增加体外受精周期低应答患者卵巢内雄激素水平并提高体外受精成功率:一项试点研究
短句来源
     The mechanisms and development of a breast cancer drug-aromatase inhabitor were briefly reviewed, and fadrozole, as a new selective, nonsteroidal aromatase inhibitor was introduced and synthesized in this thesis.
     本文对芳香酶抑制剂抗乳腺癌作用机理、分类及其发展概况作了简述,并对第二代新型芳香酶抑制剂法倔唑合成工艺进行了研究。
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  芳香化酶抑制药
     Objective To study the effect of aromatase inhibitor letrozole on the secretion of estradiol by hysteromyoma cell in vitro.
     目的探讨芳香化酶抑制药来曲唑对子宫肌瘤分泌雌二醇的影响。
短句来源
     Conclusion The aromatase inhibitor letrozole was shown to significantly decrease the amount of estradiol secreted by hysteromyoma cells,suggesting that the drug may possibly be effective in the clinical treatment of hysteromyoma.
     结论芳香化酶抑制药来曲唑可明显抑制子宫肌瘤细胞分泌雌二醇(P<0.01),这使芳香化酶抑制药治疗子宫肌瘤成为可能。
短句来源
  “aromatase inhibitor”译为未确定词的双语例句
     The effect and significance of aromatase inhibitor exemestane on the expression of β-endorphin in ectopic uterine endometrial stromal cells
     依西美坦对异位子宫内膜间质细胞β-内啡肽表达的影响和意义
短句来源
     The present results suggest that the decrease in serum 17β-estradiol (E2) and increase in 11-KTlevels may be important for sex inversion induced by aromatase inhibitor in red spotted grouper.
     这些结果表明,AI主要通过抑制内源性E2的产生并提高11-KT水平,从而诱导赤点石斑鱼由雌性转变为雄性。
短句来源
     Aromatase inhibitor alone or in combination with cyclooxygenase-2 inhibitor could decrease the serum level of E2 in rat models and slightly increase the serum levels of FSH and LH after 1 week tharepy.
     两者治疗1周可使血清E2水平降低, FSH、LH略升高;
短句来源
     To explore the possible mechanisms that estrogen reduces liver cirrhosis, the changes of estrogen receptor (ER) during the liver fibrosis, the expression of ER in the hepatic stellate cells (HSC), how to effect transforming growth factor beta-1 (TGFpβ_1) expression by estrogen, to study the fibrotic process affected by exterior estrogen, an ER antagonist tamoxifen and an aromatase inhibitor anastrozole.
     探讨雌激素缓解肝硬化的可能机理,雌激素受体(ER)在肝纤维化过程中的变化; 在肝星状细胞(HSC)的表达情况,雌激素对转化生长因子β-1(TGF β_1)表达的影响,TGF β_1与肝纤维化的关系。
短句来源
     3β-hydroxyandrost-4-en-6,17-dione (3-OHAT) is a powerful non-androgenic aromatase inhibitor. It is very effective in decreasing the rate of the recurring of breast cancer. But there wasn' t a route suitable for industrialization reported in all the document.
     2.3-羟基雄甾-4-烯-6,17-二酮(3-OHAT)是一种强效非雄性激素芳构化酶抑制剂(aromatase inhibitor),可有效减少乳腺癌的复发机率,但目前文献报道的合成路线均不适宜于工业化生产。
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  aromatase inhibitor
Long-term follow-up of patients is necessary to determine the effects of chronic aromatase inhibitor treatment on bone density, cognitive function, and other endpoints.
      
Neoadjuvant hormonal therapy with either tamoxifen or an aromatase inhibitor may benefit frail or elderly patients with HR-positive tumors for whom chemotherapy is not an option.
      
Pilot study of acupuncture for the treatment of joint symptoms related to adjuvant aromatase inhibitor therapy in postmenopausal
      
Dose Proportionality and Population Characteristics of Oral Fadrozole Hydrochloride, an Aromatase Inhibitor, in Postmenopausal W
      
To study the effects of hippocampus-derived estradiol, we inhibited hippocampal estrogen synthesis by treatment of hippocampal cell cultures with letrozole, an aromatase inhibitor.
      
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The effect of dehydroepiandrosterone(DHEA)on progesterone production in vitro by huamn trophoblast at 6~8 weeks has been investigated.The tissue explants(1mm 3), placed in medium 199 containing either no steroid or various amounts of DHEA,DHEAS and/or 10 -5 mol/L of other chemicals, were incubated for 16 hours in air at 37℃ with vibration. The medium was then collected and analyzed for progesterone by RIA. Higher concentrations(≥10 -6 mol/L)of DHEA and DHEAS markedly suppressed progesterone secretion(...

The effect of dehydroepiandrosterone(DHEA)on progesterone production in vitro by huamn trophoblast at 6~8 weeks has been investigated.The tissue explants(1mm 3), placed in medium 199 containing either no steroid or various amounts of DHEA,DHEAS and/or 10 -5 mol/L of other chemicals, were incubated for 16 hours in air at 37℃ with vibration. The medium was then collected and analyzed for progesterone by RIA. Higher concentrations(≥10 -6 mol/L)of DHEA and DHEAS markedly suppressed progesterone secretion( P <0 001). The inhibitory action of DHEA(s) was not dependent on aromatization to estrogen. Significant reduction in progesterone formation was also caused by the aromatase inhibitor 4 hydroxyandrosterone( P <0 001). The action of the aromatase inhibitor could be reversed by concomitant addition of 17β estradiol, however, 17β estradiol alone had no effect. The present results suggest that the inhibitory effect of DHEA might result from its direct action on trophoblast cells and mainly depends on its own concentration.

采用绒毛组织体外孵育模型,观察了脱氢表雄酮对人早期胎盘滋养层组织孕酮分泌的可能影响。结果表明,高浓度(10-6mol/L以上)的脱氢表雄酮及其硫酸盐可以显著地抑制体外孵育的人早期胎盘滋养层组织的孕酮分泌(P<0001),低浓度则无效应。脱氢表雄酮及其硫酸盐抑制孕酮分泌的影响不依赖于其芳香化产物雌激素。芳香化酶抑制剂4羟基雄烯二酮也能抑制孕酮分泌(P<0001),但其作用可被17β-雌二醇逆转。推测脱氢表雄酮及其硫酸盐抑制滋养层组织孕酮分泌的效应可能是其自身的功能,并依赖于其含量水平。

The experiment was carried out in the Breeder Duck Farm of Fujian Agricultural University. Three ways such as using hormones to treat the fertilized eggs by the methods of immersion, painting and spraying;infusion of oviduct in female duck and dilution of semen from drakes using arginine solution (5.0, 2.5 mg·L-1),testes tissue homogenate and aromatase inhibitor (5.0, 2.5 mg·L-1) respectively, as well as painting the fertilized eggs with aromatase inhibitor (5.0, 2.5 mg·L-1) were adopted...

The experiment was carried out in the Breeder Duck Farm of Fujian Agricultural University. Three ways such as using hormones to treat the fertilized eggs by the methods of immersion, painting and spraying;infusion of oviduct in female duck and dilution of semen from drakes using arginine solution (5.0, 2.5 mg·L-1),testes tissue homogenate and aromatase inhibitor (5.0, 2.5 mg·L-1) respectively, as well as painting the fertilized eggs with aromatase inhibitor (5.0, 2.5 mg·L-1) were adopted .The results showed that using exogenous sex hormones to treat the fertilized eggs could modify the embryonic sex differentiation tendentiously. The percentage of female was raised significantly by treating with diethylstilibesterol (P<0.05),the average percentages of the female by three different methods were (75.8±3.5)%,(79.3±3.5)%, and (75.5±1.8)% respectively. The effects of other hormones were not significant (P>0.05).In the experiment of infusion of oviduct and dilution of semen, it seemed that arginine solution could raise the proportion of male slightly, the percentage of male for each treatment was (58.2±1.5)% (oviduct infusion)and (59.2±1.1)%(semen dilution)respectively,while testes tissue homogenate could increase the proportion of female, the percentage of female for each treatment was (56.7±2.1)% (oviduct infusion) and (56.3±3.8)% (semen dilution) respectively. But there were no significant difference between these two treatments and control group (P>0.05). Infusion of oviduct in female duck and dilution of semen from drakes with aromatase inhibitor could significantly increase the percentage of male (P<0.01),the average percentage of male for each treatment was (75.4±7.4)% (oviduct infusion) and (84.4±1.5)% (semen dilution) respectively, 25.7% and 34.7% higher than that of control group, and even higher than those of the group in which the eggs was treated with aromatasc inhibitor (61.7±0.4)% by painting. Moreover,there were no adverse effects on fertility and hatchability of eggs.

本试验在福建农业大学种番鸭场进行.用了3种处理方法;(1)以外源激素分别用浸泡、涂种和喷雾的方法处理番鸭受精蛋;(2)用精氨酸溶液(5.0、2.5mgL-1),睾丸组织匀浆及芳香化酶抑制剂(5.0、2.5mgL-1)作为性控液分别灌注母鸭产道和稀释公鸭精液;(3)用芳香化酶抑制剂(5.0、2.5mgL-1)涂抹种蛋.结果表明:性激素处理法可使胚胎性别分化发生倾向性改变,其中已烯雌酚处理组明显提高雌性比例(P<0.05),3种处理方法的雌性百分比分别为:(75.8±3.5)%、(79.3±3.5)%和(75.5±1.8)%;其他几种激素处理效果不明显(P>0.05).用性控液灌注母鸭产道和稀释精液,其中精氨酸组雄性百分比略有提高,分别为(58.2±1.5)%和(59.2±1.1)%;而睾丸组织匀浆组却使雌雏增多,雌性百分比分别为(56.7±2.1)%和(56.3±3.8)%,但二者与对照组均无明显差异(P>0.05);芳香化酶抑制剂处理组极显著提高雄性比例(P<0.01),各处理组雄性百分比分别为(75.4±7.4)%和(84.4±1.5)%,比对照组(49.7±3.5)%分别提高25.7%和34.7%,也明?

The sex of birds is determined by chromosomes ZZ in the male or ZW in the female in the nature, so the sex chromosome of spermatozoa is Z and that of ovum is Z or W. In the present study an aromatase inhibitor was injected into fertilized eggs at the third day of incubation. After sex identification with a w chromosome-specific gene fragment, the females were raised until sexual maturation. Although these sex-reversed hens showed similar masculized phenotype and behaviour, they failed to ejuculate semen....

The sex of birds is determined by chromosomes ZZ in the male or ZW in the female in the nature, so the sex chromosome of spermatozoa is Z and that of ovum is Z or W. In the present study an aromatase inhibitor was injected into fertilized eggs at the third day of incubation. After sex identification with a w chromosome-specific gene fragment, the females were raised until sexual maturation. Although these sex-reversed hens showed similar masculized phenotype and behaviour, they failed to ejuculate semen. Single spermatozoa were obtained from the testes and used for sex identification with polymerase chain reaction method. The result indicated that all three sex-reversed hens examined produced W-spermatozoa in both the left and right testes.

在自然界公鸡和母鸡的性别分别由性染色体ZZ和ZW所决定,因此公鸡产生的精子其性染色体均是Z,而母鸡产生的卵子有Z和W两种。本实验在受精卵孵化的第三天注入芳香化酶抑制剂以抑制雌激素的合成,用W染色体特异的基因鉴别性别后将雌鸡饲养至性成熟。这些性反转母鸡有与公鸡相似的表型和雄性交配行为,但无精子排出。为了观察其性腺内是否有精子产生,取出睾丸在显微镜下捕获单个精子,用W染色体基因特异的寡核苷酸引物进行PCR扩增,结果表明所检测的三只性反转母鸡两侧睾丸内均有W精子。

 
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