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This paper reviews briefly the progress on biomimetic chemistry of tetrahydrofolate coenzymes, including the biomimetic organic synthesis, the chemical models of enzymatic reaction and the reaction mechanism. 本文简要地介绍了四氢叶酸辅酶仿生化学研究的进展,包括仿生有机合成、酶促反应模型和反应机理等方面。 Biomimetic chemistry is a new challenging field in modern chemistry. Imidazole cyclophanes are excellent blocks for constructing biomimetic system, bbut so far little research has been involved with them.This review describes briefly the recentdevelopments in biomimetic system of imidazole cyclophane, covering the selective synthesis of imidazole, diimidazole and theirderivatives, The design and synthesis of novel imidazole cyclophanes and imidazolium cyclophanes, and the biomimetic... Biomimetic chemistry is a new challenging field in modern chemistry. Imidazole cyclophanes are excellent blocks for constructing biomimetic system, bbut so far little research has been involved with them.This review describes briefly the recentdevelopments in biomimetic system of imidazole cyclophane, covering the selective synthesis of imidazole, diimidazole and theirderivatives, The design and synthesis of novel imidazole cyclophanes and imidazolium cyclophanes, and the biomimetic function ofimidazole cyclophanes. 仿生化学是当今化学的挑战性领域之一。咪唑环番是构筑仿生体系的优良基体,但迄今研究工作极少。本文简要评述了咪唑的选择性反应和咪唑衍生物的选择性合成、新型咪唑环番和咪唑鎓环番的设计合成及仿生功能研究的一些新进展。 In this paper,a detail review is given on the recent progress in chiral crown ether biomimetic chemistry.Attempts to understand the phenomena of molecular recognition occurring in chemical interactions involving enzymes,antibodies,stereoselective catalysts,etc.led to the rapid development of the area of synthetic host guest chemistry.The syntheses of chiral macrocycles for the selective recognition of enantiomers is an active area of research. 综述了部分开链配体的络合行为 ,对手性冠醚的合成、分子识别及仿生功能的研究进行了评述 .开链配体在络合行为上与环状化合物很相似 ,能与金属离子、中性分子形成络合物 .手性冠醚的合成是一个活跃的研究领域 ,将手性冠醚用于手性识别、手性催化及仿生化学的研究日趋活跃 ,前景十分诱人 .
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