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肿瘤学
妇产科学
皮肤病与性病
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sarcoma
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  肉瘤(
     Objective To confirm the relationship between Human herpesvirus 8(HHV8) and the pathogeny of Kaposi's sarcoma(KS) in Xinjiang.
     目的探讨8型疱疹病毒(human herpesvirus 8,HHV 8)与新疆卡波氏肉瘤(kaposi’s sarcoma,KS)发病的关系并探索HHV8 DNA的检测方法。
短句来源
     The inhibitory rates on reticuloum-cell sarcoma (LI ) were 41-50.8% and 47-61% under the doses of 22.5mg/kg/d and 45mg. kg/d.
     在22.5mg/kg/d和45mg/kg/d的剂量下对网细胞肉瘤(L_1)的抑制率为41~50.8%和47~61%。
短句来源
     Objective To discuss the diagnosis of follicular dendritic cell sarcoma(FDCS)of the appendix,clinicopathologic features and the treatment.
     目的探讨阑尾滤泡树突状细胞肉瘤(follicular dendritic cell sarcoma,FDCS)的生物学行为特征,诊断要点和临床治疗。
短句来源
     Aim: To explore the expression of hTERT mRNA and C-myc in oromaxillofacial sarcoma (OMFS) tissue.
     目的:探讨口腔颌面部肉瘤(OMFS)组织中hTERT mRNA和C-myc蛋白的表达。
短句来源
     Objective To investigate the infection of the human herpesivirus-8(HHV-8) in serum of Xinjiang classic Kaposi sarcoma(KS) and explore the role of HHV-8 in the pathogenesis of KS.
     目的了解新疆经典型Kaposi肉瘤(Kaposi’ssarcoma,KS)患者血清中人类8型疱疹病毒(humanherpesivirus8,HHV8)感染的情况,以探讨HHV8感染与经典型KS发病之间的关系。
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  肉瘤
     Objective To confirm the relationship between Human herpesvirus 8(HHV8) and the pathogeny of Kaposi's sarcoma(KS) in Xinjiang.
     目的探讨8型疱疹病毒(human herpesvirus 8,HHV 8)与新疆卡波氏肉瘤(kaposi’s sarcoma,KS)发病的关系并探索HHV8 DNA的检测方法。
短句来源
     The inhibitory rates on reticuloum-cell sarcoma (LI ) were 41-50.8% and 47-61% under the doses of 22.5mg/kg/d and 45mg. kg/d.
     在22.5mg/kg/d和45mg/kg/d的剂量下对网细胞肉瘤(L_1)的抑制率为41~50.8%和47~61%。
短句来源
     Molecular cytogenetic studies of 25 cases of soft tissue tumors,including 8 malignant fibrous histiocytomas(MFH), 13 rhabdomyosarcomas(RMS),3 Ewing’s sarcomas(ES)and 1 synovial sarcoma(SS),were performed.
     作者用染色体分析和DNA印迹实验对25例软组织肿瘤进行了研究,其中恶性纤维组织细胞瘤(MFH)8例、横纹肌肉瘤(RMS)13例、Ewing氏肉瘤(ES)3例、滑膜肉瘤(SS)1例。
短句来源
     Ki-67LI ofsarcoma was higher than that of benign tumor (P<0.05),and tended to increase with the malignancy of sarcoma (P<0.05).
     肉瘤组织中Ki-67LI(ki-67 labeling index,ki67LI)明显高于良性肿瘤(P<0.05),且随恶性程度的增加升高(P<0.05)。
     20 primary tumors (43.4%), including 3 cases of sarcomatoid carcinoma (6.5%), 11 of angiosarcoma (23.9%), 2 of epithelioid hemangioendothelioma (5%), 1 of spindle cell carcinoid (2.2%), and 3 of undifferentiated sarcoma (6.5%).
     结果20例(434%)原发肿瘤中肉瘤样癌3例(65%),血管肉瘤11例(239%),上皮样血管内皮细胞瘤2(5%)例,梭形细胞类癌1例(22%),未分化肉瘤3例(65%);
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  “sarcoma (”译为未确定词的双语例句
     Meanwhile, strong positive staining of TEIF (≥2+) was frequently observed in PNET(83%, 19/23) and synovial sarcoma (76%, 13/17).
     同时,TEIF蛋白的弥漫阳性表达(≥2+)多存在于PNET和滑膜肉瘤,分别为83%(19/23)和76%(13/17)。
短句来源
     Meanwhile,strong positive staining of NAT10(≥++) was much frequently in synovial sarcoma(53%,9/17),rhabdomyosarcoma 40%(4/10) or malignant fibrous histiocytoma 40%(8/20).
     同时,NAT10蛋白强阳性表达(≥++)多存在于滑膜肉瘤(53%,9/17)、横纹肌肉瘤(40%,4/10)及恶性纤维组织细胞瘤(40%,8/20)。
短句来源
     Results In 151 cases,49 with PCa (32%),12 with prostatic epithelial sarcoma(8%),48 with chronic prostatitis (32%) and 42 benign prostate hyperplasia (28%).
     结果151例患者中,共检出PCa49例(32%),上皮内瘤12例(8%),慢性炎症48例(32%),良性增生42例(28%)。
短句来源
     The antitumor effect of germanium citrate on transplanted tumor sarcoma(180), H22 and P388 ofmice was observed.
     观察了有机锗化合物枸橼酸锗对小鼠移植性肿瘤S(180)、H(22)和P(388)的抗肿瘤作用。
短句来源
     Karyotype Analysis of the Lymphotic Sarcoma (L_1) of Mouse Ascites Form
     小鼠腹水型淋巴肉瘤一号(L_1)核型分析
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  sarcoma
Five virulent strains induced the infection, which inhibited sarcoma-180 growth 1.5-22.0 times.
      
Comparative Study of Lipid Composition and Proliferative Activity of Rat Cholangiocarcinoma RS1 and Sarcoma M1 Depending on the
      
The proliferative activity and lipid composition (phospholipids, gangliosides) were studied in rat cholangiocarcinoma RS1 and sarcoma M1 transplanted subcutaneously or intrahepatically.
      
Dihydroceramide desaturase activity in the transplantable mouse hepatoma-22, rat hepatoma-27, M1 sarcoma, and RS1 rat cholangiocellular carcinoma has been investigated.
      
Dihydroceramide desaturase activity in subcutaneously and intrahepatically transplanted M1 sarcoma as well as in hepatoma-27 is dependent on the tumor microenvironment.
      
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An experimental study of 300 mice exposed to pitch(3 gm.dissolved in 10 ml.of 80% benzene solution)obtained from 4 different sources,name- ly Anshan coal-tar pitch,Yu-men petroleum pitch,Dairen petroleum pitch or commonly known as Russian crude oil and the Asia Oil Company, USA,was carried out over a period of 350 days. From the beginning a group of these experimen- tal animals was exposed to artificial sun-ray for 2 hours a day.The results of our experiment indicate that pathological changes of different degrees...

An experimental study of 300 mice exposed to pitch(3 gm.dissolved in 10 ml.of 80% benzene solution)obtained from 4 different sources,name- ly Anshan coal-tar pitch,Yu-men petroleum pitch,Dairen petroleum pitch or commonly known as Russian crude oil and the Asia Oil Company, USA,was carried out over a period of 350 days. From the beginning a group of these experimen- tal animals was exposed to artificial sun-ray for 2 hours a day.The results of our experiment indicate that pathological changes of different degrees of severity,such as chronic dermatitis and tumor formation,were the commonest effect of pitch on skin both in the exposed and non-ex- posed groups while the control group(exposed to 80% benzene only)showed only slightly acute dermatitis. The pathological changes as observed both in gross appearances and histological findings are given in detail. The course of tumor formation as found in both the exposed and the non-exposed groups may be classified in the order of time sequence as benign squamous papilloma,malignant squamous papilloma and finally squamous-celled carcinoma; also a few cases of sarcoma and a few cases of so- called“Myoblastoma”. Through the action of photosensitivity to the exposed group,the prolongation of the latent period of tumor formation,the effectiveness in the development of dermatitis and malignant changes in tumors were clearly observed in the process of the pathological changes. The relative potency of the carcinogenic pitch obtained from the above sources has been calculated by means of the statistical analysis of both the incidence and the length of time for the development of the cutaneous tumors.

(一)四种来源不同的沥青(鞍山煤焦油沥青、西北玉门石油沥青、大连石油沥青、和美国亚细亚公司石油沥青)经涂抹小白鼠的实验证明具有引起皮肤各种的病理变化的作用。其中包括慢性渗出性皮炎;慢性炎性上皮结缔组织增生;良性皮肤乳头状瘤;皮肤鳞状细胞癌。此外也引起了少数的肉瘤和“肌母细胞痛”。皮肤瘤发生的潜伏期由62天至406天不等。(二)光感作用可以加剧及加速煤焦油沥青皮肤炎的进展,和发炎皮肤的角化现象。至于对沥青致癌作用本实验未能证实其有显著的影响。(三)根据四种来源不同的沥青所引起皮肤良性与恶性病变的发病率和潜伏期的长短,可将其毒性的强弱顺序排列如下:(1)鞍山煤焦油沥青,(2)美国亚细亚公司石油沥青,(3)大连石油沥青(苏联原油),(4)西北玉门石油沥青。即煤焦油沥青毒性远较石油沥青为强。国产石油沥青的毒性较外产石油沥青的毒性为弱。

Since it is known that some organo-fluorine compounds such as fluoro pyrimidines, are capable of inhibiting the growth of rat tumor,it will be of interest to synthesize and study fluoro-containing amino-acids for the carcinostatic action. ω-Fluoro-a-amino butyric,-valenic and caproic acids are the only fluoro-containing aliphatic amino-acid recorded in literature.We have synthesized β-fluoro-α-amino-propionic acid by the following sequence of reactions: When 2-phenyl-4-chloromethylene-5-azlactone (Ⅰ) was treated...

Since it is known that some organo-fluorine compounds such as fluoro pyrimidines, are capable of inhibiting the growth of rat tumor,it will be of interest to synthesize and study fluoro-containing amino-acids for the carcinostatic action. ω-Fluoro-a-amino butyric,-valenic and caproic acids are the only fluoro-containing aliphatic amino-acid recorded in literature.We have synthesized β-fluoro-α-amino-propionic acid by the following sequence of reactions: When 2-phenyl-4-chloromethylene-5-azlactone (Ⅰ) was treated with anhydrous potassium fluoride in acetylacetone by UV irradiation,the corresponding fluoro-substituted azlactone (Ⅱ)was formed.The latter was hydrolyzed in aqueous alkali to the acrylic acid deri- vative,which was then hydrogenated in the presence of Adam’s catalyst and subsequently hydrolyzed with hydrochloric acid and formic acid mixture.As shown by paper chroma- tography,the product was contaminated with alanine.The latter was completely removed by azobenzene-p-sulfonic acid and followed by treatment with alumina.The β-fluoro-α- amino-propionic acid hydrochloride thus obtained was chromatographically pure.Raasch was unable to get this amino acid by malonic ester synthesis.We have made attempts to synthesize this compound by treating β-bromo-α-benzoylamido-,β-p-tosylhydroxy-α-benzoyl- amido-propionic acid or diethyl α-acetamido-α-dimethylamino-methyl malonate methyl iodide with anhydrous potassium fluoride in various solvents but the attempts was unsuccessful. A series of fluoro-containing aromatic amino-acids with the general formula given were prepared from p-fluorobenzaldehyde. R=H,OH,SH,SR′ 2-Phenyl-4-(p-fluorobenzylidene)-5-azlactone (Ⅳ) was resulted from p-fluorobenzal- dehyde via Erlenmeyer azlactone synthesis underwent an addition reaction with ethyl-or benzylmercaptans in the presence of sodium methoxide with formation of the corresponding β-(p-fluorophenyl)-S-alkyl-N-benzoylcysteine methyl ester (Ⅵ).The latter was hydrolyzed into the free amino acid in the usual way.In the case of addition of ethylmercaptan, the expected Threo-and Erythreo-isomers were separated.β-(p-Fluorophenyl)cysteine (Ⅷ)was synthesized by subsequent debenzylation of β-(p-fluorophenyl)-S-benzylcysteine (Ⅶb)with metallic sodium in liquid ammonia. A modification of the preparation of p-fluorobenzoldehyde,the key intermediate in our synthesis,has been developed. Biological tests of the indicated compounds showed that p-fluorophenyl serine prolonged the life of rat transplanted with Erhlich Ascites but with no effect toward Sarcoma 180. β-Fluoro-α-amino-propionic acid possessed some inhibiting action on the growth of Sarcoma 180 in rats.The biological tests were carried out in the laboratories of Institute of Ex- perimental Biology and Institute of Materia Media,Academia Sinica.

1.研究了由2-苯基-4-氯代亚甲基-5-间氧氮环戊酮经氟化、水解、氢化及皂化等步骤合成β-氟代-α-氨基丙酸的方法.2.由对氟苯甲醛出发合成了一系列芳香族的含氟氨基酸,包括β-对氟苯丝氨酸,β-对氟苯基-α-氨基丙酸,β-对氟苯基-β-氨基丙酸,β-对氟苯基丙烯酸及β-对氟苯基半胱氨酸的衍生物,并测得了这些外消旋氨基酸在多种溶剂系统中的 R_j 值.

Four 5-(p-substituted-phenylazo)-uracils (Ⅴ:Ⅴa,Ⅴb,Ⅴc and Ⅴd)and six 5-(p- substituted-phenylazo)-6-methyluracils (Ⅵ:Ⅵa,Ⅵb,Ⅵc,Ⅵd,Ⅵe and Ⅵf)were pre- pared as antitumor agents,However,none of them showed any significant activity against Ehrlich ascites tumour in mice. (Ⅴa)R=C1 mp.280°dec.(Ⅵa)R=G1 mp.235°dec. (Ⅴb)R=Br mp.270°dec.(Ⅵb)R=Br mp.227°dec. (Ⅴc)R=CH_3 mp.264°dec.(Ⅵc)R=CH_3 mp.223°dec. (Ⅴd)R=SCN mp.171°dec.(Ⅵd)R=OCH_3 mp.235°dec. (Ⅵe)R=SCN mp.147°dec. (Ⅵf)R=SCH_3 mp.222°dec. A of 5-substituted uracils...

Four 5-(p-substituted-phenylazo)-uracils (Ⅴ:Ⅴa,Ⅴb,Ⅴc and Ⅴd)and six 5-(p- substituted-phenylazo)-6-methyluracils (Ⅵ:Ⅵa,Ⅵb,Ⅵc,Ⅵd,Ⅵe and Ⅵf)were pre- pared as antitumor agents,However,none of them showed any significant activity against Ehrlich ascites tumour in mice. (Ⅴa)R=C1 mp.280°dec.(Ⅵa)R=G1 mp.235°dec. (Ⅴb)R=Br mp.270°dec.(Ⅵb)R=Br mp.227°dec. (Ⅴc)R=CH_3 mp.264°dec.(Ⅵc)R=CH_3 mp.223°dec. (Ⅴd)R=SCN mp.171°dec.(Ⅵd)R=OCH_3 mp.235°dec. (Ⅵe)R=SCN mp.147°dec. (Ⅵf)R=SCH_3 mp.222°dec. A of 5-substituted uracils and methyluracils (Ⅶ:Ⅶa,Ⅶb,Ⅶc,Ⅶd and Ⅷ: Ⅷa,Ⅷb,Ⅷc,Ⅷd,Ⅷe,Ⅷf,Ⅷg,Ⅷh)were also prepared.These uracils did not show any significant inhibiting action against Sarcoma 180 in mice.The phar- macological actions of the above compounds will be reported eleswhere. ~*(Ⅶa)R=NO_2 ~*(Ⅷa)R=NO_2 ~*(Ⅶb)R=NHCHO mp.312°dec.(Ⅷb)R=NHCHO mp.290°dec. ~*(Ⅶc)R=NHCOCH_2Cl mp.274°dec.(Ⅷc)R=NHCOCH_2Cl mp.252°dec. (Ⅶd)R=NHCSNH_2 mp.>320°(Ⅷd)R=NHCOCHCl_2 mp.280°dec. (Ⅷe)R=NHCOCH_2I mp.236°dec. (Ⅷf)R=NHCOCF_3 mp.282°dec. (Ⅷg)R=NHCOOC_2H_5 mp.265°dec. (Ⅷh)R=NHCSNH_2 mp.268°dec. *These compounds are known in literatures.

1.合成了四个5-对-取代基苯偶氮尿嘧啶(Ⅴ)和六个5-对-取代基苯偶氮-6-甲基尿嘧啶.上述十个化合物口服对小白鼠艾氏腹水瘤无显著抑制作用.2.又合成了四个5-取代基尿嘧啶(Ⅶ)和八个5-取代基-6-甲基尿嘧啶(Ⅷ),此十二个化合物口服或腹腔注射对肉瘤180无明显抑制作用.

 
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