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   susceptibility protein 的翻译结果: 查询用时:0.193秒
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susceptibility protein
相关语句
  易感蛋白
     Structure and function of breast cancer susceptibility protein 2
     乳腺癌易感蛋白2的结构和功能(英文)
短句来源
     Our previous study revealed that COBRA 1, a novel protein, can interact with breast cancer susceptibility protein ( BRCA1 ).
     我们以前的研究发现,COBRA1能与乳腺癌易感蛋白BRCA1相互作用。
短句来源
     BACKGROUND:Breast cancer susceptibility protein BRCA 2 encoded by BRCA2 gene is a tumor suppressor required for maintenance of chromosomal stability in mammalian cells and playing a pivotal role in biological response to DNA damage.
     背景:乳腺癌易感蛋白2(breastcancersusceptibilityprotein2,BRCA2)是由乳腺癌易感基因2编码的一种在维持哺乳动物细胞染色体稳定及DNA损伤生物应答中发挥重要作用的肿瘤抑制因子。
短句来源
  “susceptibility protein”译为未确定词的双语例句
     Results DNA hypermethylation was indentified in the NiS-transformed 16 HBE cells,and it was found that one of the DNA fragments homologized (99%) with ANKRD11 which encoded the susceptibility protein of nasopharyngeal carcinoma and another homologized (99%)with homeo box A3, which encoded a DNA-binding transcription factor which might regulate gene expression, morphogenesis, and differentiation.
     其中一基因片段与位于 16q2 4.3编码鼻咽癌易感性蛋白基因ANKRD11同源 ( 99% ) ,另一基因片段与HOXA3基因序列同源 ( 99% )。 HOXA3在脊椎动物中编码转录因子 ,编码调控基因表达 ,形态发生和变异的DNA结合转录因子。
短句来源
  相似匹配句对
     The susceptibility of C.
     海南苏铁C.
短句来源
     protein.
     protein。
短句来源
     Structure and function of breast cancer susceptibility protein 2
     乳腺癌易感蛋白2的结构和功能(英文)
短句来源
     Protein Folding
     蛋白质的折叠
短句来源
     Magnetic Susceptibility
     稀磁合金的磁化率
短句来源
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  susceptibility protein
A number of the cellular proteins which associate to E1A have been identified: the retinoblastoma-susceptibility protein (Rb), the p107 protein, cyclin A and the p33cdk2 kinase.
      


Objective To study aberrant DNA methylation potentially resulting in the changes of the NiS-transformed 16 HBE cells as a possible epigenetic methanism for nickel sulfide(NiS) carcinogenesis. Methods Genomic DNA isolated from NiS-transformed 16HBE cells was analyzed with MseI (methylation non-sensitive) or with MseI and BstuI(methylation sensitive) for aberrant methylation. The product DNA was analyzed for aberrant methylation using PCR based technique—Methylation-sensitive restriction fingerpringting(MSRF)....

Objective To study aberrant DNA methylation potentially resulting in the changes of the NiS-transformed 16 HBE cells as a possible epigenetic methanism for nickel sulfide(NiS) carcinogenesis. Methods Genomic DNA isolated from NiS-transformed 16HBE cells was analyzed with MseI (methylation non-sensitive) or with MseI and BstuI(methylation sensitive) for aberrant methylation. The product DNA was analyzed for aberrant methylation using PCR based technique—Methylation-sensitive restriction fingerpringting(MSRF). Several DNA fragments differentially methylated in the transformed cells found by MSRF were ligated to pMD-T Vector and transformed into bacteria. The plasmid DNA were sequenced and compared with data in GenBank by BLASTN. Results DNA hypermethylation was indentified in the NiS-transformed 16 HBE cells,and it was found that one of the DNA fragments homologized (99%) with ANKRD11 which encoded the susceptibility protein of nasopharyngeal carcinoma and another homologized (99%)with homeo box A3, which encoded a DNA-binding transcription factor which might regulate gene expression, morphogenesis, and differentiation. Conclusion DNA hyper-methylation is known to result in gene silencing, it appears that hypermethylation of gene may represent a possible epigenetic mechanism for NiS-induced cells transformation and carcinogenesis.

目的 对结晶型硫化镍诱导转化及成瘤的人支气管上皮细胞 ( 16HBE)基因组DNA甲基化状况进行研究 ,以寻找DNA甲基化异常的基因片段 ,并探讨镍的外遗传致癌机制。方法 抽提基因组DNA后 ,采用限制性内切酶MseI单独酶切或限制性内切酶MseI与BstuI双重酶切后 ,其酶切产物采用甲基化敏感的限制性指纹识别技术 (MSRF)进行分析 ,显示的异常甲基化基因片断 ,采用TA克隆技术构建测序载体 ,对测序结果进行同源性分析比较。结果 发现结晶型NiS诱导转化及成瘤的 16HBE细胞基因组DNA存在高甲基化的DNA片段。其中一基因片段与位于 16q2 4.3编码鼻咽癌易感性蛋白基因ANKRD11同源 ( 99% ) ,另一基因片段与HOXA3基因序列同源 ( 99% )。HOXA3在脊椎动物中编码转录因子 ,编码调控基因表达 ,形态发生和变异的DNA结合转录因子。结论 结晶型NiS诱导转化及成瘤的 16HBE细胞基因组DNA的高度甲基化可能导致基因表达抑制 ,这可能是结晶型NiS诱导 16HBE细胞转化和成瘤的一种外遗传机制。

BACKGROUND:Breast cancer susceptibility protein BRCA 2 encoded by BRCA2 gene is a tumor suppressor required for maintenance of chromosomal stability in mammalian cells and playing a pivotal role in biological response to DNA damage. Many researches showed that BRCA2 protein was closely related to the pathogenesis of hereditary breast cancer, ovarian cancer and Fanconi anemia (FA), presumably involving DNA double stranded break (DSB) repair, but the exact mechanism of its actions remains unknown....

BACKGROUND:Breast cancer susceptibility protein BRCA 2 encoded by BRCA2 gene is a tumor suppressor required for maintenance of chromosomal stability in mammalian cells and playing a pivotal role in biological response to DNA damage. Many researches showed that BRCA2 protein was closely related to the pathogenesis of hereditary breast cancer, ovarian cancer and Fanconi anemia (FA), presumably involving DNA double stranded break (DSB) repair, but the exact mechanism of its actions remains unknown. OBJECTIVE:To review the researches on BRCA2 protein structure and DNA repair so as to elucidate the mechanism of BRCA2 in DNA repair. STUDY SELECTION:The documents about BRCA2 protein and DNA repair were chosen. DATA SOURCES:The data were searched overall including electronic search, craft search and personal communication search and so on.DATA EXTRATION: The information about BRCA2 protein and DNA repair in the researched documents was surveyed. MAIN OUTCOME MEASURES:The structure, function model and mechanism of BRCA2 protein in DNA repair are explored. RESULTS:The results showed that BRCA2 protein performed important functions in tumor suppression. The DNA)binding activities of DNA binding domain(DBD) of BRCA2,in conjunction with the RAD51 binding activities of the BRC repeat, were directly associated with DSB repair during homologous recombination. CONCLUSION:BRCA2 protein plays an important role in DSB repair, but the exact process and signal transduction pathway still need further study. The study of BRCA2 may hold significant value in developing new treatment target for diseases involving DNA damage.

背景:乳腺癌易感蛋白2(breastcancersusceptibilityprotein2,BRCA2)是由乳腺癌易感基因2编码的一种在维持哺乳动物细胞染色体稳定及DNA损伤生物应答中发挥重要作用的肿瘤抑制因子。许多研究表明:BRCA2蛋白与遗传性乳腺癌、卵巢癌及范康尼氏贫血症的发生具有密切关系,猜测其与双链DNA损伤修复有关,但具体作用模型与机制仍不清楚。目的:回顾关于BRCA2蛋白结构与DNA损伤修复的研究,明确BRCA2蛋白在双链DNA损伤修复中的作用机制。研究选择:选择关于BRCA2蛋白及DNA损伤修复的文献。数据来源:进行全面的检索,检索手段包括电子检索、手工检索及个人通信等。数据提取:对检索到的BRCA2蛋白及DNA损伤修复的相关研究文章信息进行综述。主要观察指标:BRCA2蛋白的结构及其在DNA损伤修复中的作用模型与机制。结果:BRCA2蛋白在肿瘤抑制过程中行使重要功能,其C末端DBD中的DNA结合活性与BRC模体中的RAD51蛋白结合活性在双链DNA损伤修复的同源重组过程中起着直接作用。结论:BRCA2蛋白在双链DNA损伤修复中发挥重要作用,但其具体过程与整个信号通路仍需进一步研究证实,其有...

背景:乳腺癌易感蛋白2(breastcancersusceptibilityprotein2,BRCA2)是由乳腺癌易感基因2编码的一种在维持哺乳动物细胞染色体稳定及DNA损伤生物应答中发挥重要作用的肿瘤抑制因子。许多研究表明:BRCA2蛋白与遗传性乳腺癌、卵巢癌及范康尼氏贫血症的发生具有密切关系,猜测其与双链DNA损伤修复有关,但具体作用模型与机制仍不清楚。目的:回顾关于BRCA2蛋白结构与DNA损伤修复的研究,明确BRCA2蛋白在双链DNA损伤修复中的作用机制。研究选择:选择关于BRCA2蛋白及DNA损伤修复的文献。数据来源:进行全面的检索,检索手段包括电子检索、手工检索及个人通信等。数据提取:对检索到的BRCA2蛋白及DNA损伤修复的相关研究文章信息进行综述。主要观察指标:BRCA2蛋白的结构及其在DNA损伤修复中的作用模型与机制。结果:BRCA2蛋白在肿瘤抑制过程中行使重要功能,其C末端DBD中的DNA结合活性与BRC模体中的RAD51蛋白结合活性在双链DNA损伤修复的同源重组过程中起着直接作用。结论:BRCA2蛋白在双链DNA损伤修复中发挥重要作用,但其具体过程与整个信号通路仍需进一步研究证实,其有望开发为治疗与DNA损伤相关疾病的新靶点,为其预防康复提供理论依据。

Objective To study aberrant DNA methylation potentially resulting in the changes of the anti-7,8,-dihydrodiol-9,10-epoxide benzo[a]pyrene(anti-BPDE)and nickel sulfide(NiS)transformed Human bronchial epithelia(16 HBE)as a possible epigenetic mechanism for carcinogenesis.Methods The product DNA isolated from five kinds of 16HBE was analyzed for aberrant methylation using PCR based technique-methylation sensitive restriction fingerprinting technique(MSRF).Several DNA fragments differentially methylated in the transformed...

Objective To study aberrant DNA methylation potentially resulting in the changes of the anti-7,8,-dihydrodiol-9,10-epoxide benzo[a]pyrene(anti-BPDE)and nickel sulfide(NiS)transformed Human bronchial epithelia(16 HBE)as a possible epigenetic mechanism for carcinogenesis.Methods The product DNA isolated from five kinds of 16HBE was analyzed for aberrant methylation using PCR based technique-methylation sensitive restriction fingerprinting technique(MSRF).Several DNA fragments differentially methylated in the transformed cells found by MSRF were ligated to pMD18T Vector and transformed into bacteria.The plasmid DNA were sequenced and compared with data in GenBank by BLASTN.Results DNA hypermethylation was indentified in the NiS transformed 16 HBE,and it was found that one of the DNA fragments homologized(99%)with ANKRD11 which encoded the susceptibility protein of nanopbaryngeal carcinoma and another homologized(99%)with bomeo box A3.Conclusion Anti-BPDE induced 16HBE did not show aberrant genome CpG methylation,which suggestes that aberrant methylation of genes may not happen for anti-BPDE-induced cells transformation and carcinogenesis.DNA hypermethylation is known to result in gene silencing,and it appears that hypermethylation of gene may represent a possible epigenetic mechanism for NiS induced cells transformation and carcinogenesis.

目的对反式二氢二醇环氧苯并芘(anti-BPDE)和结晶型硫化镍(NiS)恶性转化人支气管上皮细胞(Hu-man bronchial epithelia,16HBE)基因组DNA甲基化状况进行研究,寻找DNA甲基化异常的基因片段,探讨反式-BPDE和NiS的表遗传致癌机制。方法采用限制性指纹识别技术(MSRF),对反式-BPDE和NiS分别诱导转化及裸鼠成瘤的4种人支气管上皮细胞株基因组进行分析;对异常甲基化基因阳性片断采用TA克隆技术构建测序载体,对测序结果进行同源性分析比较。结果发现结晶型NiS恶性转化人支气管上皮细胞基因组存在高甲基化的DNA片段,其中一基因片段与编码鼻咽癌易感性蛋白ANKRD11基因序列99%同源。另一基因片段与HOXA3基因序列99%同源;未发现反式BPDE恶性转化人支气管上皮细胞基因组DNA异常甲基化基因片段。结论结晶型NiS恶性转化人支气管上皮细胞DNA的高度甲基化可能导致基因表达抑制。可能是结晶型NiS致癌的一种表遗传机制;反式BPDE致癌过程可能与基因组磷酸胞苷酰(CpG)岛甲基化异常关系不明确。

 
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