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trial with
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     The results described above reveals that comparing with Kruskal_Wallis' Test, the repeated measurement analysis is more reasonable for multi_center clinical trial with repeated measurement data and related interaction variables.
     上述结果表明,对于多中心临床试验采用多个时点观测的情况,由于常常存在相关的交互作用的影响,应用重复测量分析方法有助于更合理地分析和解释试验的结果。
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     A trial with 2 factors quadratic regression right cross design were conducted to study the influence of dietary lysine (Lys) and methionine (Met) levels on protein deposition of 1-day to 8 weeks old young ring necked pheasants and feather growth of 8 th and 16 th weeks ages.
     本试验采用二因素二次回归正交设计 ,探讨饲粮赖氨酸 (Lys)和蛋氨酸 (Met)水平对雉鸡蛋白质沉积和羽毛生长的影响。
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     A trial with 2 factor quadratic regression right cross design was conducted to study the influence of dietary, lysine (Lys) and methionine (Met) levels on performance and feather growth of ring - necked pheasants from 9 to 6 weeks old.
     本试验采用二因素二次回归正交设计,探讨饲粮赖氨酸和蛋氨酸水平对9-16周龄雉鸡生产性能和羽毛生长的影响。
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     RB testing is a trial with high risk. This paper systematically expatiates the basic contents of the test rearch for RB control technology, and introduces the basic testing method, and approaches how to increase the successful rate and reduce the MFT.
     阐述RB控制技术试验研究的基本内容和RB试验采用的基本方法。 RB试验是一种高风险的试验,文中对如何提高试验的成功率和减少机组MFT次数进行探讨;
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     Results 22 patients finished the clinical trial with 50Gy(n=3),54Gy(n=3),58Gy(n=3),62Gy(n=13).
     结果22例完成治疗计划,分别为52Gy3例、54Gy3例、58Gy3例,62Gy13例,5例退出研究。
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     The trial, with a rate of 1 200 kg/hm\+2 compound fertilizer containing rareearths by holeseeding in seedling stage at 4 sites in 2 years, shows that the average yield of lint cotton is 1 785 kg/hm\+2 and an increase by 8.8% compared with common compound fertilizer without rareearths.
     2年 4点的试验结果表明 :棉花苗期一次性挖穴施入 1 2 0 0 kg/hm2 左右的稀土复混肥 ,平均皮棉产量 1 785kg/hm2 ,比等养分但不含稀土的普通复混肥增产 8.8%。
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     Preliminary results of therapeutic trial with ~(89)SrCl_2 in skeletal metastases
     ~(89)SrCl_2治疗转移性骨肿瘤疼痛的初步临床观察
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     In greenhouse potting trial with the ferment solutions diluted by 4 times,the relative control efficiencies to cucumber fusarium wilt were 60.61%-65.15%,to gray molds of tomato and pepper were up to 62.49%-89.76%.
     其4倍稀释液对黄瓜枯萎病的温室盆栽防效分别为65.15%和60.61%,对番茄和辣椒灰霉病的防效为62.49%~89.76%。
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     The optimum conditions of compound enzyme for enzymolysis muscle proteinare at enzyme consistency 7.5×103IU/g protein, temperature 45℃, pH6.5 and substrate consistency 5.5g protein % throughorthogonal trial with the constant time of 2 h.
     当水解时间固定为120min时,采用正交试验法优选得到复合酶水解的适宜条件为酶浓度为7.5×103IU/g蛋白质、温度为45℃、pH6.5和底物浓度为5.5g蛋白质%。
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     reporting the trial.
     试验报告。
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     On the Independence of Trial
     关于审判独立的思考
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     Trial with God's Absence
     上帝缺席的审判
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  trial with
In this paper, the drinking water biotic safety of particles and bacteria attached to fines in activated carbon process was investigated by actual treatment process and advanced treatment pilot trial with granular activated carbon.
      
A prospective, controlled, randomized clinical trial with respect to cardiovascular events and mortality in postmenopausal hormone users, the HERS (Heart and Estrogen/Progestin Replacement) study has recently been published.
      
Eighteen patients (16 male, 42 ± 9.4 yr, 249 ± 99 CD4+ lymphocytes/l) continued the trial with a daily dose of 45 g of Protectamin for six months.
      
The MERIT-HF study was a randomized, double-blind, placebo-controlled trial with a single-blind, two-week placebo run-in period.
      
Adjuvant treatment of parkinson's disease with dopamine agonists: Open trial with bromocriptine and CU 32-085
      
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This paper reports the results of the clinical use of Corydalis B as an analgesic in 72 patients with various forms of pain. In 64 cases the drug was used in a single dose, usually of 75 mg. by oral route, while in the other 8 cases repeated doses were given orally over a period of 3 to 21 days. The pain was completely abolished or definitely improved in 50 cases (78.1%) of the former group and in all 8 cases of the latter group. The analgesic effect appeared to be most marked in medical cases with dull pain...

This paper reports the results of the clinical use of Corydalis B as an analgesic in 72 patients with various forms of pain. In 64 cases the drug was used in a single dose, usually of 75 mg. by oral route, while in the other 8 cases repeated doses were given orally over a period of 3 to 21 days. The pain was completely abolished or definitely improved in 50 cases (78.1%) of the former group and in all 8 cases of the latter group. The analgesic effect appeared to be most marked in medical cases with dull pain in the chest or abdomen, as in cases of peptic ulcer and lobar pneumonia. Drowsiness was found as a side-effect in 28% of the cases after a single dose of the drug and in 6 of the 8 cases treated with repeated doses. In no case was any serious toxic action noted. According to the preliminary Observations herein reported, further clinical trial with the use of Corydalis B as an analgesic agent seems warranted.

本文报告72例试用延胡索素乙硫酸盐作为鎮痛剂的临床观察,其中64例为单剂用药,主要为一次口服75毫克,另8例为长期口服。单剂用药64例中完全止痛及疼痛减轻者共50例,占78.1%,长期服药8例均有效,鎮痛作用在内科胸腹部鈍痛病例较著。用药后未見重要副作用,单剂用药者28%发生嗜睡。长期用药的8例中6例有嗜睡,血与尿常規、大便次数、血压、心率等均无明显改变。据本文病例的初步临床应用结果,延胡索素乙对钝痛有一定的镇痛效果值,得进一步试用。

The very strong emetic action of Ch'ang Shan (Dichroa jebrifuga, Lour.) has limited its clinical use as an antimalarial. Elucidation of the mechanism of the dichroine-emesis so as to offer theoretical basis for the prevention and treatment of this side action has therefore both theoretical and practical importance. In a preliminary report, the author has pointed out that there are two possibilities for the mechanism of dichroine-emesis in pigeons, viz., through a peripheral reflex action, or through a direct...

The very strong emetic action of Ch'ang Shan (Dichroa jebrifuga, Lour.) has limited its clinical use as an antimalarial. Elucidation of the mechanism of the dichroine-emesis so as to offer theoretical basis for the prevention and treatment of this side action has therefore both theoretical and practical importance. In a preliminary report, the author has pointed out that there are two possibilities for the mechanism of dichroine-emesis in pigeons, viz., through a peripheral reflex action, or through a direct action on the vomiting center. The present paper deals with a series of chronic experiments in dogs. It has been found that: (1) Intravenous chlorpromazine in doses of 0.5 mg/kg did not affect, 1mg/kg only partly inhibited, while 2mg/kg totally inhibited the emetic action of threshold doses of intravenous β-dichroine (0.05—0.10 mg/kg). However, the 2mg/kg dosage of chlorpromazine also became ineffective as the dosage of dichroine was increased to 0.15 mg/kg. This partial antiemetic action of chlorpromazine to β-dichroine may be possibly due to its incomplete inhibition of the vomiting center. (2) The ablation of the emetic chemoreceptic trigger zone (CTZ) in the dorsal surface of the medulla oblongata resulted in complete abolition of the apomorphine-induced emesis but exerted no influence on the dichroins-emesis. (3) Supraphrenic bilateral vagotomy caused great reduction of the emetic action of both the threshold and larger doses of β-dichroine. (4) Total denervation of the gastrointestinal tract, viz., bilateral vagotomy plus sympathectomy below the level of T7, resulted in no vomiting both with threshold and larger doses of β-dichrcine and with oral copper sulfate. However, intravenous apomorphine (threshold dose) was emetic as usual in these denervated animals. In three out of ten trials with larger dose (0.15mg/kg) of β-dichroine, two of the three totally denervated dogs had nausea and retching, though no vomiting. Because two of these dogs died after such large doses, still larger doses were not tested. Thus the above results suggest that the emetic action of β-dichroine is mainly a reflex action by stimulating the afferent vagi and sympathetic nerves of the gastrointestinal tract and that certain subsidiary mechanim may also be involved when fatal doses are given.

于一系列慢性狗的实驗发現:(1)靜脉注射氯丙嗪0.5毫克/公斤不能影响常山碱乙的催吐阈,1毫克/公斤則能部分地抑制阈剂量常山碱乙的催吐,而2毫克/公斤能完全地抑制阈剂量的催吐,但对較大剂量常山碱乙的催吐无对抗;氯丙嗪的此种鎮吐作用可能是因为其对呕吐中枢的部分性抑制之故;(2)破坏延脑的CTZ能阻断阿朴嗎啡的催吐,但不能影响常山碱乙阈剂量的催吐作用,說明常山碱乙的催吐机制与CTZ无关;(3)于横膈以上的水平切断两側的迷走神經大大地减弱了阈剂量及較大剂量常山碱乙的催吐作用;(4)較彻底地切除支配胃腸道的迷走及交戚神經能完全阻止阈剂量及較大剂量常山碱乙的催吐,对于这种去胃腸道神經的狗,口服硫酸銅八倍于催吐閩的剂量也无呕吐,而靜脉注射阿朴嗎啡阈剂量則照样致吐。后二组結果証明:在我們所用的剂量吋靜脉注射常山碱乙主要是刺激胃腸道的迷走及交感神經而反射性催吐的。更大剂量(致死量)的常山碱乙于去胃腸道神經的狗可能的催吐系通过另外的次要的机制。

Compounds with high phenol coefficient have been used as effective remedies in the treatment of many diseases caused by certain kinds of worms in human body. In many instances the anthelmintic activity has paralled the antibacterial activity. These facts led the authors to prepare a number of compounds for the purpose of screening tests against Schistosomiasis Japonica. In 1958 the authors found Furacin and Xie-30 (hexachlorodiphenyl methane) to be effective in animal tests against Schistosomiasis Japonica....

Compounds with high phenol coefficient have been used as effective remedies in the treatment of many diseases caused by certain kinds of worms in human body. In many instances the anthelmintic activity has paralled the antibacterial activity. These facts led the authors to prepare a number of compounds for the purpose of screening tests against Schistosomiasis Japonica. In 1958 the authors found Furacin and Xie-30 (hexachlorodiphenyl methane) to be effective in animal tests against Schistosomiasis Japonica. This encouraged the authors to study further along this line. In this paper the syntheses of 107 derivatives of β-(5-nitro-2-furyl) acrylamides and esters are described. The amides were prepared by the condensation of β-(5-nitro-2-furyl) acryloyl chloride with various amines (alkyl, aromatic and substituted aromatic, amino acids, etc.) while esters were obtained directly from β-(5-nitro-2-furyl) acrylic acid and alcohols in suitable conditions. β-(5-nitro-2-furyl) acrylic acid was directly prepared by nitration of β-(2-furyl) acrylic acid which was obtained from furfural and sodium acetate by means of Perkin's reaction, and the corresponding acid chloride was prepared with phosphorus pentachloride or thionyl chloride under mild conditions. In screening with mice, 33 compounds were found to possess pronounced anthelmintic activity against Schistosomiasis Japonica, among which N-(iso-propyl)-β-(5-nitro-2-furyl) acrylamide (F-30066), N-(ethyl-glycinyl)-β-(5-nitro-2-furyl) acrylamide (F-30069) and N-(cyclohexyl)-β-(5-nitro-2-furyl) acrylamide (20112) were shown to be the most effective and have passed on to clinical trials with favourable results reported.

本文报导合成了硝基呋喃丙烯酰胺及其酯类衍生物107个.这类化合物的合成是从糠醛經Perkin反应制备β-呋喃丙烯酸,然后硝化成β-(5-硝基-2-呋喃)丙烯酸,再經酰氯与相应的胺类或氨基酸等縮合为酰胺。酯类则直接用酸与相应的醇酯化而得.經动物篩选后发現其中有33个化合物对感染日本血吸虫病小白鼠有显著作用.尤以β-(5-硝基-2-呋喃)丙烯酰异丙胺(I_4,F-30066)及β-(5-硝基-2-呋喃)丙烯酰甘氨酸乙酯(Ⅵ_(17),F-30069)具有强烈杀虫效力,均已試用于临床,証明有一定疗效。

 
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