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hepatitis c patients
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  丙型肝炎患者
     Results: Of 61 chronic hepatitis C patients,41(67.2%) cases were positive sera HCV RNA,4(9.8%) of 41 positive sera HCV RNA cases were positive HLA-DRB1~*1301,1302 alleles,7(35.%) of 20 negative sera HCV RNA cases were positive HLA-DRB1~*1301,1302(P=0.029,OR=0.22).
     结果:61例慢性丙型肝炎患者中血清HCVRNA阳性41例(67.2%),其中4例(9.8%)HLA-DRB1*1301,1302基因阳性,20例血清HCV RNA阴性患者中7例(35.0%)HLA-DRB1*1301,1302基因阳性(P=0.029,OR=0.22)。
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     Change of levels of IL-6 and IL-12 in the serum of hepatitis C patients and its clinical significance
     丙型肝炎患者血清IL-6和IL-12水平变化及临床意义
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     1(7.1%) of 14 hepatitis C patients;
     在 14例丙型肝炎患者中检出 1例 ( 7.1%) ;
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     Results: In the samples from 45 hepatitis C patients, the anti-TTV IgG positive rate was 37.8 % (17/45) while the TTV DNA positive rate was 42.2 % (19/45).
     结果:45例丙型肝炎患者TTV-IgG阳性率为37.8%(17/45); 巢式PCR阳性率为42.2%(19/45);
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     Conclusion The serum type 1 is the predominant in 32 hepatitis C patients.
     结论32例慢性丙型肝炎患者HCV血清1型为主;
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  丙型肝炎病人
     ELISA system for the detection of anti-E2 antibodies in patients' sera was established using aa 385-730 fragment, which detected anti-E2 in 56% of hepatitis C patients and demonstrated a correlation between anti-E2 and HCV viraemia.
     利用aa 385-730片段,建立了病人血清中抗E2抗体的ELISA检测体系,该体系在56%的丙型肝炎病人血清内检出了抗E2抗体,并且发现抗E2抗体的存在与HCV病毒血症存在正相关。
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     A survey of status quo of anxiety in chronic hepatitis C patients
     慢性丙型肝炎病人焦虑状况调查
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     Objective To analyze the 3 noncoding region (3NCR) of HCV genome from Chinese hepatitis C patients so as to facilitate further study of mechanism of HCV gene replication.
     目的分析中国丙型肝炎病人HCV基因组3′端非编码区(3′NCR),以促进对HCV基因组复制机制的研究。
短句来源
     he NS3 gene fragment of HCV was cloned from the serum of hepatitis C patients in Jiangshuprovince by RT-PCR.
     通过逆转录PCR技术,从中国江苏省丙型肝炎病人血清中扩增克隆了丙型肝炎病毒(HCV)的非结构3区的部分基因片段(C33)。
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     The results showed that positive ratio of IgM to core region (core positive/positive) was higher than that of IgM to Ns3 region (Ns3 positive/positive) in acute post-transfusion hepatitis C patients and in those anti-HCV positive with ALT-elevated pateints.
     检测结果表明,急性输血后丙型肝炎病人和HCV抗体阳性伴ALT升高者,其抗C区IgM阳性者所占比例明显大于抗Ns3区。
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  丙肝患者
     Results:The SENV-D positive rates in blood donors,acute hepatitis A patients,chronic hepatitis B patients,hepatitis C patients and hepatitis non A-E patients were 25.9%,14.5%,46%,65% and 51.2%,respectively.
     结果:无偿献血者中SENV-D感染率为25.9%,急性甲肝患者中的感染率为14.5%,慢性乙肝患者中的感染率为46%,丙肝患者中的感染率为65%,在非甲-非戊型肝炎患者中的感染率为51.2%。
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     Methods The levels of IL-8,IP-10 and Mig mRNA in peripheral blood mononuclear cells(PBMC) of chronic hepatitis C patients were detected by real-time quantitative polymerase chain reaction(RT-PCR) before,and 3,6 months after combined therapy of interferon-α(IFN-α) and Ribavirin.
     方法以Real-tim e PCR法动态检测慢性丙肝患者IFN-α联合利巴韦林治疗前、治疗3、6个月后IL-8、IP-10、M ig mRNA的表达水平。
短句来源
     (2)Autoantibodies can be found in a part of hepatitis C patients,and the prevalence is higher in the patients infected by HCV type Ⅱ,type Ⅱ and Ⅲ simultaneously than those infected by type Ⅲ alone.
     (2)部分丙肝患者可检出自身抗体,感染Ⅱ型HCV和同时感染Ⅱ型、Ⅲ型HCV的患者的自身抗体检出率高于感染Ⅲ型HCV的患者。
短句来源
     Methods The anti-HCV was monitored by indirect enzyme-linked immunosorbent assay(ELISA)and serum levels of HCVRNA quantities were tested by fluorescent quantitative PCR(FQ-PCR)in 292 cases of chronic hepatitis C patients.
     方法采用ELISA法和荧光定量PCR法检测292例慢性丙肝患者抗-HCV和HCVRNA。
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     Objectives:]To prepare BALB/c mice monoclonal antibodies against HCV NS3 antigen and to detect HCV NS3 protein in hepatitis C patients sera.
     目的:为研制抗丙型肝炎病毒(HCV)NS3抗原单克隆抗体,用于检测丙肝患者血清中的HCVNS3抗原。
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  “hepatitis c patients”译为未确定词的双语例句
     Results: The 4 highest markers of prevalence in chronic active hepatitis C patients were: anti HCV IgG 100%, IgM 85.7%, anti GOR antibodies 46.4% and HCV C33 64.3% respectively.
     结果 :抗 HCV- Ig G、抗 HCV- Ig M、HCV C33和抗 GOR抗体四种标志物在慢性活动性丙型肝炎组检出率最高 ,分别为 10 0 .0 %、85 .7%、46 .4%和 6 4.3% ;
短句来源
     RESULTS: The positive ratio for HCV antigen was 15.4%(8/52), 1.73%(19/1 099) and 1.03%(1/97) in hepatitis C patients and hepatitis B patients and hepatitis NA-NE patients, respectively.
     结果免疫酶斑点法检测表明,HCV-Ag的检出率在抗HCV抗体阳性、乙肝和非甲非戊肝炎患者中,分别为15.4%(8/52)、1.73%(19/1099)和1.03%(1/97);
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     Results Of 66 chronic hepatitis C patients, 25(38.5 %) were serotype 1;
     结果66例患者中,HCV血清型1型25例,占38.5%;
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     Results The SENV-H positive rate was 24.4% in healthy donors, 32.7% in acute hepatitis A patients,45.2% in chronic hepatitis B patients,65.0% in hepatitis C patients, 43.9% in hepatitis non A-E patients.
     结果SENV-H感染率在无偿献血者中为24.4%,在急性甲肝、慢性乙肝、慢性丙肝和非甲-非戊型肝炎患者中分别为32.7%、45.2%、65.0%和43.9%。
短句来源
     Results:Of 75 chronic hepatitis C patients,HLA-DR13 was detected in 17 patients in which 4(23.5%) patients with PBMC-HCV RNA positive. HLA-DR13 was negative in 58 patients in which 36(62.1%) patients with PBMC-HCV RNA positive,there was significant difference(χ2=7.85,P<0.01).
     结果:本组携带HLA-DR13基因者17例,PBMC阳性4例(23.5%),未携带HLA-DR13基因者58例,PBMC阳性36例(62.1%),采用四格表χ2检验,两组差异有统计学意义(χ2=7.85,P<0.01)。
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  hepatitis c patients
Our results suggest that homozygous carriage of the variant allele of codon 54 of MBL may predict poor response to interferon in chronic hepatitis C patients.
      
Understanding ribavirin's underlying mechanism of action on bone cells will enable the improved management of bone loss in chronic hepatitis C patients.
      
The Role of Optimism/Pessimism in HRQOL in Chronic Hepatitis C Patients
      
The serum levels of soluble β2-μ-associated and β2-μ-free HLA class I heavy chains were determined in 28 interferon-α nonresponder chronic hepatitis C patients retreated with interferon-α plus ribavirin and in 70 healthy subjects.
      
Circulating E-Selectin Levels in Chronic Hepatitis C Patients with Normal or Elevated Transaminase Before and After Alpha-Interf
      
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We have synthesed several peptides with moleculo-biological mettiod in the light of characteristicsof HCV genome in C and E regions of the Chinese and compared the reagents from these peptideswith that from C100-3. we have also established "nested" cPCR assay for detecting the HCV RNA inthe serum of patients. The sensitivity and specificity of anti-cp reagents were found significantly superiorto those of the reagent prepared only from C100-3. The positive percent age of anti-cp is 2.8...

We have synthesed several peptides with moleculo-biological mettiod in the light of characteristicsof HCV genome in C and E regions of the Chinese and compared the reagents from these peptideswith that from C100-3. we have also established "nested" cPCR assay for detecting the HCV RNA inthe serum of patients. The sensitivity and specificity of anti-cp reagents were found significantly superiorto those of the reagent prepared only from C100-3. The positive percent age of anti-cp is 2.8 in thenatural population, while that of anti-C100-3 is 2.1. The positive rate of anti-cp in posttransfusionhepatitis is as high as 71.7-75.9K. The observations suggest the different diagnostic reagents ofHCV have a different role to play in the diagnosis of HCV and prognosis of hepatitis C. The resultof one reagent cannot simply exclude the HCV infection. We have also established the "nested"cPCR tests based on the seqences of noncoding and NS, regions of HCV cases positive of anti-CPwere almost positive of HCV RNA by the 'nested" cPCRs. The detection of HCV RNA can be used toshow the efficiency of anti-viral drugs in hepatitis C patients.

本文用分子生物学方法根据中国人HCV基因特点进行多肽合成,研究丙型肝炎C区、E区酶标试剂的临床应用以及与抗C 100-3试剂的比较,并以 RT双 PCR的方法建立了HCV RNA的检测试剂及临床应用。结果发现抗-CP试剂敏感性、特异性均优于抗C100-3,从临床检测结果看,在自然人群中感染率抗-CP为2.8%,抗C100-3为2.1%,特别在输血后肝炎中,抗 CP阳性率高达 71.7%~75.9%。因此提出对HCV的诊断确立与愈后判断各类试剂有各自的作用,不能只根据某一试剂的某一次结果而简单地否定 HCV感染。HCV RNA测定,建立了5’末端非编码区及非结构区(NS 1),采用双PCR观察结果抗-CP阳性者绝大多数为RNA阳性,并提示将有助于抗病毒药物疗效的观察指标。

One-hundred and twenty-six hepatitis C patients were investigated. Of them, 103 cases had blood product transfusion history, 2 months after transfusion liver damage developed in 84.4% of 126 patients, 91.3% were anti-HCV positive. Anti-HCV posit-ivily was found in 82.6% of acute infections and in 95.8% of chronic cases. 18.2% of anti-HCV negative cases were found to be HCV RNA positive. In addition, a high detection rate of HCV RNA in ALT abnormal cases was observed. It suggested that HCV RNA could...

One-hundred and twenty-six hepatitis C patients were investigated. Of them, 103 cases had blood product transfusion history, 2 months after transfusion liver damage developed in 84.4% of 126 patients, 91.3% were anti-HCV positive. Anti-HCV posit-ivily was found in 82.6% of acute infections and in 95.8% of chronic cases. 18.2% of anti-HCV negative cases were found to be HCV RNA positive. In addition, a high detection rate of HCV RNA in ALT abnormal cases was observed. It suggested that HCV RNA could be related to active liver damage.

分析126例丙型肝炎病者的临床资料,丙型肝炎病毒血清抗体(抗-HCV)滴度及丙型肝炎核酸(HCV-RNA)。发现有明确输血(浆)史者103例,该病史中发现输血后2个月内有肝损者87例占84.4%。抗-HCV检出率为91.3%,其中急性病者检出率82.6%,慢性者95.8%。抗-HCV强阳性者(OD>1.0),HCV-RNA的检出率48.1%,明显高过OD<1.0的低阳性者。抗-HCV阴性者中有18·18%(2/11)检出HCV-RNA。另外,HCV-RNA的检出与谷-丙转氨酶(ALT)水平有一定关系,有肝损者比ALT正常者HCV-RNA检出率明显高。提示HCV-RNA的检出与活动性肝病有关系。

cDNA fragment of C269/831(560bp)and three cDNA fragments of C831,C801,C587corresponding to the putative nucleocapsid (C)of the HCV genome were obtained from the seraderived from Chinese carriers with HCV infection,who came from Loudi of Hunan provinceand Qinghuangdao of Hebei province of China , by application of reverse transcription (RT)and polymerase chain reaction (PCR)technique.As the sequence of the cDNA fragment ofC269/831(HCV-Hunan Strain)was determined and compared ...

cDNA fragment of C269/831(560bp)and three cDNA fragments of C831,C801,C587corresponding to the putative nucleocapsid (C)of the HCV genome were obtained from the seraderived from Chinese carriers with HCV infection,who came from Loudi of Hunan provinceand Qinghuangdao of Hebei province of China , by application of reverse transcription (RT)and polymerase chain reaction (PCR)technique.As the sequence of the cDNA fragment ofC269/831(HCV-Hunan Strain)was determined and compared with those of the corresponding regions of the HCV-Ⅰ(HCV-US )and HCV-Ⅱ(HCV-BK)genomes,the nucleotide/amino acid sequence homologies to HCV-US and HCV-BK isolates were found to be 90.3%/94.6%and 95.2%/94.6%,respectively.The prokaryotic expression vector pBV220 was employed for the overproduction of CL,CM and CS native recombinant proteins in E.coli cellderived from C831, C801 and C587 cDNA fragments.The expression products were screenedby bacterial clony hybridization ,antibody -sandwich enzyme immunoassay,and determined by Western blotting with antisera of chronic hepatitis C patients. The 20KD recombinant pro-teins CL, CM and the 14KD of recombinant protein CS were shown to account for about 11%of the total cellular soluble proteins。The recombinant expression products were ex-tracted from the bacterial lysates by lysozyme ,Triton X-100and urea treatment ,and purified through the ion exchange chromatography .The purified recombinant nucleocapsid protein CSwas used to capture and measure reactive antibodies both acute and chronic HCV infec-tions.THe study indicates that at the nucleotide level ,the C269/831 cDNA sequence homology(95.2%)between the HCV -Hunan isolate and the HCV-BK isolate is higher than the homology (90.3%)between the HCV -Hunan isolate and HCV-US isolate,but at the aminoacid level ,the sequence homogy (94.6%)is similar between the HCV-Hunan isolate and both HCV-BK or HCV-US isolate In addition,the HCV- Hunan is significantly diverse fromother HCV isolates ,which proves once more that the HCV genome is heterogeneous among the differet isolates derived from different areas.More conservative is the amino acid sequence of the N terminal two hydrophilicities of C region of the HCV genome among the all different HCV isolates ,which suggests that the N terminal two hydrophilicities of C region of the HCVgenome would have an important biological function,and would be an appropriate antigen for the HCV serodiagnosis.There is 99%of over lapping immunoreactitivity between the total nucleocapsid region and the CS,which is composed of 89 amino acods pf tje N terminaltwo hydrophilicities of C region of the HCV genome .As for the expression level and the antigen stability,recombinant protein CS was found better than CL and CM.

本文通过逆转录(RT)-聚合酶链式反应(PCR),从两份分别来自湖南省娄底地区丙型肝炎病人和河北省秦皇岛市职业献血员丙型肝炎病毒(HCV)RNA打点杂交阳性的血清中,扩增并克隆到1段563bp的HCV基因组C区抗原基因C269/831,并通过PCR得到了3个表达片段C831、C801和C587。测定C269/831基因的全序列后发现,中国人HCV湖南分离株与HCV-Ⅰ型株HCV-US和Ⅱ型株HCV-BK在该基因区段的核苷酸/氨基酸序列的同源性,分别为90.3%/94.6%和95.2%/94.6%。利用原核高效表达载体pBV220在大肠杆菌中有效地表达了非融合的C区抗原基因重组蛋白CL、CM和CS。通过免疫筛选法及Westem印迹法对约占菌体可溶性蛋白11%的表达产物进行了鉴定。采用TritonX-100和盐析处理表达产物,再进行离子交换层析纯化,得到可用于检测HCV血清抗体的核壳蛋白(C)抗原。通过不同分子量抗原的表达,发现由C区N端89个氨基酸组成的多肽CS其抗原性与由158或168个氨基酸组成的多肽CM或CL相同,但抗原的稳定性和表达量显著优于后两种抗原。本研究为研制HCV抗体诊断试剂盒奠定了重要基础。

 
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