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single oral
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  单剂口服
     Group A and B took single oral dose of 150 mg and 300 mg respectively (both R and D). The i. v.
     A、B组分别单剂口服R与D150mg和300mg。
短句来源
     Propafenone pharmacokinetics was studied after single oral administration of 600 mg in 10 health volunteers. Serum concentration-timedata were fit to a one-compartment model for 8 but 2 volunteers, whosedata required fitting to a two-compartment model. The mean eliminationt1/2 was 3.03 ±1. 38h, tmax 3.02±0.87h, AUC 8788±4841μg.
     10名健康志愿者单剂口服心律平600mg后药时曲线8名为一室模型,2名为二室模型,平均消除半衰期(t1/2)3.03±1.38h,达峰时间(t max)3.02±0.87h,曲线下面积(AUC)8788士4841μg·h/l。
短句来源
     METHODS:A single oral dose of3mg melatonin tablet was given to6beagle dogs,drug concentrations in plasma were determined by HPLC method,the pharmacokinetic parameters were calculated by3P97pharmacokinetic program.
     方法:6只Beagle犬分别单剂口服褪黑素(3mg/只),以高效液相色谱法测定血中褪黑素浓度,经3p97程序推算药动学参数。
短句来源
     [Methods]A single oral 400 mg dose of racecadotril was given to 24 healthy male volunteers according to a randomized cross-over design. The Thiophine,a active metabolity of racecadotril,concentration in plasma was determined by HPLC-MS/MS method.
     [方法]采用24例健康男性志愿者随机交叉自身对照试验设计,受试者分别单剂口服国产消旋卡多曲分散片(受试制剂)400mg及消旋卡多曲颗粒(参比制剂)400mg后,用HPLC-MS/MS测定消旋卡多曲活性代谢物(Thiophine,TP)浓度,由DASver2.0程序进行生物等效性分析。
短句来源
     Determination of Calcium and Magnesium concentrations in human serum by Flame Atomic Absorption Method after a single oral dose of Compound Famotidine Chewable Tablets
     火焰原子吸收法测定志愿者单剂口服复方法莫替丁咀嚼片血清中钙镁浓度
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  po单
     The pharmacokinetics of amiloride was determined following a single oral dose of 10 mg given to each 6 volunteers in an open randomized crossover study.
     6名健康志愿者随机交叉po单剂量10mg氨氯吡咪国产或进口片。
短句来源
     The pharmacokinetics of glipizide was determined following a single oral dose of 10 mg given to each 10 volunteers in an open randomized crossover study.
     10名健康志愿者随机交叉po单剂量10mg格列吡嗪胶囊(国产)或片(进口)。
短句来源
     A single oral dose of 200mg CBZ tablet was given to 4 Chinese male volunteers of Han nationality. Plasma levels were determined with TDx analyzer and absorption fraction were calculated according to Wagner-Nelson's formula.
     4名男性健康志愿者po单剂量200mg CBZ,用TDx分析仪测定血药浓度,并按照Wagner-Nel- son公式计算药物吸收分数.
短句来源
     METHODS:The pharmacokinetics of sultamicillin capsule was determined following a single oral dose of 750mg give to 10 volunteers in an open randomized crossover study.
     方法:10名健康志愿者随机交叉po单剂量750mg国产舒他西林胶囊和进口片剂后,采用HPLC测定血浆中的血药浓度。
短句来源
     METHODS:A microbiological agar diffusion assay using Micrococcus luteus (ATCC 28001) was used as a bioassay for clarithromycin in serum following a single oral dose 500 mg of clarithromycin capsule and tablet respectively given to 10 healthy volunteers in an open randomized cross over test.
     方法 :以藤黄八叠球菌 2 80 0 1为敏感菌株 ,采用微生物法测定 10名健康志愿受试者 po单剂量克拉霉素胶囊和进口片剂 (5 0 0mg)后血清中克拉霉素的浓度 ;
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  单剂量给药
     Results:The half life of controlled; release oxybutynin chloride tablet/capsule was elongated and the maximum plasma concentration decreased, the relative bioavailability of single oral controlled; release oxybutynin chloride tablet/capsule to normal control tablet were(107.17±10.89)% and (104.52±10.48)% respectively.
     结果:单剂量给药奥昔布宁缓释胶囊、缓释片半衰期延长,血药浓度峰值降低,相对于普通片生物利用度F(%)分别为(107.17±10.89)%和(104.52±10.48)%。
短句来源
     After a single oral dose admininstration,c_(max) was (5.79±1.57)μg·L~(-1) at (5.3±1.2)h for the test and (5.99±1.61)μg·L~(-1) at (5.5±1.1)h for the reference.
     结果单剂量给药受试缓释胶囊与市售缓释胶囊的tmax、cmax分别为(5.3±1.2)h和(5.79±1.57)μg·L~(-1)及(5.5±1.1)h和(5.99±1.61)μg·L~(-1)。
短句来源
     CONCLUSION : The bioavailability of ibuprofen controlled tablets reference to ibuprofen sustained release capsules is (97. 37±9. 98)% in single oral administration.
     结论:两种制剂量给药600mg时为生物等效; 以B为标准参比制剂,单剂量给药时A相对生物利用度为(97.37±9.98)%.
短句来源
     Conclusions: The results of single oral administration 30 mg nifidipine demonstrated that two formulations were not bioequivalent.
     结论 :两种制剂单剂量给药 30mg为生物不等效
短句来源
  “single oral”译为未确定词的双语例句
     STUDY ON PHARMACOKINETICS OF PHENITHIONATE AFFTER A SINGLE ORAL DOSE IN RATS BY QUANTI TATIVE TLC SCANNING TECHNIQUE
     应用薄层扫描研究大鼠一次口服硝硫苯酯的药代动力学
短句来源
     Study on the Pharmacokinetics of single Oral dose of Aminophylli(?)e in elderly COPD Patient
     老年COPD患者单剂量口服氨茶碱的药物动力学研究
短句来源
     SALIVA PHARMACOKINETICS OF METRONIDAZOLE AFTER SINGLE ORAL DOSE ADMINISTRATION
     单剂量口服甲硝唑在唾液中的药代动力学
短句来源
     The retention and metabolism of tritium in the rat after single oral intubation of tritiumlabelled lysine
     氚化赖氨酸一次灌胃后氚在大鼠体内的滞留与代谢
短句来源
     A Study of Pharmacokinetics on Sodium Selenite in Calfby Single Oral Dosing
     亚硒酸钠一次内服在犊牛体内药动学研究
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  single oral
The systolic blood pressure of SHRs decreases significantly after single oral administration of the brown alga hydrolysates by protease S 'Amano' (from Bacillus stearothermophilus) at the concentration of 10 (mg protein) (kg body weight)-1.
      
Each peptide was determined to have an antihypertensive effect after a single oral administration in SHRs.
      
The following results were obtained:1)A single oral application of 2 and 4 mg/kg ISDN led to increases in heart rate, decreases in central venous and arterial blood pressure and an increase in PRA over a period of 3 to 4 hours.
      
A single oral dose of Sodium valproate (VPA) given as Epilim (10 mg/kg) inhibited photoconvulsive responses, especially to 15-30 Hz frequency flicker, in seven out of ten patients with photosensitive epilepsy.
      
In five previously untreated patients with myasthenia gravis blood AChE activity decreased in accordance with the actual PPC after a single oral dose of 60 mg pyridostigmine (group A).
      
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The acute and chronic toxicities of parathion, O,O-diethyl O-p-nitrophenyl thiophosphate, in the white mice (Mm rmtseulus albus Bechstein) were investigated by oral administrations. The dosage rate was based on the weight of the mouse; and the calculated volumes of the diluted parathion emulsion in various concentrations were fed to the test animals by means of a needle of the micrometer syringe. The various dosage rates for five groups of mice were as follows:(1) A single oral dose of 20 mg. of parathion...

The acute and chronic toxicities of parathion, O,O-diethyl O-p-nitrophenyl thiophosphate, in the white mice (Mm rmtseulus albus Bechstein) were investigated by oral administrations. The dosage rate was based on the weight of the mouse; and the calculated volumes of the diluted parathion emulsion in various concentrations were fed to the test animals by means of a needle of the micrometer syringe. The various dosage rates for five groups of mice were as follows:(1) A single oral dose of 20 mg. of parathion per kg. of body weight;(2) A daily dose of 5 mg. of parathion per kg. of body weight;(3) A daily dose of 10 mg. of parathion per kg. of body weight;(4) The mouse recieved a dose of 1 mg. of parathion per kg. of body weight at the 1st day and thereafter the dosage was increased by 1 mg. per kg. of body weight with the increase of days;(5) The mouse recieved 2 mg. of parathion per kg. of body weight at the 1st day and the dosage was increased by 2 mg. per kg. with the increase of days.In the above various daily dosage rates for the different groups of mice, parathion was fed continuously over a period of 12 days except in cases when all the test animals under experiments were dead before that period of time. The experimental results may be summarized as follows.1. The symptoms of parathion poison in the white mice were observed at follows: inaction, slight tremor, followed by omitting, tears, diarrhea, and the intensive convulsion. Finally the mouse with its erected and stiffened tail ran about for a few seconds and died.2. Either in treatments of a single acute oral dose or of daily oral dosages of parathion in succesion, the poisoned mice showed no apparent differences in susceptibilities between males and females or among animals with various body weights.3. It was found that a single dase acute oral LD50 value within 24 hours was between 10 mg. and 20 mg. of parathion per kg. of body weight.4. The average period of time required from the last administrations to the dealh of the animals was about 2 hours in the treatment (1), (3), (4), and (5). The treatment (2) took about 7 hours. In all the treatments, the required time varied from only 16 minutes to 11 hours.5. In the treatment of daily dosage of 5 mg./kg. 6 mice died within 4 days after the beginning of the administration, 9 mice survived to the end of the 12 days, having taken a total dosage of 60 mg./kg.The treatment with a daily dosage of 10 mg./kg. showed that 11 out of the 15 tested mice died before the 3rd day. Of the remaining 4 mice, 2 died suddenly at the 7th day, while the other 2 survived to the end of the 12th day, having taken a total dosage of 120 mg./kg.In those cases, when the mice recieved a dose of 1 mg./kg. at the 1st day, and then dosage increased by 1 mg./kg. at the successive days, some of the mice (so treated) died at the 4th day and the death of the poisoned mice continued to happen till the end of the 12th day. Only 3 out of the 15 mice survived after haying taken a last dose of 12 mg./kg. and total dosage of 78 mg./kg.In those cases, when the mice recieved a dose of 2 mg./kg. at the 1st day and continuously recieved a dosage which increased by 2 mg/kg. at the successive days, all the 15 test mice died before the 8th day, after having taken a total dosage of 72 mg./kg.The results of the four above dosage treatments showed that the daily administration of parathion at sublethal dosages to the mice did not apparently have any accumulative action, while the daily dosages near the acute lethal level did cause some susceptible mice to die. This may be due to the possibility that the poisoned mice could not recover their cholineste-rase level enough to resist the inhibiting effects of the next applications of parathion.

1.小白鼠吞食“E.605”後的中毒症状为:痉挛、呕吐、流泪、不成次地排便,最後痉挛加剧,突然间尾竖直作惊慌状,爬行数秒钟,而倒伏气绝。 2.小白鼠吞食“E.605”致死50%剂量介於10—20毫克/千克。雌雄两性或不同体重的小白鼠对“E.605”的忍受力,未见有显明的差别。 3.小白鼠吞食“E.605”後,中毒死亡距各鼠最後一次吞食药剂的时间:吞食5毫克/千克/每日剂量的,为7小时,吞食10毫克/千克/每日,1毫克/千克/每日递增,或2毫克/千克/每日递增3种剂量的,平均各约为2小时,最快的仅为16分钟,最慢的不超过11小时。 4.小白鼠连日吞食“等剂量”的“E.605”,如吞食剂量远较各该鼠的一次吞食的致死剂量为小时,未见有因连日剂量积累而致中毒死亡的趋势,但个别对药剂忍受力小的鼠只在吞食“E.605”的剂量已接近於各该鼠的一次吞食致死剂量时,也能在再一次或多次接受一定量的“E.605”,而遭致中毒死亡。这点似可以解释为鼠体内胆硷酯酶受抑制後的恢复速度赶不上继续给药的被抑制量的缘故。小白鼠每日吞食的“E.605”剂量如果是逐日递增的,则在某一日或连续几日内的剂量已经增加到接近或达到各该鼠的致死剂量时,便中...

1.小白鼠吞食“E.605”後的中毒症状为:痉挛、呕吐、流泪、不成次地排便,最後痉挛加剧,突然间尾竖直作惊慌状,爬行数秒钟,而倒伏气绝。 2.小白鼠吞食“E.605”致死50%剂量介於10—20毫克/千克。雌雄两性或不同体重的小白鼠对“E.605”的忍受力,未见有显明的差别。 3.小白鼠吞食“E.605”後,中毒死亡距各鼠最後一次吞食药剂的时间:吞食5毫克/千克/每日剂量的,为7小时,吞食10毫克/千克/每日,1毫克/千克/每日递增,或2毫克/千克/每日递增3种剂量的,平均各约为2小时,最快的仅为16分钟,最慢的不超过11小时。 4.小白鼠连日吞食“等剂量”的“E.605”,如吞食剂量远较各该鼠的一次吞食的致死剂量为小时,未见有因连日剂量积累而致中毒死亡的趋势,但个别对药剂忍受力小的鼠只在吞食“E.605”的剂量已接近於各该鼠的一次吞食致死剂量时,也能在再一次或多次接受一定量的“E.605”,而遭致中毒死亡。这点似可以解释为鼠体内胆硷酯酶受抑制後的恢复速度赶不上继续给药的被抑制量的缘故。小白鼠每日吞食的“E.605”剂量如果是逐日递增的,则在某一日或连续几日内的剂量已经增加到接近或达到各该鼠的致死剂量时,便中毒死亡。各该鼠中毒致死前的最後一次所吞食的“E.605”剂量,起了重要的致毒作用。

It was found that F-30066, a new furacin derivative, possessed a direct effect on schistosomes in vitro. Trials were made with sheep serum-Tyrode solution (1:2) containing 0.5% glucose. When parasites were kept in the medium containing 4— 10 μg/ml of F-30066, the motility of the worms decreased gradually and the shrinkage of the worm body followed. After 24 hours, only slow body movement in the female and slow sucker movement in the male were observed. At the same time the reproductive organs of the worms degenerated...

It was found that F-30066, a new furacin derivative, possessed a direct effect on schistosomes in vitro. Trials were made with sheep serum-Tyrode solution (1:2) containing 0.5% glucose. When parasites were kept in the medium containing 4— 10 μg/ml of F-30066, the motility of the worms decreased gradually and the shrinkage of the worm body followed. After 24 hours, only slow body movement in the female and slow sucker movement in the male were observed. At the same time the reproductive organs of the worms degenerated and the number of ova in the uteri was markedly reduced. Within 48 hours, both male and female worms were killed after a long period of paralysis. In order to explore the effect of F-30066 on the survival of worms in vivo, mice infected with schistosomes were treated with F-30066 or tartar emetic in the dosage of 1/2 LD_(50) per os for 5 days. Each day worms were removed from 2—3 mice and maintained in the medium. In case of tartar emetic, the motility of the worms recovered gradually and the worms survived as long as those from the control group. In case of F-30066, the worms became sluggish and could not recover completely. After the 4th and the 5th dose, the worms survived in the medium for only 4.2—7.0 days, while the survival time of the worms from control group was 12.4 days. The difference is statistically significant. When worms were placed in serum taken from rabbits 1/2 to 8 hours after a single oral dosage of 1.3gm/kg of F-30066, the survival time of the parasites was reduced from 12.2—12.8 days to 3.2—9.1 days. It was found furthermore that the antischistosomal activity of F-30066 in vitro could be antagonized by cysteine, but not by cystine, lipoic acid, sodium dimercaptosuccinate, or vitamine C.

本文研究了F-30066,即β-(5-硝基-2-呋喃)丙烯酰异丙胺,体外抗血吸虫的作用.实验证明F-30066对体外血吸虫具有直接杀灭作用.在含F-30066 4-10微克/毫升的Tyrode液与绵羊血清混合液(2∶1)内,虫体表现为活动减弱、萎缩、肠管扭曲、生殖器官退化和子宫内虫卵数减少,终至麻痹死亡.经F-30066作用1—4小时的虫体移置于不含药物的培基中时,其活力可明显恢复,经药物作用8—16小时的则较差,至作用24小时后,虫体的活力不能恢复.在药物对宿主体内虫体生活力影响的观察中,发现小白鼠口服F-300661/2 LD_(50)×4—5天后.其体内受作用的虫体活力在培基内不能完全恢复,虫体的生活时间仅及对照组的一半左右.用吐酒石治疗的动物,于投服1/2 LD_(50)×5天后,其体内存活的虫体活力在培基内迅速恢复,虫体的生活时间与对照组的相似.F-30066的体外杀虫作用能被半胱氨酸与谷胱甘肽所拮抗,而胱氨酸、二巰基丁二酸钠、硫辛酸及维生素丙等则无此作用.用口服F-30066半小时到8小时后的家兔血清培养血吸虫时,虫体的生活时间显著缩短.

The absorption, distribution and excretion of anthraquinone derivatives in animals and in human beings receiving single oral, intramuscular or intravenous doses were studied. The anthraquinone derivatives tested were easily absorbed and excreted. The peak blood levels were reached within 2—3 hours after oral ingestion. Thereafter, the concentration fell gradually. After intramuscular injection, the peak was reached within 30 minutes, the concentration fell rapidly and then maintained a nearly constant...

The absorption, distribution and excretion of anthraquinone derivatives in animals and in human beings receiving single oral, intramuscular or intravenous doses were studied. The anthraquinone derivatives tested were easily absorbed and excreted. The peak blood levels were reached within 2—3 hours after oral ingestion. Thereafter, the concentration fell gradually. After intramuscular injection, the peak was reached within 30 minutes, the concentration fell rapidly and then maintained a nearly constant level for 4 hours. By the intravenous injection the peak was reached within 5 minutes. The concentration dropped quickly in the first 30 minutes. At the end of 1 hour, anthraquinone derivatives were not detectable in the blood. Among the anthraquinone derivatives studied, rhein was more easily absorbed than emodin. Anthraquinone derivatives were excreted by the bowel, urine and bile. The total excretion was about 46.2% of ingested does. About 23.4% was found in the feces and 22.8% in the urine. The excretion lasted 2 days. About 88% of that excreted in feces occurred in the first day and about 61% of that excreted in urine appeared in the first8 hours. Anthraquinone derivatives were distributed mainly in the liver and kidneys afterabsorption. No detectable amount was found in heart, spleen, lungs and brain.

本文以人体和动物(家兔及小鼠)实验,一次口服和注射(肌肉及静脉)大黄蒽醌衍生物,以观察其在体内的吸收、排泄和分布的情况。实验结果表明,蒽醌衍生物在体内易于吸收。口服时血中浓度在2—3小时内即达最高峯,其后慢慢下降,与注射比较,高峯较低,但持续时间较长。肌肉注射半小时内即达最高峯,其后迅速下降,在4小时内可维持一定水平。静脉注射5分钟内即达特高高峯,但维持时间极短,1小时内仅余痕迹。大黄酸似乎比大黄素更易于吸收。蒽醌衍生物在体内易由粪、尿和胆汁中排泄。由粪排出总量占摄入量的23.4%,其中88%是在第一天排出,排出可持续2—3天。尿及胆中蒽醌衍生物浓度分别以6—8及4—6小时为最高,由尿排出总量占摄入量的22.8%,以2—4小时内为最高,在前8小时内排出者占61%,由尿排出可持续2天。由尿及粪排出总和占摄入量的46.2%,说明有一半多可能在体内破坏。蒽醌衍生物在各组织和脏器的分布以肝和肾为最多,心、脾、肺和脑等没有测到。口服时肝和肾均在2小时内达最高峯,肌肉注射则在半小时内达最高峯,尤其是肾脏。

 
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