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   protein tyrosine 的翻译结果: 查询用时:0.162秒
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protein tyrosine     
相关语句
  蛋白酪氨酸
     Effects of As_2O_3 on the BCR/ABL protein tyrosine phosphorylation in K562 cells
     As_2O_3对K562细胞BCR/ABL蛋白酪氨酸磷酸化的影响
短句来源
     Protein tyrosine phosphatase 1 B (PTP1B) is a typical member of non-receptor PTP family.
     蛋白酪氨酸磷酸酯酶1B(protein tyrosine phosphatase 1B,PTP1B)是典型的非受体型PTPase家族的成员之一。
短句来源
     Objective To investigate the association of the 387 Pro-Leu polymorphism in protein tyrosine phosphatase-1B (PTP-1B) gene with senile type 2 diabetes mellitus (T2DM).
     目的 探讨蛋白酪氨酸磷酸酶-IB(protein tyrosine phosphastase-1B,PTP-1B)基因387位编码子Pro-Leu多态性与老年2型糖尿病(T2DM)的关系。
短句来源
     The immunoregulatory effect of TLSF_(JM) on the expression of T cell IL-2R and protein Tyrosine phosphorylation
     TLSF_(JM)对T细胞IL-2R表达和蛋白酪氨酸磷酸化的调节作用
短句来源
     Protein tyrosine phosphatase 1B and type 2 diabetes
     蛋白酪氨酸磷酸酶-1B与2型糖尿病
短句来源
更多       
  蛋白质酪氨酸
     Role of Protein Tyrosine Phosphatase 1B in the Type 2Diabetes and Obesity
     蛋白质酪氨酸磷酸酶1B(PTP1B)与2型糖尿病及肥胖的关系
短句来源
     Protein Tyrosine Phosphatase PRL-3 and Metastasis of Colorectal Cancer
     蛋白质酪氨酸磷酸酶PRL-3与结肠癌的转移
短句来源
     Mitogen activated protein kinase (MAPK) inhibitor PD 98059 (2-50 μmol·L -1 ), platelet derived growth factor receptor inhibitor tyrphostin AG 1296 (2-50 μmol·L -1 ) and protein tyrosine kinase inhibitor herbimycin A (2-10 μmol·L -1 ) inhibited the BCMSMC [ 3H]TdR incorporation and proliferation of BCMSMC.
     丝裂原激活蛋白激酶 ( MAPK)特异性抑制剂 PD980 59( 2 - 50 μmol· L-1) ,血小板衍生生长因子受体抑制剂酪氨酸磷酸化抑制剂 AG 1 2 96( 2 -50 μmol· L-1)以及蛋白质酪氨酸激酶抑制剂除莠霉素 A( 2 - 1 0μmol· L-1)能浓度依赖性地抑制LPC的上述作用 .
短句来源
     Results IL 1βtransiently increased protein tyrosine phosphorylation, and activated MAPKs cascades (mainly ERK2, JNK2 and P38) in RA FLS.
     结果IL 1β可以瞬时增加RAFLS蛋白质酪氨酸磷酸化的程度 ,并在短时间内激活MAPKs通路(以ERK2 ,JNK2和P38为主)。
短句来源
     Screening Inhibitors of Protein Tyrosine Phosphatase 1B
     蛋白质酪氨酸磷酸酶1B抑制剂的筛选
短句来源
更多       
  酪氨酸
     Effects of As_2O_3 on the BCR/ABL protein tyrosine phosphorylation in K562 cells
     As_2O_3对K562细胞BCR/ABL蛋白酪氨酸磷酸化的影响
短句来源
     Effects of dt_2-cAMP,IFN-γand PMA on cytosolici[Ca~(2)]i and protein tyrosine kinase-in U937 cells
     dt_2-cAMP,IFN-γ和PMA对U937胞浆Ca~(2+)和酪氨酸激酶的影响
短句来源
     Protein tyrosine phosphatase 1 B (PTP1B) is a typical member of non-receptor PTP family.
     蛋白酪氨酸磷酸酯酶1B(protein tyrosine phosphatase 1B,PTP1B)是典型的非受体型PTPase家族的成员之一。
短句来源
     Objective To investigate the association of the 387 Pro-Leu polymorphism in protein tyrosine phosphatase-1B (PTP-1B) gene with senile type 2 diabetes mellitus (T2DM).
     目的 探讨蛋白酪氨酸磷酸酶-IB(protein tyrosine phosphastase-1B,PTP-1B)基因387位编码子Pro-Leu多态性与老年2型糖尿病(T2DM)的关系。
短句来源
     The immunoregulatory effect of TLSF_(JM) on the expression of T cell IL-2R and protein Tyrosine phosphorylation
     TLSF_(JM)对T细胞IL-2R表达和蛋白酪氨酸磷酸化的调节作用
短句来源
更多       
  蛋白酪氨酸磷脂酶
     Missense mutation of Pro387Leu of protein tyro sine phosphatase-1B gene is not associated with type 2 diabetes mellitus in Guangzhou Han population
     蛋白酪氨酸磷脂酶-1B基因Pro387Leu变异与2型糖尿病的相关性研究
短句来源

 

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      protein tyrosine
    Functional Significance of Conserved Glycine 127 in a Human Dual-Specificity Protein Tyrosine Phosphatase
          
    The tyrosine phosphorylation of intracellular proteins was greatly increased after the treatment of cells with sodium n-vanadate, the inhibitor of protein tyrosine phosphatase (PTPase).
          
    Contrast to the activation of STAT5 by interleukin-2 (IL-2), the activation for STATS by sodium n-vanadate cannot be completely blocked by the inhibitor of protein tyrosine kinase (PTK).
          
    Structural basis of interaction between protein tyrosine phosphatase PCP-2 and β-catenin
          
    PCP-2 is a member of receptor-like protein tyrosine phosphatase of the MAM domain family.
          
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    The immunoregulatory effect of TLSF_(JM) on the expression of T cell IL-2R and protein Tyrosine phosphorylation (PTP) was investigated by immunohistochemistry technique. The results showed that TLSF_(JM) can markedly suppress the expression of IL-2R and PTP on PHA or TPA-stimulated human PBMC and murine IL-2 dependent cell line CTLL-2. However, there was no effect of TLSF_(JM) on the production of IL-1、IL-2 and IL-6 that play an important role in the course of T Lymphocyte prolirferation and differentiation....

    The immunoregulatory effect of TLSF_(JM) on the expression of T cell IL-2R and protein Tyrosine phosphorylation (PTP) was investigated by immunohistochemistry technique. The results showed that TLSF_(JM) can markedly suppress the expression of IL-2R and PTP on PHA or TPA-stimulated human PBMC and murine IL-2 dependent cell line CTLL-2. However, there was no effect of TLSF_(JM) on the production of IL-1、IL-2 and IL-6 that play an important role in the course of T Lymphocyte prolirferation and differentiation.

    应用免疫组化染色技术,研究了TLSF_(JM)对T细胞IL-2R表达和蛋白酪氨酸磷酸化的调节作用。结果表明:TLSF_(JM)对PHA或PA活化的人PBMC以及小鼠CTLL-2 IL-2R表达和蛋白酪氨酸磷酸化具有明显的抑制作用,但对在T淋巴细胞增殖、分化过程中起重要作用的细胞因子IL-1、IL-2和IL-6的产生无明显影响。

    Using a peptide poly (Glu,Tyr)(4:1) phosphorylated at tyrosine residue by protein-tyrosine kinase from rat spleen as substrate, purification and properties of phosphotyrosyl protein phosphatase (PTPP) from regenerating mouse liver cytosol was studied.Most of the PTPP activity in extract after (NH4)2 SO4 fraction of regenerating liver cytosol were absorbed on DEAE cellulose (DE52).The eluted PTPP indicated the presence of at least five species.The main PTPP activity was further purified...

    Using a peptide poly (Glu,Tyr)(4:1) phosphorylated at tyrosine residue by protein-tyrosine kinase from rat spleen as substrate, purification and properties of phosphotyrosyl protein phosphatase (PTPP) from regenerating mouse liver cytosol was studied.Most of the PTPP activity in extract after (NH4)2 SO4 fraction of regenerating liver cytosol were absorbed on DEAE cellulose (DE52).The eluted PTPP indicated the presence of at least five species.The main PTPP activity was further purified by chromatography on DE52,Sephadex G-200 and poly (GIu,Tyr) (4:1)-Sepharose 4B.Overall purification of about 1123-fold was achieved with 28% recovery of enzyme activity.The properties of this purified PTPP was follows, (1) The enzyme showed only one band of molecular weight about 67KDa by polyacrylamide pore gradient and SDS-gel electrophoresis;(2) It exhibited high specificity towards 32p(Tyr)poly(Glu, Tyr)(4:1), but did not hydrolysed 32p(Ser/Thr) casein and PNPP, (3) Its optimum PH was 6.8-7.1 and it was unstable to heat treatment; (4) Its activity was activated by EDTA, but not activited by Mg2+, Mn2+, Ca2+, (5) Its activity was inhibited by Zn2+, Co2+, PPi, PNPP, P-Tyr, MoO4 and citrate,but not inhibited by F-,Ac-, HPO42-, and VO43-.Low molecular weight nucleotides ATP, ADP, AMP were inhibitors.(6) Its activity was inhibited by histone and protamine, but stimulated by casein and heparin.

    以~(32)P(Tyr)-Poly Glu,Tyr(4:1)为底物,用于研究小鼠再生肝胞浆磷酸酪氨酸蛋白磷酸酶(PTPP)的分离纯化和性质。再生肝胞浆经60%饱和度硫酸铵盐析,二次DEAE纤维素层析,Sephadex G-200柱层析和Poly Glu,Tyr-Sepha-rose 4B亲和层析后,得到的PTPP分子量为67000,纯度提高1123倍,活性回收率为28%,对~(32)P(Tyr)-Poly Glu,Tyr有很高的活力,对~(32)P(Ser/Thr)-Casein(酪蛋白)和PNPP(对硝基苯酚磷酸盐)没有作用,其最适pH为6.8~7.1,对热不稳定。EDTA对酶有激活作用,Zn~(2+)、PNPP、P-Tyr、多胺化合物、焦磷酸根、钼酸根、柠檬酸根对酶有明显的抑制作用。酶对Na_3VO_4不敏感。碱性蛋白质组蛋白、鱼精蛋白对酶活力有抑制作用,酸性蛋白质酪蛋白和酸性多糖物质肝素对酶活力有激活作用,且后者能减弱前者的抑制作用。

    Analysis of the quantitative relationship between a series of substitutedbenzylidenemalononitriles and the inhibitory action on protein tyrosine Kinases were car-ried out using the Hansch- Fujita method. The results indicate that the presence of two orthree hydroxy groups attached to a phenyl ring, which connects an extended (trans form)conjugated chain, is essential to the inhibition. Compared with the structure of other kindsof inhibitors, a presumable basic structure for inhibiting the enzyme was generated....

    Analysis of the quantitative relationship between a series of substitutedbenzylidenemalononitriles and the inhibitory action on protein tyrosine Kinases were car-ried out using the Hansch- Fujita method. The results indicate that the presence of two orthree hydroxy groups attached to a phenyl ring, which connects an extended (trans form)conjugated chain, is essential to the inhibition. Compared with the structure of other kindsof inhibitors, a presumable basic structure for inhibiting the enzyme was generated.

    用QSAR方法分析了取代的亚苄丙二腈类衍生物的定量构效关系,结果表明苯环上的两个或两个以上的羟基与侧链上可极化的共轭链的存在是酪氨酸激酶抑制剂的必要结构。与其它类型的抑制剂作构效分析,衍化出对这类酶有抑制作用的基本结构。

     
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