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precancerous hepatic
相关语句
  肝脏癌变
     Conclusion: Sorbaria Sorbifolia extract has inhibitory effect on DEN\|induced precancerous hepatic in rats.
     结论 :珍珠梅提取物对DEN致大鼠肝脏癌变有抑制作用
短句来源
  “precancerous hepatic”译为未确定词的双语例句
     Inhibitory Effects of Tea and Tea Mixture on Diethylni trosamine Induced Precancerous Hepatic Lesions in Rats and its Antioxidative Mechanisms
     绿茶及混合茶抑制二乙基亚硝胺诱发大鼠肝癌前期病变的抗氧化机理研究
短句来源
     Inhibitory Effect of Sorbaria Sorbifolia on DEN-induced Precancerous Hepatic Foci and Its Antioxidative Activities in Rats
     珍珠梅提取物对二乙基亚硝胺所致大鼠肝脏癌前病变的抑制作用及抗氧化活力的影响(英文)
短句来源
     Inhibitory Effect of Sorbaria Sorbifolia Extract on DEN-induced Precancerous Hepatic in Rats
     珍珠梅提取物对DEN所致大鼠肝癌前病变抑制作用的研究
短句来源
     The above results showed that both green tea and tea mixture inhibited DEN induced precancerous hepatic lesions in rats.
     结果表明,绿茶和混合茶对DEN诱发大鼠肝癌的发生均有显著的预防作用。
短句来源
     Objective To investigate the effect of Sorbaria sorbifolia on diethylnitrosamine (DEN) induced precancerous hepatic foci and its antioxidative activities in rats.
     目的 :研究珍珠梅对二乙基亚硝胺致大鼠肝脏癌前病变灶及抗氧化活力的抑制作用。
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  相似匹配句对
     Hepatic amyloidosis
     肝脏淀粉样变性
短句来源
     PRECANCEROUS LESIONS
     癌前病变
短句来源
     A Study of the Effects of Huqi Powder on Isoenzyme in the Serum of Hepatic Precancerous Rats
     槲芪散对肝癌前病变血清同功酶影响的研究
短句来源
     Inhibitory Effect of Sorbaria Sorbifolia Extract on DEN-induced Precancerous Hepatic in Rats
     珍珠梅提取物对DEN所致大鼠肝癌前病变抑制作用的研究
短句来源
     Subclinieal Hepatic Encephalopathy
     亚临床肝性脑病
短句来源
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  precancerous hepatic
Conclusion: These results indicated that BR-H2O extract has inhibitory effect on DEN-induced precancerous hepatic foci in rats and induced TNF-α production in rats.
      
Objective: To investigate the inhibitory effect of Boschniakia rossica (BR) on rat precancerous hepatic foci induced by diethylnitrosamine (DEN) and its antioxidative activities.
      
Inhibitory effect of boschniakia rossica on den-induced precancerous hepatic foci and its antioxidative activities in rats
      


The inhibitory effects and antioxidative mechanisms of green tea and tea mixture on N nitrosodiethylamine(DEN) initiated carcinogenesis were studied in a rats model treated with multiple small doses of DEN.The results showed that oral administration of 2% green tea and 0 5% tea mixture as drinking water both resulted in significant reduction of DEN induced glutamyl transpeptidaose positive foci in the rat liver and peroxidation products(MDA,ACT,ACON,PP)formed in the rat liver microsome( P <0 01).On the other...

The inhibitory effects and antioxidative mechanisms of green tea and tea mixture on N nitrosodiethylamine(DEN) initiated carcinogenesis were studied in a rats model treated with multiple small doses of DEN.The results showed that oral administration of 2% green tea and 0 5% tea mixture as drinking water both resulted in significant reduction of DEN induced glutamyl transpeptidaose positive foci in the rat liver and peroxidation products(MDA,ACT,ACON,PP)formed in the rat liver microsome( P <0 01).On the other hand,it was found that drinking green tea increased the activities of superoxide dismutase(SOD),quinone reductase(QR) and glutatione S transferase (GST) in rat liver( P <0 01).Whereas the activities of catalase(CAT),SOD,QR,GOT were increased in tea mixture group( P <0 01).The above results showed that both green tea and tea mixture inhibited DEN induced precancerous hepatic lesions in rats.The mechanisms of such effects may involve the enhancement of the activity of antioxidative enzyme and phase Ⅱ enzyme systems and the suppression of lipid peroxidation in liver.

用二乙基亚硝胺(DEN)诱发Wistar大鼠肝癌前期病变(Solt-Farber模型)。实验前6周给大鼠饮用2%绿茶水及0.5%混合茶水,于实验第8周末宰杀动物。结果发现,绿茶组及混合茶组肝r-GT异常病灶数均明显低于阳性对照组(P<0.01)。经HPLC法分离肝微粒体脂质过氧化产物丙二醛(MDA)、乙醛(ACT)、戊醛(PP)、丙酮(ACON),与阳性对照组相比,绿茶组和混合茶组的各种脂质过氧化产物均有不同程度的降低。此外,对多种抗氧化酶和Ⅱ相代谢酶活性进行检测,其中绿茶组SOD、GST、QR活性明显高于阳性对照组;混合茶组CAT、SOD、GST、QR活性明显高于阳性对照组。结果表明,绿茶和混合茶对DEN诱发大鼠肝癌的发生均有显著的预防作用。其作用机理可能和诱导抗氧化酶及某些Ⅱ相代谢酶活性,以及抑制脂质过氧化作用有关。

Objective To investigate the effect of Sorbaria sorbifolia on diethylnitrosamine (DEN) induced precancerous hepatic foci and its antioxidative activities in rats.Methods According to the standard method,75 rats were randomly divided into 3 groups:Group A (control),Group B (model),Group C (treatment),and 25 rats in each group.Hepatic precancerous lesions in rats were induced by the modified Solt and Farber protocol and the rats were sacrificed after feeding Sorbaria sorbifolia extract for...

Objective To investigate the effect of Sorbaria sorbifolia on diethylnitrosamine (DEN) induced precancerous hepatic foci and its antioxidative activities in rats.Methods According to the standard method,75 rats were randomly divided into 3 groups:Group A (control),Group B (model),Group C (treatment),and 25 rats in each group.Hepatic precancerous lesions in rats were induced by the modified Solt and Farber protocol and the rats were sacrificed after feeding Sorbaria sorbifolia extract for 6 weeks.The expressions of glutathine S-transferase (GST-P),p53 protein were investigated by immunohistochemistry techniques.TNF-α was measured by the radioimmunoassay and antioxidative activities of SOD,GSH-Px and the content of MDA were investigated by the colorimetric method in rat serum and mitochondria of liver cells.Results GST-P stainting was 86.7% positive in Group B and 28.6% positive in Group C;p53 protein was 53.3% in Group B and 38.1% in Group C positive respectively.For the content of serum TNF-α,the activities of SOD and GSH-Px,and the content of MDA in the serum and liver cells mitochondria,there were significant differences between Group B and Group C.Conclusions Sorbaria sorbifolia extract has inhibitory effect on DEN-induced precancerous hepatic foci in rats and induces TNF-α production in rats.The antioxidative action is exhibited by the administration of Sorbaria sorbifolia extract in the early stage of chemical hepatocarcinogenesis in rat livers.

目的 :研究珍珠梅对二乙基亚硝胺致大鼠肝脏癌前病变灶及抗氧化活力的抑制作用。方法 :75只大鼠随机分为A、B、C 3组 :对照组、模型组和治疗组 ,每组 2 5只。按略改良的Solt Farber氏方法制作大鼠肝脏癌前病变模型 ,用珍珠梅提取物饲养大鼠 6周后处死 ,通过免疫组织化学检测癌前病变组织谷胱甘肽S -转移酶 (GST P)和p5 3蛋白的表达 ,放射免疫法检测血清肿瘤坏死因子 (TNF α)的含量 ,比色分析法检测血清、肝线粒体超氧化物歧化酶 (SOD)、谷胱甘肽过氧化物酶 (GSH Px)的活性及丙二醛(MDA)的含量。结果 :B和C组GST P的表达率为 86 7%和 2 8 6 % ,p5 3的表达率为 5 6 %和 36 % ,差异均有显著意义 ,P <0 0 5 ;B组血清TNF α的含量与C组比较 ,差异有显著意义 ,P <0 0 5 ;B组血清、肝线粒体SOD、GSH Px活性及MDA含量与C组比较 ,差异均有显著意义 ,P <0 0 5。结论 :珍珠梅提取物对DEN所致大鼠癌前病变灶有抑制作用 ,可诱发TNF α的生成 ,并有抗氧化作用。

Objective:To investigate the inhibitory effect of Sorbaria Sorbifolia extract on diethylnitrosamine (DEN) induced precancerous hepatic in rats.Methods: Sorbaria Sorbifolia was administrated ig. to rats with DEN\|induced precarcinogenesis,Then using the immunohistochemical S\|P method,the p53 and bcl\|2 proteins were detected.The activities of superoxide dismutase(SOD),glutathione peroxidase (GSH\|Px),and the concentrations of malondialdehyde(MDA) were investigated by colorimetric method.Results:...

Objective:To investigate the inhibitory effect of Sorbaria Sorbifolia extract on diethylnitrosamine (DEN) induced precancerous hepatic in rats.Methods: Sorbaria Sorbifolia was administrated ig. to rats with DEN\|induced precarcinogenesis,Then using the immunohistochemical S\|P method,the p53 and bcl\|2 proteins were detected.The activities of superoxide dismutase(SOD),glutathione peroxidase (GSH\|Px),and the concentrations of malondialdehyde(MDA) were investigated by colorimetric method.Results: Sorbaria Sorbifolia significantly decreased the expression of GST\|P,and increased the SOD,GSH\|Px and decreased MDA level in serum,liver cell homogenate and liver cell mitochondria.Conclusion: Sorbaria Sorbifolia extract has inhibitory effect on DEN\|induced precancerous hepatic in rats.

目的 :研究珍珠梅提取物对二乙基亚硝胺 (diethylnitrosamine,DEN)致大鼠肝脏癌前病变的抑制作用。方法 :给动物ig给药 ,用DEN制备大鼠肝脏癌前病变模型 ;用免疫组织化学S P法检测大鼠肝脏谷胱甘肽S 转移酶 (GST P)的表达水平 ,用比色分析法检测血清、肝匀浆、线粒体SOD、GSH Px的活性及MDA含量的变化。结果 :珍珠梅提取物能显著降低DEN致癌前病变大鼠肝脏GST P的表达 ,升高血清、肝匀浆、肝线粒体SOD、GSH Px的活性 ,降低MDA的含量。结论 :珍珠梅提取物对DEN致大鼠肝脏癌变有抑制作用

 
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