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a strong inhibition
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  较强的抑制作用
     min- 1 .mg-1. Hg2+ and Cu2+ have a strong inhibition while Fe2+ and Mn2+ have a increasing effect on the enzymatic reaction rate.
     Hg2+、Cu2+对酶反应有较强的抑制作用,而Fe2+、Mn2+对该酶反应则有促进作用。
短句来源
     It has an approximate molecular mass of 11kDa,a pI of 6.2 and a pH optimum of 8.0.rBTI has a strong inhibition on trypsin with the mole ratio about 1:1.5.The protein possesses thermostability in the pH range 3.0~8.0.Even after 120min of heat treatment(100℃)the inhibitor still keeps over 70% of its trypsin inhibitory activity.
     rBTI对胰蛋白酶有较强的抑制作用,抑制摩尔比(以BApNA为底物)为1:1.5。 rBTI的最适pH值为8.0,在pH3.0~8.0之间有较好的热稳定性,100℃加热120min仍保持70%的胰蛋白酶抑制活性。
短句来源
     3. rAdinbitor had a strong inhibition on the proliferation of SMMC-7721 cells and showed a dose-dependent manner (P< 0.05 ).
     ③rAdinbitor对SMMC-7721细胞的增殖具有较强的抑制作用,且随着药物浓度的增加,其抑制作用增强(P<0.05)。
短句来源
     The results show that the fermentation product had a strong inhibition on various fungi by means of mycelium growth rate, the EC_(50) value against Macrophom kawatsukai and Bipolaris sorokiniana was 146.87 mg·L~(-1) and 164.09 mg·L~(-1).
     生测结果表明,离体条件下,发酵液对农业常见的病原真菌均有较强的抑制作用,对苹果轮纹病菌和小麦根腐病菌的菌丝生长抑制作用最强,其EC50分别是146.87 mg. L-1和164.09 mg.
短句来源
     Some metal ions,such as Mn 2+ ,Fe 2+ ,Co 2+ ,Zn 2+ ,and Cu 2+ had a strong inhibition to the CN 92 phytase,but Ca 2+ ,Mg 2+ had no any effect. In addition,some compounds,such as NaNO 3 and EDTA etc were also no any effect on the activity of CN 92 phytase.
     Mn2+,Fe2+,Co2+,Zn2+,Cu2+对此植酸酶有较强的抑制作用,而Ca2+,Mg2+,NaNO3和EDTA等对其则无明显影响。
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  “a strong inhibition”译为未确定词的双语例句
     A strong inhibition of cell proliferation was observed in p15-pcDNA3.1-K562 cells as compared with that of the control K562 cell.
     表达外源性P15蛋白的p15-pcDNA3.1-K562细胞株生长速度明显慢于对照K562细胞株;
短句来源
     Ag~+, Hg~(++), Cu~(++) showed a strong inhibition on the four xylanases,however,Mn~(++) had slight stimulation on D_(x1).
     Ag~(++)、Hg~(++),Cu~(++)对四个组分的活性均有强烈的抑制作用,SDS也能产生明显的抑制效果。 Mn~(++)对D_(x1)具有促进作用。
短句来源
     Low and medium concentrations of NAA (1 and 10 mg/L) showed definite positive effects in breaking the dormancy of buds, but a high concentration (100 mg/L) showed quite a strong inhibition effect.
     中、低浓度的NAA(10、1mg/L)处理对打破休眠芽显示了一定的正效应,但高浓度(100mg/L)则显示了较强的抑制效应;
短句来源
     However,when the concentration of H_2S came up to 10 mmol/L,the corrosion current is lower than that in blank solutions and a strong inhibition was found;
     当H2S浓度为10 mmol/L时,腐蚀速率小于空白溶液,表现为对X70钢的腐蚀反应的抑制作用.
短句来源
     The reachon of AKP with PMSF NBS,TNBS, SUAN and DTT resulted in a strong inhibition of the enzyme activities which decreased with the increase of modifier concentration.
     结果表明,PMSF、NBS、TNBS、SUAN、DTT的修饰能显著抑制酶的活力,活力的降低与修饰剂的浓度相关。
短句来源
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  相似匹配句对
     A Strong Similarity
     惊人的相似——骊姬与王熙凤形象分析
短句来源
     (b) E has a strong unit;
     (b)E具有强单位元;
短句来源
     Results showed that validoxylamine A had strong inhibition on trehalase.
     实验表明井冈霉亚基胺A对海藻糖酶有很强的抑制作用。
短句来源
     G. A.
     作者采用美国燃气协会(A.G.A.)
短句来源
     (f) (S,A, );
     (f)(S,A);
短句来源
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  a strong inhibition
Physiological concentrations of ATP and citrate produce a strong inhibition of renal PFK suggesting that may participate in the control of glycolysisin vivo.
      
Both Triton X-100 and SDS maintain Ca++ accumulation in SR vesicles at detergent concentrations below 10-3 M; higher concentrations cause a strong inhibition.
      
A strong inhibition of the activity of the UPD-glucose transferases was observedin vitro at a concentration of DIMBOA as low as 0.01 mM.
      
A strong inhibition was detected when the vesicles were incubated in the presence of alanine, cysteine, or serine; in addition, histidine, but not glutamate or leucine, had a negative effect on glutamine transport.
      
Mitochondria from livers of fed rats showed a strong inhibition of succinate oxidation both in state 4 and state 3, although the rate of uncoupled respiration was normal.
      
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In clinical observations it was found that caudate stimulation brought forthalleviation of intractable pain in patients with late malignancies.SubsequentStudy in rabbits suggested that caudate analgesia might be functionally related tothe endorphins of PAG.The present work studied the effect of caudate stimulationon units sensitive to etorphine,morphine,acetylcholine and serotonin in therabbit PAG by multibarrelled microelectrodes for extracellular recording andiontophoresis.All etorphine-sensitive units manifested...

In clinical observations it was found that caudate stimulation brought forthalleviation of intractable pain in patients with late malignancies.SubsequentStudy in rabbits suggested that caudate analgesia might be functionally related tothe endorphins of PAG.The present work studied the effect of caudate stimulationon units sensitive to etorphine,morphine,acetylcholine and serotonin in therabbit PAG by multibarrelled microelectrodes for extracellular recording andiontophoresis.All etorphine-sensitive units manifested a strong inhibition which was readilyreversed by iontophoretic naloxone.Although morphine produced naloxone-reversed inhibition similar to that produced by etorphine,it also produced activa-tion in some cases.Units sensitive to opiates were unevenly distributed in the PAG,since more units were identified in the ventral than in the dorsal part(Χ~2=36.37,P<0.001).Besides opiates,the effects of iontophoretic acetylcholine,serotonin were alsoobserved.In 114 units sensitive to the drugs,the effect of caudate stimulation was exa-mined.Respones to caudate stimulation presented mainly depression with a slowonset and recovery.The response,like that induced by etorphine,could readilybe reversed by naloxone iontophoretically applied.It was found that the anteriorpart of the head of the caudate nucleus was more effective in modulating PAGunits than the posterior part.The comparison between the responses induced by iontophoretic drugs andthose by caudate stimulation revealed that most units inhibited by etorphine wereinhibited by caudate stimulation as well,there existed a significant consistence(Χ~2=26.48, P<0.001).The results indicate that the caudate nucleus is functionally related to thePAG.The possible role of the PAG in caudate stimulation produced analgesiawas discussed.

慢性实验已提示尾核镇痛可能与中央灰质内啡肽系统有关。为探讨这种机制,为临床上尾核内埋藏电极刺激治疗恶痛提供进一步实验分析的依据,本工作用多管微电极离子微电泳方法测定中央灰质神经元对羟戊甲吗啡等药物的敏感性,并观察刺激尾核对敏感神经元的影响。在55个家兔共记录了267个单位的自发放电。微电泳观察到对羟戊甲吗啡有反应的单位只表现为抑制一种类型,而对吗啡有反应的单位表现有抑制与兴奋两种类型。两种药物的抑制作用均可为微电泳纳洛酮所阻断或部分阻断。吗啡类药物敏感单位主要分布于导水管腹侧,(x~2=36.37,p<0.001)。另也用乙酰胆碱与5-羟色胺作了微电泳。以后观察了刺激尾核对这四种药物敏感单位的影响。刺激尾核的作用亦以抑制为主,且发生缓慢有后作用。部分单位对刺激尾核的抑制反应亦可为微电泳纳洛酮所阻断或部分阻断。比较刺激尾核与四种药物微电泳给药的作用后看到刺激尾核与吗啡类药物对中央灰质神经元的影响最为一致(x~2=26.48,p<0.001)。并观察到尾核头部前区(A(_4-4.5))比后区(A_(2-2.5))对中央灰质神经元影响为大(x~2=10.42,p<0.005)。表明尾核与中央灰质确有功能上的联系,提...

慢性实验已提示尾核镇痛可能与中央灰质内啡肽系统有关。为探讨这种机制,为临床上尾核内埋藏电极刺激治疗恶痛提供进一步实验分析的依据,本工作用多管微电极离子微电泳方法测定中央灰质神经元对羟戊甲吗啡等药物的敏感性,并观察刺激尾核对敏感神经元的影响。在55个家兔共记录了267个单位的自发放电。微电泳观察到对羟戊甲吗啡有反应的单位只表现为抑制一种类型,而对吗啡有反应的单位表现有抑制与兴奋两种类型。两种药物的抑制作用均可为微电泳纳洛酮所阻断或部分阻断。吗啡类药物敏感单位主要分布于导水管腹侧,(x~2=36.37,p<0.001)。另也用乙酰胆碱与5-羟色胺作了微电泳。以后观察了刺激尾核对这四种药物敏感单位的影响。刺激尾核的作用亦以抑制为主,且发生缓慢有后作用。部分单位对刺激尾核的抑制反应亦可为微电泳纳洛酮所阻断或部分阻断。比较刺激尾核与四种药物微电泳给药的作用后看到刺激尾核与吗啡类药物对中央灰质神经元的影响最为一致(x~2=26.48,p<0.001)。并观察到尾核头部前区(A(_4-4.5))比后区(A_(2-2.5))对中央灰质神经元影响为大(x~2=10.42,p<0.005)。表明尾核与中央灰质确有功能上的联系,提示中央灰质内啡肽与其受体的相互作用可能是尾核镇痛的机制之一。

Two forms of alkaline phosphatasc from Sinonovacula constricta (AKP Ⅰ& AKP Ⅱ ) were selectively modified by PMSF, TNBS, NBS, bromoacetic acid and DTNB and the changes in their activities and absorption spectra have been studied.It was found that the reaction of AKP Ⅰ and AKP Ⅱ with PMSF, TNBS and NBS resulted in a strong inhibition of enzyme activities. In the presence of 5mM PMSF) the inactivation process appeared to be of the first order reaction and the rate constants were measured to be 1.85×10-4sec-1....

Two forms of alkaline phosphatasc from Sinonovacula constricta (AKP Ⅰ& AKP Ⅱ ) were selectively modified by PMSF, TNBS, NBS, bromoacetic acid and DTNB and the changes in their activities and absorption spectra have been studied.It was found that the reaction of AKP Ⅰ and AKP Ⅱ with PMSF, TNBS and NBS resulted in a strong inhibition of enzyme activities. In the presence of 5mM PMSF) the inactivation process appeared to be of the first order reaction and the rate constants were measured to be 1.85×10-4sec-1. and 2.00×10-4sec-1. for AKP Ⅰ and AKP Ⅱ respectively. On reacting with TNBS or NBS, the catalytic activities of AKP Ⅰ and AKP Ⅱ decreased steadily with the increase of modifier concentration. Kinetic studies of inactivation of AKP by chemical modification demonstrated that Lys and Trp residues are essential for the activities of AKP Ⅰ and AKPⅡ and one of the Lys residuesis situated in the active site of AKP 1111111111. It has also been shown that His residue and SH group are indifferent to the activities of AKP Ⅰ and AKP Ⅱ.

用PMSF、TNBS、NBS、DTNB及溴代乙酸在一定条件下分别选择性地作用于缢蛏两种碱性磷酸酯酸(AKPⅠ和AKPⅡ)的Ser、Lys、Trp、His及巯基,并对酶活力的变化和吸收光谱的变化作了相应的测定。结果表明,PMSF、TNBS和NBS的修饰能显著抑制AKPⅠ和AKPⅡ的活力,活力的降低与修饰剂的浓度有关;溴代乙酸和DTNB对AKPⅠ和AKPⅡ的活力不表现抑制作用。我们初步认为,Ser、Lys和Trp残基可能是AKPⅠ和AKPⅡ的活力必需基团。AKPⅠ的TNBS失活动力学研究还表明一个Lys践基是AKPⅠ表现催化活力所必需的。

The kinetics of 2- Methylthiophnene (MT) hydrodcsulfurization (HDS) over a sulfided Co Mo/γ-Al2O3 catalyst was investigated by using a stirred flow microbalance reactor at 623K and atmospheric pressure. When the catalyst had achieved line-out, the rate data of HDS at various partial pressuer of MT, H2 and H2S were obtained by changing flow rate of the feed stream. The resuits indicate that Geactant MT and product H2S have a strong inhibition effect on HDS rate of MT, which shows that there is a competitive...

The kinetics of 2- Methylthiophnene (MT) hydrodcsulfurization (HDS) over a sulfided Co Mo/γ-Al2O3 catalyst was investigated by using a stirred flow microbalance reactor at 623K and atmospheric pressure. When the catalyst had achieved line-out, the rate data of HDS at various partial pressuer of MT, H2 and H2S were obtained by changing flow rate of the feed stream. The resuits indicate that Geactant MT and product H2S have a strong inhibition effect on HDS rate of MT, which shows that there is a competitive adsorption between MT and H2S over the HDS active sites of CoMo/γ-Al2O3 catalyst. The experimental data were best fitted with langmuir-Hinshelwood equation. The corresponding kinetic parameters of reaction rate equation were determined by the linear regression of two variables. The reaction mechanism of HDS for 2-Methyl thiophene was preliminarily discussed.

本文采用搅拌式微量天平流动反应器(Stirred flow microbalance re-actor),在常压及温度623K的条件下,考察了硫化态钴钼催化剂上2-甲基噻吩的加氢脱硫动力学。当催化剂活性达到稳态后,通过改变反应进料2-甲基噻吩、氢及硫化氢的流量,获得了不同的2-甲基噻吩、氢及硫化氢分压下的加氢脱硫速率数据。结果表明,反应物2-甲基噻吩及产物硫化氢均对加氢脱硫反应速度有明显的阻滞作用,这意味着在钴钼催化剂的加氢脱硫活性位上,硫化氢与2-甲基噻吩之间存在着竞争吸附。利用Langmuir-Hinshelwood方程较好地关联了所得到的实验数据,通过二元线性回归,确定了速率方程中相应的动力学参数,文中对2-甲基噻吩加氢脱硫的反应机理进行了初步的探讨。

 
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