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entered the analysis of results
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  进入结果分析
    RESULTS: All the 135 patients with essential tremor entered the analysis of results.
    结果:135例原发性震颤患者均进入结果分析
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    RESULTS: All the 30 patients entered the analysis of results.
    结果:30例患者全部进入结果分析
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    RESULTS: During the experiment, 1 and 2 rats died in the saline group and ethanol group respectively, and there was no deletion in the anisodamine+saline group and anisodamine+ethanol group, finally 17, 16, 18 and 18 rats entered the analysis of results in the 4 groups respectively.
    结果:实验过程中生理盐水组1只大鼠和乙醇组2只大鼠死亡、山莨菪碱+生理盐水组、山莨菪碱+乙醇组无脱失。 4组大鼠进入结果分析数量分别为17、16、18、18只。
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    RESULTS: All the 20 subjects entered the analysis of results.
    结果:20人均进入结果分析
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    RESULTS: One case in the test group and 3 cases in the control group lost to the follow-up. Finally 119 patients entered the analysis of results with 60 cases in the test group and 59 cases in the control group.
    结果:试验组失访1例,对照组失访3例,进入结果分析患者119例,试验组60例,对照组59例。
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AIM To compare the differences of motor function and disease progress between patients with Parkinson disease treated with surgery plus medicine and those treated with medicine only after 1 year. METHODS Twenty-four patients with primary Parkinson disease were selected from the Department of Neurosurgery Tangdu Hospital of the Fourth Military Medical University of Chinese PLA between March 2003 and March 2005.They were all refractory to drug therapyand clinically evaluated to receive surgery for globus pallidus...

AIM To compare the differences of motor function and disease progress between patients with Parkinson disease treated with surgery plus medicine and those treated with medicine only after 1 year. METHODS Twenty-four patients with primary Parkinson disease were selected from the Department of Neurosurgery Tangdu Hospital of the Fourth Military Medical University of Chinese PLA between March 2003 and March 2005.They were all refractory to drug therapyand clinically evaluated to receive surgery for globus pallidus impairment.Twelve cases received unilateral surgery for globus pallidus impairment and had follow-up data after 1 year were taken as the surgery group still received drug therapy after 1 yearanother 12 cases could not accept surgery for different reasons and only received drug therapy as the non-surgery group.The disease condition and progress were assessed with the unified Parkinson disease rating scale motor score UPDRSin the surgery group at the first diagnosis and at 1 week and 1 year after surgery and in the non-surgery group at the first diagnosis and at 1 year after surgery respectively. RESULTS According to intention-to-treat analysis24 patients all entered the analysis of results.The score of UPDRS at the first diagnosis had no significant difference between the surgery group and non-surgery group 30.41±5.6529.30±5.50P > 0.05it was significantly decreased in the surgery group at 1 week after surgery20.17±2.31it was significantly lower I the surgery group than in the non-surgery group at 1 year after surgery 25.66±3.1536.12±5.22P=0.000. The score had no difference in the surgery group at 1 week and 1 month after surgery also in the non-surgery before and after 1 year t= -0.352P=0.726. CONCLUSION The follow-up observation proves that the ameliorated degree of motor function in the patients accepted surgery for globus pallidus impairment is obviously superior to that in those did not accepted but there is no difference in the velocity of postoperative disease process between the patients accepted the surger or not. So when the effect of drug therapy is no so good surgery can obviously ameliorate the symptoms and improve their quality of life.

目的:比较手术加药物治疗的帕金森病患者和单纯药物治疗的患者1年后运动功能以及病情进展速度的差异。方法:选择2003-03/2005-03解放军第四军医大学唐都医院神经外科收治的原发性帕金森病患者24例,均为药物难治性,经临床评估可以接受苍白球毁损术者。其中12例接受单侧苍白球毁损术治疗并且有1年后随访资料者为手术组(术后1年仍接受药物治疗),另12例因各种原因不能接受手术仅进行单纯药物治疗者为非手术组。手术组首诊、术后1周及1年后,非手术组首诊及1年后均进行统一帕金森病评定量表运动部分评分(总分108分,评分越高,运动功能越差)评估病情和进展。结果:按意向处理分析,24例患者全部进入结果分析。首诊时手术组和非手术组患者统一帕金森病评定量表运动部分评分比较无差异(30.41±5.65,29.30±5.50,P>0.05),术后1周手术组评分显著下降(20.17±2.31);1年后手术组评分显著低于于非手术组(25.66±3.15,36.12±5.22,P=0.000);而手术组术后1周与术后1年的评分差值与非手术组1年前后的评分差值比较无差异(t=-0.352,P=0.726)。结论:随访观察证明,接受了苍白球...

目的:比较手术加药物治疗的帕金森病患者和单纯药物治疗的患者1年后运动功能以及病情进展速度的差异。方法:选择2003-03/2005-03解放军第四军医大学唐都医院神经外科收治的原发性帕金森病患者24例,均为药物难治性,经临床评估可以接受苍白球毁损术者。其中12例接受单侧苍白球毁损术治疗并且有1年后随访资料者为手术组(术后1年仍接受药物治疗),另12例因各种原因不能接受手术仅进行单纯药物治疗者为非手术组。手术组首诊、术后1周及1年后,非手术组首诊及1年后均进行统一帕金森病评定量表运动部分评分(总分108分,评分越高,运动功能越差)评估病情和进展。结果:按意向处理分析,24例患者全部进入结果分析。首诊时手术组和非手术组患者统一帕金森病评定量表运动部分评分比较无差异(30.41±5.65,29.30±5.50,P>0.05),术后1周手术组评分显著下降(20.17±2.31);1年后手术组评分显著低于于非手术组(25.66±3.15,36.12±5.22,P=0.000);而手术组术后1周与术后1年的评分差值与非手术组1年前后的评分差值比较无差异(t=-0.352,P=0.726)。结论:随访观察证明,接受了苍白球毁损术的患者运动功能改善程度明显优于未接受手术的患者;但是手术组患者术后的病情进展速度与非手术组患者无差别。因此,当患者药物治疗效果欠佳时,选择手术治疗可明显改善症状,提高生活质量。

AIM To establish animal model of temporal epilepsy in rat and investigate the effects of infusing dopamine D1 antagonist SCH23390 into different encephalon regions on temporal epilepsy induced by kainic acid. METHODS The experiment was performed in the Military Research Institute of Neurology Zhujiang Hospital affiliated to Southern Medical University from August to December 2004.①Grouping Thirtty Spraque-Dawley SD rats were randomized into physiological saline group n=3 kainic acid group n=3 and experimental...

AIM To establish animal model of temporal epilepsy in rat and investigate the effects of infusing dopamine D1 antagonist SCH23390 into different encephalon regions on temporal epilepsy induced by kainic acid. METHODS The experiment was performed in the Military Research Institute of Neurology Zhujiang Hospital affiliated to Southern Medical University from August to December 2004.①Grouping Thirtty Spraque-Dawley SD rats were randomized into physiological saline group n=3 kainic acid group n=3 and experimental group n=24. The experimental group was divided into 3 subgroups with 5 rats in each subgroup hippocampus group striatum group and substantia nigra group. SCH23390 were injected into hippocampus striatum and substantia nigra respectively with contrast physiological saline was injected to the corresponding positionsn=3 respectively.②Model establishment Rats in the kainic acid group and experimental group were made into models of temporal epilepsy by injecting kainic acid 5 μg 2.5 g/L into the right ventricle and those in the physiological saline group were unilaterally injected with physiological saline 2 μL.③Administration SCH23390 1 g/L for each was injected on the right side successively and simultaneouslywith contrast physiological saline was injected in the same position.④Observed indexes The changes of behavior and electroencephalogram were observed in each group. Rats were killed at 3 days after injection. The section of brain was marked by TUNEL so as to observe apoptosis of hippocampus neurons cell. RESULTS All the 30 rats entered the analysis of result.① Behavioral changes The physiological saline group did not show the epileptic seizure. The epileptic seizure occurred at 10 minute after injecting kainic acid in lateral ventricle and reached the peak at 1 hour following the injection. ② EEG record In the physiological saline groupthere was not epileptic activity manifestationslike sharp wavespike wave spike slow comprehensive wave etc.In the kainic acid group epileptic wave presented immediately at 10 minutes after injection the seizure developed to the peak at about 1 hourthe wave amplitude was decreased at 3 to 6 hourspresenting paroxysmal slow and spike slow waves and no epileptic wave appeared after 12 hours.The wave amplitude was decreased perfectly in striatum group as compared with the kainic acid groupwhich showed significant difference.The wave amplitude was also decreased in the substantia nigra group but not in the hippocampus group as compared with the kainic acid groupwhich did not show significant difference.③Neuronal apoptosis Hippocampus neurons cell apoptosis occurred after epileptic seizure and reached the peak at 3 days.After injecting dopamine D1 antagonist SCH23390 in different encephalon regionshippocampus neurons cell apoptosis reduced in different level.The quantities of apoptosis in the striatum group was the least as compared with kainic acid groupwhich showed significant difference P﹤0.01.CONCLUSION Injecting kainic acid into lateral ventricle could induce animal model of temporal epilepsy.Hippocampus neurons cell apoptosis occurred following epilepsy seizure which resulted from kainic acid.The quantities of apoptosis showed difference after injected SCH23390 in different encephalon regions and reached the least in striatum.it was implied that the role of different encephalon regions was distinction in temporal epilepsy occurred by kainic acid.

目的:建立颞叶癫痫模型,探讨不同脑区给予多巴胺D1受体拮抗剂SCH23390对红藻氨酸所致的颞叶癫痫的影响。方法:实验于2004-08/12在解放军第一军医大学珠江医院全军神经医学研究所进行。①分组:取SD大鼠30只,随机分为生理盐水组3只,红藻氨酸组3只和实验组24只,实验组又分为海马、纹状体、黑质注射组各5只(共15只),以及同部位生理盐水注射作为对照,每组3只(共9只)。②造模:红藻氨酸组及实验组大鼠给红藻氨酸酸5μg(2.5g/L)右侧脑室注射制备颞叶癫痫模型,生理盐水组同部位给生理盐水2μL。③给药:实验组中的海马、纹状体、黑质注射组在相应部位缓慢注入1g/L的SCH233901μL,各部位以相同剂量生理盐水注入作为对照。④观察指标:观察各组间的大鼠行为变化及脑电图变化。3d后取脑作海马部TUNEL染色,观察海马部神经细胞凋亡情况。结果:30只大鼠全部进入结果分析。①行为变化:生理盐水组无癫痫发作。红藻氨酸组大鼠均出现癫痫发作,发作于脑室注射红藻氨酸后10min开始,1h达高峰。②脑电图变化:生理盐水组无尖波、棘波、棘慢综合波等痫性电活动表现,红藻氨酸组于注射后10min即有痫性波出现,其波幅为中幅...

目的:建立颞叶癫痫模型,探讨不同脑区给予多巴胺D1受体拮抗剂SCH23390对红藻氨酸所致的颞叶癫痫的影响。方法:实验于2004-08/12在解放军第一军医大学珠江医院全军神经医学研究所进行。①分组:取SD大鼠30只,随机分为生理盐水组3只,红藻氨酸组3只和实验组24只,实验组又分为海马、纹状体、黑质注射组各5只(共15只),以及同部位生理盐水注射作为对照,每组3只(共9只)。②造模:红藻氨酸组及实验组大鼠给红藻氨酸酸5μg(2.5g/L)右侧脑室注射制备颞叶癫痫模型,生理盐水组同部位给生理盐水2μL。③给药:实验组中的海马、纹状体、黑质注射组在相应部位缓慢注入1g/L的SCH233901μL,各部位以相同剂量生理盐水注入作为对照。④观察指标:观察各组间的大鼠行为变化及脑电图变化。3d后取脑作海马部TUNEL染色,观察海马部神经细胞凋亡情况。结果:30只大鼠全部进入结果分析。①行为变化:生理盐水组无癫痫发作。红藻氨酸组大鼠均出现癫痫发作,发作于脑室注射红藻氨酸后10min开始,1h达高峰。②脑电图变化:生理盐水组无尖波、棘波、棘慢综合波等痫性电活动表现,红藻氨酸组于注射后10min即有痫性波出现,其波幅为中幅及高幅波,但出现频率较低;1h左右癫痫发作达高峰时其波幅大部为高幅波,出现频率高;3~6h后波幅降低,12h后无痫性波出现。实验组中纹状体注射组波幅降低明显,与红藻氨酸组相比差异显著;黑质注射组亦有下降,而海马注射组无明显下降,与红藻氨酸组相比无差异。③细胞的凋亡:癫痫发作后伴随有海马细胞的凋亡,3d时明显。各脑区给予SCH23390后,海马部细胞凋亡减轻不一致,纹状体注射组阳性细胞数最少,与红藻氨酸组相比其差值有统计学意义(P﹤0.01)。结论:①一侧侧脑室注入红藻氨酸可成功建立癫痫模型。②红藻氨酸致痫后伴有海马神经凋亡改变,给予多巴胺D1受体拮抗剂SCH23390后,海马神经元凋亡减轻。③不同部位注射产生的凋亡细胞数不同,其中以纹状体注射所产生的凋亡细胞数最少,提示各部位在红藻氨酸所致的颞叶癫痫中的作用不同。

AIM: To analyze the clinical characteristics of elderly people clearly diagnosed to have essential tremor based on baseline population of aging and multi-dimensional study in Beijing city. METHODS: Between July and September 2000, totally 2 835 residents aged 55 years old and above in Beijing city were investigated based on community. Totally 135 cases of them were found to have essential tremor through the screening and diagnosis of essential tremor, including 83 males and 52 females, aged 55-101 years with...

AIM: To analyze the clinical characteristics of elderly people clearly diagnosed to have essential tremor based on baseline population of aging and multi-dimensional study in Beijing city. METHODS: Between July and September 2000, totally 2 835 residents aged 55 years old and above in Beijing city were investigated based on community. Totally 135 cases of them were found to have essential tremor through the screening and diagnosis of essential tremor, including 83 males and 52 females, aged 55-101 years with an average of (75.8±7.9) years. There were 7 males and 2 females aged 55-64 years, 31 males and 14 females aged 65-74 years, 45 males and 36 females aged 75 years and above. Their disease histories were collected, they all participated in the physical examination and tremor evaluation and functional assessment, and then the clinical features of essential tremor were analyzed. RESULTS: All the 135 patients with essential tremor entered the analysis of results. ① Upper limbs (100%) and head (20%) were the most frequently affected. ② The total score of tremor was insignificantly higher in females than in males (7.2±3.4, 6.5±2.5, P=0.150), and the total score of limb's tremor was also not obviously different between males and females (6.3±2.4, 6.0±2.2, P=0.421). The probability of head tremor was insignificantly higher in females than in males (25%, 16.9%, P > 0.05). ③ The total score of limb's tremor in the head tremor group was insignificantly different from that in the without head tremor group (6.6±4.1, 6.0±1.6, P=0.506). ④ The positive family history was only 3%. 69.6% of patients were reported to have been aware of the history of tremor. The high peak of onset was older than 50 years old (90.4%). ⑤ The probability of head involvement in the history group was obviously higher than that in the without history group (25.5%, 7.3%, P=0.015), but there were no obvious differences in the total scores of tremor and limb's tremor (6.8±2.7, 6.5±3.1; 6.1±2.1, 6.2±2.7, P > 0.05). CONCLUSION: ① Upper limbs and head are the most frequently affected in patients with essential tremor, and the severity of tremor and characteristics have no gender differences. ② Accompanied by head tremor or not has no influence on the severity of tremor. ③ The onset age of most patients with essential tremor is older than 50 years. ④ Head tremor is a main factor that affects the awareness of tremor history.

目的:在北京市老龄化多维纵向研究基线人群基础上,对抽样筛查确诊的中老年人原发性震颤的临床特征进行分析。方法:2000-07/09以社区为基础调查了北京市55岁以上2835名中老年人群,通过原发性震颤的筛查和诊断,最终共确诊原发性震颤患者135例,其中男83例,女52例;年龄55~101岁,平均(75.8±7.9)岁。55~64岁年龄段男7例,女2例;65~74岁年龄段男31例,女14例,≥75岁年龄段男45例,女36例。对调查发现的135例原发性震颤患者进行病史收集、体格检查、震颤评分和功能评价,进而分析原发性震颤的临床特点。结果:135例原发性震颤患者均进入结果分析。①震颤部位以上肢(100%)、头部震颤(20%)为主。②女性震颤总分高于男性,但差异无显著性(7.2±3.4,6.5±2.5,P=0.150);男性和女性肢体震颤总分差异也不明显(6.3±2.4,6.0±2.2,P=0.421)。女性头部震颤几率高于男性,但差异无统计学意义(25%,16.9%,P>0.05)。③头部震颤组肢体震颤总分与无头部震颤组比较差异无显著性(6.6±4.1,6.0±1.6,P=0.506)。④阳性家族史报告仅占3%,有6...

目的:在北京市老龄化多维纵向研究基线人群基础上,对抽样筛查确诊的中老年人原发性震颤的临床特征进行分析。方法:2000-07/09以社区为基础调查了北京市55岁以上2835名中老年人群,通过原发性震颤的筛查和诊断,最终共确诊原发性震颤患者135例,其中男83例,女52例;年龄55~101岁,平均(75.8±7.9)岁。55~64岁年龄段男7例,女2例;65~74岁年龄段男31例,女14例,≥75岁年龄段男45例,女36例。对调查发现的135例原发性震颤患者进行病史收集、体格检查、震颤评分和功能评价,进而分析原发性震颤的临床特点。结果:135例原发性震颤患者均进入结果分析。①震颤部位以上肢(100%)、头部震颤(20%)为主。②女性震颤总分高于男性,但差异无显著性(7.2±3.4,6.5±2.5,P=0.150);男性和女性肢体震颤总分差异也不明显(6.3±2.4,6.0±2.2,P=0.421)。女性头部震颤几率高于男性,但差异无统计学意义(25%,16.9%,P>0.05)。③头部震颤组肢体震颤总分与无头部震颤组比较差异无显著性(6.6±4.1,6.0±1.6,P=0.506)。④阳性家族史报告仅占3%,有69.6%的患者曾意识到震颤的存在,大部分患者(90.4%)均于50岁以后起病。⑤按照有无病史将原发性震颤患者分为两组,发现有病史组头部受累几率明显高于无病史组(25.5%,7.3%,P=0.015),而震颤总分和肢体震颤总分差异均不明显(6.8±2.7,6.5±3.1;6.1±2.1,6.2±2.7,P>0.05)。结论:①上肢与头部是原发性震颤患者的主要震颤部位,震颤程度与特点无明显性别差异。②是否合并头部震颤不影响肢体震颤程度。③大部分原发性震颤患者于50岁之后发病。④头部震颤与否是影响震颤病史汇报的主要因素。

 
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