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   its clinicopathological significance 的翻译结果: 查询用时:0.193秒
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its clinicopathological significance
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  临床病理意义
     Detection of API2-MALT1 fusion transcript in gastric MALT lymphoma and its clinicopathological significance
     胃MALT淋巴瘤中API2-MALT1的检测及其临床病理意义
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     Expression of Cyclin E,p27~(kip1) in Colorectal Carcinomas and Its Clinicopathological Significance
     大肠癌中Cyclin E、p27~(kip1)的表达及临床病理意义
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     Expression of P16 and P21 proteins in hepatocellular carcinoma and its clinicopathological significance
     肝细胞癌组织中P16、P21蛋白表达的临床病理意义
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     EBER_(_1) Expression and its Clinicopathological Significance in Nasopharyngeal Carcinoma
     鼻咽癌组织中EBER_(_1)表达及其临床病理意义
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     Expression of AKR1C2 in human renal carcinoma tissue and its clinicopathological significance
     人类肾癌中AKR1C2基因的表达及其临床病理意义
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  临床病理学意义
     Expression of HER-2/neu and P53 in cervical adenocarcinoma and its clinicopathological significance
     宫颈腺癌HER-2/neu和P53的表达及其临床病理学意义
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     Objective To detect the COL1A1/PDGFB fusion transcripts and discuss its clinicopathological significance in dermatofibroscoma protuberans.
     目的 检测隆突性皮肤纤维肉瘤 (DFSP)中COL1A1/PDGFB融合基因的表达并探讨其临床病理学意义
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     Immunohistochemical Detection of ras P_(21) Expression in Pancreatic Adenocarcinoma and Its Clinicopathological Significance
     Ras P_(21)在胰腺癌组织中的表达及其临床病理学意义
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     Alterative Expression of P~(53) protein IGF-r in Human Pancreatic Carcinoma and its Clinicopathological Significance
     胰腺癌组织中P53蛋白、IGF-r异常表达及临床病理学意义
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     EBER-1expression and its clinicopathological significance in nasopharyngeal carcinoma detected by immunohistochemistry
     鼻咽癌组织中EBER-1表达及其临床病理学意义
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  “its clinicopathological significance”译为未确定词的双语例句
     The Expression of CD_(44)V6,VEGF,MMP-2 in human esophageal carcinoma and its clinicopathological significance
     食管癌组织中CD_(44)V6、VEGF、MMP-2的表达及其与临床病理特征的关系
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     Expressions of RhoC,CD44v6 and ICAM- 1 in human gastric cancer and its clinicopathological significance
     胃癌中RhoC和CD44v6及ICAM-1的表达及其相关性的初步研究
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     Expression of HOX A9 mRNA and Its Clinicopathological Significance in Benign and Malignant Lesions of Pancreas
     胰腺良恶性疾病中HOX A9 mRNA的表达及其临床意义
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     EXPRESSION OF P16 PROTEIN AND mRNA IN SALIVARY GLAND TUMORS AND ITS CLINICOPATHOLOGICAL SIGNIFICANCE
     涎腺肿瘤中P16蛋白和P16 mRNA的表达及意义
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     THE ANTI KI 67 ANTIBODY MIB 1 EXPRESSION IN COLORECTAL EPITHELIAL TUMOURS AND ITS CLINICOPATHOLOGICAL SIGNIFICANCE
     抗Ki-67抗体MIB-1在大肠上皮性肿瘤中的表达及临床意义
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  its clinicopathological significance
Overexpression of cyclin B1 in gastric cancer and its clinicopathological significance: an immunohistological study
      


Objective: To probe into the diagnosis in midline malignant reticulosis (MMR) and its clinicopathological significance. Methods: MMR was studied clinicopathologically and immunophenotypically. Results: The study showed that of the 50 cases of MMR there were 43 cases of T cell lymphoma, 2 cases of B cell lymphoma, and 5 cases being of uncertain lineage in the study. This study also covered the differential diagnosis of MMR from some other diseases. Conclusion: 1) the results suggest that most of MMR are...

Objective: To probe into the diagnosis in midline malignant reticulosis (MMR) and its clinicopathological significance. Methods: MMR was studied clinicopathologically and immunophenotypically. Results: The study showed that of the 50 cases of MMR there were 43 cases of T cell lymphoma, 2 cases of B cell lymphoma, and 5 cases being of uncertain lineage in the study. This study also covered the differential diagnosis of MMR from some other diseases. Conclusion: 1) the results suggest that most of MMR are T cell lymphoma (socalled midline T cell lymphoma (MTL); 2) it is believed that the clinical manifestations and pathologic features combined with immunophenotyping technique could help make a definite diagnosis of MMR.

目的:探讨中线恶网的诊断及其临床病理意义,与其他一些疾病的鉴别诊断。方法:对中线恶网进行临床病理分析和免疫表型标记。结果:50例中线恶网中,T细胞淋巴瘤43例,B细胞淋巴瘤2例,余5例尚不能分类。结论:结果表明本病多数是T细胞淋巴瘤(即所谓的中线T淋巴瘤)。认为本病的临床、病理特点结合免疫标记技术有助于中线T淋巴瘤的确诊。

Objective To investigate the expression of p16 gene in non Hodgkin′s lymphoma (NHL) and its clinicopathological significance. Methods Paraffin embedded biopsies from 64 patients with NHL were analysed for p16 gene expression by immunohistochemical methods and in situ hybridization technique. Results Of the 64 NHL cases, 34(53.1%) were positive for p16 protein, 30(46.9%) lacked p16 protein, most of the positive signals were seen in the nuclei; 45(70.3%) were p16 mRNA positive, 19(29.7%) lost p16 mRNA...

Objective To investigate the expression of p16 gene in non Hodgkin′s lymphoma (NHL) and its clinicopathological significance. Methods Paraffin embedded biopsies from 64 patients with NHL were analysed for p16 gene expression by immunohistochemical methods and in situ hybridization technique. Results Of the 64 NHL cases, 34(53.1%) were positive for p16 protein, 30(46.9%) lacked p16 protein, most of the positive signals were seen in the nuclei; 45(70.3%) were p16 mRNA positive, 19(29.7%) lost p16 mRNA and p16 mRNA was clearly observed in the cytoplasm of lymhocytes. p16 expression did not show correlation with such factors as sex, age and immunophenotype in NHL, but there was a significant difference between the pattern of expression of p16 in well differenciated lymphomas and poorly differentiated lymphomas ( P <0.05). Moreover, 42 patients were followed postoperatively for over 3 years, both p16 protein and mRNA correlated with the prognosis of these patients. Conclusion There was a higher incidence of negative expression of p16 mRNA and protein in NHL, which indicates that p16 gene inactivation may play an important role in the genesis and development of some NHL. The frequency of negative expression of p16 mRNA was lower than that of p16 protein suggests that it may be due to post transcriptional regulation or the unsteadiness of mRNA or protein expressed. The positive expression of both p16 mRNA and p16 protein may be features for favorable prognosis in patients with NHL.

目的探讨在非Hodgkin淋巴瘤(NHL)中p16基因的表达情况及临床病理意义。方法应用免疫组化LSAB法和原位杂交技术检测64例NHLp16蛋白及p16mRNA表达情况,同时结合病人的临床病理资料进行分析。结果64例NHL中,p16蛋白阳性表达率531%,阴性率469%,阳性反应以胞核分布为主。64例NHLp16mRNA阳性表达率703%,阴性率297%,阳性信号显示于胞浆中。p16蛋白及p16mRNA在NHL中的阳性表达与患者性别,年龄及免疫分型无明显相关性,但均与组织分化程度明显相关,高度恶性组的阳性率分别为333%及467%,低度恶性组的阳性率分别为714%及857%(P<005),随访发现均与预后相关。结论NHL存在较高比例的p16mRNA及p16蛋白阴性表达,说明在NHL的发生发展中,p16基因失活起着重要作用。NHL中p16mRNA比p16蛋白阴性表达率低,提示与转录后调节、mRNA或蛋白不稳定有关。两者的阳性表达均有一定的预后意义。

Objective To investigate the expression of p16 mRNA in primary breast carcinoma and its clinicopathological significance. Methods In vitro transcriptional RNA probe labeled with biotin and in situ hybridization method were used in this study to detect p16 mRNA in the paraffin embedded tissue of human primary breast carcinoma from 120 cases. Results 85 breast carcinomas showed expression of p16 mRNA with a positive rate of 70 8%. The p16 mRNA expression was not obviously correlated with patient age,...

Objective To investigate the expression of p16 mRNA in primary breast carcinoma and its clinicopathological significance. Methods In vitro transcriptional RNA probe labeled with biotin and in situ hybridization method were used in this study to detect p16 mRNA in the paraffin embedded tissue of human primary breast carcinoma from 120 cases. Results 85 breast carcinomas showed expression of p16 mRNA with a positive rate of 70 8%. The p16 mRNA expression was not obviously correlated with patient age, tumor size, estrogen and progesterone receptor status ( P >0.05), but the positive rate of 54.4% for the lymph node metastasis group was significantly lower than 85.7% of the non metastasis group ( P <0.001). Moreover, the positive rate of 58.3% for the poor differentiate invasive duct carcinoma was also lower than that 89.7% for the well differentiated ( P <0.05). The patients after operation were followed up. The mortality of 25% (21/85) in the p16 mRNA positive group was significantly lower than that of the negative group 57% (20/35) ( P <0.01). Conclusion Abnormal expression of p16 mRNA may play animportant role in the development of human breast carcinoma.

目的探讨p16mRNA在原发性乳腺癌的表达情况及其临床病理意义。方法体外转录法生物素标记RNA探针,用原位杂交技术检测p16mRNA在120例乳腺癌标本中的表达。结果p16mRNA的阳性表达率708%(85/120),与患者年龄、肿瘤大小及雌、孕激素受体状态无相关性;淋巴结转移组的阳性率54%(31/57),未转移组86%(54/63)(P<001);p16mRNA表达阳性组的3年以上病死率为25%(21/85),阴性组为57%(20/35)(P<001)。结论p16mRNA的异常表达在乳腺癌的发生发展中可能起重要作用。

 
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