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all of the rats survived
相关语句
  全部动物存活
     Results On e week after treatment, all of the rats survived;
     结果给药1周后全部动物存活
短句来源
  相似匹配句对
     All were survived
     全组病例术后均存活。
短句来源
     All rats
     ②手术对照组:给大鼠施予与实验组大鼠相同
短句来源
     All the survived rats were decapitated at 3 h、
     存活的各组大鼠分别再灌注3小时,24小时,48小时,72小时,在各时间点将大鼠断头取大脑。
短句来源
     (Results:All) rats survived before killed.
     结果:①动物全部成活。
短句来源
     RESULTS All rats survived before killed.
     结果:①动物全部成活。
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Objective To observe the preventive and therapeutic effect of Ka ng laite Injection (KI) on acute nephrotoxicity in rats induced by cisplatin (DDP) and gemzar.Methods Forty SD rats, male and female in a half, were randomized in to normal control group, KI group, DDP+ Gemzar group and KI+ DDP+ Gemzar gro up, 5 male and 5 female in each group. The KI+ DDP+ Gemzar group were given K I 10 mL/kg first,DDP injection 6 mg/kg 2 hours later and Gemzar injection 90 mg/ kg 4 hours later. After treatment, acute nephrotoxicity...

Objective To observe the preventive and therapeutic effect of Ka ng laite Injection (KI) on acute nephrotoxicity in rats induced by cisplatin (DDP) and gemzar.Methods Forty SD rats, male and female in a half, were randomized in to normal control group, KI group, DDP+ Gemzar group and KI+ DDP+ Gemzar gro up, 5 male and 5 female in each group. The KI+ DDP+ Gemzar group were given K I 10 mL/kg first,DDP injection 6 mg/kg 2 hours later and Gemzar injection 90 mg/ kg 4 hours later. After treatment, acute nephrotoxicity was observed.Results On e week after treatment, all of the rats survived; the body weight of the male an d female rats in group was similar in KI group and in the normal control group, but lower in DDP+ Gemzar group, in particular the male rats, than that in norma l control group. Body weight in KI+ DDP+ Gemzar group was lower than that in the normal control group but higher than that in DDP+ Gemzar group.The serum le vels of biochemical parameters were similar in KI group and the normal control g roup; serum levels of total protein (TP) and albumin(ALB) were markedly lower bu t those of blood urea nitrogen (BUN) and creatine (CRE) higher in DDP+ Gemzar g roup than those in the normal control group; the above indexes were improved in KI+ DDP+ Gemzar group as compared with those in DDP+ Gemzar group and arrive to the normal level.Conclusion KI has preventive and therapeutic effect on acu te nephrotoxicity in rats induced by DDP and Gemzar.

目的观察康莱特注射液对顺铂(DDP)、健择(Gemzar)化疗引起的大鼠肾毒性的防治作用。方法采用SD大鼠雌雄各20只,雌雄分开再随机盲法分为正常对照组、康莱特注射液组、DDP+Gemzar组、康莱特注射液组+DDP+Gemzar组,每组5只。静脉注射康莱特注射液、DDP+Gemzar、康莱特注射液+DDP+Gemzar,先给予康莱特注射液(10mL/kg),2h后注射DDP6mg/kg,4h后注射Gemzar90mg/kg,进行急性毒性试验。结果给药1周后全部动物存活。给药1周后康莱特注射液组雌、雄大鼠体重与对照组相似,而DDP+Gemzar组雌、雄大鼠体重与对照组相比明显降低,雄性动物更为明显;康莱特注射液+DDP+Gemzar组动物体重也较对照组低,但显著高于DDP+Gemzar组。康莱特注射液组的血清生化指标与对照组基本相似。DDP+Gemzar组的血清总蛋白、白蛋白均明显低于对照组,而BUN、Cr均明显高于对照组,康莱特注射液+DDP+Gemzar组与DDP+Gemzar组相比有明显改善,更接近正常动物。结论康莱特注射液对DDP和Gemzar引起的大鼠急性肾毒性有很好的预防和防治作用。

 
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