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时间-效应
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  time-effect
    The time-effect and dose-effect relations could be induced for the expression of some protein spots upon irradiation, which might be a reflection of the response to the irradiation damages.
    γ射线照射后不同时间,某些蛋白的表达量显示出一定的时间-效应关系; 不同剂量γ射线照射后,某些蛋白的表达量具有一定的剂量-效应关系。
短句来源
    [Objective] To investigate the relationship between silica exposure and TGF-β1 protein expression with emphasis on its dose- and time-effect in alveolar macrophage (AM) and its possible role in the pathogenesis of silica-induced lung fibrosis. [Methods] Mice AM primary culture was prepared after bronchoalveolar lavage, and then the cells were treated by silica in different dose and for different periods.
    [目的]观察石英与小鼠肺泡巨噬细胞(Alveolar Macrophage,AM)转化生长因子-β1(Transforming Growth Factor-β1,TGF-β1)蛋白表达水平之间的剂量-效应关系和时间-效应关系,从而探讨TGF-β1在石英引起肺纤维化中的作用。
短句来源
  “时间-效应”译为未确定词的双语例句
    1 was treated with different doses(1,10,50,100,500 and 1 000 μg·L~(-1))of LPS and the changes of CD14 surface expression were observed.
    1细胞CD14表达的变化。 结果:在时间-效应关系上,当LPS浓度为1μg.
短句来源
    Among these six CpG-N ODNs, CpG-N ODN208 was the strongest. It could inhibit TNF-a release from hPBMC induced by CpG-S ODN in a time-dependent manner.
    CpG-NODN208抑制CpG-S ODN释放TNF-α的活性最强,并呈显著的时间-效应关系;
短句来源
    The results showed that mercuric chloride (HgCl2) exerts its toxici-ty on hepatocytes in a time- and dose-dependent fashion and the lowest concentration of Hg-Cl2 at which cytotoxicity becomes evident is 5 μmol/L. Reduced glutathione and protein thi-ols content also declined in the presence of the higher concentration of HgCl2, suggesting this decline to be a manifestation of the toxic response.
    结果显示,氯化汞具有明显的肝细胞毒性,呈现时间-效应和剂量-效应关系,其产生明显细胞毒性的最低剂量(5 μmol/L)低于其使细胞内巯基耗损的最低剂量,表明巯基的耗损并非其毒性的原因;
短句来源
    Conclusion The experiment shows there is some effect of irritative fast on metablism of the elements of zinc, copper, iron and magnesium in the guinea pig and for some elements time-rela ted effect exists.
    结论 说明禁食应激对豚鼠体内的锌、铜、铁、镁元素的代谢具有一定的影响 ,有的元素并呈现出一定的时间 -效应关系。
短句来源
    Methods DCs isolated from the spleens of male Wistar rats were seeded on 96-well (1×10~5 cells/well) cell culture plates,and the cells were stimulated with HMGB1 for various lengths of time and in different concentrations. After being stimulated,DCs were denatured in cell culture plates to determine the expressions of costimulatory molecules including CD80,CD86 and major histocom- pability complex (MHC)Ⅱ.
    方法分离正常Wistar大鼠脾脏DC后置于96孔培养板(1×10~5/孔),采用HMGB1刺激,观察HMGB1刺激与DC表面共刺激分子CD80、CD86和主要组织相容性复合物(MHC)Ⅱ表达的时间-效应关系及剂量-效应关系。
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  time-effect
Time-effect relationship of acupuncture in improving cardiac vegetative nerve function in patients with type II DM
      
By calculating the area under the curve (AUC), of the time-effect curves of the prodrugs, a significantly improved duration of action was found for those prodrugs which have a slow in vitro hydrolysis rate.
      
From time-effect curves the area under the curve for separate time intervals was taken as a measure of dopaminergic activity during that interval.
      
Dose-response and time-effect curves were determined for morphine (1.0-30 mg/kg), levorphanol (0.1 to 3.0 mg/kg), methadone (0.1-3.0 mg/kg), meperidine (1.0-30 mg/kg), oxymorphone (0.03-1.0 mg/kg), and d-amphetamine (0.1-3.0 mg/kg).
      
Dose-response and time-effect curves were also determined for morphine (1.0-30 mg/kg) in rats that had received multiple injections of morphine over a period of 3 days.
      
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Epichlorohydrin can raise the concentration of blood sugar

环氧氯丙烷具有升高血糖作用。血糖升高有良好的剂量效应关系和时间效应关系。血糖达峰值后恢复10%,50%,90%的效应与持续时间曲线斜率随剂量增加而递减,提示环氧氯丙烷在体内消除和转运具有多房室模型特性,血糖达峰值持续时间较长。说明环氯氧丙烷升高血糖作用部位在周边室。环氧氯丙烷引起肾上腺皮质束状带细胞光面内质网增多和脂滴增加,髓质肾上腺素细胞分泌颗粒增多和高尔基复合体发达。说明环氧氯丙烷作用于肾上腺皮质束状带细胞,引起糖皮质激素增加,诱导髓质肾上腺素细胞内PNMT增加和活性增强,促使肾上腺素增多,导致血糖升高。

Relationship between the hepatotoxicity and lipid peroxidation was studied in isolated rat hepatocytes. The results showed that mercuric chloride (HgCl2) exerts its toxici-ty on hepatocytes in a time- and dose-dependent fashion and the lowest concentration of Hg-Cl2 at which cytotoxicity becomes evident is 5 μmol/L. Reduced glutathione and protein thi-ols content also declined in the presence of the higher concentration of HgCl2, suggesting this decline to be a manifestation of the toxic response. The addition...

Relationship between the hepatotoxicity and lipid peroxidation was studied in isolated rat hepatocytes. The results showed that mercuric chloride (HgCl2) exerts its toxici-ty on hepatocytes in a time- and dose-dependent fashion and the lowest concentration of Hg-Cl2 at which cytotoxicity becomes evident is 5 μmol/L. Reduced glutathione and protein thi-ols content also declined in the presence of the higher concentration of HgCl2, suggesting this decline to be a manifestation of the toxic response. The addition of the antioxidant N. N-diphenyl-p-phenylenediamine to the cell suspensions inhibited the HgCl2-induced lipid peroxidation, but did not cause any reduction in the HgQ2 toxicity in isolated hepatocytes. This finding indicates that lipid peroxidation is not directly responsible for the cell injury.

本文研究了氯化汞对大鼠游离肝细胞的毒性及其与膜脂质过氧化和细胞内巯基含量的关系。结果显示,氯化汞具有明显的肝细胞毒性,呈现时间-效应和剂量-效应关系,其产生明显细胞毒性的最低剂量(5 μmol/L)低于其使细胞内巯基耗损的最低剂量,表明巯基的耗损并非其毒性的原因;应用抗氧化剂二苯基对苯二胺抑制氯化汞的脂质过氧化能力,并不能使肝细胞免于氯化汞的毒性作用,从而证实脂质过氧化亦非氯化汞毒性的原因,而仅为一种伴随现象。

The effects of carbon tetrachloride(CCl_4)on intracellular calcium ions and the activities of calmodulin and Ca~(++)—Mg~(++)—

本研究采用原代游离肝细胞培养技术,观察了CCl_4对肝细胞内游离钙浓度、钙调蛋白(CaM)、Ca~(++)-Mg-ATP酶活性的影响。结果发现,低浓度的CCl_4对肝细胞内CaM的活性无明显影响,当培养液中CCl_4浓度增至0.96mg/ml时。肝细胞内CaM的活性明显下降,并随着作用时间的延长而下降趋势明显,呈明显的时间效应关系。同时肝细胞内Ca~(++)-Mg-ATP酶活性随之下降,细胞内游离钙浓度升高,培养介质中LDH的活性不断增加,培养介质中LDH活性与肝细胞内游离钙水平升高之间呈正相关(r=0.997,P<0.01)。表明CCl_4对肝细胞膜的损伤与其引起的钙稳态失调有关。肝细胞内CaM活性下降与肝细胞内CCl_4含量之间并无相关关系(r=0.122,P>0.05),提示CaM活性的降低并非CCl_4原形所致。

 
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