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时间-效应
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  time-effect
    A obvious dosage-effect and time-effect correktion were obtained, its half inhibitory concentrations (IC50) at 24,48 and 72 h were 10.66,2.43 and 0.46 μmol·L-1 ,respectively.
    结果As2O3可显著抑制U20S细胞生长,且剂量-效应和时间-效应关系显著(P<0.05),其24,钙和72 h的IC50值分别为10.66,2.43和0.46 μmol·L-1。
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    ②Time-effect on cell proliferation: The A value was also increased with the culture time. After 5 days, the A value reached the peak, indicating the effect on proliferation was the most obvious. The A value began to decrease until the 7th day.
    ②对细胞增殖的时效作用:重组胰岛素生长因子对鼠成骨细胞的促增殖作用还存在时间-效应的关系,随着培养作用时间的延长,吸光度值增高,作用5d后,吸光度值达到最高峰,促增殖作用最为明显,到第7天后,吸光度值下降。
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  time-response
    Conclusion Dose-response and time-response relationships exist between injury severity of the hippocampal tissue and intensity of Gamma irradiation in the model of irradiation,and hippocampal neurons are less radiosensitive than glial cells and endotheliocytes.
    结论海马组织的损伤程度与伽玛刀的照射强度存在剂量-效应关系和时间-效应关系,海马神经元比胶质细胞和血管内皮细胞更具放射耐受性。
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  “时间-效应”译为未确定词的双语例句
    (2) The antiproliferation effect was both concentration and time dependent.
    (2)番茄红素对MDA-MB-435S细胞的增殖抑制作用有剂量-效应关系和时间-效应关系。
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  time-effect
Time-effect relationship of acupuncture in improving cardiac vegetative nerve function in patients with type II DM
      
By calculating the area under the curve (AUC), of the time-effect curves of the prodrugs, a significantly improved duration of action was found for those prodrugs which have a slow in vitro hydrolysis rate.
      
From time-effect curves the area under the curve for separate time intervals was taken as a measure of dopaminergic activity during that interval.
      
Dose-response and time-effect curves were determined for morphine (1.0-30 mg/kg), levorphanol (0.1 to 3.0 mg/kg), methadone (0.1-3.0 mg/kg), meperidine (1.0-30 mg/kg), oxymorphone (0.03-1.0 mg/kg), and d-amphetamine (0.1-3.0 mg/kg).
      
Dose-response and time-effect curves were also determined for morphine (1.0-30 mg/kg) in rats that had received multiple injections of morphine over a period of 3 days.
      
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  time-response
Aufbauend auf Real-Time-Response-Daten kann die zentrale Bedeutung deutlich gemacht werden, die bereits vor der Debatte vorhandene Einstellungen für die Wahrnehmung der Kandidaten haben.
      
Dieser Beitrag geht der Frage nach, ob Real-Time-Response-Messungen valide und reliable Ergebnisse liefern und damit den Anforderungen der empirischen Sozialforschung genügen.
      
Time-response curves were established and subjected to Arrhenius analysis.
      
In contrast to the time course of these cytokine mRNAs, c-fos and zif268 mRNAs, two early response genes, displayed a greater and earlier time-response profile.
      
In time-response studies, animals were administered 5 mg Hg/kg as HgCl2 and sacrificed after 3, 9, 18, 24, and 48 h.
      
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Purpose To evaluate the time - response and effect of different fraction radiotherapy in the treatinent ofmatastatic bone pain. Methods one hundred and twenty-three cases of painful bone metastases received different fraction radiotherapy 4uring May 1992 to May 1997 in our hospital. Results The relieving pain rate of regular fractionat-ed,hyperfractionated and the large dose and low fractionated radiotherapy were 5. 41%, 10. 3 % and 65. 2 % respective-ly at the time of a week later during the therapy. After...

Purpose To evaluate the time - response and effect of different fraction radiotherapy in the treatinent ofmatastatic bone pain. Methods one hundred and twenty-three cases of painful bone metastases received different fraction radiotherapy 4uring May 1992 to May 1997 in our hospital. Results The relieving pain rate of regular fractionat-ed,hyperfractionated and the large dose and low fractionated radiotherapy were 5. 41%, 10. 3 % and 65. 2 % respective-ly at the time of a week later during the therapy. After radiotherapy and three months later the rate were 70. 3%,70. 0%, 73. 3% and 67. 6%, 74. 2 %, 65. 0%- The difference of low fractionated radiotherapy was significant. Conclu-sious The efficacy of low fraction was high and in short time. After radiotherapy and three months later the rate wasinsignificant. lt showed that the efficacy of low fractionated is better than that of others in the treatment of metastaticbone pain. We can give the low fractionated radiotherapy 10 Gy at first,then hyperfractionated or regular fractionatedto 40 Gy in the treatment of metastatic bone pain

目的比较不同分割放射治疗骨转移癌患者的时间效应,评价不同分割放疗的止病疗效。材料与方法对1992年5月~1997年5月我院收治的123例骨转移癌患者分别给予常规分割组、超分割组及大剂量低分割组不同的放射治疗,观察各组姑息止痛的放疗有效率.结果放疗1周时,止痛有效率为5.41%、10.3%及65.2%;放疗结束时为70.3%、77.3%与77.3%;放疗结束后3个月为65.0%、67.6%及74.2%.经统计学分析发现放疗1周时大剂量低分割组止痛有效率与其它组比较有明显差异。结论大剂量低分割放疗止痛率高,疗效出现早,而放疗结束时及结束后3月3组止病率无差异。故在骨转移癌的放疗中可考虑采用先大剂量低分割放疗后继常规或超分割的放疗方式。

Objective To study the growth inhibitory and apoptosis inducting effect of paclitaxel on human osteoblastic cell line U-2 OS. Methods U-2 OS cells were treated with various concentrations of paclitaxel. Proliferation was determined by cell count in a Neubauer cytometer chamber. Viability was assessed by trypanblau dye exclusion. Paclitaxel induced morphologic alterations were visualized, using light and transmission electron microscopy. The extent of paclitaxel induced apoptosis was determined by flow cytometry...

Objective To study the growth inhibitory and apoptosis inducting effect of paclitaxel on human osteoblastic cell line U-2 OS. Methods U-2 OS cells were treated with various concentrations of paclitaxel. Proliferation was determined by cell count in a Neubauer cytometer chamber. Viability was assessed by trypanblau dye exclusion. Paclitaxel induced morphologic alterations were visualized, using light and transmission electron microscopy. The extent of paclitaxel induced apoptosis was determined by flow cytometry and immunohistochemical detection (TdT mediated dUTP nick end labeling technique, TUNEL). Results Paclitaxel had a growth inhibitory and apoptosis inducting effect on U-2 OS cell. The cell treated with paclitaxel initially show G2/M arrest; follow by apoptosis. A characteristic apoptosis change including nuclear disintegration and chromatin agglomerate were displayed. Lots of multinucleate cells appeared, which was not seen on the cell treated with other chemotherapeutic agents such as cisplatin and adriamycin. Also, extensive DNA cleavage was detected by immunohistochemical technique. Conclusion Paclitaxel has an obvious growth inhibitory and apoptosis inducting effect on osteosarcoma cell line by induce a G2/M arrest and inhibit the mitosis. The effect of paclitaxel displays a time dependent and dose dependent manner.

目的研究抗微管新药紫杉醇对成骨肉瘤细胞系U-2OS的生长抑制及诱导凋亡作用,并探讨其诱导凋亡作用的机制。方法将不同浓度的紫杉醇作用于成骨肉瘤细胞系U-2OS,应用形态学观察、台盼蓝染色、流式细胞术、电镜、原位末端标记(TUNEL)等方法,检测其诱导骨肉瘤细胞凋亡的时间效应和剂量效应,并与其它化疗药物比较。结果紫杉醇对U-2OS细胞具有生长抑制及诱导凋亡作用,且呈时间依赖和剂量依赖性。表现为细胞G2/M期阻滞、出现明显的凋亡峰;有核碎裂、染色体凝集、DNA断裂等凋亡特征,并出现大量多核细胞。经其它化疗药物诱导的U-2OS细胞未出现多核现象。结论紫杉醇通过抑制细胞有丝分裂,对骨肉瘤细胞有明显的生长抑制及促凋亡作用,且其作用有独特的机制。

Objective To investigate the effects of various carotenoids on the proliferation, cell cycle, apoptosis and expression of bcl 2 gene in breast cancer cell MCF 7. Methods Time and dose effects of individual carotenoids were detected using the MTT assay. The effects of individual carotenoids on cell cycle and the apoptosis were observed by flow cytometry. The expression of bcl 2 mRNA gene was detected using the RT PCR method. Results All 4 carotenoids tested inhibited the proliferation of MCF 7 cell line,...

Objective To investigate the effects of various carotenoids on the proliferation, cell cycle, apoptosis and expression of bcl 2 gene in breast cancer cell MCF 7. Methods Time and dose effects of individual carotenoids were detected using the MTT assay. The effects of individual carotenoids on cell cycle and the apoptosis were observed by flow cytometry. The expression of bcl 2 mRNA gene was detected using the RT PCR method. Results All 4 carotenoids tested inhibited the proliferation of MCF 7 cell line, but with different potencies.β carotene and lycopene were the most active inhibitors(inhibition rate 88.2% and 87.8%, respectively)followed by zeaxanthin and astaxanthin. All 4 carotenoids did not induce cell apoptosis. Cell cycle progression was blocked at G 2/M phase with 60 μmol/L lycopene and at G 0/G 1 phase with 60 μmol/L zeaxanthin dipalmitate.Carotenoids downregulated bcl 2 gene expression. Conclusion Carotenoids could inhibit the proliferation of human beast cancer MCF 7 cell line in vitro and the action of carotenoids may be worked through different pathways.

目的 观察类胡萝卜素对体外培养的人乳腺癌MCF 7细胞存活率、细胞周期和凋亡 ,以及对凋亡相关基因bcl 2的影响。方法 用MTT检测类胡萝卜素对MCF 7细胞作用的时间效应和剂量效应 ;流式细胞仪观察类胡萝卜素处理人乳腺癌细胞后细胞周期以及细胞凋亡的改变。用RT PCR检测凋亡相关基因bcl 2的变化。结果  6种结构不同的类胡萝卜素对MCF 7乳腺癌细胞展现出不同的增殖抑制效果 ,60 μmol/L的 β 胡萝卜素和番茄红素在第 4天的抑制率分别为 88 4%和87 8% ,而玉米黄素、角黄素、虾青素和玉米黄素双棕榈酸酯的抑制作用较弱。类胡萝卜素并不诱导MCF 7细胞凋亡 ,番茄红素可阻滞细胞周期于G2 /M期 ,玉米黄素双棕榈酸酯可阻滞细胞周期于G0 /G1 期 ,而其他类胡萝卜素并不影响细胞周期。类胡萝卜素可不同程度地下调凋亡相关基因bcl 2mRNA的表达 ,bcl 2基因的下调与类胡萝卜素的抑制作用呈较明显的相关性。结论 类胡萝卜素可直接抑制人乳腺癌细胞MCF 7的增殖 ,不同结构的类胡萝卜素可能具有不同的抑制机制

 
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