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时间-效应
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  time-effect
    The results showed that: (1) there is no significant difference onicuring rate and time-effect among the three groups, (2) antibiotics showed effect to neonatal intestinal microflora, and the longer the antibiotics was used , the more significant the effect was;
    结果表明:(1)青霉素组、头孢组、联合用药组的治愈率以及时间-效应分析的结果无显著性差异; (2)使用抗生素对新生儿肠道菌群有影响,其影响随着抗生素使用时间的增加而增大;
短句来源
    Results The results showed that:①there is no significant difference on curing rate and time-effect among the three groups;
    结果①青霉素组、头孢组、联合用药组的治愈率以及时间-效应分析的结果无显著性差异;
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  time-effect
Time-effect relationship of acupuncture in improving cardiac vegetative nerve function in patients with type II DM
      
By calculating the area under the curve (AUC), of the time-effect curves of the prodrugs, a significantly improved duration of action was found for those prodrugs which have a slow in vitro hydrolysis rate.
      
From time-effect curves the area under the curve for separate time intervals was taken as a measure of dopaminergic activity during that interval.
      
Dose-response and time-effect curves were determined for morphine (1.0-30 mg/kg), levorphanol (0.1 to 3.0 mg/kg), methadone (0.1-3.0 mg/kg), meperidine (1.0-30 mg/kg), oxymorphone (0.03-1.0 mg/kg), and d-amphetamine (0.1-3.0 mg/kg).
      
Dose-response and time-effect curves were also determined for morphine (1.0-30 mg/kg) in rats that had received multiple injections of morphine over a period of 3 days.
      
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In this paper,after radiating rats with different small dose ultraviolet light for l2 weeks,we imitated an nonshine exposure for a season,observing the situation of serum 25-OHD3,chemical index and ossify,discussed the relationship between U V R and rickets curation.The results showed that every group had distinct time-effects relationship.On the time of ceasing U V R 12 weeks,vitamin D difficiency occured in l/8MED group; l/4MED and l/2M ED groups had no vitamin D dificiency.1/4MED is best dose to synthetize...

In this paper,after radiating rats with different small dose ultraviolet light for l2 weeks,we imitated an nonshine exposure for a season,observing the situation of serum 25-OHD3,chemical index and ossify,discussed the relationship between U V R and rickets curation.The results showed that every group had distinct time-effects relationship.On the time of ceasing U V R 12 weeks,vitamin D difficiency occured in l/8MED group; l/4MED and l/2M ED groups had no vitamin D dificiency.1/4MED is best dose to synthetize vitamin D.It is suggested that person exposing to sunshine l/4MED per day in summer and autumn can maintain vitamin D without rickets in whole winter even no erythermal U V R can be obtained.

本文探讨大鼠长期受小剂量紫外线照射及照射后其抗佝偻病作用的时间效应关系。结果表明:各剂量组血清25羟基维生素D_3衰减呈对数方式,有明显的时间效应关系。1/8MED组衰减最快,停照12周时已出现维生素D异常,36%骨化异常;1/4MED组衰减最慢,停照12周时可处于正常水平;1/2MED组效应低于1/4MED组,表明1/4MED剂量是合成维生素D的最佳剂量,过量紫外线照射无增强作用。提示人体夏秋季日照射1/4MED,即使冬季无照射,贮存的维生素D可维持血液维生素D水平正常至冬季,预防佝偻病的发生。

Objective To understand the results of antibiotics use in curing neonatal pneumonia and to evaluate the time effect of different drugs. Methods Through stratified sampling,all the hospitalized cases of neonatal pneumonia from 5 hospitals with different levels in Hunan province in five years were retrospectively studied. Analysis of time effect for different antibiotics was done through Kaplan Meier. Results Twenty six kinds of anti bacterium drugs were used in 685 cases of neonatal pneumonia, among...

Objective To understand the results of antibiotics use in curing neonatal pneumonia and to evaluate the time effect of different drugs. Methods Through stratified sampling,all the hospitalized cases of neonatal pneumonia from 5 hospitals with different levels in Hunan province in five years were retrospectively studied. Analysis of time effect for different antibiotics was done through Kaplan Meier. Results Twenty six kinds of anti bacterium drugs were used in 685 cases of neonatal pneumonia, among which penicillin and ampicilin were mostly used but cephalosporins also became one of the main drugs used in treating neonatal pneumonia. Most cases were discovered ( 51.1 %) using two kinds of antibiotics during the course of diseases through time effect analysis. We found the effect of penicillin was better than others in treating neonatal pneumonia when used as basic medicine. It was not desirable to use two or more medicines at the beginning of the treatment. Conclusion Penicilline and ampicillin were still the main drugs used in treating neonatal pneumonia but more cephalosporins were used than ever. The blindness in applying antibiotics should be recovered. From Kaplan Meier analysis, we could better understand and evaluate the time effects of different drug treatments. [

目的 了解新生儿肺炎治疗中抗生素的使用现状和评价不同药物治疗的时间效应。方法 分层抽样对湖南省 5所不同级别医院中 5年内的所有新生儿肺炎住院病历进行回顾性调查 ;运用Kaplan Meier(K M)法对不同的抗生素组配进行时间 效应分析。 结果  6 85例新生儿肺炎共使用 2 6种抗菌药物 ,其中选用了青霉素和氨苄青霉素的病例最多 ,分别为 2 87例和 2 6 9例 ;头孢菌素类药物亦成为新生儿肺炎的主要抗菌药物。用药以两种抗生素联合使用最多 ,K M法分析发现单用青霉素组的治愈时间短于其他方案组。结论 目前治疗新生儿肺炎仍以青霉素和氨苄青霉素为主 ,头孢菌素类药物使用的增加和盲目的抗生素联合使用应引起重视。K M法可更全面的评价不同药物疗效

Objective:To investigate the current situation of microecological preparations therapy in children with diarrhea and to assess the effect of several microecological preparations on the treatment of diarrhea among young children less than 3 years of age Methods:The authors analyzed the clinical data of inpatients with diarrhea in the department of pediatrics, the first affiliated hospital of Fujian Medical University during 1997~2001 and used time effect analysis to evaluate the effect of different microecological...

Objective:To investigate the current situation of microecological preparations therapy in children with diarrhea and to assess the effect of several microecological preparations on the treatment of diarrhea among young children less than 3 years of age Methods:The authors analyzed the clinical data of inpatients with diarrhea in the department of pediatrics, the first affiliated hospital of Fujian Medical University during 1997~2001 and used time effect analysis to evaluate the effect of different microecological preparations on children's diarrhea by Kaplan Meier assay Results:Among 470 young children with diarrhea,453(96 4%) were treated with microecological preparations There were 237 with Bifid Triple Viable Capsule,198 with Bacillus Licheniformis Capsule and 83 with combinations of different microecological preparations By Kaplan Meier assay, a course of Bifid Triple Viable Capsule was the most effective treatment for acute diarrhea Whatever acute,chronic or persistent diarrhea,the course of combinations of different microecological preparations had not the advantage of being shorter comparing to the other two Conclusions:Microecological preparations play an important role in the treatment for diarrhea Proper use of this kind of drug could contribute to the recovery from diarrhea But it is not reasonable to use combinations of different microecological preparations blindly

目的 :评价微生态制剂治疗婴幼儿腹泻病的临床疗效 ,为合理应用微生态制剂治疗婴幼儿腹泻提供指导。方法 :对婴幼儿腹泻病患儿住院治疗期间应用微生态制剂治疗情况进行回顾性调查 ,运用Kaplan- Meier( K- M)法对不同微生态制剂治疗婴幼儿腹泻病的临床疗效进行时间 -效应分析。结果 :4 70例婴幼儿腹泻病患儿住院治疗期间 ,有 4 5 3例患儿有应用微生态制剂治疗 ,占 96 .4 % ;其中 ,选用培菲康、整肠生的病例最多 ,分别有 2 37例和 198例 ;多种微生态制剂联合应用有 83例 ( 18.32 % )。K- M法分析显示 :培菲康治疗婴幼儿急性腹泻病的疗效优于整肠生组及多种微生态制剂联合应用组 ;无论是急性腹泻病 ,还是迁延性、慢性腹泻病 ,多种微生态制剂联合应用治疗的临床治愈时间均不优于单用微生态制剂组。结论 :适当应用微生态制剂有助于婴幼儿腹泻的恢复 ,但盲目采用多种微生态制剂联合治疗并不能提高临床疗效 ,甚至不利于婴幼儿腹泻病的康复

 
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