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时间-效应
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  time-effect
    A obvious dosage-effect and time-effect correktion were obtained, its half inhibitory concentrations (IC50) at 24,48 and 72 h were 10.66,2.43 and 0.46 μmol·L-1 ,respectively.
    结果As2O3可显著抑制U20S细胞生长,且剂量-效应和时间-效应关系显著(P<0.05),其24,钙和72 h的IC50值分别为10.66,2.43和0.46 μmol·L-1。
短句来源
    【Methods】The time-effect relationship and concentration-effect relationship between celebrex and the expression of COX-2 mRNA and PGE_2 in bladder cancer T24 cell lines were studied by enzyme-linked immuno-absordent assay(ELISA) and reverse transcriptase polymerase chain reaction(RT-PCR).
    【方法】体外培养人膀胱癌细胞株T24细胞,应用逆转录聚合酶链反应(RT-PCR)和酶联免疫吸附测定(ELISA)方法,检测选择性COX-2抑制剂Celebrex与膀胱癌T24细胞株COX-2 mRNA和PGE2表达的时间-效应关系和剂量-效应关系。
短句来源
    There were obvious dosage-effect and time-effect correlations (P<0.05). The half inhibitory concentrations (IC_ 50 ) at 24 h, 48 h and 72 h were 14.28 μmol/L, 13.63 μmol/L and 2.34 μmol/L, respectively.
    结果:(1)As2O3可显著抑制U251细胞生长,且剂量-效应和时间-效应关系显著(P<0·05),其24h、48h和72h的IC50值分别为14·28μmol/L、13·63μmol/L和2·34μmol/L。
短句来源
    Results The condition of proliferation in curcumin groups decreased compared with the control group,there were dose-effect(10-500μM)and time-effect(12h,24h,48h,72h) relation in diferent curcumin groups.
    结果姜黄素各组较对照组增殖降低; 姜黄素各组,存在剂量-效应关系(10~500μM)和时间-效应关系(12h,24h,48h,72h)。
短句来源
    Conclusions The rsults showed that pyridoxine had a certain inhibition on the growth hepatona H22 in vitro and does-effect and time-effect could be found.
    结论 吡哆醇对体外培养的H_(22)小鼠肝癌细胞系的生长具有抑制作用,且二者之间有剂量-效应关系和时间-效应趋势。
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  time-response
    Results: The growth of cancer cells were inhibited evidently after treated by isorhmnetin, the growth inhibition of cancer cells versus the concentration of isorhmnetin exhibited a dose-response and time-response relationship.
    结果显示:异鼠李素能强烈抑制肿瘤细胞的增殖,对细胞生长的抑制作用具有浓度-时间和时间-效应关系;
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  “时间-效应”译为未确定词的双语例句
    Conclusions Pae may inhibit HT-29 cells proliferation and induce apoptosis. The possible mechanism may be through down-regulation the ratio of bcl-2/bax expression.
    结论Pae可抑制HT-29细胞增殖并诱导其凋亡,并呈现明显的剂量-效应关系和时间-效应关系,其作用机制可能与下调bcl-2/bax的表达比例有关。
短句来源
    RT-PCR and immunohistochemistry was performed to determine mRNA and protein expression of c-myc and p53. Results Within the range of 8 - 96 × 10 7mol/L, NP stimulated proliferation in PE04 cells with a dose-dependent and time-dependent fashion.
    结果与溶剂对照组相比,在(8-96)×10-7mol/L浓度范围内, NP与8× 10-mol/L雌二醇作用类似可显著促进PE04细胞增殖(P<0.05),并表现出良好的剂量-效应和时间-效应关系。
    Results: The EPSs from the five species all could kill A431 cancer cell, and at the dose-time-dependent pattern.
    结果:EPSs在体外能够杀死A431细胞,并且有剂量-时间-效应依赖关系,凋亡率随时间延长增加;
短句来源
    (3) MTT study showed that selective COX-2 inhibitor produced a dose-dependent and a time-dependent inhibition of H0-8910 proliferation.
    (3)MTT法显示COX-2抑制剂与卵巢癌细胞株HO8910的增殖之间有较好的剂量-效应和时间-效应依赖性。
短句来源
    1.CLA of 12.5,25.0,50.0,100.0,200.0μmol/L inhibited the growth of MGC-803 cells in a concentration dependent manner.
    1.MTT比色法测定结果显示,不同浓度CLA(25.0、50.0、100.0、200.0μmol/L)能抑制体外培养人胃癌MGC-803细胞的增殖,且有剂量-效应和时间-效应关系(P<0.05)。
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  time-effect
Time-effect relationship of acupuncture in improving cardiac vegetative nerve function in patients with type II DM
      
By calculating the area under the curve (AUC), of the time-effect curves of the prodrugs, a significantly improved duration of action was found for those prodrugs which have a slow in vitro hydrolysis rate.
      
From time-effect curves the area under the curve for separate time intervals was taken as a measure of dopaminergic activity during that interval.
      
Dose-response and time-effect curves were determined for morphine (1.0-30 mg/kg), levorphanol (0.1 to 3.0 mg/kg), methadone (0.1-3.0 mg/kg), meperidine (1.0-30 mg/kg), oxymorphone (0.03-1.0 mg/kg), and d-amphetamine (0.1-3.0 mg/kg).
      
Dose-response and time-effect curves were also determined for morphine (1.0-30 mg/kg) in rats that had received multiple injections of morphine over a period of 3 days.
      
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  time-response
Aufbauend auf Real-Time-Response-Daten kann die zentrale Bedeutung deutlich gemacht werden, die bereits vor der Debatte vorhandene Einstellungen für die Wahrnehmung der Kandidaten haben.
      
Dieser Beitrag geht der Frage nach, ob Real-Time-Response-Messungen valide und reliable Ergebnisse liefern und damit den Anforderungen der empirischen Sozialforschung genügen.
      
Time-response curves were established and subjected to Arrhenius analysis.
      
In contrast to the time course of these cytokine mRNAs, c-fos and zif268 mRNAs, two early response genes, displayed a greater and earlier time-response profile.
      
In time-response studies, animals were administered 5 mg Hg/kg as HgCl2 and sacrificed after 3, 9, 18, 24, and 48 h.
      
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Since the 1980s of this century,a series of studies on the experiments with nutritional inter-vention have been successively conducted in population groups of high-incidence areas of cancer of the esopha-gus along the Tai Hang Mountains in North China. The drugs used included predominantly vitamins,trace ele-ments and others. Brief facts are now reported in this paper with what the authors themselves have exper-ineced and what they have heard of.Of the population groups experimented on,smaller ones was composed...

Since the 1980s of this century,a series of studies on the experiments with nutritional inter-vention have been successively conducted in population groups of high-incidence areas of cancer of the esopha-gus along the Tai Hang Mountains in North China. The drugs used included predominantly vitamins,trace ele-ments and others. Brief facts are now reported in this paper with what the authors themselves have exper-ineced and what they have heard of.Of the population groups experimented on,smaller ones was composed of300 people while larger ones could be made up of 30,000 people. As to the duration of observation it might beas short as one year but as long as 10 years. Generally speaking,in spite of the reasonability in the planning ofthe experiments and carefulness in their observations,the results found had been disappointing,Nevertheless,the disappointments had provided us with much food for thought why had these experiments not yieldedthe resulted anticipated,and why had no anticancer role been played by a multiplicity of nutrients? In this pa-per,analyses and discussions were made in terms of time effect,specificity of tissues and body organs and pop- ulation groups involved,the negative effects of the nutrients as well as the continuous exposure to other car-cinogens. Besides,suggestions hopes and different points of view on the nutritional intervention in human can-cers,especially cancer of the esophagus,were presented.

从本世纪80年代开始,在中国华北食管癌高发地带——太行山区,相继开展了一系列食管癌人群营养干预试验研究。所用药物大多是维生素、微量元素之类不等。作者以自身经历和所见所闻,简要报道这些事实。这些研究人群,少者300多人,大者3万多人;观察时间,短则1年,长则10年。总的来讲,这些研究,设计合理、观察严密,然而结果多数令人失望。失望之余,催人深思。这些试验为什么没有得到预期效果?或者说效果不理想,诸多营养素为什么没有显示出防癌作用呢?作者从时间效应;组织、器官及人群特异性;营养素的负效应;以及其它致癌物的继续暴露等方面进行了分析和讨论。并对人类癌症,特别是对食管癌的营养干预,提出了不同看法、希望和建议。

Epidermal growth factor (EGF) is a polypeptide important to the proliferation and differentiation of either normal cells or cancer cells, through binding with their receptors (EGF R) on these cells. The study is designed to investigate relationships between the expression of EGF R on gastroenteric cancer cells (SGC7901, KATOⅢ, MKN45, SMMC7721, HT29) and the proliferation of these cells by using receptor radiobinding assay. The results showed 125 I EGF, which specific activity was 6234.5 MBq/mg and bioactive...

Epidermal growth factor (EGF) is a polypeptide important to the proliferation and differentiation of either normal cells or cancer cells, through binding with their receptors (EGF R) on these cells. The study is designed to investigate relationships between the expression of EGF R on gastroenteric cancer cells (SGC7901, KATOⅢ, MKN45, SMMC7721, HT29) and the proliferation of these cells by using receptor radiobinding assay. The results showed 125 I EGF, which specific activity was 6234.5 MBq/mg and bioactive fraction analysed by Lindmo method was 71%, could bind to SGC 7901 more easily and rapidly but not steadily at 37℃ than at 4℃. The numbers of EGF R on these cells were (1.23±0.46)×10 5, (2.13±0.61)×10 5, (1.5±1.47)×10 4, (1.34±0.15)×10 5, (5.68±0.58)×10 4 sites/cell and the dissociation constants were (2.61±0.30)×10 -9 , (8.01±2.01)×10 -9 , (3.52±0.51)×10 -9 , (8.53±1.11)×10 -10 and (8.75±3.84)×10 -9 mol/L, respectively. Interestingly, EGF could stimulate the growth of these cells. Its stimulative effects varied with the types of tumor cell and were correlated with the expression of EGF R on these cells. These results suggest that the expression of EGF R plays an important role in the proliferation of these cells.

为研究表皮生长因子(EGF)受体功能性表达在消化系肿瘤细胞生长调节上的意义,建立了EGF受体放射分析法.Lindmo生物活性分数分析显示自标记125I-EGF具有高的生物活性,温度、时间效应分析确立4℃,3h为最佳受体分析条件.一组消化系肿瘤细胞SGC7901,KATOⅢ,MKN45,SMMC7721,HT29的EGF受体数目分别为(1.23±0.46)×105,(2.13±0.61)×105,(1.5±1.47)×104,(1.34±0.15)×105,(5.68±0.58)×104个/细胞;其解离常数分别为(2.61±0.30)×10-9,(8.01±2.01)×10-9,(3.52±0.51)×10-9,(8.53±1.11)×10-10,(8.75±3.84)×10-9mol/L.细胞增殖实验显示EGF对消化系肿瘤细胞生长具有促进作用,促进作用的强弱与其受体的数目一致.结果提示消化系肿瘤细胞EGF受体功能表达水平与肿瘤生长相关.

In the present study, the biological effect of hyperthermia and H2O2 or 3AT in combined on glioblastoma multiforme (G) was investigated by using M.T.T assay, Ki-67 labelling index and GJIC (Gap Junc tion Intercellular Communication) as indices for evaluating the survival, proliferation and differentiation of G cells. The results showed that there was stronger inhibition on the survival and proliferation of G cells following treatment with hyperthermia combined with H2O2 or 3AT than only with hyperthermia, H2O2,...

In the present study, the biological effect of hyperthermia and H2O2 or 3AT in combined on glioblastoma multiforme (G) was investigated by using M.T.T assay, Ki-67 labelling index and GJIC (Gap Junc tion Intercellular Communication) as indices for evaluating the survival, proliferation and differentiation of G cells. The results showed that there was stronger inhibition on the survival and proliferation of G cells following treatment with hyperthermia combined with H2O2 or 3AT than only with hyperthermia, H2O2, 3AT. H2O2 and 3AT exerted a synergic effect with hyperthermia on survival and proliferetion activity in a dose and time depen dent manner. GJIC of G cells was enhanced following hyperthermia and H2O2 or 3AT in combined. It was sug gested that the combination of hyperthermia therapy with agents enhancing oxygen stress was promising.

本文就加热及同时增加细胞内氧自由基水平对恶性胶质瘤细胞存活、增殖和细胞间隙连结通讯的影响做初步观察。用M.T.T法测定胶质瘤细胞存活率;用Ki-67抗增殖细胞核抗原单克隆抗体,通过免疫组织化学ABC染色分析胶质瘤细胞的增殖活性;用划痕染料示踪技术观察胶质瘤细胞的细胞间隙连结通讯。结果表明,H2O2和3AT能增强加热对胶质瘤细胞存活与增殖的抑制作用,促进胶质瘤细胞间隙连结通讯的改善,存在着明显的剂量和时间效应。实验结果提示,通过内外源性增加胶质瘤细胞内的氧自由基水平,将有助于强化加热治疗胶质瘤效果,并可以减少加热的剂且,降低副作用。

 
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