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increased the dosage
相关语句
  增加剂量
     The patients in therapeutic group received betaloc on the basis of traditional therapy. A initial dosage (12.5 mg·d -1 ),and then increased the dosage gradually to (25~50 mg·d -1 ). The parameters of heart rate variability(HRV) pre-treatment and 3 months after 3 treatment were analized.
     方法 对照组常规抗心衰治疗 ,治疗组在常规抗心衰治疗的基础上加服倍他乐克 ,从小剂量 12 .5mg·d-1开始 ,缓慢增加剂量至 2 5~ 5 0mg·d-1,治疗前和治疗 3个月后分别进行心率变异性 (HRT)分析。
短句来源
     Methods A total of 50 case of CHF were classified as the treatment group (n=29) with betaloc and normal treatment group (n=21). Began with the minimum dosage, and then increased the dosage gradually. Holter tape was performed in 50 patients at the end of the fouth week.
     方法符合该研究入选标准的慢性心力衰竭患者50例,随机分成常规治疗组为对照组(n=21),常规治疗基础上加用倍他乐克者为治疗组(n=29),从小剂量开始,缓慢增加剂量,于第4周末行24小时动态心电图检查,比较两组心功能和HRV各项时域指标。
短句来源
     The patients in the therapeutic group received metoprolol on the basis of traditional therapy. A initial dosage (12.5 mg/d), and then increased the dosage gradually to (25-50 mg/d). The parameters of heart rate variability (HRV) pretreatment and 3 months after treatment were analyzed.
     方法对照组常规抗心衰治疗,治疗组在常规抗心衰治疗的基础上加服美托洛尔,从12.5mg/d开始,缓慢增加剂量至25~50mg/d,治疗前和治疗3个月后分别进行心率变异性(HRV)分析。
短句来源
  “increased the dosage”译为未确定词的双语例句
     Having increased the dosage of sodiumsalicylate from 10 mM to 50 mM,lysis of some erythrocytes began after 4 hoursof incubation;
     待加大水杨酸钠剂量至50mM,保温4小时可见少数红细胞开始溶解;
短句来源
     Method: began with intraveous drop of dopamine in 0. 25/kg per minute , then increased the dosage gradually, observing the relation between the heart failure controlling and the dosage of dopamine.
     方法,从每分钟0.25ug/kg开始静脉滴注多巴胺,并逐渐提高用药剂量,观察心衰控制情况与多巴胺应用剂量之间的关系;
短句来源
     With the dosage increased, the dosage AHCSE was 75 μg/mL, the rate of inhibition to BEL-7404 cells and SMMC-7721 cells did not rise significantly, P=0.095, 0.115, but an inhibition to LO2 cells appeared (P=0.049).
     当剂量增至75μg/mL,AHCSE对7404细胞和7721细胞抑制率上升不明显,P值分别为0·095和0·115,但是出现对LO2细胞的抑制作用,P=0·049。
短句来源
     Methods 30 subjects with essential tremor in two hospital were administrated arotinolol 10 mg per day for 4 weeks, and increased the dosage to 15 mg for another two weeks for those patients in whom the effect of arotinolol was not satisfactory.
     方法 采用多中心开放试验 ,对 30例原发性震颤患者给予阿尔马尔 10mg ,每日一次 ,共 4周。
短句来源
     Result: Compared with the NS group, sample 1 and sample 2 both significantly prolonged the beginning time of VF of isolated heart and increased the dosage of aconitine, sample 3 reduced the beginning time of VF of isolated heart and decreased the dosage of a-conitine, sample 1 and sample 2 both greatly prolonged the beginning time of VE, VT, VF, HA; sample 3 greatly reduced the beginning time of VT, VF.
     结果:与空白对照组比,样品1、样品2使大鼠离体心脏室颤出现时间延长,出现所需乌头碱量增加,样品3使大鼠离体心脏室颤出现时间缩短,出现所需乌头碱量减少; 样品1、样品2显著延长整体大鼠早搏、室速、室颤、心脏停搏出现时间,样品3使整体大鼠室速、室颤出现时间缩短。
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     DD increased;
     毛细血管扩散距离(DD)增大。
短句来源
     The collagens increased.
     胶原原纤维增多。
短句来源
     IgG was increased.
     免疫球蛋白IgG上升。
短句来源
     The Iysosome increased.
     内质网数量增加,内质网池扩张;
短句来源
     2g, the dosage.
     Pd/C催化剂用量为1.2g;
短句来源
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The metabolism of NaHSO_3-andrographolide in rats was studied by means ofNaHSO_3(~(35)S)-andrographolide.The compound was labeled at the 12th C atom of andrographolide with NaHSO_3(~(35)S)solution by additive reaction.The efficiency of labelling was 92%.The samples of urine and stool of the animal were taken at definite intervals.Thesamples of C.N.S.and viscera were taken from sacrificed animal after intravenousinjection in the tail.The radioactivity of these samples was determined in a liquid scintillation...

The metabolism of NaHSO_3-andrographolide in rats was studied by means ofNaHSO_3(~(35)S)-andrographolide.The compound was labeled at the 12th C atom of andrographolide with NaHSO_3(~(35)S)solution by additive reaction.The efficiency of labelling was 92%.The samples of urine and stool of the animal were taken at definite intervals.Thesamples of C.N.S.and viscera were taken from sacrificed animal after intravenousinjection in the tail.The radioactivity of these samples was determined in a liquid scintillation counter.The metabolism of the labeled compound in the rat's body showed that in the C.N.S.the compound mainly accumulated in the spinal cord.The accumulation was of thedescending type.It could probably lead to dilatation of the peripheral vessels andreduction of the muscular tone,thus in turn lowering down the body temperature.In viscera,it chiefly accumulated in the duodenum and rectum.This fact mightexplain why this drug was used for the treatment of enteritis and bac.dysentery.This drug could be absorbed and excretal rapidly.About 86.2% was excreted in72 hrs.after injection.So the clinicians are advised to increase the dosage or shortenthe interval of administration.Because most of the NaHSO_3(~(35)S)-andrographolide is chiefly unchanged excretedin the urine,we considered it might be effective in the treatment of urinaryinfection.

本文是用放射性同位素~(35)硫标记NaHSO_3-穿心莲内酯做动物实验.以阐明NaHSO_3(~(35)S)-穿心莲内酯在体内的代谢过程。动物实验是用NaHSO_3(~(35)S)-穿心莲内酯注入大白鼠。实验用的药物是用NaHSO_3(~(35)S)溶液用加成反应标记于穿心莲内酯的第12位碳上。标记率达92%。标记化合物的性能和浓度与治疗用商品注射针剂NaHSO_3-穿心莲内酯相同。大小便标本是注射后连续按一定间隔时间取出的,组织标本是按一定间隔时杀死的动物身上取出的。标本的放射性是用液体闪烁计数器测量的。标记化合物在大白鼠的体内代谢表明,NaHSO_3(~(35)S)-穿心莲内酯进入体内后,在中枢神经系统中主要选择性地蓄积于脊髓中,并且呈下行性蓄积,可因此导致肌紧张度减低和外周血管扩张,引起体温下降。在脏器中此药较明显地蓄积于十二指肠、直肠,这是临床采用此药治疗肠炎和菌痢的有力依据。实验也指出,此药在体内迅速吸收,迅速排泄,72小时内在尿粪中总排除量达86.2%,建议临床酌情增加剂量或次数。NaHSO_3(~(35)S)-穿心莲内酯大多在尿中主要以原形排出,从而考虑对泌尿系统感染可能有一定疗效。

Anisodine was administered to 4 groups of rabbits intraventricularly (5, 10, 15 and 20 mg). It was observed that 5 mg doses were effective to make the animals lose their righting reflexes. Increasing the dosage prolonged and aggravated the central depressant effect of anisodine.Following administraton of anisodine (10 mg), the duration of loss of righting reflex lasted 25.0±2.6 minutes. The combined use of anisodine with physostigmine (0.2mg i. v.), noradrenaline or adrenaline (100μg intraventricularly)...

Anisodine was administered to 4 groups of rabbits intraventricularly (5, 10, 15 and 20 mg). It was observed that 5 mg doses were effective to make the animals lose their righting reflexes. Increasing the dosage prolonged and aggravated the central depressant effect of anisodine.Following administraton of anisodine (10 mg), the duration of loss of righting reflex lasted 25.0±2.6 minutes. The combined use of anisodine with physostigmine (0.2mg i. v.), noradrenaline or adrenaline (100μg intraventricularly) induced loss of righting reflex of short duration, 15.1±3.2, 11.0±1.4 and 14.8±3.1 minutes, respetively (P<0.01); and at the same time, the central depressant effect became less marked. On combination with regitine (1 mg intraventricularly), the duration of loss of righting reflex was prolongted to 50.0+10 minutes (P<0.05) with the central depressant effect potentiated.Following intraventricular anisodine (0.4 mg), a gradual EEG change from low voltage rapid wave to high voltage slow wave was observed lasting for about 6 hours. Additional intravenous physostigmine 0.2 mg/kg, given 15 minutes after the administration of anisodine, produced a reappearance of low voltage rapid wave lasting for about 30 minutes, while the similar use of noradrenaline or adrenaline (150 μg intraventricularly) gave a trasient reappearance, lasting 3~4 minutes only.These results suggested that the central depressant effect of anisodine can be antagonized by physostigmine and adrenomimetics, while regitine is synergistic.

将樟柳碱注入家兔侧脑室,可引起翻正反射消失,皮层自发电活动呈现不规则高幅慢波,表明该药有中枢抑制作用。在一定剂量范围内,剂量加大,抑制作用增强,维持时间延长。毒扁豆碱、去甲肾上腺素、肾上腺素能拮抗樟柳碱的中枢抑制作用,而苄胺唑啉则与之有协同作用。结果提示樟柳碱的中枢抑制作用,不仅与其抗胆碱作用有关,还可能与其抗肾上腺素能作用有一定关系。

A morphological study on the erythroeytes of Hb Shuangfeng propositus wascarried out by electron microscopy during incubation with the isotonic solution(pH7.4)of sodium salicylate or sulfadiazine in vitro.They were changed into typicalspherocytes after incubating for 1-2 hours.Having increased the dosage of sodiumsalicylate from 10 mM to 50 mM,lysis of some erythrocytes began after 4 hoursof incubation;the hemolysis became worse 8 hours later.But under the same con-ditions the erythrocytes of Hb E heterozygote...

A morphological study on the erythroeytes of Hb Shuangfeng propositus wascarried out by electron microscopy during incubation with the isotonic solution(pH7.4)of sodium salicylate or sulfadiazine in vitro.They were changed into typicalspherocytes after incubating for 1-2 hours.Having increased the dosage of sodiumsalicylate from 10 mM to 50 mM,lysis of some erythrocytes began after 4 hoursof incubation;the hemolysis became worse 8 hours later.But under the same con-ditions the erythrocytes of Hb E heterozygote showed no prominent change andsevere crenation existed in those of a normal subject.These results further indicatethat the sudden onset of hemolytic jaundice and anemia in this Hb Shuangfengpropositus following administration of“common cold remedies”may be provokedby aspirin and sulfa drngs.

在体外条件下添加10mM 水杨酸钠或磺胺嘧啶等渗溶液(pH7.4)保温,对 Hb 双峰先证者红细胞形态进行了电镜观察。保温1—2小时后,该红细胞变成了典型的球形红细胞。待加大水杨酸钠剂量至50mM,保温4小时可见少数红细胞开始溶解;保温8小时后溶血加重。而正常人和HbE 先证者的红细胞则否。以上结果进一步证实,Hb 双峰先证者服“感冒药”惹发的溶血性黄疸和贫血可能与阿斯匹林和磺胺类药物有关。

 
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