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direct compression method
相关语句
  直接压片法
     OBJECTIVE Study on preparing cefixime tablets with direct compression method .
     目的粉末直接压片法研究制备头孢克肟片.
短句来源
     The gel properties of xanthan gum and HPMC were investigated by direct compression method.
     采用直接压片法 ,研究黄原胶与 HPMC的凝胶特性。
短句来源
  “direct compression method”译为未确定词的双语例句
     CONCLUSION The domestic MCC can not be applied to direct compression method but can be applied to wetting-granule method.
     结论 国产微晶纤维素不宜用于粉末直接压片 ,但能够应用于湿法制粒
短句来源
     METHODS The tablets were prepared by direct compression method and the concent rations of PPA in the release media were determined by HPLC.
     方法 粉末直接压片法制备骨架片 ,反相高效液相色谱法检测释放介质中PPA的浓度。
短句来源
     Famotidine dispersible tablets were prepared by direct compression method.
     采用全粉末直接压片法制备法莫替丁分散片。
短句来源
     Through many experiments,this direct compression method acquired lower distortion,and interpolated color image could produce excellent results in terms of both subjective and objective image quality measures.
     通过实验验证,这种贝尔数据直接压缩方法带来的失真很小,插值后恢复的全彩图像在主观视觉和客观质量评价中也能获得令人满意的效果。
短句来源
     Experiment results show: this direct compression method acquired the lower distortion and bit rate,and interpolated color image could produce excellent results in terms of both subjective and objective image quality measures.
     实验结果表明,笔者提出的压缩算法带来的失真很小,压缩的比特率很低,且插值后恢复的全彩图像在主观视觉和客观质量评价中都能获得令人满意的效果。
短句来源
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  相似匹配句对
     A DIRECT METHOD OF DESIGNING COMPRESSION RODS
     压杆设计的直接法
短句来源
     The Direct Method of English
     英语直接教学法
短句来源
     The method is fast and direct.
     测定速度快 ,直接测定最多 2min即可测一个样品 ;
短句来源
     The Method of Intrapicture Compression
     静止图像数据的压缩方法
短句来源
     Image Compression Method
     图像压缩技术
短句来源
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  direct compression method
Overall, the dissolution properties of tablet formulations prepared by the direct compression method were superior to those of tablets prepared by the wet granulation method.
      
Matrix tablets of tramadol (dose 100 mg) were produced by direct compression method.
      
In summary, this study clearly demonstrated that one could develop a quick disintegrating calcium tablet by using a direct compression method.
      
Direct compression method was employed for formulations L1 to S3.
      


Sustained release coprecipitates of ibuprofen(IBF) with polyacrylic resin Ⅱ were prepared by dissolving the drug and the polymer in ethanol followed by the addition of a non solvent with agitation . Two different and novel approaches were employed to prepare the coprecipitates at different drug to polymer ratios. Using these precipitates, matrix type tablets were also prepared by direct compression method. Scanning electron microscopy(SEM), differential scanning calorimetry(DSC) and infrared(IR) absorption...

Sustained release coprecipitates of ibuprofen(IBF) with polyacrylic resin Ⅱ were prepared by dissolving the drug and the polymer in ethanol followed by the addition of a non solvent with agitation . Two different and novel approaches were employed to prepare the coprecipitates at different drug to polymer ratios. Using these precipitates, matrix type tablets were also prepared by direct compression method. Scanning electron microscopy(SEM), differential scanning calorimetry(DSC) and infrared(IR) absorption spectroscopy were carried out for the characterization of the coprecipitates. The investigation focuses on the influence of the concentration of polyacrylic resin Ⅱ, the pH of the dissolution media , and the preparation methodology of the coprecipitates on IBF release rate from the IBF polyacrylic resin Ⅱ matrix tablets. In vitro dissolution experiments were performed in dissolution media with different pH environments. Generally, in all the formulations prepared at various drug to polymer ratios, the polyacrylic resin Ⅱ could considerably prolong the drug release in polymer concentration dependent manners. Increasing pH of the dissolution media also played an important role in enhancing the cumulative percentage release of the drug. It was also investigated that the cumulative percentage of IBF released from the formulations prepared by method B was higher than that prepared by method A. Moreover, formulations prepared by method A exhibited comparatively linear release profiles.

将药物及高分子材料溶于乙醇后边搅拌边加入非溶剂制成布洛芬-聚丙烯酸树脂Ⅱ共沉淀物。通过A、B两种方法并以不同的药物-聚丙烯酸树脂Ⅱ比例制成了共沉淀物,再以这些共沉淀物直接压片制成骨架片。通过差热分析(DSC)、扫描电镜(DSC)及红外光谱(IR)研究了共沉淀物的性质。研究主要集中在处方中高分子材料所占的比例,溶出介质的pH及制备共沉淀物的方法对布洛芬从骨架中释放的影响。体外溶出实验分别在不同的pH条件下进行。处方研究表明随着聚丙烯酸树脂Ⅱ用量的增加,药物的释放过程显著延长。另外,增加溶出介质的pH会显著增加药物的累积释放百分数。此外实验还表明以方法B制成的共沉淀物的骨架片中药物的累积释放百分数要高于A法制成的骨架片,然而方法A中制得的骨架片中药物的释放却更接近于线性释放。

Direct compression method was used to prepare cefixime tablets in order to prevent degradation by the conventional process. Each quality index complied with the requirements. The human relative bioavailability was about 99.0%, as compared with its capsules.

为了防止头孢克肟的效价降低 ,采用原药粉末直接压片法制备其片剂 ,各项指标符合质量标准要求 ,10 min的溶出度 >80 %。人体生物利用度试验 ,和其胶囊剂相比相对生物利用度为 99.0

In this study sustained release Phenylpropanolamine Hydrochloride (PPA(HCl) hydrophilic matrix tablets containing HPMC K100M and Carbopol 971P were prepared by direct compression method, and the release tests were performed. In all cases the plot of cumulative drug release percentage against t1/2 produced a straight line (r>0.98, P<0.01). The composition of polymers was selected employing orthogonal design. The chosen formulation showed consistent performance. The release profiles of the test and reference...

In this study sustained release Phenylpropanolamine Hydrochloride (PPA(HCl) hydrophilic matrix tablets containing HPMC K100M and Carbopol 971P were prepared by direct compression method, and the release tests were performed. In all cases the plot of cumulative drug release percentage against t1/2 produced a straight line (r>0.98, P<0.01). The composition of polymers was selected employing orthogonal design. The chosen formulation showed consistent performance. The release profiles of the test and reference preparation were similar in 0.1 mol(L-1 HCl, distilled water, phosphate buffer pH 5.0, 6.8, 7.4 and in 0.1 mol(L-1 HCl for 2 h followed by release in phosphate buffer pH 6.8 for 10 h, for in these cases, the values of "similarity factor, f2" varied within the range of 63~74. The rate of PPA(HCl released in 0.1 mol(L-1 HCl was significantly higher than in other four media (P<0.05). It was found that in the ranges examined, the rate of PPA(HCl released in distilled water decreased with the content of HPMC K100M or Carbopol 971P increased (P<0.05), but variations of the polymers ratio (using the same total content of polymers), the content of magnesium stearate or hardness of matrices appeared to insignificantly affect release rates (P>0.05).

选用HPMC K100M和卡波普971P为骨架材料,粉末直接压片法制备骨架片,考察释放度,反相高效液相色谱法检测盐酸苯丙醇胺(PPA(HCl)的浓度。释药曲线均符合Higuchi方程(R>0.98,P<0.01)。运用正交设计法,以美国市场的PPA(HCl缓释片Acutrim(r)为对照,相似因子f2值为指标,筛选获得了最优处方。其工艺重现性合格。研制片在0.1 mol(L-1 HCl,H2O (pH 6.5),磷酸盐缓冲液(PBS) pH 5.0,6.8和7.4的介质中,以及在0.1 mol(L-1 HCl中释放2 h,转移至PBS6.8中释放10 h,相对于对照品的f2值为63~74,表明在各介质中两制剂的释药曲线相似。释药影响因素的考察结果表明:在本实验考察的范围内,骨架片在水中的释药速率与HPMC K100M和卡波普 971P的用量呈负相关。HPMC K100M和卡波普 971P的比例(保持聚合物总用量相同),硬脂酸镁用量和骨架片硬度对释药速率无显著性影响。

 
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