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whole collagen
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  总胶原
     The whole collagen content in myocardium was measured. Relative LV myocardial mRNA levels of MMPs (MMP 2, MMP 9) and tissue inhibitor (TIMP 1, TIMP 2) were detected with semi quantitative RT PCR.
     动物处死后取大鼠心脏测定心肌组织中总胶原含量 ,用半定量RT PCR方法检测心肌组织中MMP 2 ,MMP 9及其抑制剂TIMP 1,TIMP 2的基因表达。
短句来源
     The whole collagen content, MDA and SOD in myocardium were measured.
     动物处死后取大鼠心脏测定心肌组织中总胶原含量、MDA的含量及SOD活性。
短句来源
     RESUIT: The whole collagen content and proα2 (Ⅰ) collagen mRNA expression were decreased in L thyroxine group and increased in the group CPU 0213. In L thyroxine group the activity of SOD was decreased but increased in CPU 0213 group and the content of MDA in L thyroxine group was increased but decreased in CPU 0213 group.
     结果 :L thy心肌病组大鼠心肌中的总胶原含量减少 ,SOD活性下降 ,MDA含量增多 ,MMPs的活性被抑制。 RT PCR结果显示L thy组的大鼠左心室proα2 (Ⅰ )collagen的基因表达下调。
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  “whole collagen”译为未确定词的双语例句
     Compared with normotensive group,the ratio of whole collagen thickness to wall thickness, the ratio of collagen area to arterial cross-sectional area and the ratio of collagen type I or Ⅴ thickness to wall thickness were significantly increased in the hypertension group.
     血管组织胶原总厚度 /血管壁总厚度比值、血管壁横截面的血管组织胶原总面积 /血管壁总面积比值和Ⅰ、Ⅴ型胶原总厚度 /血管壁总厚度 ,高血压组均较正常血压组显著增高。
短句来源
     RESUITS: The whole collagen content in myocardium induced by L thy decreased but it increased in the group CPU 0213. The expression of MMPs (MMP 2, MMP 9) mRNA was downregulated in L thy group and the expression of TIMPs mRNA was upregulated in L thy group markedly.
     结果 :L thy诱导的大鼠肥大心肌中 ,MMPs的表达下调。 TIMPs的表达上调。
短句来源
  相似匹配句对
     The whole collagen content, MDA and SOD in myocardium were measured.
     动物处死后取大鼠心脏测定心肌组织中总胶原含量、MDA的含量及SOD活性。
短句来源
     induced by collagen.
     以胶原为诱导剂 :清半夏 >羌活 >天冬 >苦楝皮 ;
短句来源
     The quantity of collagen
     h-脯氨酸掺入法检测肝星状细胞的胶原生成量。
短句来源
     The whole cells of R.
     直接将霉菌R.
短句来源
     uniform the whole with individual;
     整体化与个体化相统一的原则;
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  whole collagen
Although only one-third of the carbon atoms in collagen are peptide-bonded, they account for most of the observed change with age of the stable carbon isotope ratio of the whole collagen.
      
Whole collagen matrices were fixed in 10% neutral-buffered formalin overnight.
      
Up to a concentration of 3 pM, the blocking capacities of CB10 and the whole collagen type II molecule were similar.
      
Immobilized whole collagen fibers offered no distinct advantage over acid-soluble collagen.
      


Objective To study the pathological characteristics of adventitia of small artery in human essential hypertension. Methods The specimens of renal hilum artery were obtained from surgical operation. The morphological analysis of histological cross-sectional areas of vessels from patients with essential hypertension was compared with those from normotensive controls. The distribution of collagen typeⅠ and Ⅴ in arterial adventitia was determined by an immunohistochemical technique. An image system was used...

Objective To study the pathological characteristics of adventitia of small artery in human essential hypertension. Methods The specimens of renal hilum artery were obtained from surgical operation. The morphological analysis of histological cross-sectional areas of vessels from patients with essential hypertension was compared with those from normotensive controls. The distribution of collagen typeⅠ and Ⅴ in arterial adventitia was determined by an immunohistochemical technique. An image system was used for quantitative measurement of vessel wall. Results The collagen type I and Ⅴ are mainly distributed in the adventitia in normotensive patients, while the deposition of collagen could be observed throughout vascular media and intima from hypertensive patients. Compared with normotensive group,the ratio of whole collagen thickness to wall thickness, the ratio of collagen area to arterial cross-sectional area and the ratio of collagen type I or Ⅴ thickness to wall thickness were significantly increased in the hypertension group. Conclusion The adventitia remodeling exists in essential hypertension, showing an increase in adventitial thickness and its collagen deposition. It is suggested that arterial adventitia may participate in the remodeling process of vessel wall in hypertension.

目的 阐明高血压病患者小动脉外膜的组织病理改变特点。方法 采用手术切除的肾脏组织 ,对 6例高血压病患者的肾门小动脉外膜进行组织学观察 ,用免疫组化法检查Ⅰ、Ⅴ型胶原在血管外膜中的分布情况 ,与 7例正常血压者血管进行比较 ,并用图像分析技术进行定量研究。结果 Ⅰ、Ⅴ型胶原蛋白大多分布于血管外膜部分 ,高血压病患者血管中膜及内膜中出现大量胶原物质。血管组织胶原总厚度 /血管壁总厚度比值、血管壁横截面的血管组织胶原总面积 /血管壁总面积比值和Ⅰ、Ⅴ型胶原总厚度 /血管壁总厚度 ,高血压组均较正常血压组显著增高。结论 高血压病患者小动脉血管外膜的胶原蛋白明显增多 ,外膜增厚 ,提示血管外膜在高血压血管重塑中的重要性。

AIM: To observe the alterations of matrix metalloproteinases (MMPs) and TIMPs (the inhibitor of MMPs) and to study the influence of a new endothelin receptor antagonist CPU 0213 on MMPs mRNA and TIMPs mRNA in rats with hypertrophic myocardium induced by L thyroxin (L thy). METHODS: Male Sprague Dawley rats were randomly divided into three groups and sc administrated suspension of L thy ( 0.4 mg·kg -1 ·d -1 ) for consecutive 10 d except for normal group. On the 7th day, the rats treated with L...

AIM: To observe the alterations of matrix metalloproteinases (MMPs) and TIMPs (the inhibitor of MMPs) and to study the influence of a new endothelin receptor antagonist CPU 0213 on MMPs mRNA and TIMPs mRNA in rats with hypertrophic myocardium induced by L thyroxin (L thy). METHODS: Male Sprague Dawley rats were randomly divided into three groups and sc administrated suspension of L thy ( 0.4 mg·kg -1 ·d -1 ) for consecutive 10 d except for normal group. On the 7th day, the rats treated with L thy were given CPU 0213(ig, 100 mg · kg -1 ·d -1 ) for 3 d . The whole collagen content in myocardium was measured. Relative LV myocardial mRNA levels of MMPs (MMP 2, MMP 9) and tissue inhibitor (TIMP 1, TIMP 2) were detected with semi quantitative RT PCR. RESUITS: The whole collagen content in myocardium induced by L thy decreased but it increased in the group CPU 0213. The expression of MMPs (MMP 2, MMP 9) mRNA was downregulated in L thy group and the expression of TIMPs mRNA was upregulated in L thy group markedly. Treated with CPU 0213, the expressions of MMP 9 and TIMP 1 mRNA were downregulated, whereas the expression of MMP 2 mRNA coming from CPU 0213 group tended to upregulate. But there was no statistical significance among these groups. CONCLUSION: CPU 0213 can inhibit the expression of MMPs and increase collagen content, which can improve heart function.

目的 :观察左甲状腺素 (L thy)诱导的大鼠肥大心肌中基质金属蛋白酶 (MMPs)及其抑制剂(TIMPs)的基因表达和新内皮素受体拮抗剂CPU 0 2 13对基因表达的影响。方法 :雄性SD大鼠 ,随机分成 3组 ,除对照组外 ,大鼠皮下注射L thy(0 .4mg·kg-1·d-1)共 10d ,在d 7给予CPU 0 2 13(ig ,10 0mg·kg-1·d-1)干预 ,连续 3d。动物处死后取大鼠心脏测定心肌组织中总胶原含量 ,用半定量RT PCR方法检测心肌组织中MMP 2 ,MMP 9及其抑制剂TIMP 1,TIMP 2的基因表达。结果 :L thy诱导的大鼠肥大心肌中 ,MMPs的表达下调。TIMPs的表达上调。给予CPU 0 2 13后TIMP 1的表达下调 ,TIMP 2的表达基本不改变 ,MMPs的表达变化不明显。结论 :CPU 0 2 13通过抑制MMPs的表达 ,增加心肌胶原的含量 ,改善心肌病理性重构。

AIM:To study the activity alteration of matrix metalloproteinases (MMPs) in the rat cardiomyopathy induced by L thyroxine and involved mechanism. METHOD: Male Sprague Dawley rats were randomly divided into three groups and administrated suspension of L thyroxine (sc,0.4 mg/kg·d -1 ) for consecutive 10 d except for normal group. L thyroxine treated rats were given CPU 0213(po, 100 mg/kg·d -1 )in group CPU 0213 for 3 d. The whole collagen content, MDA and SOD in myocardium were...

AIM:To study the activity alteration of matrix metalloproteinases (MMPs) in the rat cardiomyopathy induced by L thyroxine and involved mechanism. METHOD: Male Sprague Dawley rats were randomly divided into three groups and administrated suspension of L thyroxine (sc,0.4 mg/kg·d -1 ) for consecutive 10 d except for normal group. L thyroxine treated rats were given CPU 0213(po, 100 mg/kg·d -1 )in group CPU 0213 for 3 d. The whole collagen content, MDA and SOD in myocardium were measured. Relative left ventricular activity level of MMPs was determined by substrate zymography. Furthermore, relative left ventricular mRNA level of proα2 (Ⅰ) collagen were detected with semi quantitative RT PCR. RESUIT: The whole collagen content and proα2 (Ⅰ) collagen mRNA expression were decreased in L thyroxine group and increased in the group CPU 0213. In L thyroxine group the activity of SOD was decreased but increased in CPU 0213 group and the content of MDA in L thyroxine group was increased but decreased in CPU 0213 group. The activity of MMPs (MMP 2, MMP 9) was downregulated in L thyroxine group and CPU 0213 group had litter effect on the activity of MMPs. CONCLUSION:Myocardial hypertrophy induced by L Thyroxin, a kind of cardiac hypertrophy that is accompanied by less cardiac fibrosis is mediated partly by ET 1. In L thyroxine induced hypertrophic myocardium oxidative stress is enhanced. CPU 0213 could inhibit oxidative stress and increase collagen content. The hypertrophic myocardium mechanic induced by L thyroxine was related to ET 1.

目的 :通过新内皮素受体拮抗剂CPU 0 2 13对左 甲状腺素 (L thy)诱导的大鼠肥大心肌中基质金属蛋白酶 (MMPs)的改变 ,探讨内皮素参与诱导心肌肥大和细胞外基质改变的机制。方法 :雄性SD大鼠随机分成 3组 ,除对照组外 ,大鼠每日给予L thy (sc ,0 .4mg/kg)共 10d ,药物干预组在第 7天时给新型内皮素受体拮抗剂CPU 0 2 13(po ,10 0mg/kg) ,连续 3d。动物处死后取大鼠心脏测定心肌组织中总胶原含量、MDA的含量及SOD活性。大鼠左心室的MMPs的活性由明胶酶谱法测定 ,Ⅰ型胶原基因 (proα2 (Ⅰ )collagen)的基因表达由半定量RT PCR方法确定。结果 :L thy心肌病组大鼠心肌中的总胶原含量减少 ,SOD活性下降 ,MDA含量增多 ,MMPs的活性被抑制。RT PCR结果显示L thy组的大鼠左心室proα2 (Ⅰ )collagen的基因表达下调。给予CPU 0 2 13干预后大鼠心肌总胶原含量及SOD活性上升 ,MDA含量减少 ,大鼠左心室中MMPs活性被抑制 ,左心室中proα2 (Ⅰ )collagen的基因表达上调。结...

目的 :通过新内皮素受体拮抗剂CPU 0 2 13对左 甲状腺素 (L thy)诱导的大鼠肥大心肌中基质金属蛋白酶 (MMPs)的改变 ,探讨内皮素参与诱导心肌肥大和细胞外基质改变的机制。方法 :雄性SD大鼠随机分成 3组 ,除对照组外 ,大鼠每日给予L thy (sc ,0 .4mg/kg)共 10d ,药物干预组在第 7天时给新型内皮素受体拮抗剂CPU 0 2 13(po ,10 0mg/kg) ,连续 3d。动物处死后取大鼠心脏测定心肌组织中总胶原含量、MDA的含量及SOD活性。大鼠左心室的MMPs的活性由明胶酶谱法测定 ,Ⅰ型胶原基因 (proα2 (Ⅰ )collagen)的基因表达由半定量RT PCR方法确定。结果 :L thy心肌病组大鼠心肌中的总胶原含量减少 ,SOD活性下降 ,MDA含量增多 ,MMPs的活性被抑制。RT PCR结果显示L thy组的大鼠左心室proα2 (Ⅰ )collagen的基因表达下调。给予CPU 0 2 13干预后大鼠心肌总胶原含量及SOD活性上升 ,MDA含量减少 ,大鼠左心室中MMPs活性被抑制 ,左心室中proα2 (Ⅰ )collagen的基因表达上调。结论 :L thy诱导的大鼠心肌肥大是一种缺少纤维化的肥大 ,肥大心肌中自由基增多且脂质膜受损。内皮素 1(ET 1)参与介导心肌MMPs活性的调节 ,新内皮素受体拮抗剂CPU 0 2 13能明显上调proα2(Ⅰ )collagen的基因表达及改善心肌病理性重构

 
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