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family stroke history
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     After adjustment for age, sex, hypertension, smoking, drinking alcohol, family stroke history and other serum lipids, the odd radio for LP(a) and cerebral infarction was 0.74 (95% CI : 0.27- 1.98 ).
     logistic回归分析示高脂蛋白 (a)的相对危险度比值比 (OR)为 0 .74 ,95 %CI:0 .2 7~ 1.98。
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     In theunivariate analysis, we found the age, hypertension, hearthistory, family stroke history, the whole blood low shearreduced constrast viscosity, hematorit, plasma viscosity,blood velocity, vascular elasticity and critical pressurewere positively associated with prognosis (p<0.0Ol).
     与发展为完全性脑梗死相关的因素,在P<0.01水平上有年龄、高血压、糖尿病史、心脏病史、家族卒中史、全血低切粘度、红细胞压积、血浆粘度、血流速度、血管弹性和闭锁状态指标等,且均与预后成正相关。
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     Conclusion age, hypertension, historyof family stroke history and abnormal of hemorheology wereimportant marks of bad prognosis. In secondary prevention ofTTA, taking hypotensor regularly and intervening hemorheologyabnorma were effective preventive measures to control riskfactors.
     结论 提示在缺血性脑卒中二级预防工作中,可将高血压、家族卒中史、血浆粘度、全血低切粘度作为识别高危复发人群的重要标志,病后长期规律服用降压药及对血液流变学异常进行干预是改善TIA预后的有效措施。
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Objective:To determine the important prognostic factors which identify patients with carotid transient ischemic attacks who are at high risk of complete infarction and to derive a predication model (equation).Methods:A hospital based cohort of 84 patients affected by carotid TIA was investigated and followed up during 1994~1999 Results:The results showed that 26 cases had developed complete infarction ,1 month,1,2 and 3 years cumulative occurrence rates were 7 14%,13 9%,28 14% and 46 15% respectively ...

Objective:To determine the important prognostic factors which identify patients with carotid transient ischemic attacks who are at high risk of complete infarction and to derive a predication model (equation).Methods:A hospital based cohort of 84 patients affected by carotid TIA was investigated and followed up during 1994~1999 Results:The results showed that 26 cases had developed complete infarction ,1 month,1,2 and 3 years cumulative occurrence rates were 7 14%,13 9%,28 14% and 46 15% respectively By Cox proportional hazards analysis it was found that there were five independent risk factors of ischemic stroke: history of family stroke history (RR:7 355,P=0 016 9),hypertension (RR:4 039,P=0 096 2),elevated plasma viscosity (RR:1 681,P=0 085 8),elevated whole blood low shear viscosity (RR:1 568,P=0 186 1)and age (RR:0 791,P=0 191 6) Conclusion:Age,hypertension,history of family stroke history and abnormal of hemorheology were important marks of bad prognosis In secondary prevention of TIA,taking hypotensor regularly and intervening hemorheology abnormal were effective preventive measures to control risk factors

目的:探讨颈内动脉系统短暂性脑缺血发作(TIA)发展为完全缺血性脑梗死的预测因子及预后模式。方法:采用以医院为基础的队列研究,对近4年颈内动脉系统TIA门诊或住院病人84例进行随访调查。结果:发现其1个月、1年、2年及3年完全性脑梗死的累积发生率分别为7.14%、13.9%、28.14%及46.15%。多因素分析显示:年龄、家族卒中史、高血压、血浆粘度、全血低切粘度等是影响预后的独立危险因素。结论:提示在缺血性脑卒中二级预防工作中,可将高血压、家族卒中史、血浆粘度、全血低切粘度作为识别高危复发人群的重要标志,病后长期规律服用降压药及对血液流变学异常进行干预是改善TIA预后的有效措施

Objective To investigate the relation between lipoprotein (a) 〔LP(a)〕 and cerebral infarction in young adults. Methods Serum LP(a) of 90 young adults (age below 45 years) with cerebral infarction was measured. Serum lipids include triglyceride (TG), total cholesterol(TC), high density lipoprotein cholesterol, low density lipoprotein cholesterol, apolipoprotein A-Ⅰ(ApoA-Ⅰ) and apolipoprotein B(ApoB) were also measured. Other possible risk factors such as hypertension, smoking, drinking and family stroke...

Objective To investigate the relation between lipoprotein (a) 〔LP(a)〕 and cerebral infarction in young adults. Methods Serum LP(a) of 90 young adults (age below 45 years) with cerebral infarction was measured. Serum lipids include triglyceride (TG), total cholesterol(TC), high density lipoprotein cholesterol, low density lipoprotein cholesterol, apolipoprotein A-Ⅰ(ApoA-Ⅰ) and apolipoprotein B(ApoB) were also measured. Other possible risk factors such as hypertension, smoking, drinking and family stroke history were reviewed. Results There was no significant difference of serum LP(a) value between stroke patients and controls. TG ( P < 0.01 ) and ApoB ( P < 0.01 ) values in patients with crerebral infarction were significant higher than those in controls. Lipoprotein(a) was correlated with total cholesterol and low density prolipotein cholesterol, with the values of correlation coefficient (r) 0.28 and 0.23 (both P < 0.01 ). After adjustment for age, sex, hypertension, smoking, drinking alcohol, family stroke history and other serum lipids, the odd radio for LP(a) and cerebral infarction was 0.74 (95% CI : 0.27- 1.98 ). The odd radio for elevated TG was 3.57 (95% CI : 1.34- 9.49 ); The odd radios for hypertension, heart diseases and smoking as risk factors for cerebral infarction in young patients showed as: hypertension OR = 8.18 ,95% CI : 2.54- 26.33 ; heart diseases: OR = 8.51 ,95% CI : 2.27- 31.85 ; smoking: OR = 3.21 ,95% CI : 1.27- 8.13 . Conclusion LP(a) might not be a risk factor for cerebral infarction in young patients while elevated triglyceride, hypertension,heart diseases and smoking were important risk factors in young adults with cerebral infarction.

目的 研究脂蛋白 (a)与年轻人脑梗死发病的关系。方法 检测 90例发病年龄 16~ 4 5岁脑梗死患者脂蛋白 (a)与甘油三酯、总胆固醇、高密度脂蛋白胆固醇、低密度脂蛋白胆固醇、载脂蛋白A Ⅰ、载脂蛋白B等 ,同时分析患者的高血压、吸烟、饮酒、卒中家族史等因素。结果 与对照组相比 ,脑梗死患者的脂蛋白 (a)无显著性增高。而甘油三酯、载脂蛋白B在脑梗死患者中却显著增高。相关分析显示 ,脂蛋白 (a)与血清总胆固醇和低密度脂蛋白胆固醇正相关 (P <0 .0 1)。logistic回归分析示高脂蛋白 (a)的相对危险度比值比 (OR)为 0 .74 ,95 %CI:0 .2 7~ 1.98。高甘油三酯对于脑梗死的OR值为 3.5 7,95 %CI :1.34~ 9.4 9;高血压对于脑梗死的OR值为 8.18,95 %CI:2 .5 4~ 2 6 .33;心脏病对于脑梗死的OR值为 8.5 1,其 95 %CI:2 .2 7~ 31.85 ;吸烟的OR值为 3.2 1,95 %CI:1.2 7~ 8.13。结论 脂蛋白 (a)可能不是年轻人脑梗死的危险因素。高甘油三酯、高血压、心脏病和吸烟是年轻人脑梗死重要的...

目的 研究脂蛋白 (a)与年轻人脑梗死发病的关系。方法 检测 90例发病年龄 16~ 4 5岁脑梗死患者脂蛋白 (a)与甘油三酯、总胆固醇、高密度脂蛋白胆固醇、低密度脂蛋白胆固醇、载脂蛋白A Ⅰ、载脂蛋白B等 ,同时分析患者的高血压、吸烟、饮酒、卒中家族史等因素。结果 与对照组相比 ,脑梗死患者的脂蛋白 (a)无显著性增高。而甘油三酯、载脂蛋白B在脑梗死患者中却显著增高。相关分析显示 ,脂蛋白 (a)与血清总胆固醇和低密度脂蛋白胆固醇正相关 (P <0 .0 1)。logistic回归分析示高脂蛋白 (a)的相对危险度比值比 (OR)为 0 .74 ,95 %CI:0 .2 7~ 1.98。高甘油三酯对于脑梗死的OR值为 3.5 7,95 %CI :1.34~ 9.4 9;高血压对于脑梗死的OR值为 8.18,95 %CI:2 .5 4~ 2 6 .33;心脏病对于脑梗死的OR值为 8.5 1,其 95 %CI:2 .2 7~ 31.85 ;吸烟的OR值为 3.2 1,95 %CI:1.2 7~ 8.13。结论 脂蛋白 (a)可能不是年轻人脑梗死的危险因素。高甘油三酯、高血压、心脏病和吸烟是年轻人脑梗死重要的危险因素。

 
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