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   transdermal 在 药学 分类中 的翻译结果: 查询用时:0.201秒
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transdermal
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  透皮
    Design and Evaluation of Vinpocetine Transdermal Delivery System
    长春西汀透皮给药系统的设计与评价
短句来源
    Study on Transdermal Therapeutic System of Clonidine and Scopolamine
    可乐定、东莨菪碱透皮给药体系的研究
短句来源
    DETERMINATION OF GLYCERIN TRINITRATE IN NITROGLYCERIN TRANSDERMAL FILMS BY HPLC
    硝酸甘油透皮吸收膜主药的HPLC测定
短句来源
    TRANSDERMAL ABSORPTION OF METRONIDAZOLE THROUGH MICE SKIN IN VITRO
    甲硝唑经小鼠离体皮肤的透皮吸收
短句来源
    Study on the Niclosamide Transdermal Therapeutic System
    氯硝柳胺透皮控释给药的研究
短句来源
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    Design and Evaluation of Vinpocetine Transdermal Delivery System
    长春西汀皮给药系统的设计与评价
短句来源
    Study on Transdermal Therapeutic System of Clonidine and Scopolamine
    可乐定、东莨菪碱皮给药体系的研究
短句来源
    DETERMINATION OF GLYCERIN TRINITRATE IN NITROGLYCERIN TRANSDERMAL FILMS BY HPLC
    硝酸甘油皮吸收膜主药的HPLC测定
短句来源
    TRANSDERMAL ABSORPTION OF METRONIDAZOLE THROUGH MICE SKIN IN VITRO
    甲硝唑经小鼠离体皮肤的皮吸收
短句来源
    Study on the Niclosamide Transdermal Therapeutic System
    氯硝柳胺皮控释给药的研究
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  “transdermal”译为未确定词的双语例句
    FACILITATED TRANSDERMAL DELIVERY OF INSULIN EY PULSE CURKENT
    脉冲电流对胰岛素经皮渗透的促进作用
短句来源
    Determination of Content and the Controlled Release of Estradiol in Transdermal Delivery Patches
    雌二醇控释贴片的含量测定及体外释放度试验
短句来源
    Study of Transdermal Iontophoresis of Diclofenac Sodium Gelatin
    双氯芬酸钠明胶海绵经皮直流电离子导入的研究
短句来源
    Flexible nano-liposomes as carriers for transdermal delivery of cyclosporine
    柔性纳米脂质体作为环孢素经皮渗透载体的体外研究
短句来源
    Iontophoretic Transdermal Delivery of LHRH II. Development of Iontophoretic Device and Pharmacokinetic Study of LHRH Hydrogel Patch on Rats
    LHRH离子电渗透皮给药系统的研究 II.离子电渗仪的研制和LHRH的大鼠药动学研究
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  transdermal
The biological activity of the compounds, namely, their antispasmodic activity in mice, was evaluated by antagonism with a spasmodic agent, Corazol, upon transdermal administration.
      
The aim of the double-blinded study was to assess whether a single transdermal estradiol administration also has an effect on the sympathovagal balance and may additionally explain the acute effects of estradiol.
      
Conclusion A single transdermal application of estradiol did not modify heart rate or heart rate variability of women with coronary artery disease.
      
A critical evaluation of transdermal clonidine in the treatment of hypertension
      
Transdermal treatment with clonidine-a new approach in the management of hypertension
      
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The rate of percutaneous absorption of Transdermal Nitroglycerin Patches was measured in vivo and in vitro using radioisotope tracing technique.The average rate of percutaneous absorption in vivo is 10.5μg/h/cm~2 for 24h in mise.And in vitro the average permeabilites(μg/h/cm~2)throughvarious species skins are follows:10.4 in mise,9.52 in rats,8.6 in guinea pig and 8.7 in human.The permeabilities vary with different species of animals,but the total accumulated amounts of nitroglycerin permeated through...

The rate of percutaneous absorption of Transdermal Nitroglycerin Patches was measured in vivo and in vitro using radioisotope tracing technique.The average rate of percutaneous absorption in vivo is 10.5μg/h/cm~2 for 24h in mise.And in vitro the average permeabilites(μg/h/cm~2)throughvarious species skins are follows:10.4 in mise,9.52 in rats,8.6 in guinea pig and 8.7 in human.The permeabilities vary with different species of animals,but the total accumulated amounts of nitroglycerin permeated through skins for various species are proportional to test time.

本文用放射性同位素示踪技术,以体外和体内两种方法测定了硝酸甘油贴剂(心泰膏Nitrogum)中硝酸甘油的透皮吸收速率。体内法测定结果表明,小鼠在24h内每小时的透皮吸收平均速率为10.5μg/cm~2。不同种属的动物皮肤,经体外测定,每小时平均渗透速率(μg/cm~2)如下:10.4(小鼠)、9.5(大鼠)、8.6(豚鼠)和8.7(人皮)。说明不同种动物其皮肤渗透速率是不同的。在实验测定时间内,各种皮肤的渗透累积量与时间成正比,表明硝酸甘油恒速渗透。

Qinghaosu, also known as artemisinin and arteannuin, is a new type of antimalarial drug isolated from Artemisa annua L. Its low solubility in water and oil limited its widespread clinical use. Artesunate (sodiure dihydroqinghaosu hydrogen hemisuccinate monoester) is easily soluble in water and is used i v in the treatment of acute cerebral and malignant malaria. However, artesunate was shown to have a very short half-life when given i v in animals as well as in human beings. A transdermal dosage form of...

Qinghaosu, also known as artemisinin and arteannuin, is a new type of antimalarial drug isolated from Artemisa annua L. Its low solubility in water and oil limited its widespread clinical use. Artesunate (sodiure dihydroqinghaosu hydrogen hemisuccinate monoester) is easily soluble in water and is used i v in the treatment of acute cerebral and malignant malaria. However, artesunate was shown to have a very short half-life when given i v in animals as well as in human beings. A transdermal dosage form of artesunic acid had been prepared and was reported to have reliable suppressing and killing effects on plasmobium berghei in mice.This paper reports results of pharmacokinetic studies of this preparation when applied onto a fixed area of the shaved skin of mice and rabbits. Serum concentration of the drug was determined by a method of radioimmunoassay. The drug was found to be easily absorbed from the skin. The serum concentration-time curve is depicted in figures i. Peak concentration of 1.8μg/ml was reached at about 2 h when a dose of 25 mg/kg was given to rabbits. For mice, peak serum concentrations of 2.05 and 7.11μg/ml were attained in about 0.5 h after doses of 31.3 and 71.4 mg/kg, respectively, while at a dose of 6.7 mg/kg a peak level of 0.82 μg/ml (a concentration more than 5000 times the IC_(50) of artesunate in in vitro tests on plasmodium berghei for antimalarial activity) was attained at about 4 h after application of the drug. The half-lives of the drug were found to be more than 2 h for both mice and rabbits.

将青蒿琥酯溶于苯二甲酸二甲酯,加适量氨酮制成皮肤擦剂。给兔脱毛后,皮肤涂抹此擦剂25mg/kg后,血药浓度达峰时间平均为2 h,峰浓度平均为1.80μg/ml。药物在兔体内平均驻留时间为3.54 h,清除半衰期约为2.46 h。给小鼠脱毛皮肤涂抹擦剂6.7,31.3和71.4 mg/kg,血药浓度在给药后0.5~4 h达高峰,峰浓度分别为0.82,2.05和7.11μg/ml,体内药物平均驻留时间为3.39,2.79及3.54 h,清除半衰期为2.35,1.93及2.45 h。可见,给兔及小鼠皮肤擦剂后,青蒿琥酯吸收良好,血药浓度维持时间较长。

A special kind of silicone matrix containing estradiol (E_2) formaking of "microreservoir partition-controlled transdermal drug delivery system"is introduced. With. Franz diffusion cell and Valia-Chien diffusion cell, the resultsshowed: (1) E_2 release from the TDS fitted the Higuchi equation; (2) E_2 skinpermeation rate was nearly zero-order. The E_2 transdermal rate and amountcould be adjusted by changing the component proportions and/or adding variousenhancers of different proportions in matrix....

A special kind of silicone matrix containing estradiol (E_2) formaking of "microreservoir partition-controlled transdermal drug delivery system"is introduced. With. Franz diffusion cell and Valia-Chien diffusion cell, the resultsshowed: (1) E_2 release from the TDS fitted the Higuchi equation; (2) E_2 skinpermeation rate was nearly zero-order. The E_2 transdermal rate and amountcould be adjusted by changing the component proportions and/or adding variousenhancers of different proportions in matrix.

报道了一种采用国产硅橡胶为骨架材料的“微小贮库分配控制型”药物透皮释放系统(TDS)。Franz渗透池TDS体外释放试验和Valia-Chien渗透池皮肤渗透试验表明;①雌二醇从TDS的体外释放规律符合Higuchi方程式;②雌二醇TDS的皮肤渗透速率接近零级速率。改变TDS配方中不同组分的比例或加入不同类型、不同比例的透皮吸收促进剂可以调节雌二醇的皮肤渗透速率与渗透量。

 
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