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modified release
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  缓释
     CONCLUSION:The established method is suitable for the determination of oxpentifylline modified release capsule.
     结论:本方法可用于己酮可可碱缓释胶囊血药浓度的测定。
短句来源
     Objective; To investigate the in vitro - in vivo correlation of two clarithromycin modified release capsules and establish dissolution.
     目的:研究两种释药机理的克拉霉素缓释胶囊试验制剂体内-体外相关性,建立与体内吸收相关的释放度测定法。
短句来源
     Aim To develop and validate a rapid, sensitive and selective LC/MS/MS method for the determination of gliclazide in human plasma and to evaluate the bioequivalence of gliclazide modified release tablet by the validated LC/MS/MS method.
     目的:建立快速、灵敏、专属的液相色谱-串联质谱(LC/MS/MS)法,测定人血浆中的格列齐特浓度,并应用于格列齐特缓释片人体生物等效性评价。
短句来源
     OBJECTIVE: To prepare pentoxifylline(PTX) modified release capsule and to investigate its in vitro drug release characteristics.
     目的:制备己酮可可碱(PTX)缓释胶囊,并考察其体外释药特性。
短句来源
     The dosage was 10-60mg for every 12 hours. Results The effective rate of morphine modified release tablets was 90. 9% (120/22) in treating moderate carcinomatous pain patients,and it was 91. 3 % (42/46) in severe carcinomatous pain patients. The common side effects were nausea,vomiting, lethargy, dizziness and constipation.
     结果吗啡缓释片对中度癌性疼痛者,有效率为90.9%(20/22),重度癌痛者为91.6%(22/24),总有效率为91.3%(42/46),常见副作用为恶心、呕吐、嗜睡、头昏、便秘等。
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  “modified release”译为未确定词的双语例句
     A self-Crossover Double-Blind Controlled clinical study of Domestic and ImportedMorphine Sulphate Modified Release Tablet for Analgesia in Terminal Cancer
     国产与进口硫酸吗啡控释片用于癌症止痛自身交叉双盲对照试验
短句来源
     The observation of curative effect in Cancer Pain controlled with the Morphine Sulphate modified release tablets by oral and rectal.
     硫酸吗啡控释片口服与直肠给药控制癌痛疗效观察
短句来源
     Preparation, Characterization and Application of Carboxymethyl Chitosan Pharmaceutical Hydrogel Excipient for Modified Release
     羧甲基壳聚糖缓控释凝胶新辅料的制备、表征及应用研究
短句来源
     In order to evaluate the analgesia effect of MS CONTIN (Morphine Sulfate Modified release Tablets) to severe cancer pain, 100 patients suffering severe cancer pain were recruited and divided into group A and B at random. Patients in group A were given MS CONTIN p. o.
     目的:观察美施康定(硫酸吗啡控释片)对重度癌痛的镇痛效果,方法:自1995年1月至1997年4月,将100例重度癌痛患者随机分为A、B两组,A组:口服美施康定,每次30mg,每日2次,B组:肌注度冷丁,每次100mg,每日2次。
短句来源
     Aim: To study the analgesic effect and side effects of MS CONTIN (Morphine Sulfate Modified Release Tablets) via different routes for severe cancer pain.
     目的:观察美施康定( 硫酸吗啡控释片) 口服和直肠给药方式在重度癌痛治疗的止痛效果和副作用。
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  相似匹配句对
     of modified P.R.
     R.
短句来源
     Longevity of Controlled Release Modified Resin Fertilizer
     水溶性树脂包膜控释肥料肥效期快速检测方法研究
短句来源
     The modified Freundlich equation was suit to the second release process.
     Cd~(2+)释放第二阶段动力学过程,符合分数幂函数方程。
短句来源
     MODIFIED POLYPROPYLENE
     聚丙烯的改性
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     The release of Windows.
     Windows.
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  modified release
In vitro dissolution tests confirmed a modified release of the drug from the polymer matrixes.
      
The obtained results show that hydrotalcite may be used to prepare modified release formulations.
      
The proposed method can be extended to the modified release formulations that are designed to release a drug over 6, 18, or 24 hours.
      
This treatment led to the formation of multiple layers of drug particles around an inert core resulting in the production of pellets that can further be coated by different polymers to obtain modified release formulations.
      
In Vivo Validation of the Release Rate and Palatability of Remoxipride-Modified Release Suspension
      
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In order to evaluate the analgesia effect of MS CONTIN (Morphine Sulfate Modified release Tablets) to severe cancer pain, 100 patients suffering severe cancer pain were recruited and divided into group A and B at random. Patients in group A were given MS CONTIN p.o., 30mg, bid; Patients in group B were given Dolantine, i.m., 100mg bid. The significant effective rate was 86% in group A and 66% in group B respectively (P<0.01, χ 2 test). The average analgesia duration ( x ±S) was 4.3±1.1h in...

In order to evaluate the analgesia effect of MS CONTIN (Morphine Sulfate Modified release Tablets) to severe cancer pain, 100 patients suffering severe cancer pain were recruited and divided into group A and B at random. Patients in group A were given MS CONTIN p.o., 30mg, bid; Patients in group B were given Dolantine, i.m., 100mg bid. The significant effective rate was 86% in group A and 66% in group B respectively (P<0.01, χ 2 test). The average analgesia duration ( x ±S) was 4.3±1.1h in group A and 3.0±1.4h in group B respectively (P<0.01,t test). Nausea and constipation were the main side effects but no psychological dependence was found in group A. We suggest that MS CONTIN is a more effective analgesic than Dolantin for severe cancer pain with longer lasting duration and less side effects. It can be used as first choice drug for severe cancer pain.

目的:观察美施康定(硫酸吗啡控释片)对重度癌痛的镇痛效果,方法:自1995年1月至1997年4月,将100例重度癌痛患者随机分为A、B两组,A组:口服美施康定,每次30mg,每日2次,B组:肌注度冷丁,每次100mg,每日2次。结果:镇痛显著有效率,A组为86%,高于B组(66%),P<0.01;镇痛平均维持时间(X±S),A组(4.3±1.1小时)长于B组(3.0±1.4小时),P<0.01。A组副作用主要为恶心、呕吐、便秘等,无精神依赖。结果显示:美施康定控制重度癌痛,具有镇痛效果好,镇痛作用时间长,副作用少,应用方便等优点,为重度癌痛首选镇痛药物

Objective To observe the therapeutic effectiveness of morphine sulfate controlled release tablets in treating advanced carcinomatous pain. Methods We used novel morphine sulfate modified release tablets produced by American pharma CO. LTD. to treat moderate and severe cancer patients. The dosage was 10-60mg for every 12 hours. Results The effective rate of morphine modified release tablets was 90. 9% (120/22) in treating moderate carcinomatous pain patients,and it was 91. 3 % (42/46) in severe carcinomatous...

Objective To observe the therapeutic effectiveness of morphine sulfate controlled release tablets in treating advanced carcinomatous pain. Methods We used novel morphine sulfate modified release tablets produced by American pharma CO. LTD. to treat moderate and severe cancer patients. The dosage was 10-60mg for every 12 hours. Results The effective rate of morphine modified release tablets was 90. 9% (120/22) in treating moderate carcinomatous pain patients,and it was 91. 3 % (42/46) in severe carcinomatous pain patients. The common side effects were nausea,vomiting, lethargy, dizziness and constipation. Conclusion Morphine modified release tablets were analgesic to advanced cancer patients with significant therapeutic effectiveness. It was easy and safe to take,and had no addiction and respiratory inhibition.[

目的观察硫酸吗啡缓释片治疗晚期癌性疾病的效果。方法采用美国路坦医药公司的新型硫酸吗啡缓释片(即路泰),应用于中重度癌症患者,用量为10~60mg/次,隔12小时口服1次。结果吗啡缓释片对中度癌性疼痛者,有效率为90.9%(20/22),重度癌痛者为91.6%(22/24),总有效率为91.3%(42/46),常见副作用为恶心、呕吐、嗜睡、头昏、便秘等。结论吗啡缓释片作为晚期癌痛患者止痛治疗,疗效明显,服用方便,安全,无成瘾性及呼吸抑制现象。

Aim: To study the analgesic effect and side effects of MS CONTIN (Morphine Sulfate Modified Release Tablets) via different routes for severe cancer pain. Method: 42 patients in our hospital from June, 1997 to July, 1998 were recruited. At the beginning all the patients were given MS CONTIN p.o. Refractory nausea, deglutition difficulty or both occurred. So we shifted to rectal medication. Results obtained by the two methods were compared. Results: Oral medication lasted for an average of 82.5 days...

Aim: To study the analgesic effect and side effects of MS CONTIN (Morphine Sulfate Modified Release Tablets) via different routes for severe cancer pain. Method: 42 patients in our hospital from June, 1997 to July, 1998 were recruited. At the beginning all the patients were given MS CONTIN p.o. Refractory nausea, deglutition difficulty or both occurred. So we shifted to rectal medication. Results obtained by the two methods were compared. Results: Oral medication lasted for an average of 82.5 days and rectal medication 22.5 days. The average dosage per day for oral use was 55.7mg, q12h, and rectal use 53.6mg, q12h (P>0.05). The occurrence rate of nausea for oral use was 74%, which was significantly higher than that for rectal use (50%, P<0.05). No psychic dependence was found in any cases. No local mucous irritation occurred. Conclusion: Rectal MS CONTIN is an effective method for the control of severe cancer pain, with less side effect of nausea.

目的:观察美施康定( 硫酸吗啡控释片) 口服和直肠给药方式在重度癌痛治疗的止痛效果和副作用。方法:病例来源于1997 年6 月至1998 年7 月在本院住院和门诊就诊病人,共42 例晚期癌痛患者。开始时所有患者均口服美施康定,后因顽固性恶心呕吐或吞咽困难改为直肠给药,并与其口服时自身对照。结果:所有口服和直肠给药用美施康定的病人疼痛均得到持续性控制,剂量平均为前者55 .7mg q12h ,后者为53 .6mg q12h , P> 0 .05 ( t 检验) ,两者差异无显著性。口服和直肠给药的主要副作用是恶心呕吐和便秘,无精神依赖。直肠给药恶心呕吐的发生率(50 % ) 少于口服给药(74 % ) ,χ2 检验P< 0 .01 。所以,不能口服时直肠给予美施康定能很好的控制疼痛,是一种安全有效、简便的给药方式。

 
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