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activated cells
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  活化细胞
     Whereas after activation with high dose of IL-2, except a dramatic elevation in the proportion of activated cells which highly expressed CD69 and CD25, no change was found in the proportion of the other cell subgroups.
     经大剂量IL-2短期活化后,各种细胞亚群比例未见改变,但活化细胞(包括CD69+和CD25+细胞)亚群比例显著升高。
短句来源
     Results Anti-CD 28 stimulated cells could kill T 24 bladder cancer cells more effectively than other activated cells, CpGODN stimulated cells could kill Scarber bladder cancer cells more stronger.
     结果 CD2 8共刺激细胞对T2 4 杀伤作用较强 ,达到 69.35 %± 1 .1 7% ,而CpGODN诱导的活化细胞对Scarber杀伤较强 ,达到 63.1 1 %± 2 .0 3%。
短句来源
  “activated cells”译为未确定词的双语例句
     Results The proliferation of BCG activated cells and LAK cells were respectively 46.39% at 24 day and 20.76% at 18 day. The cytotoxicity of BCG activated cells against TBC-1 at the different E/T ratio 40:120:110:1 were 42.36%±3.86%、29.19%±2.39%、14.36%±1.68%.
     结果BCG刺激的淋巴细胞于不同效靶比40∶1、20∶1、10∶1对TBC-1的杀伤活性分别为(42·36±3·86)%、(29·19±2·39)%、(14·36±1·68)%。
短句来源
     Five min later microbubbles were incubated with leukocytes, the number of cells interacting with microbubbles was greater for activated cells than for nonactivated cells( 20.3 ± 2.7 vs 4.5 ± 1.4 ,P< 0.01 ).
     蛋白微泡与佛波醇 (PMA )激活的白细胞接触后 5min大量结合到白细胞表面 ,未激活的白细胞表面少有微泡粘附 ( 2 0 .3± 2 .7对 4.5± 1.4,P <0 .0 1)。
短句来源
     RESULTS: A minimum of 50 cells were identified under transillumination. 5 min after microbubbles were incubated with leukocytes, the number of cells interacting with microbubbles was greater for activated cells than for nonactivated cells(20 30±2 67 vs 4 50±1 43, P <0 01).
     结果 :蛋白微泡与PMA激活的白细胞接触后 5min大量结合到白细胞表面 ,未经激活的白细胞表面少有微泡粘附 (2 0 30± 2 67vs4 50± 1 43 ,P <0 0 1 )。
短句来源
     Conclusion Both CD 28 mAb and CpG ODN combined with CD 3mAb could induced PBMC proliferation, and the activated cells included NK cells , CD 4 +/CD 8 -,CD 4 -/CD 8 +T cells.
     结论 CD2 8、CpGODN均能协同CD3 单抗诱导PBMC活化增殖 ,CD2 8单抗激活无剂量线性相关 ,而CpGODN激活有剂量正相关。 激活的细胞是以NK细胞、CD4+ CD8-、CD4- CD8+ T细胞为主体的异质细胞群。
短句来源
     Results The average number of epidermic HLA DR + DCs was about 8 per mm 2 ,and HLA DR + DC didnt express FⅩⅢa and Somatostatin. A few HLA DR + DC expressed CD1a and S 100. Conclusions HLA DR might express on many activated cells.
     结果 表皮中 HL A - DR+ DC数量约为 8个 / mm2 ,这种细胞不表达 F a和 Somatostatin,部分表达CD1a和 S- 10 0。
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  相似匹配句对
     Activated NK and T cells secrete it.
     IFN-γ是巨噬细胞强有力的活化因子,可由激活的T细胞、NK细胞或巨噬细胞自身分泌。
短句来源
     U cells.
     Li/TK细胞3d,即可将其杀死.
短句来源
     Most of T cells were non-activated.
     ②肺癌局部T细胞多处于非活化状态。
短句来源
     The whole cells of R.
     直接将霉菌R.
短句来源
     DON was activated by
     应用单克隆抗体12D1建立的DON间接竞争ELISA
短句来源
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  activated cells
Mitochondria are of special interest in that Ca2+ stimulates respiration and oxidative phosphorylation to meet the energy needs of activated cells.
      
The presence of CD4+CD25+ T lymphocytes in the IR fraction reflects changes in the Ca2+-signaling pathway at this differentiation step of activated cells.
      
Although the percentages of T3, T4 and T8 positive cells in rIL-2-activated cells did not differ significantly from those of control cellsin vitro, the former showed stronger cytotoxicity than control cells to PG tumor cellsin vitro.
      
Furthermore, as autonomously activated cells, scleroderma fibroblasts may be unresponsive to blockade of TGF-β signaling.
      
The changes in tumor cytotoxicity were paralleled by changes in the amounts of lymphotoxin produced by the activated cells.
      
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In our experiment, it was shown that PBL from healthy subjects and cancer patients became suppressive after 48 hrs incubation in the presence of Con A. These Con A-activated cells suppressed DNA synthesis in cultures of allogeneous lymphocytes exposed to PHA. It was also demonstrated that the degree of suppression by the mitogen-activated cell depended upon the ratio of suppressor to effector cells.PBL from normal individuals became suppressive after 48 hrs incubation even in the absence of...

In our experiment, it was shown that PBL from healthy subjects and cancer patients became suppressive after 48 hrs incubation in the presence of Con A. These Con A-activated cells suppressed DNA synthesis in cultures of allogeneous lymphocytes exposed to PHA. It was also demonstrated that the degree of suppression by the mitogen-activated cell depended upon the ratio of suppressor to effector cells.PBL from normal individuals became suppressive after 48 hrs incubation even in the absence of Con A. There was no significant difference between the activities of Con A-induced suppressor cells from normal individuals and cancer patients.

正常人或实体癌病人外周血淋巴细胞在体外经高浓度刀豆蛋白A诱导可产生抑制性细胞,可抑制异体正常人外周血淋巴细胞对植物血凝素的反应。抑制程度与抑制性细胞同反应细胞的比例有关.单纯培养基培养的正常人外周血淋巴细胞也有一定的抑制活性.刀豆蛋白A诱导的正常人和中期癌病人外周血抑制性细胞的活性并无明显差异.

With the combination effect of heat shock and concanavalin A stimulation on human T lymphocytes,an in vitro model system was established for studying the mechanism of natural immune response to infection accompanied with fever.T cells were known to synthesize many proteins of importance in cell growth and proliferation during con A activation.When further subjected to heat shock,some of the proteins were synthesized synergetically while the others were under depression in these cells.In view of the facts that...

With the combination effect of heat shock and concanavalin A stimulation on human T lymphocytes,an in vitro model system was established for studying the mechanism of natural immune response to infection accompanied with fever.T cells were known to synthesize many proteins of importance in cell growth and proliferation during con A activation.When further subjected to heat shock,some of the proteins were synthesized synergetically while the others were under depression in these cells.In view of the facts that the synthesis of proteins with noticeable cellular function,such as actin.was less affected and the higher potential of inducing heat shock proteins (HSP) in con A activated T cells as compared with resting T cells,we suggested that con A activated cells were more resistant to elevated temperature.This notion may be of significance in both the understanding of the regulation of immune response and the application of hyperthermia treatment in the clinic.

为模拟天然免疫条件下,病毒等抗原对T淋巴细胞激活同时伴有体温升高的环境,我们建立了人外周血T淋巴细胞体外激活和热休克的模型。热休克对ConA激活细胞中多肽的合成既有协同也有抑制作用。ConA激活细胞受热休克的影响较静止细胞小,而其热休克蛋白(HSP)的诱导合成则较强,为了解HSP在淋巴细胞中的作用提供了线索。

A study on the interactions of NK cellwith targets was carried out.Effector cellswere obtained from normal CBA spleens orfrom the spleens of mice injected i.p.withpoly I:C 18—24 hr before harvesting.Tumortargets were of YAC-1,AV,1 C 2,R.1.1,R.1.X and were treated with 4℃,52℃,sonication,radiation,monosaccharides,pro-teasa,and/or cycloheximide.NK cell-nediat-ed cytolysis against these targets were calcu-lated by (51)~Cr-release assay,and comparedwith alloimmune cytotoxic T cell-mediatedlysis.Cold target...

A study on the interactions of NK cellwith targets was carried out.Effector cellswere obtained from normal CBA spleens orfrom the spleens of mice injected i.p.withpoly I:C 18—24 hr before harvesting.Tumortargets were of YAC-1,AV,1 C 2,R.1.1,R.1.X and were treated with 4℃,52℃,sonication,radiation,monosaccharides,pro-teasa,and/or cycloheximide.NK cell-nediat-ed cytolysis against these targets were calcu-lated by (51)~Cr-release assay,and comparedwith alloimmune cytotoxic T cell-mediatedlysis.Cold target inhibition assays werealso performed.A pair of lymphoma cell va-riants derived from L 5178 Y,AV (an NK-insusceptible variant) and 1 C 2 (an NK-sus-ceptible variant) were selected to analyse onfluorescence-activated cell sortor.The resultsndicated that NK cell lyse a wide range oftumor target cells,which are not restricted toH-2 antigen.An intact target cell structurewith metabolic activity may be necessary forNK cell-mediated lysis.Protease and cyclohe-ximide treatments could decrease NK cell ac- Fig 1.AV and 1 C 2 were labled withanti-Gg_3cer followed by fluorescei-nated goat anti-mouse immuniglo-bulins and analyzed on the fluo-rescence-activated cell sorter asdescribed in materials and methods.Abscissa,cell size as determinedby light scatter,and ordinate,fluo-rescence.tivity significantly (Table 6,8).The NK-susceptible target,1 C 2 was able to speciallybind with monoclonal anti-Gg 3 cer,butAV was not (Fig.1).The results men-tioned above gave evidences to suggest thatNK cell has its recognition sites,and the gly-coprotein and/or glycolipid at the cell sur-face might be involved in the recognition si-tes by NK cells.

本文对NK细胞与正常的,以及经低温、加热、超声、辐射、单糖、蛋白酶、和/或环己亚胺处理的靶细胞(AV、1C2、YAC-1、R.1.1,R.1.X)的相互作用进行了研究。并且与混合淋巴细胞培养产生的细胞毒作用进行了比较。试验并对来自L 5178 Y的一对变株AV(NK不敏感株)和1C2(NK敏感株)作了FACS分析。结果表明:NK细胞对多种瘤细胞均有杀伤作用,不受H-2限制,NK细胞介导的这一细胞毒作用可能需要一个完整的,有代谢活性的靶细胞结构。蛋白酶和环己亚胺处理能显著降低NK细胞的活性。FACS分析结果表明:1C2能特异地与抗Gg 3cer糖脂的单抗结合,而AV则不能。以上提示:NK细胞有它一定的识别作用。糖蛋白和/或糖脂可能是NK细胞所识别的靶的结构。

 
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