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     The w (Au)/ w (Ag) ratio, an important indicator for the evaluation of gold deposits, may provide us with some important information on the origin of the gold deposits.
     w(Au) /w(Ag)比值在金矿床评价方面是一个重要的标志 ,也可以提供金矿成因的重要信息 .
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     Conclusion:T3 and cortisol may be the index to decide prognosis of the asphyxiated newborns,Continual monitor endocrine change of the asphyxiated newborns may provide the evidence to decide prognosis,but also it may take the correct treatment promptly to reduce injury induced by stress.
     结论 T3和皮质醇可作为判断窒息新生儿预后的指标,持续监测窒息新生儿的内分泌变化可以提供判断预后的证据,还可及时采取相应正确的治疗措施以减少应激反应对机体的损害。
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     Conclusions TTE is a safe, non-invasive, practical and prompt diagnosis tool for PE, which may provide diagnostic, therapeutic and prognostic information.
     结论TTE是一种安全、无创、实用、快速的诊断工具,TTE可以提供PE的诊断线索,有助于临床决策、早期治疗; TTE可用以观察PE的治疗效果,PASP还可作为预后判断指标。
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     Conclusions The increase of HSP70 may provide cells with toxic tolerance or cyto protection within a narrow concentration range of benzene exposure.
     结论 HSP70的增加可以提供一定程度的毒物耐受能力或细胞保护功能。
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     The host system may provide different host software implementation to realize same host behavior.
     USB主机可以提供不同的软件系统实现方法 ,完成相同的主机行为。
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     GC and GC/MS analyses of F_1(H-heptane) of oil reveal the presence of n-alkance(C_(13)-C_(31)), isoprenoids and the series of long chain alkyl benzene. n-Alkanes are the main components of F_1(n-heptane), the odd-over-even predominance of n-alkanes was found. These compounds may provide useful geochemical information of Fushun bituminous coal.
     GC和GC/MS的分析结果表明,油段分中存在正构烷烃(C_(13)—C_(31))、类异戊二烯化合物及长链烷基苯系列,这些化合物可提供抚顺烟煤的地球化学信息。
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     Conclusion:The new technology application may provide the information of the coronary artery flow supplying the myocardium.
     结论:该项技术的应用可提供人心肌内冠脉血流供应信息。
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     Therefore, the immobile trace element records of the sediments of Core NS93 5 may provide evidences for the environmental changes of the terrestrial source areas in the continental crust.
     NS935钻孔沉积物的不活泼元素记录,可提供反映输入陆壳物源区的环境演变证据。
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     The systemic establish may provide a good Fieldbus experiment environment flat roof and advance the ability of using Fieldbus.
     该系统的建立可提供一个很好现场总线更深刻实验平台,并提高应用现场总线的能力。
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     Lumbar X-ray examination may provide a diagnostic clue,but myelogram or noninvasive spinal CT and MRI are very important in diagnosis.
     在诊断上腰椎X线平片可提供一定的线索,脊髓造影或无创伤性脊髓CT及MRI检查是本病的最主要手段。
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     [Conclusion] The serum β-HCG at 12-14 days after IVF-ET is an effective predictor for pregnancy outcome,which may provide a reference for clinical counseling and management.
     [结论]IVF-ET后12~14d血清β-HCG是早期预测妊娠结局的有效指标,可供正确指导咨询、及时处理参考。
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     Conclusion The accuracy of location and distribution of CD20 positive cells in the nuclei of B cells of early human embryo liver may provide an important clue for further exploration of the functional mechanism of CD20 in the process of B cell proliferation and differentiation.
     结论在人早期胚内,CD20定位于肝内的B细胞,并分布在细胞核内; 该研究结果为深入探讨CD20阳性细胞的功能和作用机制提供了重要线索。
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     The mechanism,which wasn't dependent on COX-2 expression,may provide the experimental evidence for nimesulide used for the prevention and treatment of the metastatic breast cancer.
     结论:nimesulide以剂量依赖性方式下调MDA-MB-231、MCF-7乳腺癌细胞株MMP-2、MMP-9mRNA的表达,而MDA-MB-231细胞对nimesulide更敏感,这种作用是COX-2非依赖性途径,为nimesulide用于转移乳腺癌的治疗与预防提供了实验依据。
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     Combined detection of the expression of CD44v6 and Ki-67 may provide some value to know the biological behavior of colorectal carcinoma and to estimate the prognosis of patients.
     结论大肠癌CD44v6、Ki-67表达与其发生发展和浸润转移密切相关,联合检测对了解大肠癌的生物学行为和判断患者预后有一定的实用价值。
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     Conclusion The pENTRTM/U6-p498 siRNA expression vector can specifically and efficiently inhibit 4-1BB gene expression,which may provide a foundation to construct 4-1BB Lentivirus and study 4-1BB gene function in mouse T lymphocytes.
     其余siRNA载体,几乎无干扰效应,与无关干扰组比较,差异无统计学意义(P>0.05)。 结论我们所构建的p498 siRNA真核表达载体,能明显干扰m4-1BB蛋白的瞬时表达,可望用于m4-1BB Lentivirus干扰表达系统的构建,进一步在小鼠原代T淋巴细胞内实现高效4-1BB表达沉默,以深入研究4-1BB对T淋巴细胞的生物学影响。
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Thus, PPARα/γ dual agonists may provide superior therapy to the current PPARγ-selective agonists, due to the additional lipid control afforded by the PPARα component.
      
The fundamental experimental outcome above may provide a new clue for red tide chemical forecast by inspecting the NO change.
      
This work may provide theoretical guidance for choosing solvents for these kinds of reactions and also may serve as basis for further industrialization.
      
Insight into these aspects may provide better understanding of the effects of high magnetic fields on diffusional phase transformations and is of both theoretical significance and technical interest.
      
The appearance and preserved forms of the macroalgal holdfasts may provide some data to the study of the living and buried environments of macrobiota.
      
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Using the histochemical and cytological method of Bromine-Iodine-Glacial acetic acid fluid, we have observed the location, time, and processes of rubber formation in the pericarp of Decaisnea farpesii and the ontogenetic changes of the epidermal cells in these processes of the same plant. The following results are presented: 1. The formation of rubber is limited in the protoplasm of the secretory epider- mis of pericarp. Generally, about ten days after blooming and fertilization, the rubber granules begin to...

Using the histochemical and cytological method of Bromine-Iodine-Glacial acetic acid fluid, we have observed the location, time, and processes of rubber formation in the pericarp of Decaisnea farpesii and the ontogenetic changes of the epidermal cells in these processes of the same plant. The following results are presented: 1. The formation of rubber is limited in the protoplasm of the secretory epider- mis of pericarp. Generally, about ten days after blooming and fertilization, the rubber granules begin to appear in the epidermal cells which are located in the depressions of the young pericarps. And then, following the formation and development of the secretory epidermis, the rubber granules increase progressively and stop till 60 days old. when the secretory epidermis lyses into laticiferous canals, the formation of rubber granules disappears. The rubber is stored up within the laticiferous canals. 2. During the course of fruiting, the epidermal cells of the carpel wall dif- ferentiate into the pericarpial epidermis and the secretory epidermis. To adapt it- self to its peculiar functions, each part forms its own particular feature, which is prominently different from the other. The cells of the secretory epidermis including dense protoplasm, enlarge rapidly, and retain their vigorotis activity. During this period, they form rubber granules successively. Finaly when these cells are full of granules, they lose their vital functions and lyse into laticiferous canals. 3. The limitation of distribution and formation period of the rubber in Decaisnea fargesii is closely correlated with the ontogenetic processes of its secretory epidermis. This characteristics has never been observed in other rubber plants. Decaisnea fargesii may provide a satisfactory material for the study of the mechanism of rubber biosynthesis. We hope that the present observation will provide some useful information for the improvement of rubber yield in this plant.

通过溴-碘-冰醋酸变性试剂的组织化学方法和细胞学方法的研究,观察到猫儿屎的橡胶是局限在果皮的分泌表皮细胞的原生质中形成的。通常在开花、受精后10天左右,开始出现橡胶颗粒,直到分泌表皮溶生为乳汁道时才逐渐停止。此种分泌表皮不同于果实的外表皮,其细胞体积迅速扩大,原生质浓厚,长期保持活跃的活动能力,最后,由于细胞被橡胶颗粒所充满,失去生活能力,溶生为乳汁道。猫儿屎的橡胶在分布上和形成时间上的局限性是和分泌表皮的形成方式密切相关的。此种特点,为掌握橡胶的生物合成机理提供了较好的研究材料,并为今后提高该植物的橡胶产量提供了参考资料。

Adventitious buds derived from the hypocotyl and cotyledon in the early and young embryos in six strain's of apple and in one strain of pear have been successfully induced. These buds developed in a cluster. In our experiment MS medium was used as the basic medium and was supplemented with 1-3 ppm BAP and 0-5 ppm NAA. But in our further experiments similar results were obtained with the above mentioned medium devoid of the growth substance. In the medium of potato juice with the addition of 0.5 ppm IBA the in...

Adventitious buds derived from the hypocotyl and cotyledon in the early and young embryos in six strain's of apple and in one strain of pear have been successfully induced. These buds developed in a cluster. In our experiment MS medium was used as the basic medium and was supplemented with 1-3 ppm BAP and 0-5 ppm NAA. But in our further experiments similar results were obtained with the above mentioned medium devoid of the growth substance. In the medium of potato juice with the addition of 0.5 ppm IBA the in vitro induced shoots derived from the hypocotyl and from the base of the cotyledon of the young embryos formed roots and eventually developed into the whole plantlets. This result may provide a practical method for overcoming the sterility at the young embryo stage as commonly occured in cross breeding of the pomological and the cereal plants and for the asexual multiplication of the clones of these cultivated plants.

由6个苹果品种和1个梨品种的幼胚下胚轴及子叶基部直接诱导出不定芽。不定芽的发生是成从的。实验使用MS作基础培养基,其中附加细胞分裂素和生长素的浓度为BAP 1—3ppm,NAA 0.5ppm。但是,我们在进一步实验中表明,在上述培养基中除去了生长素亦得到同样结果。在含有0.5ppm IBA的土豆培养基上,离体诱导下胚轴及子叶基部处在发育中的不定芽生根,成长为完整植株。这一结果为克服果树及农作物杂交育种中常见的幼胚不育和扩大繁殖优良品种的无性系植株,提供一个可能的实用方法。

In connection with the study of the mechanism of carcinogenesis,we have underta-ken an investigation on the relative changes in activities of the proliferating enzymesuch as aspartate carbamyl transferase(ACT)and the tissue-specific enzymes such asornithine carbamyl transferase(OCT)and carbamyl phosphate synthetase(CPS_1)in amodel system of hepatocarcinogenesis of rats induced by diethylnitrosamine(DENA).Similar observations have also been made during development of rat liver.(1)Based on the pathological study...

In connection with the study of the mechanism of carcinogenesis,we have underta-ken an investigation on the relative changes in activities of the proliferating enzymesuch as aspartate carbamyl transferase(ACT)and the tissue-specific enzymes such asornithine carbamyl transferase(OCT)and carbamyl phosphate synthetase(CPS_1)in amodel system of hepatocarcinogenesis of rats induced by diethylnitrosamine(DENA).Similar observations have also been made during development of rat liver.(1)Based on the pathological study and enzymatic changes of liver in the presentexperiment,the process of carcinogenesis may be tentatively divided into three stages:(1)stage of simple hyperplasia—the early 6 weeks of DENA feeding.Changes in therelative ratio of ACT,OCT,and CPS_1 activities in this stage are reversible,similar tothose observed in the regenerating liver.(2)stage of malignant transformation—fromthe 6th to the 16th week of feeding the carcinogen.In this stage there appears anaplastichyperplasia of liver cells characterized by an irreversible change of the relative ratioof enzyme activities and (3)stage of the development of hepatocellular carcinoma—fromthe 16th to the 30th week of carcinogenesis.(2)During carcinogenesis of rat liver(after the 6th week of feeding DENA),activities of OCT and CPS_1 decreased while those of ACT increased gradually till theformation of cancer.In hepatocellular carcinoma the activities of OCT and CPS_1 areabout 10~20% of the normal liver,while those of ACT being about 2~3 times higher than the normal liver.The pattern of relative changes in activities of both groups ofenzyme during carcinogenesis was found to be the reverse of those observed in thedevelopment of rat liver.(3)The above enzymes in hepatocellular carcinoma and normal liver are probablyidentical entities,as shown by the similarities of pH optima and distribution patternsof enzyme activity in polyacrylamide gel electrophoresis.Similar K_m values anddifferent V_m values of OCT and ACT in hepatocellular carcinoma and normal liverpreparations suggested that changes in enzyme activities during carcinogenesis maypossibly be the result of an alteration in the amount of enzyme proteins.Furthermore,the specific activities of OCT and CPS_1 in the mitochondria of hepatocellular carcinomahave been found to be much lower than those of normal liver,although the proteincontent in the mitochondria of hepatocellular carcinoma decreased to an extent of about40% of that of normal liver.(4)The possible correlation between cell proliferation and differentiation to themechanism of carcinogenesis is discussed.As seen from Fig.3,the process of carcinogenesisseems to be a reversal of that of normal differentiation(development).Changes in enzymeactivities during carcinogenesis may be explained as a result of repression andderepression of the tissue-specific operons and mitotic operons,which are closelylinked and mutually repressed.It appears likely that cell proliferation may provide afundamental condition for the malignant transformation of the hepatocytes,while lossor decrease in the activities of tissue-specific function may be of primary importance tothe initiation of carcinogenesis.It is thus concluded that carcinogenesis would be dueto a random impairment of the control mechanism for gene activities of certain tissue-specific operons,leading to irreversible changes in nucleic acid biosynthesis and intissue-specific metabolism and their key enzyme activities which in turn give rise to anirreversible disturbance of the normal balance between cell proliferation and tissue-specific function,resulting in an abnormal growth and finally the formation of cancer.

本实验以二乙基亚硝胺诱发大鼠肝癌为动物模型,结合病理形态学研究了细胞增殖与组织特异代谢关键性酶ACT 及OCT,CPS_1活性的相互改变及其与癌变的关系,同时作了鼠肝发育过程中酶活性变化的比较研究。(1)根据DENA 引癌过程中酶活性CPS_Ⅰ/ACT,OCT/ACT 及ACT/CPS_Ⅰ,ACT/OCT 相对比值的变化,以及病理形态观察结果,DENA 引癌过程大致可分为三个阶段:喂DENA6周以内为单纯性增生期。此时期酶活性相对比值的改变是可逆的,与再生肝相似。第6周以后至16周为癌变期。此时期出现肝细胞异型性增生及癌变病灶。酶活性相对比值的改变是不可逆的。16周到30周为癌变细胞发展成为肝细胞癌期。(2)癌变过程中(喂DENA6周以后),OCT 及CPS_Ⅰ活性持续降低,同时ACT 活性持续增高。肝癌结节中OCT 及CPS_Ⅰ活性约为正常肝的10~20%,ACT 活性约为正常肝的2倍。癌变过程中这两类酶活性的相互改变与发育过程中的情况正好相反。在发育过程中,胚胎肝内OCT 及GPS_Ⅰ活性较成年水平低,而ACT 活性则较高。新生后CPS_Ⅰ及OCT 活性升高,同时ACT 活性降低。(3)肝与肝癌上述酶可能...

本实验以二乙基亚硝胺诱发大鼠肝癌为动物模型,结合病理形态学研究了细胞增殖与组织特异代谢关键性酶ACT 及OCT,CPS_1活性的相互改变及其与癌变的关系,同时作了鼠肝发育过程中酶活性变化的比较研究。(1)根据DENA 引癌过程中酶活性CPS_Ⅰ/ACT,OCT/ACT 及ACT/CPS_Ⅰ,ACT/OCT 相对比值的变化,以及病理形态观察结果,DENA 引癌过程大致可分为三个阶段:喂DENA6周以内为单纯性增生期。此时期酶活性相对比值的改变是可逆的,与再生肝相似。第6周以后至16周为癌变期。此时期出现肝细胞异型性增生及癌变病灶。酶活性相对比值的改变是不可逆的。16周到30周为癌变细胞发展成为肝细胞癌期。(2)癌变过程中(喂DENA6周以后),OCT 及CPS_Ⅰ活性持续降低,同时ACT 活性持续增高。肝癌结节中OCT 及CPS_Ⅰ活性约为正常肝的10~20%,ACT 活性约为正常肝的2倍。癌变过程中这两类酶活性的相互改变与发育过程中的情况正好相反。在发育过程中,胚胎肝内OCT 及GPS_Ⅰ活性较成年水平低,而ACT 活性则较高。新生后CPS_Ⅰ及OCT 活性升高,同时ACT 活性降低。(3)肝与肝癌上述酶可能是相同的。因为酶活性的最适pH 和在聚丙烯酰胺凝胶电泳图上的分布都是一致的。肝与肝癌OCT 及ACT 的K_m 相同而V_m 不同,说明癌变过程中酶活性的变化,主要是由于酶蛋白量的改变。此外,肝癌线粒体的蛋白量减少,但OCT 及CPS_Ⅰ的比活性(单位/毫克线粒体蛋白)仍较正常肝线粒体的低。(4)讨论了增生和分化与癌变的关系。初步认为,肝细胞的癌变是反分化(分化逆转)问题,和正常分化一样系由于基因表现的改变,不一定包含基因结构的改变。就与癌变有关的细胞增殖和分化的矛盾而言,细胞增殖及其有关酶活性的增高,可能是癌变发生的基础,而组织特异功能及其关键性酶活性的降低,可能与癌变的关系更为密切。因此癌变的发生,可能是由于在细胞分裂过程中致癌物使肝细胞特异功能基因的调节控制失常,从而引起增生代谢与特异代谢关键性酶活性不可逆的改变,使之失去肝细胞增殖与特异功能的正常平衡,而代之以不受控制的增生,最后形成癌细胞。

 
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