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potency of
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  效价
    Different concentration of m-Nis(1×10-5,1×10-6,1×10-8,1×10-10 mol·L-1) could antagonize the contractile responses of isolated rabbit coronary artery branch induced by ET-1 and reduce both efficacy and potency of ET-1.CONCLUSION m-Nis antagonizes the contraction responses of rabbit coronary artery smooth muscle induced by KCl and ET-1.
    不同浓度的m-Nis(1×10-5、1×10-6、1×10-8、1×10-10mol.L-1)均可以抑制ET-1引起的离体家兔冠状动脉分支收缩; m-Nis使ET-1收缩冠状动脉的效能和效价均降低,随着剂量的增大,抑制作用增强。
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    The effects of Bingxing capsules on NK cells activity and potency of interferon in experimental Cosackie B3 viral myocarditis
    病心胶囊对实验性柯萨奇B_3病毒性心肌炎NK细胞活性和干扰素效价的影响
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    Results: Potency of the gentamicin irradiated to 37.5 kGy and treated by the physical management did not change.
    结果:37.5kGy电子束和物理处理对庆大霉素的效价无影响;
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    sovcaine, 22. (3) Sciatic nerve block test in mice: the potency of procaine, 1;
    沙夫卡因,22。 (3)小白鼠坐骨神經传导阻滞試驗:如以普魯卡因的效价为1;
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    sovcaine, 39. (4) Spinal anaesthesia in winter toad: the potency of procaine, 1;
    沙夫卡因,39.(4)蟾蜍脊髓麻醉:普魯卡因的效价为1;
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  效价为
    sovcaine, 22. (3) Sciatic nerve block test in mice: the potency of procaine, 1;
    沙夫卡因,22。 (3)小白鼠坐骨神經传导阻滞試驗:如以普魯卡因的效价为1;
短句来源
    sovcaine, 39. (4) Spinal anaesthesia in winter toad: the potency of procaine, 1;
    沙夫卡因,39.(4)蟾蜍脊髓麻醉:普魯卡因的效价为1;
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    (2) Intracutaneous-wheal test in guinea pigs (Bülbring and Wajda's method):the potency of procaine,1;
    (2)豚鼠皮內丘样試驗:普魯卡因的效价为1;
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    The result showed that the SD, CV and mean potency of the reference were 0. 1579,14.1 % and 11000U/ampoule respectively. All the other items meet the requirements for national standard.
    SD=0.1579.CV=14.1%,平均效价 为l1000U/支,其他项目均达到国家标准品要求。
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    The results showed that mean immunological potency of T 4 working standard to present kit standard is 946 ng per ampoule with confident limit of 915-976 ng at 95% probability level.
    以T4药盒标准品为对照品 ,工作标准品平均免疫效价为 94 6ng/安瓿 ,95 %概率水平的可信限为 915 - 976ng/安瓿。
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    Study of the Difference in Anti-proliferative Potency of a New Thymidylate Synthase Inhibitor Nolatrexed and Its Mechanism
    新型胸苷酸合成酶抑制剂洛拉曲克抗增殖作用的差异及其机理的研究
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    Application and comparison of three methods in evaluating the potency of psychic dependence
    三种精神依赖性评价方法的比较及应用
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    Studies on synthesis, secondary structure and hypocalcemic potency of salmon calcitonin analogue [Glu 31 ,Pro 32 N(C 2H 5) 2]sCT
    鲑降钙素类似物[Glu~(31),Pr~o(32)-N(C_2H_5)_2]sCT的合成、二级结构及活性研究
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    Determination of anesthetic potency of propofol
    异丙酚的麻醉强度测定
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    Development of A Method for Determination of Potency of Heat Shock Protein 65-MUC1 Antigen Peptide Fusion Protein
    热休克蛋白65-MUC1抗原肽融合蛋白效力测定方法的建立
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  potency of
The data obtained in the in vitro models clearly establish the antioxidant potency of the polysaccharides extracted from Lyceum barbarum fruits.
      
The ADM can be used as an accessory marker in estimating the malignant potency of LE and judging the prognosis of LES, and as a novel molecular target of anti-angiogenic and anticarcinogenic strategies.
      
There was no correlation between potency of MAO inhibition and activation of human platelet soluble guanylate cyclase.
      
The phagocytic potency of macrophages isolated from blood of breast cancer patients was lower than engulfment ability of macrophages obtained from healthy donors and depended on tumor degree.
      
The potency of the oligosaccharides SiaLex, SiaLea, HSO3Lex, and HSO3Lea, their conjugates with polyacrylamide (PAA, 40 kD), and other monomeric and polymeric selectin inhibitors has been compared with that of the polysaccharide fucoidan.
      
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The "Compound Mixture of Two Fairies" has been used clinically for treatment of hypertension. It is composed of Curculigo ensifolio, Epimedium, sp., Morinda officinalis, Phellodendron chinense, Anemarrhena asphodeloides, and Angelica sinensis. In normal dogs, intragastric administrations of 6g (crude drugs) per kg t.i.d, for 20 days produced no toxic reactions: If the dosage was increased 3—4 times, emesis and diarrhea occurred, probably due to alimentary disorder from the bulk of the decoction. When the Compound...

The "Compound Mixture of Two Fairies" has been used clinically for treatment of hypertension. It is composed of Curculigo ensifolio, Epimedium, sp., Morinda officinalis, Phellodendron chinense, Anemarrhena asphodeloides, and Angelica sinensis. In normal dogs, intragastric administrations of 6g (crude drugs) per kg t.i.d, for 20 days produced no toxic reactions: If the dosage was increased 3—4 times, emesis and diarrhea occurred, probably due to alimentary disorder from the bulk of the decoction. When the Compound Mixture was introduced 6. g/kg into the lumen of duodenum in anesthetized cats, the blood pressure began to descend at 30 minutes, and lowered an average of 30% below the original level in 2 hours. Four Goldblatt renal hypertensive dogs were given the Compound Mixture by stomach tube. The dose for the first 10 days Was 9 g/kg/day, and doubled for the next, 10 days. The post-medication observation period was another 10 days. Blood pressure was measured daily by auscultation on the carotid loop. The average reduction of the diastolic pressure in the space of 30 days was 10 mm Hg (8%), and that for the lowest 5 days running was 16 mm Hg (12%). A therapeutic action (a reduction of at least 11 mm Hg diastolic) was demonstrated in 3 dogs. Among them 2 dogs received a second course of treatment which appeared to be equally efficacious. Intraperitoneal injections of the Compound Mixture 6 g/kg to anesthetized dogs resulted in a decrease of cardiac output during the hypotension, while the dilatation of peripheral vessels was insignificant. Comparative experiments on the 6 ingredients revealed that the hypotensive action of "Compound Mixture of Two Fairies" could be primarily attributed to Phellodendron chinense and Epimedium sp., whereas Curculigo ensifolio alone had little effect. Eight hypertensive dogs were fed daily the Compound Mixture or a mixture of 6 decoctions of the components. Analysis of variance disclosed that the hypotensive potency of the former was no better than the latter. Hypertensive dogs were fed the Compound Mixture which was devoid of Morinda officinalis, and the therapeutic potency was shown to be no less than that of "Compound Mixture of Two Fairies". Hence, we deem that Morinda officinalis is dispensable.

复方“二仙合剂”由仙茅、淫羊藿、巴戟天、黃蘗、知母及当归組成,所用药液均为水煎剂。正常狗每日灌胃給二仙合剂18克/公斤,連服20天,无毒性反应。增加剂量3—4倍,則有嘔吐泄泻,可能由于药液容量过大,影响消化道的机能。麻醉猫十二指腸注射二仙合剂6克/公斤,30分钟后血压开始下降,2小时后平均降低原水平的30%。慢性腎型高血压狗斗只,每日灌胃給二仙合剂2次,第1—10天剂量为9克/公斤/天,第11—20天剂量为18克/公斤/天,停药10天。舒张压“30天平均降压值”平均为10毫米汞柱(8%),“最低5天降压值”平均为16毫米汞柱(12%)。4狗中3狗呈現疗效(舒张压下降11毫米汞柱或以上),其中2狗重复一次試驗依然降压有效。麻醉狗腹腔注射二仙合剂6克/公斤,在急性降压时有心脏指数的减少,而外周血管的扩张并不明显。单味药的比較試驗証明黃蘗和淫羊藿为二仙合剂降压作用的主要有效成分,而仙茅几无降压效能。高血压狗8只,每天服二仙合剂或分煎合剂,变异数分析証明分煎合剂的降压效果不亚于二仙合剂。高血压狗灌胃試驗二仙減巴合剂,降压效果并不較二仙合剂为弱,所以我們建議复方二仙合剂中可減省巴戟天。

The sedative-tranquilizing actions of corydalis L and J were investigated in comparison with corydalis B. Their antielectroshock and analgesic actions were also examined. Both corydalis L and B could potentiate the hypnotic action produced by subthreshold doses of sodium pentobarbital, and their ED_(50) were 60 and 30 mg/kg respectively. After these respective doses the sleeping times were 27±4 (m±s.e.) and 35±6 minutes. In mice, corydalis L and B exerted an inhibitory action on the orientational hypermotility...

The sedative-tranquilizing actions of corydalis L and J were investigated in comparison with corydalis B. Their antielectroshock and analgesic actions were also examined. Both corydalis L and B could potentiate the hypnotic action produced by subthreshold doses of sodium pentobarbital, and their ED_(50) were 60 and 30 mg/kg respectively. After these respective doses the sleeping times were 27±4 (m±s.e.) and 35±6 minutes. In mice, corydalis L and B exerted an inhibitory action on the orientational hypermotility during hunger, and their ED_(50) were 29 and 22 mg/kg respectively. Both antagonized the action of mescaline, the ED_(50) for corydalis L was 53 mg/kg and for corydalis B 35 mg/kg. Corydalis L in large doses diminished the toxicity of amphetamine, but its action was weaker than corydalis B. It may be concluded from these results that the sedative-tranquilizing potency of corydalis L is weaker than that of corydalis B. The analgesic and sedative-tranquilizing effects of corydalis J were very poor Neither corydalis J nor corydalis L had any anti-electroshock action.

本文报告了延胡索丑素和癸素的鎮靜鎮定作用,并与乙素作了比較,对它們的抗电休克和鎮痛作用也进行了試驗。获得的結果如下: (一)丑素与乙素都能加強戊巴比妥鈉20毫克/公斤阈下睡眠作用,它們使半数小白鼠入睡的有效剂量(ED_(50)),各为60和30毫克/公斤。用該剂量产生的睡眠时間各为27±4分和35±6分。丑素与乙素对小白鼠自发活动有抑制作用,其ED_(50)各为29和22毫克/公斤。它們还能对抗墨西卡林的作用,ED_(50)各为53与35毫克/公斤。丑素大剂量时也能对抗苯丙胺的毒性,但作用不及乙素明显,所以丑素的鎮靜鎮定作用不及乙素強。 (二)癸素的鎮靜鎮定作用和鎮痛效能均很弱。 (三)丑素和癸素无抗电休克作用。

The adrenocortical hormone activities of △~6-6-methyl cortisone acetate (△~6), synthesized by the Institute of Organic Chemisty of the Academia Sinica, are studied and compared with those of cortisone. When adrenalectomized rats, weighing 100—200grams were injected subcutaneously with a dose of 1 mg of △~6 once daily for 4 days, the developments of granuloma on subcutaneous implantation of cotton pellets and of egg-white-induced oedema of the hind paws were inhibited markedly. Involution of the thymus of these...

The adrenocortical hormone activities of △~6-6-methyl cortisone acetate (△~6), synthesized by the Institute of Organic Chemisty of the Academia Sinica, are studied and compared with those of cortisone. When adrenalectomized rats, weighing 100—200grams were injected subcutaneously with a dose of 1 mg of △~6 once daily for 4 days, the developments of granuloma on subcutaneous implantation of cotton pellets and of egg-white-induced oedema of the hind paws were inhibited markedly. Involution of the thymus of these rats was also noted. The potency of △~6 in these respects was similar to that of cortisone. In adrenalectomized rats and mice, the liver glycogen deposition activity of △~6 was 4—5 times as potent as cortisone. When rats were pre-treated with △~6 at a dosage of 0.75 mg/rat, the emotional stress activated secretion of pituitary ACTH was markedly inhibited. With respect to water and electrolyte regulation, △~6 differs from cortisone and deoxycorticosterone in that, in stead of possessing water and sodium retaining actions, it induces diuresis in adrenalectomized rats. From these findings it would appear, therefore, that the adrenocortical hormone activities of △~6 resemble those of 6α-methyl prednisolone, triamcinolone, and dexamethasone.

△~6-6-甲基皮质酮乙酸酯为我国化学家合成的一种皮质激素同型物,我们研究了其肾上腺皮质激素样作用。结果表明,此同型物对大鼠棉球肉芽肿和后足炎性水肿及胸腺组织的抑制作用与同剂量皮质酮大致相似;其肝糖原堆积作用约为皮质酮的4—5倍,对垂体ACTH条件反射性分泌的抑制作用亦较皮质酮强;对水盐代谢的影响则与皮质酮及脱氧皮质甾酮不同,不但不引起水分和钠储留,反而有明显利尿作用。

 
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