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radial arm maze
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  八臂迷宫
     IVHA at a dose of 0. 2 mg . kg-1 ip significantly reversed scopolamine-induced working memory and reference memory impairments in radial arm maze.
     ip给与IVHA0.2 mg·kg~(-1)翻转东莨菪碱导致的八臂迷宫记忆障碍.
短句来源
  “radial arm maze”译为未确定词的双语例句
     Radial arm maze and sensorimotor functional tests were administered from 30 to 35 postnatal days.
     至 30日龄开始对各组动物进行放射形迷宫测试以及感觉运动功能检测。
短句来源
     Methods Step-down test was performed to observe the mice learning and memory abilities impaired by scopolamine and sodium nitrite,and radial arm maze task was used to study the learning and memory ability of rats impaired by(+)MK-801.Results EXB,BS and ST-n-2 can markedly improve memory acquisition impairment induced by scopolamine and memory consolidation impairment induced by sodium nitrite.
     方法采用跳台法观察东莨菪碱和亚硝酸钠所致学习记忆障碍小鼠的学习记忆能力,八臂放射状迷路法观察(+)-MK-801致学习记忆障碍大鼠的学习记忆能力。 结果文冠果果壳乙醇提取物、总皂苷及ST-n-2均显著改善东莨菪碱所致的记忆获得障碍和亚硝酸钠所致的记忆巩固障碍,文冠果果壳乙醇提取物显著改善(+)-MK-801所致的工作记忆和参照记忆障碍。
短句来源
     Methods The radial arm maze task and the object recognition test were used.
     方法采用八方向放射状迷路及新物体辨别实验方法。
短句来源
  相似匹配句对
     Applied anatomy of radial nerve in arm
     桡神经在臂部的应用解剖
短句来源
     Unspecific Radial Nerve Compression in Upper Arm
     不明原因的上臂桡神经卡压
短句来源
     Radial Bogis
     径向转向架
短句来源
     Methods The radial arm maze task and the object recognition test were used.
     方法采用八方向放射状迷路及新物体辨别实验方法。
短句来源
     METHODS: Eight-arm radial maze performance was used to measure spatial memory in rats.
     方法:采用八臂迷宫学习的程序研究大鼠的空间记忆。
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  radial arm maze
Lurcher mutants were impaired in the object localization and radial arm maze tasks but not in the left-right discrimination task.
      
The Effects of the Lurcher Mutation on Object Localization, T-Maze Discrimination, and Radial Arm Maze Tasks
      
Castration may have affected performance in the radial arm maze and not in the water maze because the radial arm maze was a more difficult task or because the water maze was aversively motivated while the radial arm maze was appetitively motivated.
      
In the radial arm maze, castrates committed significantly more working memory errors and significantly fewer reference memory errors than did shams.
      
The spatial memory of eight castrated and eight sham-castrated adult male rats was compared using a working-reference memory version of the eight-arm radial arm maze followed by a reference memory version of the Morris water maze.
      
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AIM:To study the effects of isovanihuper-zine A (IVHA) on cholinesterase and scopo-lamine-induced memory deficit. METHODS: AChE and BuChE activities were determined by the colorimetric method of Ellman. The K, value was determined by the plotting method of Lineweaver and Burk. In a behavioral test, fats were trained to perform a radial arm maze task using a partially baited procedure. RESULTS: The anti-AChE activity of IVHA was comparable to huperzine A (Hup-A) , and was more potent than those of physostigmine...

AIM:To study the effects of isovanihuper-zine A (IVHA) on cholinesterase and scopo-lamine-induced memory deficit. METHODS: AChE and BuChE activities were determined by the colorimetric method of Ellman. The K, value was determined by the plotting method of Lineweaver and Burk. In a behavioral test, fats were trained to perform a radial arm maze task using a partially baited procedure. RESULTS: The anti-AChE activity of IVHA was comparable to huperzine A (Hup-A) , and was more potent than those of physostigmine and galanthamine with an IC50 value of 0. 11 umol.L-1.IVHA was a mixed competitive type with a Ki value of 32 nmol .L-1. It bound to AChE in a reversible manner. IVHA at a dose of 0. 2 mg .kg-1 ip significantly reversed scopolamine-induced working memory and reference memory impairments in radial arm maze. CONCLUSION: IVHA is a new potential reversible AChE inhibitor and merits further study as a cognitive enhancer.

目的:研究石杉碱类似物异香兰石杉碱甲(IVHA)对胆碱酯酶的抑制作用和东莨菪碱导致的记忆障碍的影响.方法:乙酰胆碱酯酶和丁酰胆碱酯酶活力用Ellman比色法测定.抑制常数K_i值抑制机制用Lineweaver和Burk的双倒数作图法测定.行为测试用八臂迷宫装置.结果:IVHA的抗AChE作用稍弱于Hup-A.它对红细胞膜AChE的IC_(50)为0.11 μmol·L~(-1).作用强于Phys和Gal.属混合型抑制剂,K_i值为32 nmol·L~(-1).不同于异氟磷,与AChE为可逆性结合.ip给与IVHA0.2 mg·kg~(-1)翻转东莨菪碱导致的八臂迷宫记忆障碍.结论:IVHA是一个新的强效可逆胆减酯酶抑制剂,值得进一步研究.

AIM: To study the effects of huperzine A on nucleus basalis magnocellularis (NBM) lesion induced spatial working memory impairment. METHODS: A delayed non match to sample radial arm maze task was used to study spatial working memory. The choline acetyltransferase (ChAT) activity was determined by the conversion of acetyl CoA to ACh . RESULTS: Unilateral NBM lesion by kainic acid 0 02 μmol impaired rats ability to perform this working memory task as evidenced by fewer correct choices after different...

AIM: To study the effects of huperzine A on nucleus basalis magnocellularis (NBM) lesion induced spatial working memory impairment. METHODS: A delayed non match to sample radial arm maze task was used to study spatial working memory. The choline acetyltransferase (ChAT) activity was determined by the conversion of acetyl CoA to ACh . RESULTS: Unilateral NBM lesion by kainic acid 0 02 μmol impaired rats ability to perform this working memory task as evidenced by fewer correct choices after different delay intervals and more total errors to complete the task. This behavioral impairment associated with a decrease in the activity of ChAT by about 40 % in the ipsilateral cerebral cortex. Huperzine A (0 2 mg·kg -1 ip 30 min before testing) ameliorated this spatial working memory impairment. Physostigmine (0 2-0 3 mg·kg -1 ip 20 min before testing) also attenuated the NBM lesion induced memory deficit. CONCLUSION: The integrity of NBM is critical for spatial working memory processing, and this working memory impairment induced by NBM lesion can be ameliorated by huperzine A and physostigmine.

目的:研究石杉碱甲对基底核大细胞部(NBM)损毁诱导的工作记忆障碍的影响.方法:采用八臂迷宫延迟插板的程序研究空间记忆.胆碱乙酰转移酶(ChAT)活力测定采用[3H]乙酰辅酶A转变成[3H]乙酰胆碱的方法.结果:单侧损毁NBM(卡因酸002μmol)导致空间记忆障碍.在不同的延迟间隔,大鼠完成程序产生的正确数减少和错误数增多.损毁侧大脑皮层ChAT酶的含量下降了大约40%.石杉碱甲(02mg·kg-1实验前30minip)改善这种空间记忆障碍.毒扁豆碱(02-03mg·kg-1实验前20minip)也有改善作用.结论:完整的NBM是空间记忆形成的关键.石杉碱甲有效的改善NBM损毁导致的空间记忆障碍.

Objective To investigate the protective effects of hyperbaric oxygen (HBO) against hypoxic ischemic brain damage (HIBD) of neonatal rats. Methods Seven-day-old Sprague-Dawley (SD) rat pups were randomly divided into 4 groups (n=10 each): Control group, HIBD group, Hyperbaric air (HBA) group, and Hyperbaric oxygen (HBO) group. The HIBD model was produced by permanent occlusion of left common carotid artery and followed by exposure to a mixture of 8% oxygen and 92% nitrogen for 2 hrs (at 37℃). HBO and HBA treatments...

Objective To investigate the protective effects of hyperbaric oxygen (HBO) against hypoxic ischemic brain damage (HIBD) of neonatal rats. Methods Seven-day-old Sprague-Dawley (SD) rat pups were randomly divided into 4 groups (n=10 each): Control group, HIBD group, Hyperbaric air (HBA) group, and Hyperbaric oxygen (HBO) group. The HIBD model was produced by permanent occlusion of left common carotid artery and followed by exposure to a mixture of 8% oxygen and 92% nitrogen for 2 hrs (at 37℃). HBO and HBA treatments [2 atmosphere absolute (ATA) for 1 hr] were administered once daily to rats in the HBO and HBA group respectively after hypoxia for 7 days. Radial arm maze and sensorimotor functional tests were administered from 30 to 35 postnatal days. At the end of the behavior trials, the rats were sacrificed and cerebral histology was analyzed. The CA 1 subfield neurons numbers were counted to evaluate the brain damage. Results In the behavior test, the HIBD group showed different degrees of neurological damage. HBO treatment resulted in significant protection against hypoxia-ischemia induced behavior impairments (all P< 0.01). However, the HBA group did not show any significant improvement. There was a significant reduction of CA 1 neuron density in the left hemisphere of HIBD and HBA groups, compared with that of the Control group and the HBO group (all P< 0.01). Conclusion HBO therapy can attenuate brain damage and improve learning, memory and sensorimotor functions in neonatal rats after HIBD.

目的 探讨高压氧 (HBO)治疗对新生大鼠缺氧缺血性脑损伤 (HIBD)的保护作用。方法  7日龄Sprague Dawley(SD)新生大鼠随机分为 4组 (n =10 ) :正常对照组 ,HIBD组 ,高压空气治疗组 (HBA)和高压氧治疗组 (HBO)。HBA组和HBO组于缺氧缺血后分别行HBA和HBO治疗 [2个绝对压 (ATA) ,1h],每日 1次连续 7d。至 30日龄开始对各组动物进行放射形迷宫测试以及感觉运动功能检测。行为学试验验结束后 (日龄 35天 ) ,采用尼氏染色检测海马CA1区锥体细胞密度。结果 HIBD组大鼠的学习、记忆和感觉运动功能受损严重 ,HBO组行为学损伤明显改善 ,而HBA组改善不明显。HIBD组和HBA组左脑CA1区锥体细胞密度低于HBO和对照组(P <0 .0 1)。结论 HBO治疗能够减少新生大鼠缺氧缺血后脑损伤 ,促进学习记忆功能和感觉运动功能的改善。

 
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