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-arm radial maze
相关语句
  八臂迷宫
     Effect of H_1 antagonists on spatial memory deficit evaluated by 8-arm radial maze in rats
     组胺H_1受体阻断剂对大鼠八臂迷宫空间记忆的影响<英文>
短句来源
     Neurological function was examined up to 28 days after ischemia and then learning and memory evaluated using 8-arm radial maze on days 30~35 after ischemia.
     缺血后第1~28天进行神经症状评分,第30~35天采用八臂迷宫评价学习记忆功能。
短句来源
     So our AIM: To investigate whether or not exogenous and endogenous histamine is involved in spatial memory deficits induced by dizocilpine (MK-801) asevaluated by 8-arm radial maze of rats.
     因此本文的目的:研究和阐明海马外源性和内源性组胺对地佐环平(MK-801)诱发大鼠的八臂迷宫记忆障碍的作用及探讨海马组胺受体在空间记忆中的作用。
短句来源
     Methods Forty-two Kun-ming mice were divided into four groups : 8-arm radial maze-stressed group ( A) . 8-arm radial maze of non-stressed group (B) , Barnes maze of stressed group(C) , Barnes maze of non-stressed group(D).
     方法 雄性昆明小鼠42只随机分成4组,即:八臂迷宫心理应激组(A)、八臂迷宫对照组(B)、Barnes迷宫心理应激组(C)、Barnes迷宫对照组(D),每组10只。
短句来源
     The changes of learning and memory behavior of mice were respectively observed with 8-arm radial maze and Barnes maze after 2 day psychological stress.
     旁观应激2d后,用放射状八臂迷宫和Barnes迷宫进行空间学习记忆能力的测试。
短句来源
  “8-arm radial maze”译为未确定词的双语例句
     However, few behavioral studies were made on the interaction of histamine and NMDA receptors in cognition process. We have previously reported histamine reversed memory deficits of rats induced by MK-801 in 8-arm radial maze performance.
     我们曾报道了组胺改善MK-801诱发的空间记忆障碍,但是它采用全身和侧脑室给药的方式,无法阐明局部海马内组胺与NMDA受体之间的关系以及海马组胺受体在记忆调节中的地位,也未区分组胺对不同类型记忆的作用。
短句来源
     Both of 2-month and 6-month- old rats are more efficient in acquisition of SDM in 8-arm radial maze than that of 1-month-old rats;
     在SDM测试中,2m、6m大鼠的训练和测试成绩都强于1m大鼠;
短句来源
     ATM: To evaluate effects of certain H1-antagonists on spatial memory with 8-arm radial maze performance of rats.
     目的:研究和阐明组胺H_1受体阻断剂对大鼠空间记忆的作用机制。
短句来源
  相似匹配句对
     METHODS: 8-Arm (4-arm baited) radial maze was used to measure spatial memory in rats.
     方法:采用八臂迷宫(四臂放饵)来研究大鼠的空间记忆。
短句来源
     Effect of H_1 antagonists on spatial memory deficit evaluated by 8-arm radial maze in rats
     组胺H_1受体阻断剂对大鼠八臂迷宫空间记忆的影响<英文>
短句来源
     ATM: To evaluate effects of certain H1-antagonists on spatial memory with 8-arm radial maze performance of rats.
     目的:研究和阐明组胺H_1受体阻断剂对大鼠空间记忆的作用机制。
短句来源
     Methods The radial arm maze task and the object recognition test were used.
     方法采用八方向放射状迷路及新物体辨别实验方法。
短句来源
     J8;
     J_8为第五类单系;
短句来源
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  -arm radial maze
Animals were repeatedly tested in 8-arm radial maze at 1 week, 3, 10 and 16 months after the surgery to investigate long term effects of 2VO on spatial learning and memory.
      
Control (N = 17) and EC-SOD overexpressing mice (N = 13) acquired the 8-arm radial maze over 21 sessions of training.
      
Dramatic impairments in spatial learning in the win-shift 8-arm radial maze were seen in both EC-SOD knockout mice and EC-SOD overexpressing mice.
      
The errors in the 8-arm radial maze trial were increased at 1 month.
      
All rats were tested (i) for home cage activity, (ii) for activity and reactivity in an open field and (iii) for learning ability in a 8-arm radial maze.
      
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Objective To observe the developmental changes of learning and memory in different models in rats.Methods Several behaviour models such as active avoidance reaction (AAR), passive avoidance reaction (PAR), spatial discrimination memory(SDM),conditioned taste aversion(CTA) were used to research the ontogeny of learning and memory. Results 2-month-old rats show the best ability in the acquisition and retention of AAR and PAR, 1-month-old rats learn more slowly than that of 2-month and 6-month-old rats; Both of...

Objective To observe the developmental changes of learning and memory in different models in rats.Methods Several behaviour models such as active avoidance reaction (AAR), passive avoidance reaction (PAR), spatial discrimination memory(SDM),conditioned taste aversion(CTA) were used to research the ontogeny of learning and memory. Results 2-month-old rats show the best ability in the acquisition and retention of AAR and PAR, 1-month-old rats learn more slowly than that of 2-month and 6-month-old rats; Both of 2-month and 6-month- old rats are more efficient in acquisition of SDM in 8-arm radial maze than that of 1-month-old rats; 10-day-old rats learn more rapidly than 21-day and 2-month-old rats in CTA which saccharin is paired with footshock. Conclusions Different types of learning and memory emerged according to different deevelopmental timetables.

目的研究发育过程中不同类型学习记忆的变化特点.方法采用主动回避反应(AAR)、被动回避反应(PAR)、空间分辨记忆(SDM)和味觉厌恶条件反射(CTA)四种模式对学习和记忆过程进行系统研究。结果2月龄(2m)大鼠在AAR、PAR两种模式中,学习和记忆成绩最好,1m大鼠成绩最差;在SDM测试中,2m、6m大鼠的训练和测试成绩都强于1m大鼠;以足电震为非条件刺激的CTA模式中,年龄越小建立越快。结论大鼠发育过程中,不同类型的学习记忆有独特的时间出现过程.

Objective To examine the relationship between dopamine receptor function and the working memory performance in aged rats Methods Twenty eight male Sprague Dawler rats (20 months old) trained to run through an 15 arm radial maze for food reinforcement were injected intraperitoneally with 0 1% ascorbic acid vehicle or dopaminergic drugs,which included Dihydrexidine (DHX,0 1~2 4 mg/kg),SCH23390(0 01~0 02 mg/kg),Quinpirole (0 1~0 4 mg/kg),Haloperidol (0 1~0 4 mg/kg) and Clozapine (1~4 mg/kg)...

Objective To examine the relationship between dopamine receptor function and the working memory performance in aged rats Methods Twenty eight male Sprague Dawler rats (20 months old) trained to run through an 15 arm radial maze for food reinforcement were injected intraperitoneally with 0 1% ascorbic acid vehicle or dopaminergic drugs,which included Dihydrexidine (DHX,0 1~2 4 mg/kg),SCH23390(0 01~0 02 mg/kg),Quinpirole (0 1~0 4 mg/kg),Haloperidol (0 1~0 4 mg/kg) and Clozapine (1~4 mg/kg) Results (1) The memory performance was improved by D 1 agonists DHX at 0 6 mg/kg dose but impaired at 2 4 mg/kg dose,whereas the working memory was impaired by D 1 antagonist SCH23390 at either 0 01 mg/kg or 0 02 mg/kg (2) The D 2 agonists Quinpirole at 0 1~0 4 mg/kg or Haloperidol (0 2 mg/kg) impaired working memory (3) As compared with normal aged rats,the memory impaired ones were relatively insensitive to DA receptor agonists,but oversensitive to DA receptor antagonists (4) The effects of dopaminergic drugs on working memory may be either independent or in conjunction with motor function Conclusions The working memory function may be linked to D 1 receptor,which indicates that D 1 agonists may have potential in the treatment of memory disorder

目的 探讨多巴胺( D A) 受体功能与工作记忆的关系。方法 测试28 只雄性 Sprague Dawley 老年鼠在15 臂放射状迷宫中的操作成绩。观测 D A 受体配体对操作成绩的影响。结果 (1)适量的 D1 受体激活剂二羟西汀(06 mg/kg) 直接作用或低量的 D2 类受体拮抗剂氟哌啶醇(01 mg/kg)通过 D2 突触前受体作用均可改善 D1 受体功能而提高工作记忆能力;而 D1 受体拮抗剂 S C H23390(001 mg/kg ,002 mg/kg) 则损害工作记忆。(2) D2 类受体激活剂奎因哌洛尔在01 ~04 mg/kg 与较大剂量拮抗剂( 氟哌啶醇≥02 mg/kg) 均损害工作记忆。(3) 有记忆障碍的老年鼠对 D A 受体激活剂相对不敏感,而对 D A 拮抗剂则相对过敏。(4) D A 受体配体对工作记忆的影响既有直接作用也可通过影响运动功能而加强。结论 工作记忆与 D A D1 受体功能相关, D1 受体激活剂可能具有治疗某些记忆障碍的潜能。

Effects of saponin fraction extracted from Panax ginseng root (Gin R) or stem and leaf (Gin L,S) on scopolamine induced spatial memory disruption were examined using the 8 arm radial maze task in rats. Scopolamine (0.3 mg/kg, i.p.) significantly decreased the percentage of correct responses in the 8 arm radial maze task. Not only the crude saponin extracted from the PG root (12.5~50 mg/kg, p.o.) but also the saponin from PG stem andleaf (12.5~50 mg/kg, p.o.), improved the disruption effect of...

Effects of saponin fraction extracted from Panax ginseng root (Gin R) or stem and leaf (Gin L,S) on scopolamine induced spatial memory disruption were examined using the 8 arm radial maze task in rats. Scopolamine (0.3 mg/kg, i.p.) significantly decreased the percentage of correct responses in the 8 arm radial maze task. Not only the crude saponin extracted from the PG root (12.5~50 mg/kg, p.o.) but also the saponin from PG stem andleaf (12.5~50 mg/kg, p.o.), improved the disruption effect of scopolamine in the radial maze task. These results suggest that the crude saponin fraction of PG stem and leaf, as well as that of PG root, possess beneficial effects on spatial memory deficit in rats.

采用八肢放射迷路研究人参根及茎叶皂甙对由东莨菪碱所致的大鼠学习记忆损伤的影响。东莨菪碱 ( 0 .3 m g/kg,i.p.)能显著地降低大鼠在放射迷路中最初正确选择数。实验证明人参根皂甙 ( 2 5~ 5 0 m g/ kg,p.o.)和人参茎叶皂甙 ( 12 .5~ 2 5 mg/ kg,p.o.)均能显著地降低由东莨菪碱所致总错误选择。结果表明 ,人参根及茎叶皂甙对东莨菪碱所致大鼠的空间学习记忆损伤有很好的改善作用。

 
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