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detecting aberrant
相关语句
  检测异常
     Objective To investigate the value of fluorescence in situ hybridization (FISH) in detecting aberrant chromosomes in acute lymphoblastic leukemias.
     目的 研究荧光原位杂交技术(FISH) 在检测异常染色体中的应用价值及其意义。
短句来源
  “detecting aberrant”译为未确定词的双语例句
     The Evaluation in Clinical Application of Detecting Aberrant Methylation of p16 Gene by Microfluidic Chips in Lung Cancer Patients
     微流控芯片检测肺癌患者血浆中p16基因异常甲基化在临床应用的评价
短句来源
     The Method Foundation of Detecting Aberrant Methylation of p16 Gene By Microfluidic Chips in Lung Cancer Patients
     微流控芯片检测肺癌患者p16基因异常甲基化方法的建立
短句来源
     The classic method of detecting aberrant methylation is methylation specific PCR. But its sensity is limited, the method is time-consuming, it is not automated, so it cannot be widely used.
     目前人们检测p16基因甲基化的经典方法之一是甲基化特异性PCR(methylation-specific PCR,MSP)法。
短句来源
  相似匹配句对
     the results could provide help for detecting the event constituted by aberrant wavelets.
     为检测由畸变子波构成的同相轴提供一定的可能.
短句来源
     A new method detecting the aberrant IgA in serum for IgA nephropathy diagonosis
     血清异常IgA测定诊断IgA肾病的新方法
短句来源
     On the Counterwork of Detecting and Its Skills
     论侦查对抗及其谋略
短句来源
     Extension Detecting Technology
     可拓检测技术
短句来源
     ③aberrant methylation ;
     ③反常甲基化;
短句来源
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  detecting aberrant
This has led to the suggestion that E2F-1 may function as a tumor surveillance mechanism, detecting aberrant proliferation and engaging apoptotic pathways to protect the organism from developing tumors.
      
A normally distributed person-fit index is proposed for detecting aberrant response patterns in latent class models and mixture distribution IRT models for dichotomous and polytomous data.
      
Working in the higher range also reduces the possibility of detecting aberrant phosphatase activity due to promiscuity of certain phosphatases.
      
We investigated the feasibility of detecting aberrant DNA methylation in the urine and serum samples of renal cancer patients.
      
Predicting lung cancer by detecting aberrant promoter methylation in sputum.
      
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Objective To investigate the value of fluorescence in situ hybridization (FISH) in detecting aberrant chromosomes in acute lymphoblastic leukemias. Methods Conventional banding techniques and FISH were used to detect trisomy 17,18 and 21 in 38 patients with acute lymphoblastic leukemia.Lymphoid DNA probes specific for chromosomes no.17,18 and 21 were used for FISH. Results Out of the 38 patients,18 had +17,22 +18 and 23 +21.The number of trisomy cells ranged from 7% to 80%. Ten normal bone marrow...

Objective To investigate the value of fluorescence in situ hybridization (FISH) in detecting aberrant chromosomes in acute lymphoblastic leukemias. Methods Conventional banding techniques and FISH were used to detect trisomy 17,18 and 21 in 38 patients with acute lymphoblastic leukemia.Lymphoid DNA probes specific for chromosomes no.17,18 and 21 were used for FISH. Results Out of the 38 patients,18 had +17,22 +18 and 23 +21.The number of trisomy cells ranged from 7% to 80%. Ten normal bone marrow samples were hybridized with the chromosomes 17,18 and 21 probes.Conclusion FISH is more sensitive than conventional cytogenetic analysis and allows systematic study on large cohort of patients without the need of metaphase preparations.

目的 研究荧光原位杂交技术(FISH) 在检测异常染色体中的应用价值及其意义。方法 用FISH方法和染色体G分带技术对比观察急性淋巴细胞白血病(ALL) 患者染色体的变化。结果 对38 例患者17 ,18 和21 号染色体进行G分带技术检查,结果分别有11,13 和18 例患者细胞染色体存在三倍体细胞。FISH 检查结果,除上述病例发现三倍体细胞外,染色体G分带检查正常者中也有部分病例存在三倍体。结论 FISH检测异常染色体,方法简便、灵敏、可靠,与常规细胞遗传学方法比较,FISH 方法不需要培养细胞,对分裂期和分裂间期细胞均可进行基因定位检测,尤其在有核细胞少等不适于进行细胞遗传学分析的情况下,FISH 方法仍可得到有意义的数据。

Purpose To detect aberrant of fragile histidine traid(FHIT)gene exons in tissues of renal cell carcinoma(RCCs),surrounding RCCs,and normal kidney,in order to understand the features of FHIT gene exons alteration in RCC,to inquire the relationship between FHIT gene alteration and development of RCC. Methods Tissues of RCCs and surrounding neoplasms were obtained from surgical specimens.Genemic DNA and mRNA were purified from tissues.Probes of full length FHIT cDNA and β actin were generated.polymerase...

Purpose To detect aberrant of fragile histidine traid(FHIT)gene exons in tissues of renal cell carcinoma(RCCs),surrounding RCCs,and normal kidney,in order to understand the features of FHIT gene exons alteration in RCC,to inquire the relationship between FHIT gene alteration and development of RCC. Methods Tissues of RCCs and surrounding neoplasms were obtained from surgical specimens.Genemic DNA and mRNA were purified from tissues.Probes of full length FHIT cDNA and β actin were generated.polymerase chain reaction(PCR) amplications of individual FHIT exons were carried out.PCR products and RNA were transferred to nylon membranes and hybridized with DIG labeled cDNA probes. Results Sixty eight percent of (15/22)RCCs and 37.5%(6/14) of surrounding cancer tissues have alterations of FHIT gene exons for protein.Abnormal of E5 and E8 were 40.9% and 36.4%,respectively.Positive signals of FHIT mRNA were identified in 12(42.8%) samples of RCC,12(75%) tissues of surrounding cancer,and all cases of normal kidney.Meantime,substantially reduced FHIT mRNAs were noted in cancerous tissues.In addition,descending or absent FHIT mRNAs expression were related to high grade and stage of RCCs. Conclusions A large percent of RCC contain deletion or aberrant of FHIT exons for protein.Alterations of FHIT mRNA expression are consistent with lesions at DNA level,and related to high grade and stage of RCC cases.Our results suggest that FHIT may play a role as tumor suppressor gene in renal tumorigenesis.

目的 检测肾细胞癌 (RCC)组织脆性组氨酸三联体 (fragilehistidinetraid ,FHIT)基因蛋白编码外显子及mRNA表达情况 ,了解RCC组织中FHIT基因异常特征 ,探讨FHIT基因与RCC发生发展的关系。方法 收集RCC及相应癌周肾组织标本 ,提取组织DNA及RNA。DIG标记FHIT全长cDNA探针。PCR法扩增FHIT基因E5~E9。扩增产物电泳转膜后行Southernblot杂交。RNA转膜后行Northernbolt杂交。结果  6 8.2 %(1 5 / 2 2 )RCC组织、37.5 % (6 / 1 4 )相应癌周肾组织存在FHIT基因蛋白编码外显子缺失或异常。E5和E8异常(缺失、突变等 )发生率为 40 .9% (9/ 2 2 )和 36 .4% (8/ 2 2 )。 42 .8% (1 2 / 2 8)RCC及 75 % (1 2 / 1 6 )癌周肾组织存在Northernblot阳性条带。FHITmRNA失表达与RCC组织学高分级及临床高分期关系密切 (P <0 .0 5 )。存在FHIT基因蛋白编码外显子缺失或异常的 1 5例RCC中 1 4例 (93.3%...

目的 检测肾细胞癌 (RCC)组织脆性组氨酸三联体 (fragilehistidinetraid ,FHIT)基因蛋白编码外显子及mRNA表达情况 ,了解RCC组织中FHIT基因异常特征 ,探讨FHIT基因与RCC发生发展的关系。方法 收集RCC及相应癌周肾组织标本 ,提取组织DNA及RNA。DIG标记FHIT全长cDNA探针。PCR法扩增FHIT基因E5~E9。扩增产物电泳转膜后行Southernblot杂交。RNA转膜后行Northernbolt杂交。结果  6 8.2 %(1 5 / 2 2 )RCC组织、37.5 % (6 / 1 4 )相应癌周肾组织存在FHIT基因蛋白编码外显子缺失或异常。E5和E8异常(缺失、突变等 )发生率为 40 .9% (9/ 2 2 )和 36 .4% (8/ 2 2 )。 42 .8% (1 2 / 2 8)RCC及 75 % (1 2 / 1 6 )癌周肾组织存在Northernblot阳性条带。FHITmRNA失表达与RCC组织学高分级及临床高分期关系密切 (P <0 .0 5 )。存在FHIT基因蛋白编码外显子缺失或异常的 1 5例RCC中 1 4例 (93.3% )FHIT基因mRNA表达阴性。结论 RCC组织常发生FHIT基因蛋白编码外显子缺失或突变。FHITmRNA失表达与FHIT基因异常基本一致 ,其表达情况可提示患者预后。本实验结果支持FHIT基因可能是肿瘤抑制基因

Purpose:To detect aberrant of FHIT gene(fragile histidine traid) exons in tissues of RCCs(renal cell carcinoma), surrounding RCCs, and normal kidney, in order to understand the feature of FHIT gene exones alteration in RCC, to inquire into the relationship between FHIT gene and development of RCC.Methods:A total of 22 RCCs and 14 surrounding tissues were obtained from surgical specimens. PCR (polymerase chain reaction) amplications of individual FHIT exons were carried out. PCR products were hybridized...

Purpose:To detect aberrant of FHIT gene(fragile histidine traid) exons in tissues of RCCs(renal cell carcinoma), surrounding RCCs, and normal kidney, in order to understand the feature of FHIT gene exones alteration in RCC, to inquire into the relationship between FHIT gene and development of RCC.Methods:A total of 22 RCCs and 14 surrounding tissues were obtained from surgical specimens. PCR (polymerase chain reaction) amplications of individual FHIT exons were carried out. PCR products were hybridized with DIG-labeled cDNA probes.Results:Sixty eight percent of RCCs (15/22) and 37.5% (6/16) of surrounding cancer tissues have deletion or aberrant of FHIT exons for protein, and abnormal of FHIT E5 and E8 are much more common than other exons for protein. These alterations usually involve more than one locus of FHIT exon.Conclusion:Lesions at the FHIT DNA level may be the early event in the development of RCC.

目的 :检测肾细胞癌 ( RCC)组织 FHIT基因 ( fragile histidine triad)蛋白编码外显子异常情况 ,了解 RCC中 FHIT基因异常特征 ,探讨 FHIT基因与 RCC发生的关系。方法 :收集 RCC及相应癌周肾组织标本 2 2份和 1 6份 ,提取组织 DNA。DIG标记 FHIT全长 c DNA探针。PCR扩增 FHIT基因 E5~ E9,产物行 Southern blot杂交。结果 :1 5份 ( 68.2 % )癌组织标本、6份( 37.5% )癌周肾组织标本存在 FHIT基因蛋白编码外显子缺失或突变 ,其中 1 0份同时存在两个外显子异常改变。癌组织及癌周肾组织 E5异常 (含缺失、异常 )发生率分别为 40 .9% ( 9/ 2 2 )和2 5.0 % ( 4 / 1 6)。结论 :FHIT基因异常可能是 RCC发生过程中的早期事件。

 
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