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hsv
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     ConclusionThe resistance of HSV-1 to C.
     结论HSV1在含C.
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     Treatment of HSK With HSV-Ab
     HSV-Ab治疗单疱性角膜炎的初步报告
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  hsv
Derivatives on Herpes simplex virus type 1 (HSV-1), Mayaro virus (MAY) and vesicular stomatitis virus (VSV) were investigated.
      
Compounds 2d, 3f, 3a, and 3c exhibited antiviral activity against HSV-1, MAY, and VSV virus with EC50 values of 6.8, 2.2, 4.8, 0.52, 2.5, and 1.0.
      
A study was made of the adjuvant effect of the mouse tumor necrosis factor α (mTNFα) on DNA immunization against the herpes simplex virus type 1 (HSV1).
      
The HSV1 gD gene (pDNAgD) served as an immunogen; mTNFα or its gene cloned in an eukaryotic expression vector (pDNAmTNF) were used to modulate the immune response.
      
A single injection of mTNFα along with inactivated HSV1 allowed a twice higher antibody titer and a fourfold higher T-cell response as compared with immunization with HSV1 alone.
      
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This paper reports an experimental study of the inhibition of HSV by using cyclocytidine, or heparin or the combination of both. It was confirmed that the ocmbination of both might decrease the dosage used, and enhance the inhabition action of HSV obviously.

本文报告了环胞苷、肝素及二者联合应用对HSV—1的抑制作用,并对实验研究的结果进行了讨论。

Though the study on cultivation and molecular bialogy of HSV has beenfar advanced, the pathogenicity and the interactions between HSV and diffe-rent cells, especially the most sensitive cells still require to elucidate indepthso as to establish a complete speetrum of patholog ical changes in different cells. The patterens of multiplication and specific cytopathic effects on sensitivetissue culture cells have been studied by using primary rabbit kidney tissueculture cells (PRK). The results are as...

Though the study on cultivation and molecular bialogy of HSV has beenfar advanced, the pathogenicity and the interactions between HSV and diffe-rent cells, especially the most sensitive cells still require to elucidate indepthso as to establish a complete speetrum of patholog ical changes in different cells. The patterens of multiplication and specific cytopathic effects on sensitivetissue culture cells have been studied by using primary rabbit kidney tissueculture cells (PRK). The results are as follows:1. The experiments proved that the eclipse period was 1:3 hrs by direct tit-ration method with the infecting dose of 100 TCID 50/ml on PRK cells. Thetitec of the virus went up to 10~2. ~(17)TCID 50/0. 1ml 24 hrs after infections. Itsoared repidly with 24-48 hrs and kept rising for 48-72 hrs with tites reaching10~(6.5) TCID 50/0. 1ml. When the dynamics of mhltiplication was indicated byCPE, the same results were obtained.2. The pathologic festures were described systimatically. The change ofintranuclear structure disorder of chromatin and its reorganization, the forma-tion of intracytoplasmic and intranuclear acidophilic inclusion bodies and theformation of giant synthetial cells as well were the main features of CPE. There is a discussion about the results in this paper.

用敏感的兔肾细胞培养HSV-1,对HSV的生长规律及致CPE的特点进行了研究。主要的细胞病理学变化是细胞核内部结构改变,核染质紊乱及重新组合,形成嗜酸性包涵体,细胞融合成巨大合胞体。

This paper reports an experimental study of the inhibition of HSV by using cyclorylidine, or hcparin or the combination cf both. It was confirmed that the ocmbination of both might decrease the dosage used, and enhance the inhabition action of HSV obviously.

本文报告了环胞苷、肝素及二者联合应用对HSV—1的抑制作用,并对实验研究的结果进行了讨论。

 
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