[Methods]A single oral 400 mg dose of racecadotril was given to 24 healthy male volunteers according to a randomized cross-over design. The Thiophine,a active metabolity of racecadotril,concentration in plasma was determined by HPLC-MS/MS method.
METHODS: The study was conducted as a 3- way crossover design in 18 healthy volunteers whose plasma concentrations of cefixime were determined by HPLC after receiving a single oral dose of 200 mg trial preparations or reference preparation.
A blind test set, including 20 new cancer cases and 10 healthy women, was used to validate the sensitivity and specificity of this multivariate model, which had a corresponding results of 60% in specificity and 75% in sensitivity, respectively.
The relation of heart volume and other circulatory parameters during acute orthostatic stress was investigated in 10 healthy persons.
In 10 healthy persons and 40 patients with neurogenic and myogenic lesions the ulnar nerve was stimulated percutaneously by sqare wave impulses and the evoked muscle potentials of the m.abductor digiti V were recorded with two needle electrodes.
20 patients with Parkinson's disease and 10 healthy subjects underwent EMG examination of the supraspinatus muscle on both sides, with the arms held in the normal dependent position parallel to the body.
In 10 healthy subjects stimulation of the accessory nerve in the posterior triangle of the neck always elicited action potentials in all 3 parts of the trapezius muscle.