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all drugs
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  所有药物
     All drugs were administered by intramuscular injection. Group GM and group GM+SA were all injected with gentamicin 150 mg/kg per day for 10 days.
     所有药物均经肌肉注射 ,GM组和GM +SA组每天注射庆大霉素 15 0mg/kg ,共 10d ;
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     Results The average cost of antiinfective drugs for each patients was 1427.18 RMB, which accounted for 17. 6% of medical expense of hospitalization or 50.94% of total expense for drug. The average therapeutic course was 20.9 days. DUI of All drugs was less than 1,73 cases were cured and 17 cases were improved.
     结果101例骨科患者抗茵药物的平均费用为1427.18元,抗菌药费分别占住院总费用、总药费的17.67%和50.94%,平均住院时间为20.9d,调查的所有药物DUI≤1,治愈73例,好转17例,治愈率72.28%。
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  “all drugs”译为未确定词的双语例句
     ? Results The rate of drug resistance to all drugs were 59.6%,76.3%,70.5% and 50.8% respectively;
     结果1992、1996、2000、2004年耐药率分别为59.6%、76.3%、70.5%5、0.8%;
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     All drugs were given by intra-peritoneum injection with micro-pump,in the rate of 0.5 ml/h.
     药物以0.5ml/h经腹腔由微量注射器注入。
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     To determine the times of spontaneous motion (as indication of sedation) in mice, given MEKOL 22.2, 44.4 g·kg -1 and diazepam 2 mg·kg -1 . All drugs above were given by i.g.
     测定 MEKOL 2 2 .2、4 4.4 g· kg- 1、安定 2 m g·kg- 1小鼠自主活动次数。
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     ABR thresholds in the mice 3 days after withdrawal of all drugs were close to those of normal control group(P>0.05).
     停药3 d后,小鼠的ABR阈值均恢复到接近正常对照组的阈值(均P>0.05)。
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     Methods:23 patients received radiotherapy administered to the pelvis. L-OHP30mg/(m2·day) in 30min infusion,followed by bolus LV 100mg/(m2·day) and 5-Fu 375 mg/(m2·day). All drugs were given 4 days during Week1 and 5 of standard radiotherapy.
     方法23例无法手术的晚期复发直肠癌患者进行盆腔放疗,在放疗的第1、5周前一天开始给予L OHP30mg/m2静滴0.5h,LV100mg/m2和5Fu375mg/m2静滴4h,连用4d。
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     All.
     建议All.
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     V(I) for all f.
     V(I)对所有f.
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     All the 8 kinds of drugs were sensitive to the isolates.
     所选8种药物对受试真菌均有较好的敏感性。
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     All patients were given drugs for 6 months.
     6个月为一疗程。
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     The Antimicrobial Drugs
     抗菌药
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  all drugs
All drugs given alone improved sarcolemmal ability to bind calcium.
      
When tested separately in each patient group, the difference was significant for the patients off all drugs, and for those changing from phenytoin to other drugs.
      
All drugs were administered perorally for seven days.
      
was resistant to all drugs, whileCitrobacter freundii was sensitive to every antibiotic tested.
      
All drugs were active against a panel of 11 strains each ofEscherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa, andStaphylococcus aureus.
      
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Salvia miltrorrhiza Bge (S. M. B.) is a medicinal herb widely used in traditional Chinese medicine. In this article some results of studies on the action of S. M. B. on the central nervous system is reported.Crude extract of S. M. B. was used in the experiments. The dosage was expressed in terms of the weight of the crude drug. All drugs were prepared in aqueous solution and administered by the intraperitoneal or oral route to groups of 10—20 animals.When S. M. B. was administered, animals became...

Salvia miltrorrhiza Bge (S. M. B.) is a medicinal herb widely used in traditional Chinese medicine. In this article some results of studies on the action of S. M. B. on the central nervous system is reported.Crude extract of S. M. B. was used in the experiments. The dosage was expressed in terms of the weight of the crude drug. All drugs were prepared in aqueous solution and administered by the intraperitoneal or oral route to groups of 10—20 animals.When S. M. B. was administered, animals became calm and tame. The spontaneous activity was significantly decreased and the effect increased with increased dosage. At the dosage of 0.5 g/kg, the spontaneous activity was only slightly diminished, while at 4 g/kg and 16 g/kg the percentages of inhibition were 60% and 90%, respectively. The inhibitory effect on spontaneous activity of chlorpromazine at the dosage of 0.5 mg/kg or of meprobamate at 100 mg/kg was not obvious, but when given in combination with S. M. B. the inhibitory effect was markedly enhanced. The S. M. B. did not show obvious anticonvulsive effect, but the stimulating effect of amphetamine on spontaneous activity was antagonized by S. M. B..While 2 of 20 control animals were put into sleep after administration of 25 mg/kg of pentobarbital, all of 20 animals fell into sleep after treatment by pentobarbital and S. M. B.. After the administration of 125 mg/kg of barbital, 1 in 10 animals fell into sleep. When the barbital was used in combination with S. M. B., 9 out of 10 animals fell asleep. Chloral hydrate given by mouth at 250 mg/kg was not hypnotic. However, when it was administered in combination with S. M. B., 4 out of 10 animals fell a sleep. Although S. M. B. can strengthen markedly the hypnotic effect of barbiturates as well as nonbarbiturate, sleep is not induced, however, by S. M. B. alone. It may be postulated on the basis of these results that S. M. B. possesses the properties of a tranquilizer.

丹参使小鼠安静、驯服,对动物的自主活动有明显的抑制作用,该作用与剂量大小成正比。与氯丙嗪和眠尔通合并应用,使其作用增强。丹参抗惊厥作用不明显,但对抗苯丙胺的精神运动兴奋作用却较明显。丹参虽然有明显的镇静作用,但不能引起动物睡眠,若与巴比妥类或非巴比妥类镇静催眠药合并应用,可以非常明显的增强这些药物的催眠作用,其作用与已知的安定药相似。

In order to elucidate the mechanism of hypertensive and antishock effects of Citrus aurantium L. and its active principles (synephrine and N-methyltyramine), carotid arterial blood pressure (BP), left ventricular pressure (LVP), left ventricular end diastolic pressure (LVEDP), the first derivative of the left ventricular pressure (dp/dt), central venous pressure (CVP), EGG, heart rate (HR), and cardiac output (CO) were monitored in 6 anethetized open chest dogs. The tracings were recorded on RM-86 Polygraph....

In order to elucidate the mechanism of hypertensive and antishock effects of Citrus aurantium L. and its active principles (synephrine and N-methyltyramine), carotid arterial blood pressure (BP), left ventricular pressure (LVP), left ventricular end diastolic pressure (LVEDP), the first derivative of the left ventricular pressure (dp/dt), central venous pressure (CVP), EGG, heart rate (HR), and cardiac output (CO) were monitored in 6 anethetized open chest dogs. The tracings were recorded on RM-86 Polygraph. EGG, LVP, LVEDP and dp/dt signals were recorded simultaneously on Data Recorder and were reproduced in speed of 100 mm per sec. after experiment, so as to measure the numeral value of LVEDP, t-dp/dt, tension time index of ventricular ejection (TTI) and common peak isovolumetric pressure (CPIP). Cardiac index (CI), stroke index (SI), left ventricular work index (LVWI), peripheral vascular resistance (PVR), and dp/dt/CPIP (VcEat CPIP)were calculated. Citus auruntium extract (0.5g/kg), synephrine (1 mg/kg), N-methyltyramine (0.25 mg/kg) with the well-known cardiac stimulants dopamine (DA), dobutamine (DB) as positive control were injected in sequence of Latinsquare design.All drugs markedly increased the cardiac function indices in similar patterns including increase of dp/dt max, V_(CE) at CPIP and CI; shortening of t-dp/dt max. and lowering of LVEDP. Since V_(CE) at CPIP is independent of variations of ventricular afterload initiated by these drugs, it was concluded that similar to DA and DB, crude extract of Citrus aurantiurn and its active principlcs do possess inotropic action by increasing myocardial contractility. It is their pump-stimulant action and elevation of PVR that offer the pharmacological basis to their anti shock effect. As to the relative efficiency on PVR, N-methyltyramine was weaker than crude extract of Citrus aurantiurn and synephrine. As to the heart rate stimulant action, the reverse was true.At the equivalent dosage to CI increment, crude extract of Citus aurantiurn synephrine, N-methyltyramine and hypertensive dose of DA augmented the LVWI and TTI×HR (as energy and oxygen consumption index) far beyond the ratio of CI increment. This difference could attribute to the increase of ventricular afterload as a result of vasoconstriction.DB and DA in small doses lowered arterial blood pressure and PVR. Consequently the LVWI and TTI×HR were not significantly altered.

麻醉犬实验表明枳实及其有效成分辛弗林和N-甲基酪胺与多巴胺、多巴酚丁胺相似,能显著增强多种心肌收缩性和泵血功能的指标:增大左室压变化速率峰值和在共同最高等容收缩压(CPIP)时的心肌收缩成分的缩短速率(V_(CE)),增加心脏指数(GI),缩短左室从开始收缩到开始射血的时间,降低左室舒张末压。由于在CPIP时的V_(CE)不受心室后负荷(动脉压)的影响,故可以排除上述指标的增强是由于药物对血压的影响。由于枳实及其有效成分的强心、增加心输出量和收缩血管提高总外周阻力,导致左室压力和动脉血压上升,这是它们抗休克的药理学基础。N-甲基酪胺升高外周阻力的作用比枳实和辛弗林稍弱,但加快心率的作用则较强。这两种成分在作用上是各有特点的。在增加心搏指数等效剂量下,枳实、辛弗林、N-甲基酪胺与大剂量多巴胺增加左室作功指数和射血的张力-时间指数的比值远超过增加心搏指数的百分率,这可能是升压增加左室后负荷造成的。多巴酚丁胺和小剂量多巴胺不同于枳实及其有效成分在于能降低外周血管阻力,降低动脉血压,而不明显增加左室作功指数和射血的张力-时间指数,提示不象枳实那样增加心肌的能量消耗。

Asatum heterotropoides (A. H) was shown to improve the left ventricular pump function and myocardial contractility in dogs.After an intravenous injection of A.H at a dose of 0.1~0.4ml(1:2)/kg in the dog heart-lung preparation (HLP), the results were as follows: LVSP↑, LVEDP↓, MAP↑, CO↑, HR↑, SV↓, dp/dt max↑, -dp/dt max↑, t-dp/dt max↓, Vpm↑, Vce-cpip↑, Vmax↑, After an intravenous injection of A.H at a dose of 0.05~0.4 ml (1:2)/kg in anesthetized open-chest dogs, with exception of MAP↑, and SV↑, similar resulte...

Asatum heterotropoides (A. H) was shown to improve the left ventricular pump function and myocardial contractility in dogs.After an intravenous injection of A.H at a dose of 0.1~0.4ml(1:2)/kg in the dog heart-lung preparation (HLP), the results were as follows: LVSP↑, LVEDP↓, MAP↑, CO↑, HR↑, SV↓, dp/dt max↑, -dp/dt max↑, t-dp/dt max↓, Vpm↑, Vce-cpip↑, Vmax↑, After an intravenous injection of A.H at a dose of 0.05~0.4 ml (1:2)/kg in anesthetized open-chest dogs, with exception of MAP↑, and SV↑, similar resulte were obtained (LVSP↑, LVEDP↓, CO↑, HR↑, dp/dt max↑,-dp/dt max↑, t-dp/dt max↑, Vpm↑, Vce-cpip↑, Vmax↑). In the two experiments, positive down curve of Lissajous figure were removed to the right up position.Since the HLP is devoid of inferences of the pre-and after-load of the heart, the increase of pump function by A. H seems to be the result of direct action on myocardial contractility.The result of A. H on cardiac functions and hemodynamics in comparison with Higenamine (H. G) and Isoprenaline (I. S) showed that all drugs increased the left ventricle function. The only difference was that A. H increased SV and H. G、I. S decreased SV. The difference could attribute to the effect of A. H to heart rate that make the increase of heart rate in more proper level than the other two agents.After β-Adrenergic blockade, the effect of A. H on the elevation of CO was unchanged.

实验表明细辛可使狗左室泵功能和心肌收缩性能明显改善。在心肺制备狗,主要表现为LVSP↑,LVEDP↓,MAP↑,CO↑,HR↑,SV↓,dp/dt_(max)↑,-dp/dt_(max)↑,t—dp/dt_(max)↓,V_(px)↑,V_(ce-cpip)↑,V_(max)↑;在麻醉开胸狗,除MAP降低和SV增加外,对其它指标的作用方向与心肺制备实验结果基本一致;两个实验中测取的Lissajous图形的正向前降支均向右上方移位。从而排除了前、后负荷的影响,说明泵功能的改善似由于细辛增强心肌收缩性能所致。通过细辛与去甲乌药硷、异丙肾上腺素的比较研究,提示三者的作用基本相似,唯SV显示不同的结果。细辛使SV增加,去甲乌药硷、异丙肾上腺素却使SV减少,这可能与细辛增加HR的比率较二者为低密切相关。肾上腺素能β受体阻滞后,细辛增加CO的作用仍然存在,值得进一步研究。

 
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