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b-cell chronic lymphocytic leukemia
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  慢性b淋巴细胞白血病
     We describe a patient with concomitant B-cell chronic lymphocytic leukemia (CLL) and multi- ple myeloma (MM).
     研究一例慢性B淋巴细胞白血病(CLL)伴多发性骨髓瘤(MM)的患者。
短句来源
     We describe a patient with concomitant B-cell chronic lymphocytic leukemia(CLL)and multi- ple myeloma(MM).
     研究一例慢性 B 淋巴细胞白血病(CLL)伴多发性骨髓瘤(MM)的患者。
短句来源
     CD38 is a prognostic molecule in B-cell chronic lymphocytic leukemia cells,the diagnostic factor of autoimmune response diabetes . In recent years CD38 is applied to detect AIDS and cytomegalovirus infections,and monitor the pathogenetic condition of SLE.
     近年来临床研究发现CD38分子是慢性B淋巴细胞白血病的预测因子,自身免疫反应性糖尿病的诊断指标,并可用于艾滋病及巨细胞病毒的检测及系统性红斑狼疮的病情监测。
短句来源
  b细胞慢性淋巴细胞白血病发生
     Bcl-1 rearrangement in B-cell chronic lymphocytic leukemia
     B细胞慢性淋巴细胞白血病发生Bcl-1基因重排的研究
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  “b-cell chronic lymphocytic leukemia”译为未确定词的双语例句
     Serum CD44 level in low grade non-hodgkin lymphom a and B-cell chronic lymphocytic leukemia patients during interferon-α treatment
     低恶度非霍奇金淋巴瘤和慢性淋巴细胞白血病患者应用干扰素-α检测血清CD44的临床意义
短句来源
     ‘Specific’cutaneous infiltrate of B-cell chronic lymphocytic leukemia at the site of a florid herpes simplex infection
     B细胞慢性淋巴细胞白血病在鲜红色单纯疱疹感染部位的特异皮肤浸润
短句来源
  相似匹配句对
     Bcl-1 rearrangement in B-cell chronic lymphocytic leukemia
     B细胞慢性淋巴细胞白血病发生Bcl-1基因重排的研究
短句来源
     T-Cell chronic lymphocytic leukemia:Case report and literature review
     T细胞性慢性淋巴细胞白血病1例报告和文献复习
短句来源
     Clinical, immunophenotypic and cell cyclic analysis of chronic lymphocytic leukemia(CLL)
     慢性淋巴细胞白血病的临床免疫分型和细胞周期分析
短句来源
     Defective expression of B7.2 in B cell chronic lymphocytic leukemia B cells
     慢性B淋巴细胞白血病B细胞B7.2分子表达缺陷的研究
短句来源
     Molecular Cytogenetics of Chronic Lymphocytic Leukemia
     慢性淋巴细胞白血病的分子细胞遗传学
短句来源
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  b-cell chronic lymphocytic leukemia
Patients with B-cell chronic lymphocytic leukemia (CLL) have an increased risk of second malignancy and may develop diffuse large-cell non-Hodgkin's lymphoma (DLCL) also known as Richter's syndrome (RS).
      
Abnormal T-cell functions in B-cell chronic lymphocytic leukemia do not imply T-lymphocyte involvement in the leukemic process:
      
R-etodolac is a novel pro-apoptotic agent with potential antitumor activity against B-cell chronic lymphocytic leukemia (B-CLL).
      
Phase I study of a novel pro-apoptotic drug R-etodolac in patients with B-cell chronic lymphocytic leukemia
      
Likewise, impaired PP2A phosphatase activity has been linked to B-cell chronic lymphocytic leukemia, Philadelphia-chromosome positive acute lymphoblastic leukemia and blast crisis chronic myelogenous leukemia.
      
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Nonrandom chromosome aberrations are associated with human malignancies and belived to play a key role in the pathogenesis of these diseases by disturbing cellular genes involved in the control of cell growth, bcl-2 Gene becomes transcriptionally deregulated in the majority of low-grade non-Hodgkin's lymphomas as a result of t( 14, 18) translations that place the bcl-2 gene at 18q21 into juxtaposition with the Ig heavy-chain locus at 14q32. This rearrangement and non-rearranged overexpression of bcl-2 gene have...

Nonrandom chromosome aberrations are associated with human malignancies and belived to play a key role in the pathogenesis of these diseases by disturbing cellular genes involved in the control of cell growth, bcl-2 Gene becomes transcriptionally deregulated in the majority of low-grade non-Hodgkin's lymphomas as a result of t( 14, 18) translations that place the bcl-2 gene at 18q21 into juxtaposition with the Ig heavy-chain locus at 14q32. This rearrangement and non-rearranged overexpression of bcl-2 gene have been reported to occur in some cases of B-cell chronic lymphocytic leukemia(B-CLL). By using immunohistochemical staining method and polymerase chain reaction (PCR) analysis, the expression and rearrangement of bcl-2 gene in 11 cases of chronic lymphocytic leukemia(CLL) were detected. Overexpression of bcl-2 gene was found in all cases; 1 of 11 cases had t(14,18) (q32, q21) translations. The data indicated that high levels of bcl-2 gene expression occur frequently in CLL, and bcl-2 gene plays a pivotal role in pathogenesis and progression of CLL.

人类恶性肿瘤常伴有非随机性染色体异常,并由于使调控细胞生长的基因表达失控而在肿瘤的发生中发挥十分关键的作用。bcl-2基因由于t(14,18)染色体易位而激活在低恶度的非霍奇金淋巴瘤的发生和演变中的作用已举世公认。类似的重排和非重排引起的bcl-2过度表达也见于慢性淋巴细胞白血病。我们应用免疫组化染色和聚合酶链反应检测了11例慢性淋巴细胞白血病bcl-2基因表达和重排,结果发现所有病例均高度表达Bcl-2蛋白,1例有t(14,18)(q32,q21)染色体易位。结论提示慢性淋巴细胞白血病普遍存在bcl-2基因高表达,bcl-2基因在慢性淋巴细胞白血病的发生和发展中发挥着十分重要的作用。

Objective To study the rearrangement of Bcl 1 gene (Bcl 1/IgH gene rearrangement)in B cell chronic lymphocytic leukemia,and its clinical signification.Methods Hemi nested polymerase chain reaction (PCR) was used to amplify the genomic DNA obtained from fresh peripheral blood and bone marrow.The rearrangment of Bcl 1 gene was analyzed in 13 patients with chronic lymphocytic leukemia (CLL) and 10 volunteers (with normal bone marrow) as controls.Results Four(31%)CLL patients...

Objective To study the rearrangement of Bcl 1 gene (Bcl 1/IgH gene rearrangement)in B cell chronic lymphocytic leukemia,and its clinical signification.Methods Hemi nested polymerase chain reaction (PCR) was used to amplify the genomic DNA obtained from fresh peripheral blood and bone marrow.The rearrangment of Bcl 1 gene was analyzed in 13 patients with chronic lymphocytic leukemia (CLL) and 10 volunteers (with normal bone marrow) as controls.Results Four(31%)CLL patients displayed Bcl 1 rearrangem entahile,no volunteers showed the rearrangement of the Bcl 1 gene.All 13 patients with CLL had B cell neoplasms.Conclusions Bcl 1 rearrangement is often present in B cell chronic lymphoproliferative leukemia.B cell chronic lymphoproliferative leukemia with Bcl 1 rearrangement has a higher proportion of lymphoblast and prolymphocytes in peripheral blood.

目的 探讨Bcl- 1基因重排 (即Bcl- 1/IgH基因重排 )在B细胞慢性淋巴细胞白血病中的发生情况及其临床意义。方法 我们对 13例慢性淋巴细胞白血病 (CLL)进行了Bcl- 1基因重排的检测 ;对照组为 10例骨髓正常者。运用半筑巢式多聚酶链反应 (PCR)技术对从外周血、骨髓中提取的基因组DNA进行扩增。结果 这 13例CLL均为B细胞型 ,在 13例CLL中检出 4例 (31% )的Bcl- 1基因重排 ;10例骨髓正常者的对照组中未检测出Bcl- 1/IgH基因重排。结论  (1)B细胞慢性淋巴细胞白血病常发生Bcl- 1基因重排 ,骨髓正常者未检出Bcl- 1/IgH基因重排。 (2 )发生Bcl- 1基因重排的B细胞慢性淋巴细胞白血病外周血中原始或幼稚淋巴细胞增多。

Objective To investigate the characteristic immunophenotype of B cell chronic lymphoid leukemia in china. Method Single and multiparameter flow cytometry were used to analysis 163 cases of B cell chronic lymphoid leukemia. Results 71.8%(117/163) of cases co-expressed CD5 and B cell markers. The patients were classified into category of B cell chronic lymphocytic leukemia(B-CLL), hairy cell leukemia(HCL) and other B-cell lymphoproliferative disorders(LPDs)...

Objective To investigate the characteristic immunophenotype of B cell chronic lymphoid leukemia in china. Method Single and multiparameter flow cytometry were used to analysis 163 cases of B cell chronic lymphoid leukemia. Results 71.8%(117/163) of cases co-expressed CD5 and B cell markers. The patients were classified into category of B cell chronic lymphocytic leukemia(B-CLL), hairy cell leukemia(HCL) and other B-cell lymphoproliferative disorders(LPDs) by using the scoring system that was recommended by world health organization (WHO). The B-CLL typically display the composite phenotypes: CD5+,CD23+,CD20+,CD19+,HLA-DR+,but the CD22,CD11c,CD25 and FMC7 were variable present in some B-CLL cases.CD103 seems the most specific marker for HCL.To differentiate diagnosis of atypical B-CLL with B-prolymphocytic leukemia(B-PLL) or mantle cell lymphoma(MCL), one must not rely exclusively on immunophenotypic dates, cytogenetic or molecular biology detection would be helpful. The index of froward scatter( FSC) and antigens expression of tumor B cells could be calculated by dividing the relevant value of residual normal T cell within same sample as internal control, so the cell size and the intensity of antigen expression could be comparable each other and quantitative between different investigations. Conclusion immunophenotypic analysis is an extremely useful adjunct in the diagnosis of chronic lymphoid leukemia.

目的 研究国内慢性淋巴细胞系统白血病的免疫表型特点。方法 采用单参数和多参数流式细胞术分析了 16 3例慢性淋巴细胞系统白血病的免疫表型。结果  71 8% ( 117/ 16 3)患者共表达CD5和B细胞标志。采用WHO引用的计分系统 ,将病例分为B 慢性淋巴细胞白血病 (B CLL) ,毛细胞白血病 (HCL)和其他B淋巴细胞增殖性疾病。典型的B CLL表达CD5、CD2 3、CD2 0、CD19、HLA DR ,但仍有部分患者表达CD2 2、CD11c、CD2 5和FMC7。CD10 3似为HCL最特异的标志。但仅仅依靠免疫表型难以鉴别非典型B CLL、B细胞 幼淋巴细胞白血病 (B PLL)和外套细胞淋巴瘤 (MCL) ,细胞遗传学或分子生物学检查将有助于鉴别诊断。以同一标本中残存的正常淋巴细胞为内参照 ,计算前向角光散射 (FSC)指数和抗原表达指数 ,可定量地表示细胞的大小和抗原表达的强度 ,使不同的标本具有可比性。结论 免疫表型分析是诊断慢性淋巴细胞系统白血病非常有用的依据。

 
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