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chronic constriction
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  慢性压迫性
     Objective: To investigate the effect of intracerebroventricular(i.c.v.) injection of endomorphin-1(EM-1) on IL-6 mRNA expression level in hippocampus and on PAG in chronic constriction injury(CCI) model of rats.
     目的:观察侧脑室微量注射内吗啡肽-1(endomorphin-1,EM-1)对坐骨神经慢性压迫性损伤(chronic constriction injury,CCI)大鼠痛阈以及海马和中脑导水管周围灰质(periaqueductal gray,PAG)中白细胞介素-6(interleukin-6,IL-6)mRNA表达的影响。
短句来源
     Objective:To investigate the changes of phosphorylated p38MAPK expression in DRG neurons in rats with chronic constriction injury (CCI)of sciatic nerve.
     目的:观察背根神经节(DRG)磷酸化的p38丝裂原活化蛋白激酶(p -p38MAPK)在大鼠坐骨神经慢性压迫性损伤(CCI)后表达的变化,探讨慢性神经痛的发生机制。
短句来源
     The present study was to investigate the changes of TTX R sodium currents and NaN/SNS2 sodium channel transcripts in DRG neurons in chronic constriction injury (CCI) of sciatic nerve 14 days after surgery.
     目的 :观察电压门控钠通道NaN /SNS2在大鼠坐骨神经慢性压迫性损伤 (chronicconstric tioninjury ,CCI) 14天后的变化 ,探讨慢性神经痛的发生机制。
短句来源
     AIM: To study the influence of tramadol on synaptic remodeling of astrocytes in the rat spinal cord after chronic constriction injury (CCI) of sciatic nerve.
     目的:探讨曲马多对大鼠坐骨神经慢性压迫性损伤脊髓星形胶质细胞突触重塑的影响。
短句来源
     Effects of tramadol on synaptic remodeling in the rat spinal cord after chronic constriction injury of sciatic nerve
     曲马多对慢性压迫性坐骨神经损伤模型大鼠脊髓突触重塑的影响
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  慢性坐骨神经
     Methods On the chronic constriction injury (CCI) rats, 32 rats were randomly divided into four groups (n=8): NS group, Bac1 group, Bac2 group and Bac3 group.
     方法行为学实验,建立慢性坐骨神经结扎损伤模型,神经结扎后3d形成神经病理性痛的32只SD大鼠随机分为4组(n=8):NS组,Bac1组,Bac2组,Bac3组,鞘内分别注射生理盐水、0·1μg、0·3μg或1·0μg巴氯芬,注射容积均为10μL。
短句来源
     Aim To investigate the role of T type calcium channel of spinal cord and supraspinal on the pain threthold of the rats following chronic constriction injury(CCI) of the sciatic nerve.
     目的观察鞘内和侧脑室内注射T型钙通道阻断剂对慢性坐骨神经结扎大鼠痛阈的影响,探讨脊髓和脊髓上水平T型钙通道在神经病理性疼痛中的作用。
短句来源
     Effect of Intrathecal Ketamine Injection on the Expresstion of NMDA-2B Protein in the Spinal Cord on Rat Models by Chronic Constriction Injury
     氯胺酮鞘内注射对慢性坐骨神经损伤大鼠脊髓NMDA-2B蛋白表达的影响
短句来源
     Objective To compare the establishment and afficacy of three neuropathic pain models:chronic constriction injury of sciatic nerve(CCI), spinal nerve ligation (SNL) and spared nerve injury(SNI).
     目的比较慢性坐骨神经缩窄损伤(CCI)、脊神经结扎(SNL)、保留性神经损伤(SNI)三种神经病理性疼痛模型产生疼痛的效果。
短句来源
     Objective To investigate the effects of ketamine(Ket)on apoptosis and expression of apoptosis-related protein of spi- nal dorsal horn neurons in rat model of chronic constriction injury(CCI)to sciatic nerve.
     目的观察氯胺酮(Ket)对慢性坐骨神经压迫性损伤(CCI)大鼠脊髓背角神经元凋亡及凋亡相关蛋白Bax和Bcl-2表达的影响。
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  “chronic constriction”译为未确定词的双语例句
     ③Chronic constriction injury (CCI) test: Eighty mice were assigned into negative control group, positive control group (morphine, 5 mg/kg), TTX group (0.19,0.39 and 0.79 μg/kg), TTX combined with indoxacarb group [TTX (0.19 μg/kg)+indoxacarb(1.4,2.8,5.6 mg/kg)].
     ③坐骨神经慢性轻度结扎损伤实验:80只小鼠分为阴性对照组、阳性对照组(吗啡,5mg/kg)、单用河豚毒素组(0.19,0.39,0.79μg/kg)、联合给药组犤河豚毒素(0.19μg/kg)+indoxacarb(1.4,2.8,5.6mg/kg)犦。
短句来源
     ③Chronic constriction injury(CCI)test in sciatic nerve of mice:Fifty mice were randomly assigned into negative control group,morphine control group,indoxacarb(1.4,2.8,5.6 mg/kg)groups with 10 in each group.
     ③小鼠坐骨神经慢性轻度结扎损伤实验:50只小鼠随机分为阴性对照组、吗啡对照组、Indoxacarb1.4,2.8,5.6mg/kg组,每组10只。
短句来源
     AMG(50,100,200 mg kg-1) strikingly demonstrated analgesic effects in the rat formalin test (second phase 15-30min) and chronic constriction injury.
     AMG(50,100与200mg·kg~(-1))对大鼠福尔马林致痛模型第二时相疼痛具有明显的镇痛作用。
短句来源
     There are seldom reports about relationships between changes of IL - 6 and monopathathic pain after sciatic nerve chronic constriction injury in rat. This report is in order to study the possibility of modified CCI model and the role of IL - 6 in monopathetic pain and monopathetic pain mechanism.
     大鼠坐骨神经慢性挤压性损伤后,血清IL-6的变化与神经源性疼痛的关系鲜见报道。 本研究旨在通过观察大鼠坐骨神经慢性挤压性损伤后痛阈变化及血清IL-6的浓度变化,初步探讨改良CCI模型的可行性及血清IL-6在神经源性疼痛形成中的作用及其可能机制。
短句来源
     Effects of intrathecal H89 on phosphorylation of cAMP element binding protein in the spinal dorsal horn neurons hiduced by chronic constriction injury to sciatic nerve in rats
     鞘内注射H-89对神经病理痛大鼠脊髓背角磷酸化cAMP反应元件结合蛋白表达的影响
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  chronic constriction
The results from the present study indicated that the major activation of NO-cGMP pathway in the chronic constriction injury model of neuropathic pain.
      
The aim of the present study was to test the sensitivity of PDE5 inhibitor sildenafil in chronic constriction injury (CCI) model a rat model of neuropathic pain.
      
Chronic constriction injury (CCI) and partial ligation (PSNL) of the sciatic nerve induce a similar neuropathic pain syndrome in rats.
      
Chronic constriction injury (CCI) of the rat sciatic nerve increases the dorsal horn excitability.
      
Objective: The present study was designed to examine the involvement of bradykinin in thermal and mechanical hyperalgesia induced by chronic constriction nerve injury (CCI) using B1 and B2 receptor antagonists and mutant kininogen-deficient rats.
      
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Objective: To study the changes of somatostatin(SOM) mRNA containing neurons in dorsal root ganglia and dorsal horn following a chronic constriction to the rat lumbar nerve root. Methods: Both experiment and control group consisted of 12 Wistar rats. In situ hybridization histochemistry combined with the quantitative image analysis were performed. Results: After a chronic constriction to the rat lumbar nerve root for 4 weeks, there was a statistically significant increase in average area and the...

Objective: To study the changes of somatostatin(SOM) mRNA containing neurons in dorsal root ganglia and dorsal horn following a chronic constriction to the rat lumbar nerve root. Methods: Both experiment and control group consisted of 12 Wistar rats. In situ hybridization histochemistry combined with the quantitative image analysis were performed. Results: After a chronic constriction to the rat lumbar nerve root for 4 weeks, there was a statistically significant increase in average area and the number of SOM mRNA containing neurons in dorsal root ganglia and dorsal horn in the experiment group compared with the control group. Conclusion: The expression of SOM in dorsal root ganglia and dorsal horn of the spinal cord is upregulated after a chronic constriction to the rat lumbar nerve root. SOM mRNA takes part in radicular pain modulation.

目的 :探讨大鼠腰神经根受压后背根神经节和脊髓后角含生长抑素 m RNA阳性神经元的变化。方法 :选用12只 Wistar大鼠 ,随机分为实验组和正常组 ,实验组用硅胶管压迫右 L4脊神经后根 ,采用原位杂交法结合图像分析进行研究。结果 :大鼠腰神经根受压 4周后 ,实验组背根神经节和脊髓后角内生长抑素 m RNA阳性神经元神经元的数量和平均面积明显增多 ,与正常组相比均有显著性差异。神经元以中、小型神经元为主。结论 :大鼠腰神经根受压后可使背根神经节和脊髓后角内神经元生长抑素 m RNA的表达上调 ,提示生长抑素可能与根性腰腿痛的发生有关

Objective: To study the changes of nitric oxide synthase (NOS1) positive neurons in dorsal root ganglias (DRG) and dorsal horn following a chronic constriction to the rat lumbar nerve root. Mechods: Both experiment and control group consisted of 12 Wistar rats. Immunohistochemistry combined with image quantitative analysis were performed. Results: After a chronic constriction injury to the rat lumbar nerve root for 4 weeks, there was a statistically significant increase in quantity and average area...

Objective: To study the changes of nitric oxide synthase (NOS1) positive neurons in dorsal root ganglias (DRG) and dorsal horn following a chronic constriction to the rat lumbar nerve root. Mechods: Both experiment and control group consisted of 12 Wistar rats. Immunohistochemistry combined with image quantitative analysis were performed. Results: After a chronic constriction injury to the rat lumbar nerve root for 4 weeks, there was a statistically significant increase in quantity and average area of NOS positive neurons in DRG and in average area of NOS positive neurous endings in dorsal horn in the experiment group compared the control group; NOS positive neurons were middle and small neurons. Conclusion: The expression of NOS in dorsal root ganglions and dorsal horn of spinal cord is higher after a chronic constriction injury to the rat lumbar nerve root. NO takes part in radicular pain modulation.

目的 :探讨大鼠腰神经根受压后后背根神经节和脊髓后角神经元型一氧化氮合酶阳性神经元的变化规律。方法 :选用 12只 Wistar大鼠 ,随机分为实验组和正常组 ,采用免疫组织化学 ABC法结合图像分析系统进行研究。结果 :大鼠腰神经根受压后 4周 ,实验组背根神经节中神经元型一氧化氮合酶阳性神经元细胞数、平均面积明显增多 ,脊髓后角神经元型一氧化氮合酶阳性神经末梢也明显增多 ,与正常组相比均有显著性差异。神经元形态以中、小型细胞为主。结论 :大鼠腰神经根受压后感觉神经元神经元型一氧化氮合酶表达上调 ,提示神经元型一氧化氮合酶可能与根性腰腿痛的发生有关

Objective To investigate the changes in small-diameter sensory neuron (SNS)/ peripheral nerve type 3(PN3) Na+ channel transcript and in tetrodotoxin-resistant (TTX-R) Na+ current in dorsal root ganglion (DRG) neurons in a chronic constriction injury (CCI) model of neuropathic pain. Methods Eighteen rats were divided into 6 groups of 3 animals each. Chronic constriction injury model was established after Dib-Hajj et al. Pain threshold was significantly lowered after CCI as compared with that in control...

Objective To investigate the changes in small-diameter sensory neuron (SNS)/ peripheral nerve type 3(PN3) Na+ channel transcript and in tetrodotoxin-resistant (TTX-R) Na+ current in dorsal root ganglion (DRG) neurons in a chronic constriction injury (CCI) model of neuropathic pain. Methods Eighteen rats were divided into 6 groups of 3 animals each. Chronic constriction injury model was established after Dib-Hajj et al. Pain threshold was significantly lowered after CCI as compared with that in control group. The animals were deeply anesthetized and rapidly decapitated 14 days after surgery. The L4-5 DRG of the operated side was removed and crushed and total RNA was extracted with trizol reagent. The DRG of the contralateral side was used as control. The change in SNS/PN3 Na + channel expression was determined by semi-reverse transcriptase-PCR. The DRG neurons were isolated enzymatically and the change in voltage-gated TTX-R Na+ current was recorded using whole-cell patch clamp technique. Results Sensory neuron specific TTX-R Na+ channel transcript SNS/PN3 was down-regulated by 60% 14 days after CCI as compared with that in control group. TTX-R Na+ current density was significantly reduced but its activation and steady state inactivation were unchanged. Conclusions Na+ channel SNS/PN3 is involved in the hyperextability of the primary sensory neurons after CCI.

目的 通过观察背根神经节(DRG)电压门控钠通道SNS/PN3在大鼠坐骨神经压迫性损伤(CCI)的变化,以探讨慢性神经痛的发生机制。方法 对大鼠建立慢性神经痛模型,14d后,将神经痛模型大鼠18只,均分为6组,每组3只,组内同侧(CCI)与对侧自体对照(Control),在深麻醉下快速断头,分别取L4和 L5 DRG,用Trizol试剂提取DRG总RNA。以逆转录多聚酶链反应(RT-PCR)半定量分析CCI后大鼠背根神经节钠通道SNS/PN3转录物的变化,以及全细胞膜片钳技术记录CCI对急性分离大鼠背根神经节TTX-R钠电流的影响。结果CCI术后14d,感觉神经元特异性的TTX-R钠通道转录物 SNS/PN3下调,与对照组相比,下降了大约60%,TTX-R钠电流密度明显减弱,但不影响其激活与稳态失活。结论 钠通道 SNS/PN3与慢性神经痛后初级感觉神经元过度兴奋有关。

 
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