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in melanoma
相关语句
  黑色素瘤
     Expression and Significance of p21~(ras) 、p~(53) in Melanoma of Eye
     眼内黑色素瘤中p21~(ras)及p53基因蛋白的表达及其意义
短句来源
     Influence of arsenic trioxide on the expression of telomerase activity in melanoma B_(16) cells
     三氧化二砷对黑色素瘤B_(16)细胞端粒酶活性影响
短句来源
     The in Vivo Study on Transfer of Human Sodium/Iodide Smporter Gene Enhancing Radioiodine (~(125)I,~(131)I)Uptake in Melanoma Cells
     hNIS基因转导黑色素瘤细胞介导放射性碘(~(125)I,~(131)I)摄取的体内实验
短句来源
     Because both T_1 and T_2 were relatively shortened in melanoma,on T weighted MR image,the tumor was seen as an area of moderately high signal and on T.
     黑色素瘤据有短 T_1和 T_2弛豫时间,T_1加权象(T_1WI)为中等强信号。
短句来源
     CONCLUSION: IL-1β induced apoptosis in melanoma A375-S2 cells by activating caspase pathway. [
     结论 :IL -1β能够诱导人黑色素瘤A375 -S2细胞凋亡 ,这种作用可能依赖于激活一类介导凋亡的caspase家族蛋白酶
短句来源
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  对恶性黑色素瘤
     Inhibitory Effects of Arsenic Trioxide on Telomerase Activity in Melanoma A_(375) Cells
     三氧化二砷对恶性黑色素瘤A_(375)细胞端粒酶活性的抑制作用
短句来源
     Conclusions:As2O3 can inhibit nucleic acid biosynthesis and induce apoptosis and necrosis in melanoma B 16 cells.
     结果:As2O3对恶性黑色素瘤B16细胞核酸合成抑制和诱导凋亡及细胞毒作用有显著的浓度和时间依赖关系(P<0.01)。
短句来源
     BACKGROUND&AIM: To study the influence of arsenic trioxide(As 2 O 3 )on the telomerase activity and the growth inhibition in melanoma B 16 cells,aim to provide new theoretical and experimental bases for the treatment of melanoma by As 2 O 3 . MATERIAL AND METHODS: The growth inhibition was analyzed by methyl thiazolyl tetrazolium(MTT);
     背景与目的:研究三氧化二砷(As2O3)对恶性黑色素瘤B16细胞生长抑制作用及对端粒酶活性表达的影响,探讨砷及其化合物治疗恶性黑色素瘤的作用机制,为临床治疗恶性黑色素瘤提供新的理论和实验依据。
短句来源
     Methods:The nucleic acid biosynthesis in melanoma B16 cells were detected by incorporation of 3H-TdR and 3H-UdR into DNA and RNA,respectively. Apoptosis and necrosis in B 16 cells were analyzed by flow cytomertry.
     方法:采用3HTdR和3HUdR掺入肿瘤细胞DNA和RNA的方法,观察不同浓度的As2O3对恶性黑色素瘤B16细胞核酸生物合成的抑制作用;
短句来源
  “in melanoma”译为未确定词的双语例句
     Mutation of the tumour suppressor p33~(ING1b) is rare in melanoma
     黑素瘤中罕见肿瘤抑制因子p33~(ING1b)的突变
短句来源
     Combined Effects of Bcl-x1 and Mcl-1 Antisense Oligonucleotides in Melanoma Drug Resistance.
     联合应用反义Bcl-x1和反义Mcl-1寡核苷酸对恶性黑素瘤细胞耐药性影响的研究
短句来源
     The expression of HMB-45 in melanoma was more specific than that of S-100 protein and NSE.
     HMB-45表达与S-100蛋白和NSE相比特异性较高。
短句来源
     (Conclusion): Cloning of human MIA/CD-RAP promoter can form a base for the investigation of expression regulation of MIA/CD-RAP in melanoma in future.
     结论:人黑素瘤MIA/CD-RAP启动子序列的克隆,可为进一步研究MIA/CD-RAP基因的表达调控奠定基础。
短句来源
     Results The B16 cells mainly expressed MMP2 in vitro, while both MMP2 and MMP9 were abundantly expressed in melanoma tissue.
     结果B16细胞在体外培养条件下主要表达MMP-2,而在肿瘤微环境中则同时表达MMP-2和MMP-9。
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  in melanoma
Expression of the p53 Gene and Activation of p53-Dependent Transcription in Melanoma Cell Lines
      
It was shown that the DO-1 epitope is not derived from p53, ruling out cytoplasmic retention of p53 in melanoma cell lines.
      
Autoradiography of [18F]FET demonstrates a remarkable accumulation in melanoma with high contrast.
      
The cloning of tumor antigen genes has proceded most rapidly in melanoma because of the ease with which melanoma-specific T-cells can be propagated in vitro.
      
This work has furthered our understanding of the basis of malignancy, as well as the development of novel strategies aimed at targeting aberrant growth in melanoma.
      
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Ten choroidal melanomas studied were with computed tomography(CT,nine cases)and magnetic resonance imaging (MRI,one case).Both techniques detected all the intraocular tumors with localization and determination of the extent of the lesions.Three of them were found to have extraocular extention.Because both T_1 and T_2 were relatively shortened in melanoma,on T weighted MR image,the tumor was seen as an area of moderately high signal and on T.weighted image, melanoma appeared as an area of low signal.MRI...

Ten choroidal melanomas studied were with computed tomography(CT,nine cases)and magnetic resonance imaging (MRI,one case).Both techniques detected all the intraocular tumors with localization and determination of the extent of the lesions.Three of them were found to have extraocular extention.Because both T_1 and T_2 were relatively shortened in melanoma,on T weighted MR image,the tumor was seen as an area of moderately high signal and on T.weighted image, melanoma appeared as an area of low signal.MRI can provide a histological diagnosis of this tumor.

本文报告脉络膜黑色素瘤 CT 扫描9例,磁共振成象(MRI)1例。两种技术均发现了眼内肿瘤,准确定位和确定病变范围,其中3例发现眼外蔓延。黑色素瘤据有短 T_1和 T_2弛豫时间,T_1加权象(T_1WI)为中等强信号。而 T_2加权象(T_2WI)为低信号,因而 MRI 对脉络膜黑色素瘤有组织学诊断意义。

Objective:To evaluate the relationship between tumor growth and somatostatin level and study the cause of the changes of somatostatin content.Metbods: Somatostatin and sulfhydryl group were measured by SSRIA and by means of absorption spectrum in melanoma S91,Lewis lung cancer,sarcoma S180and their surrounding normal tissues. Results:Somatostatin levels in all the tumors decreased compared to their surrounding tissues,whereas the amount of sulfhydryl group in tumors increased evidently. Conclusion:The...

Objective:To evaluate the relationship between tumor growth and somatostatin level and study the cause of the changes of somatostatin content.Metbods: Somatostatin and sulfhydryl group were measured by SSRIA and by means of absorption spectrum in melanoma S91,Lewis lung cancer,sarcoma S180and their surrounding normal tissues. Results:Somatostatin levels in all the tumors decreased compared to their surrounding tissues,whereas the amount of sulfhydryl group in tumors increased evidently. Conclusion:The low level of somatostatin is a very important role in tumor growth. The loss of somatostatin may be induced by sulfhydryl group, which destroys the intramolecular disulfide bond of somatostatin.

目的:探讨肿瘤组织中生长抑素含量的变化与肿瘤的生长关系,并进一步对导致这些变化的原因进行研究。方法:采用生长抑素的放射免疫测定和巯基光吸收法,对S91黑瘤、Lewis肺癌和S180肉瘤等恶性肿病与瘤周组织中生长抑素与巯基含量进行测定。结果:发现所有肿瘤组织中的生长抑素含量均低于瘤周组织,而巯基的含量则完全相反。结论:生长抑素含量的降低参与了肿瘤的生长;生长抑素含量降低的原因,可能是含量高的巯基破坏了生长抑素分子结构中的双硫键。

Correlation between DNA flow cytometric and necleolar organizer region data was analyzed in 30 patients with malignant melanoma, 26with narvocytic narvus and 5 normal skin specimens. Following results were found: the percentage of aneuploidy in melanoma was 96.7%; and DNA index, the mean number AgNOR per nucleus and abnormal AgNOR rate in melanoma were much higher than these of narvocytic narvus and normal specimen. The positive relationships between DI and the number of AgNOR per nucleus as well...

Correlation between DNA flow cytometric and necleolar organizer region data was analyzed in 30 patients with malignant melanoma, 26with narvocytic narvus and 5 normal skin specimens. Following results were found: the percentage of aneuploidy in melanoma was 96.7%; and DNA index, the mean number AgNOR per nucleus and abnormal AgNOR rate in melanoma were much higher than these of narvocytic narvus and normal specimen. The positive relationships between DI and the number of AgNOR per nucleus as well as abnormal AgNOR rate were found. The discussion on the significance of our data was made.

用流式细胞仪和银染核仁组成区(AgNOR)技术对比研究了30例恶黑、26例痣细胞痣及5例正常人皮肤标本的DNA含量、每核AgNOR数目及异行率,探讨了它们之间的相互关系。结果发现:恶黑组异倍体率为96.7%,DNA指数、每核AgNOR数及异形率均明显高于痣细胞痣及正常人。且DI与每核AgNOR数及异形率呈正相关。并就其意义进行了讨论。

 
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