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in the mouse
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  在小鼠
     At the same time, the ORF of SLC24A6 was cloned into green fluorescence protein vector pEGFP-C3 to study the location of SLC24A6 in the mouse insulinoma β-TC3 cells.
     将SLC24A6基因构建到绿色荧光真核表达载体pEGFP-C3,利用共聚焦显微镜观察SLC24A6在小鼠胰岛素瘤β-TC3细胞中的定位。
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     The Expression and Role of mTOR and Its Substrate S6K1 in the Mouse Zygotes
     mTOR及其底物S6K1在小鼠受精卵中的表达及作用
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     Expression of WNK genes in the mouse kidney
     WNK家族基因在小鼠肾脏表达的特性分析
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     STUDY ON THE RETENTION OF ENRICHED UO_2F_2 IN THE MOUSE AND ITS RADIOGENOTOXICOLOGICAL EFFECTS
     浓缩铀UO_2F_2在小鼠体内的滞留诱发放射遗传毒理效应的研究
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     Expression and location of p38 MAPK in the mouse testis during postnatal development
     p38 MAPK在小鼠睾丸不同发育阶段的表达和定位
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  “in the mouse”译为未确定词的双语例句
     The localization of SLC24A6 in the mouse insulinoma β-TC3 cells was located in the membrane of the cells.
     重组载体pEGFP-C3-SLC24A6转染后,定位于小鼠胰岛素瘤β-TC3细胞膜上。
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     In the mouse genome, A, T, AC, AG, AT, AAC, AAG, AGG, AAAC, AAAG, AAAT, AACC, AAAAC, AAAAG, AAAAT, AAACC, AAAGG, AAGAG, AAAAAC, AAAAAG, AAAAAT, AAAGAG, ACACAT, ACAGAG, ACAGGC, ACATAT were the predominant repeat types while certain pentanucleotide repeats were absent in a certain chromosome or even in several chromosomes
     A,T,AC,AG,AT,AAC,AAG,AGG,AAAC,AAAG,AAAT,AACC,AAAAC,AAAAG,AAAAT,AAACC,AAAGG,AAGAG,AAAAAC,AAAAAG,AAAAAT,AAAGAG,ACACAT,ACAGAG,ACAGGC,ACATAT是老鼠基因组中主要的SSR类型,而一些5碱基重复单元的SSR在老鼠基因组的某一条甚至某几条染色体都不存在
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     In the mouse uterus of early pregnancy,mRNA expression of CD82/KAI1 gradually increased day by day,and protein expression of CD82/KAI1 also gradually increased in quantity and range as well.
     在早孕子宫中,CD82/ KAI1mRNA的表达逐渐增多,蛋白质表达的量和范围也逐渐增强。
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     The Defection of DNA Fingerprints with M13 phage DNA Probe in the Mouse
     用M13DNA探针检测小鼠DNA指纹
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     Effect of IL-11 on the expression of IL-11 receptors in the mouse after neutron irradiation
     IL-11对中子辐射小鼠肠道IL-11受体表达的影响
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  in the mouse
Though only two esters showed antiinflammatory activity similar to that of the parent drug at equivalent dose levels, all the esters were equipotent to indomethacin in the mouse acetic acid-induced writhing assay for analgesic action.
      
Microarray Technology in Studying the Effect of Melatonin on Gene Expression in the Mouse Heart
      
Upstream of 1U and 1L exons, the respective specific promoters, U and L, are located at a considerable distance from each other (67 kb in the mouse otf-1 locus).
      
A Comparative Analysis of Regulatory Regions of the Transthyretin Gene in the Mouse, Human, and Chimpanzee Genomes
      
The Mechanisms and Frequencies of Cell Nuclei Division in the Mouse Trophoblast and Decidua during Postimplantation Embryogenesi
      
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1. By treatment with sodium sulfite and sodium tetrathionate, the disulfide linkages in theinsulin molecule were split into S-sulfonate groups. From the split products, pure A and B chainswere obtained by ion-exchange chromatography or by zone electrophoresis on cellulose powder. 2. The S-sulfonates of A and B chains were completely inactive in the mouse-convulsion test.After reduction of the S-sulfonate groups by excess thioglycolate to sulfhydryl groups followed byaerobic oxidation at pH 8.5, neither...

1. By treatment with sodium sulfite and sodium tetrathionate, the disulfide linkages in theinsulin molecule were split into S-sulfonate groups. From the split products, pure A and B chainswere obtained by ion-exchange chromatography or by zone electrophoresis on cellulose powder. 2. The S-sulfonates of A and B chains were completely inactive in the mouse-convulsion test.After reduction of the S-sulfonate groups by excess thioglycolate to sulfhydryl groups followed byaerobic oxidation at pH 8.5, neither pure A chain nor pure B chain alone gave active product, butwhen reduced A and B chains were reoxidized together at pH 8.5, considerable insulin activitywas regenerated. The activity recovered was usually about 5-10% of the activity of crystallineinsulin. 3. Regeneration of insulin activity also took place when the reduced form of one of the chainswas incubated with the S-sulfonate of the other chain. 4. Purification of the active, reoxidized product resulted in a crystalline material which had aspecific activity of 18.4 international units/mg in the mouse-convulsion test and possessed the samehypoglycemic activity as insulin. It was indistinguishable in crystal shape from insulin (Fig. 7),and had the same electrophoretic property (Fig. 9) as well as the same R_F values in three solventsystems (Fig. 10) as those of crystalline insulin. 5. By two-dimensional paper electrophoresis-paper chromatography the peptic digests of crystal.line insulin and of this crystalline material gave essentially the same "finger-prints" (Fig. 11).

(1)用亚硫酸盐及四硫硫酸盐将胰岛素的硫-硫键拆成S-磺酸基后,再经过离子交换或板型电泳分离,可以得到纯的A及B链。(2)用小白鼠惊厥法检查,S-磺酸型A及B链都不具有生物活力。用过量巯基乙酸将纯的A或B链的S-磺酸基还原为巯基,然后分别将还原型的A或B链溶液(pH 8.5)单独在空气中氧化也不产生活力。但将还原型A及B链混合,在同样条件下氧化时,可以获得有活力的产物。活力一般恢复到原活力的5-10%左右。(3)用还原型的A或B链分别与S-磺酸型的B或A链共同保温都可以得到有活力的产物。(4)将恢复活力的重氧化产物进行提纯的结果得到比活力为每毫克18.4国际单位的结晶。这样所获得的晶体其结晶形状、降血糖性质、电泳性质以及在三种溶剂系统中的比移都和结晶胰岛素相同。(5)以上晶体和结晶胰岛素的胃蛋白酶酶解图谱也基本上相同。

Using the technique of paper chromatography, we have investigated the transaminationreactions between twenty-two different amino acids and α-ketoglutaric acid in the homogenate ofSchistosoma japonicum. The formation of glutamic acid was demonstrated with alanine, arginineand aspartic acid as substrates. The activities of glutamic-pyruvic transaminase (GPT) and glutamic-oxaloacetic transaminase(GOT) in the homogenates of the worms were determined. For paired worms, the averagevalues found were in micromol./mg.N/hour,...

Using the technique of paper chromatography, we have investigated the transaminationreactions between twenty-two different amino acids and α-ketoglutaric acid in the homogenate ofSchistosoma japonicum. The formation of glutamic acid was demonstrated with alanine, arginineand aspartic acid as substrates. The activities of glutamic-pyruvic transaminase (GPT) and glutamic-oxaloacetic transaminase(GOT) in the homogenates of the worms were determined. For paired worms, the averagevalues found were in micromol./mg.N/hour, 20.1 and 16.9 for GPT and GOT respectively.When estimated separately, the activities for female worms were found to be higher than those ofthe male worms. The optimal pH for both enzymes was 7.2-7.5; the optimal substrate concentrations werefound to be 0.02 M for α-ketoglutaric acid, and 0.2-0.4M for both DL-alanine and DL-asparticacid. Tartar emetic, Sb-58 and Fouadin had a notable inhibitory effect on GPT of S. japonicum.It was shown that both the forward and the reverse reactions were inhibited 50% by 10~(-4)Mtartar emetic. This inhibitory effect could be reversed by the addition of sodium dimercaptosuc-cinate. All these three compounds did not show any inhibitory effect on GPT in the mouse liver,but acted on the enzyme of Fasciola hepatica in a similar way as on that of S. japonicum. TheGOT of S. japonicum was inhibited only by Sb-58 but not by the other two antimonial drugs.

用纸上层析法测定了日本血吸虫匀浆对22种氨基酸与α-酮戊二酸的转氨作用,当用丙氨酸、精氨酸及天门冬氨酸作底物时,可明显地测出谷氨酸的生成。日本血吸虫的谷氨酸-两酮酸转氨酶(谷丙酶)及谷氨酸-草酰乙酸转氨酶(谷草酶)的活力经用比色法多次测定,所得结果波动不大,雌雄合抱虫活力的平均值(微克分子/毫克氮量/60分)谷丙酶为20.1,谷草酶为16.9。在雌雄虫分别测定中,雌虫的酶活力较高。二种酶的最适pH均为7.2—7.5,底物最适浓度α-酮戊二酸为0.02M,DL-丙氨酸及DL-天门冬氨酸同为0.2-0.4M。吐酒石、Sb-58及(月弟)芬对日本血吸虫的谷丙酶有明显的抑制作用,当吐酒石的浓度为10~(-4)M时正逆二个方向的反应均被抑制约5O%,这种抑制作用能被二巯基丁二酸钠所解除。锑剂对小白鼠肝脏的谷丙酶无作用,但对肝吸虫的作用与血吸虫相似。血吸虫的谷草酶亦能被Sb-58所抑制,但不受其他二种锑剂的影响。

The pathological effects of N-formylsarcolysin (N-F) in the mouse were investigated. At the dose level of 150mg/kg (i. p.), lesions were found in the bone marrow, thymus, lymph nodes, spleen, intestine, and testis, while other organs including the heart, lungs, kidneys, brain, etc. remained unchanged morphologically. The changes of the above organs might appear in 4—8 hours after administration of N-F but did not become evident until 24 hours later, and then reached their maximum in 2—4 days. Regeneration...

The pathological effects of N-formylsarcolysin (N-F) in the mouse were investigated. At the dose level of 150mg/kg (i. p.), lesions were found in the bone marrow, thymus, lymph nodes, spleen, intestine, and testis, while other organs including the heart, lungs, kidneys, brain, etc. remained unchanged morphologically. The changes of the above organs might appear in 4—8 hours after administration of N-F but did not become evident until 24 hours later, and then reached their maximum in 2—4 days. Regeneration began on the 5th to 7th day in survived animals. For the purpose of comparing the susceptibility of various tissue cells to the destructive action of N-F, various dose levels of N-F were chosen, and the following kinds of tissue cells were counted in a given number of microscopic fields: neutrophil granulocytes, eosinophil granulocytes, erythropoietic cells, and megakaryocytes in the bone marrow; lymphocytes in the thymus; epithelial cells and Paneth cells in the crypts of Lieberkuehn of the small intestine; and spermatogonia of type A and B in the testis. According to the cell counts of various dosage groups, the 50 per cent injurious dose (ID_(50)) of N-F for different tissue cells was calculated. It was found that the susceptibility of various tissue cells to the action of N-F was quite different. Type A spermatogonia, type B spermatogonia, and eosinophil granulocytes were most sensitive, and the ID_(50) was 25.2, 17.5, and 32.7mg/kg, respectively. Erythropoietic cells and lymphocytes were also sensitive, the ID_(50) being 64 and 151 mg/kg, while epithelial cells of the Lieberkuehn's crypt and neutrophil granulocytes of the bone marrow were less sensitive. Megakaryocytes and Paneth cells were most resistant, the ID_(50) was higher than 300 mg/kg. It appears that the quantitative histological method presented in this paper is useful in studying toxic effects of antitumour drugs.

本实验使用形态学方法在切片上计算细胞数以比较N-甲酰溶肉瘤素对小鼠各种器官所引起病变的发展过程,并从数量上去衡量各种细胞对药物的敏感性。结果发现小鼠腹腔內注射N-甲酰溶肉瘤素150毫克/公斤后,病变主要见于骨髓、胸腺、淋巴结、脾脏、小肠、大肠和睾丸。各种组织的病变发展过程不同,一般在给药后2—4天最为严重。在敏感的器官中,不同类型组织细胞对N-甲的敏感性有很大差別,最敏感的是睾丸的精原细胞和骨髓的嗜酸性粒细胞。

 
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