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in toxicity
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  毒性
     In toxicity tests, the LD_(50) of SIPIyy24-A1 (1030-1202 mg/kg) and SIPIyy24-A2 (1171-1259mg/kg) were larger than those of SIPIyy24-B1 (300-400mg/kg) and SIPIyy24-B2 (200-250mg/kg).
     毒性试验研究显示,SIPIyy24-A1和SIPIyy24-A2的LD_(50)值相当(分别为1030~1202mg/kg和1171~1259mg/kg)远比SIPIyy24-B1和SIPIyy24-B2的LD_(50)值(分别为300~400mg/kg和200~250mg/kg)大。
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     (2)Fed 100mg/kgAA group,50mg/kg AA,50mg/kg AA+200μg/kg Se,50mg/kg AA+50mg/kg VitE for five weeks, resulted in an decrease in toxicity of liver ,kidney,hemopoietic system,and mutagenicity and the amount of MDA in the serum of mice caused by acrylamide.
     (2)对照组、100mg/kgAA组、50mg/kgAA组、50mg/kgAA+200μg/kgSe组、50mg/kgAA+50mg/kgVitE组小鼠饲养五周,结果表明硒与维生素E可降低丙烯酰胺所致的神经毒性和肝、肾、造血系统损伤,也可降低其遗传毒性和脂质过氧化产物MDA含量。
短句来源
     It would result in toxicity if the dosage was too great (greater than 11.1 MBq).
     放射剂量过大 (>11.1MBq)可产生毒性
短句来源
     A standard microtox procedure was used in toxicity of X-81 oil dispersant: EC50 = 7000mg/L and 95% confident interval being 5600-8400mg/L. Toxicity of the dispersant could be classified as mild toxicity.
     采用标准化的Microtox技术对油分散剂X-81作了毒性检测:EC_(50)=7000mg/L,95%的置信区间为5 600~8400mg/L,毒性分级属微毒。
短句来源
     THE USE OF BIVALVE FILTRATION RATE IN TOXICITY STUDY ON MARINE POLLUTANTS
     双壳类清滤率在海洋污染物毒性研究中的应用
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  “in toxicity”译为未确定词的双语例句
     RESULTS: CHL and CHO were 109.38 mg/ml; it was negative in toxicity.
     对CHO和CHL细胞的IC50均为109.38 mg/ml,并且在该剂量之下为阴性结果。
短句来源
     The author used white mice as experimental animals to study the effect in toxicity and the result showed that the LD_50 of "Gong Jian I " was 28.26 ± 0.50g/kg;
     毒理学试验结果显示:“攻尖Ⅰ号”的LD_(50)为28.26±0.50g/kg;
短句来源
     Results: The response rate of treatment group was 83.3%,and 61.5% for the control group(P<0.05). There was no difference in toxicity between two groups.
     结果:A组控制胸水的总有效率为83.3%,B组为61.5%■P<0.05■,A组与B组生活质量好转率分别为70.8%和46.1%(P<0.05)。
短句来源
     Results: The response rate of treatment group was 85% , and 59.1 % for the control group( P < 0.05 ). There was no difference between in toxicity two groups.
     结果:胸水控制率治疗组为85%,对照组为59.1%,治疗组疗效明显优于对照组(P<0.05)。
短句来源
     The median volume of PTVs was 629.1 cm 2 (range 258.9-1204.3 cm 2 ). The fraction size of radiotherapy was 200cGy/fx and the median dose was 6100cGy(range 4000-6400cGy)。 RTOG radiation toxicity criteria was used in toxicity evaluation.
     肿瘤PTV的中位体积为629.1(258.9~1204.3)cm3,所有患者均接受200cGy/次的常规分割照射,中位处方剂量为6100(4000~6400)cGy。
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  相似匹配句对
     It is of high toxicity.
     该菌具有较强的毒力。
短句来源
     The Toxicity of Acrylamide
     丙烯酰胺毒性研究进展
短句来源
     Toxicity of Vitamine
     维生素的毒性
短句来源
     Toxicity of cycloprothrin on paramecium.
     乙氰菊酯对草履虫的毒性
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  in toxicity
Exposure to 0.25 mM NiCl2 × 6H2O for 5 days resulted in toxicity symptoms, such as formation of reddish-brown mottled spots on the leaf blade.
      
A model describing the time course and variability in toxicity of hydrophobic chemicals to aquatic organisms
      
The variability in toxicity (such as EC10, EC50, EC90) derived from the model equations agreed well with those experimentally observed.
      
This interaction may be important in toxicity to these drugs, but can also result in reduced activity in pus and necrotic tissue.
      
Reluctance to adopt a new standard of care is rooted in toxicity concerns.
      
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The LD_(50) of ammonium antimony gluconate (AAG) after intraperitoneal injection was 16.8mg/kg for mice fed on a diet containing 0.01% thyroxine, 166mg/kg for mice on a diet containing 0.1% propylthiouracil and 90mg/kg for control mice It is concluded that feeding mice with thyroxine for two weeks significantly increases the susceptibility of the mice to the acute toxicity of AAG, whereas propylthiouracil feeding increases the resistance of the mice. After intraperitoneal injection of Sb~(124)-labelled AAG to...

The LD_(50) of ammonium antimony gluconate (AAG) after intraperitoneal injection was 16.8mg/kg for mice fed on a diet containing 0.01% thyroxine, 166mg/kg for mice on a diet containing 0.1% propylthiouracil and 90mg/kg for control mice It is concluded that feeding mice with thyroxine for two weeks significantly increases the susceptibility of the mice to the acute toxicity of AAG, whereas propylthiouracil feeding increases the resistance of the mice. After intraperitoneal injection of Sb~(124)-labelled AAG to normal rats or rats fed thyroxine or propylthiouracil, high radioactivity levels were found in the liver and the gastrointestinal tract (including its contents), while the Sb~(124) levels in the kidney, thyroid, blood, spleen, lung and other tissues were very low. There seems to be no significant difference between the distribution patterns of radioactivity in tissues for the three groups of rats. The excretions of Sb~(124) for the three groups were also similar. It appears that the difference in toxicity of AAG between control rats and rats with altered thyroid function is not explicable by differences in the distribution and excretion of antimony after administration of AAG.

小鼠連續服用甲狀腺素兩週後,對銻銨急性毒性的敏感性顯著增加,而連續服用丙基硫氧嘧啶,則可增加對銻銨急性毒性的耐受性。腹腔注射銻銨於甲狀腺機能亢進狀態,甲狀腺機能不足及正常大鼠後,銻~(124)在组織中分佈的濃度均以肝及胃腸道为最高,腎臟次之,在甲狀腺中的濃度均很低。腹腔注射銻”銨後,銻~(124)的排泄總量三组動物無明顯區别。因此,銻銨對甲狀腺機能亢進狀態,甲狀腺機能不足及正常小鼠毒性的不同,似並非由於注射銻銨後,銻的分佈和排泄不同所致。

The "Compound Mixture of Two Fairies" (Ⅰ) has been used as a hypotensive drug. One of its chief ingredients is Phellodendron chinense (Ⅱ). Berberis spp. (Ⅲ)contains also much berbcrine. Hence Ⅱhas been substituted by Ⅲ in making the Compound Mixture Ⅳ. In this paper Ⅱand Ⅲ were studied in the form of fluidextracts. The dosages used were expressed in terms of crude drugs. The intraperitoneal LD_(50) in mice were 2.7 g/kg for Ⅱ and 3.1 g/kg for Ⅲ. Intraperitoneal injections in anesthetized cats produced, in...

The "Compound Mixture of Two Fairies" (Ⅰ) has been used as a hypotensive drug. One of its chief ingredients is Phellodendron chinense (Ⅱ). Berberis spp. (Ⅲ)contains also much berbcrine. Hence Ⅱhas been substituted by Ⅲ in making the Compound Mixture Ⅳ. In this paper Ⅱand Ⅲ were studied in the form of fluidextracts. The dosages used were expressed in terms of crude drugs. The intraperitoneal LD_(50) in mice were 2.7 g/kg for Ⅱ and 3.1 g/kg for Ⅲ. Intraperitoneal injections in anesthetized cats produced, in 90 minutes, an average “% of hypotensive areas”of -30%for Ⅰ(4g/kg),—30% forⅡ(2g/kg),—42% for Ⅲ(2g/kg), and —32% for Ⅳ(4g/kg). Six renal hypertensive dogs were fed Ⅳ 15—30 g/kg/day for 20 days. There were no remarkable changes in blood pressure, EKG, BSP retention, and blood NPN. Three normal dogs were fed daily Ⅳ 45 g/kg for 3 weeks. Abnormal alteration was not found in EKG, liver and kidney function tests, nor was toxic sign noticed in the microscopic examinations. Sixteen water-soluble portions from different fractions of Ⅲ were screened over by single intravenous injections in anesthetized cats, 2—3 cats for each portion. Six of them yielded an average“%of hypotensive areas” exceeding —30%. Since Ⅲ is abundant in China and low in toxicity, it seems to be a promising source of hypotensive drugs.

复方二仙合剂降压有效,其中以黄蘗的降压作用較強。三顆針是小蘗科植物,与黄蘗同为小蘗碱的資源植物,来源充沛。本文試驗其毒性与疗效。小白鼠腹腔注射1次三顆針或黃蘗流浸膏,观察3天的LD_(50)各为3.1与2.7克生药/公斤,相差不显著。麻醉猫腹腔注射三顆針或黄蘗流浸膏2克/公斤,90分钟內平均降压面积百分比:三顆針組为-42%,黃蘗組为-30%,相差显著。而注射針仙合剂(三顆針代黄蘗加入二仙合剂)或二仙合剂4克/公斤,90分钟內的平均降压面积百分比均为-30%左右。 腎型高血压狗每天灌服針仙合剂15—30克/公斤,共20天,血压变化不明显。心电图、肝对磺溴酞鈉的排泄机能及全血非蛋白氮量的測定,无明显改变。正常狗每天灌服針仙合剂45克/公斤,3周后,检查心电图、肝及腎机能无异常,其中1狗內脏作組織切片,无明显中毒現象。对麻醉猫靜脉注射由三顆針提取的不同部位的水溶液2—10毫克/公斤,篩过16种成分,其中6种的平均降压面积百分比超过-30%。三顆針药源广、口服毒性小,是一种較有希望的降压药源。

In this investigation, the binding of a number of phenylalanine derivatives of nitrogen mustard with rat plasma was studied using the ultrafiltration method. N-formylsarcolysine (NF) was used as a model to study the factors influencing this binding. NF and other N-acylated phenylalanine mustard derivatives were found to be bound to an extent of more than 60% to rat plasma, while sarcolysine and other related compounds with a free amino-group were found to be 24% bound. The former compounds exhibited a lower...

In this investigation, the binding of a number of phenylalanine derivatives of nitrogen mustard with rat plasma was studied using the ultrafiltration method. N-formylsarcolysine (NF) was used as a model to study the factors influencing this binding. NF and other N-acylated phenylalanine mustard derivatives were found to be bound to an extent of more than 60% to rat plasma, while sarcolysine and other related compounds with a free amino-group were found to be 24% bound. The former compounds exhibited a lower toxicity, while the latter ones possessed higher toxicity. This finding led us to advance the assumption that the difference in the degrees of binding between the two series of compounds contributes, at least in part, to their differences in toxicity. When the chloroethyl groups in the molecule were hydrolyzed to hydroxyethyl groups, the bonding capacity of the compound was shown to be lost almost entirely. When the carboxyl group of NF was esterified, however, the degree of binding was similar to its parent compound. It appears that the chloroethyl group is necessary for this binding, while the carboxyl group is not as important. Since the degree of binding is not affected by changes of room temperature, it is suggested that the binding is a physical process rather than alkylation. When the acidity of the rat plasma was adjusted to pH values of 2 to 8, the highest degree of binding of NF was shown to be at pH 3.6. At this pH, the highest solubility of NF in organic solvent was obtained. This result is in accord with the assumption that it is the unionic form which participates in the binding. It was found that, within a certain limit, the degree of NF binding decreased as the degree of dilution of the plasma was increased. The binding of NF with various tissue homogenates of normal rats and tumor-bearing animals was also investigated. The binding capacity may be listed in decreasing order as follows: liver, 81.5%; plasma, 71.9%; Kidney, 69.7%; spindle cell carcinoma B_(22)(NF-resistant), 60.9%. Yoshida solid carcinoma(NF-sensitive), 57.9%. It seems that the difference of binding between the NF-sensitive and NF-resistant tumors was insignificant.

本文用超过滤法比较了几种苯丙氨酸氮芥与大鼠血浆的结合,并以N-甲酰溶肉瘤素(以下简称N-甲)为例,对影响结合的因素进行了探讨。 N-甲等氨基被酰化的衍生物与大鼠血浆结合的程度均大于60%,而溶肉瘤素等氨基未被酰化的衍生物结合程度均低于24%。分子中的氯乙基可能是此种结合所必要的基团,而游离羧基并非必要。但此结合不受溫度的影响。N-甲与血浆结合的最适pH为3.6;在一定范围內,结合程度随血浆稀释度增加而减少。所试各种组织匀浆与N-甲结合程度以下列次序递减:肝,81.5%;血浆,71.9%;肾,69.7%;梭形细胞肉瘤B_(22)(N-甲不敏感瘤),60.9%;吉田肉瘤(N-甲敏感瘤)57.9%。

 
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