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increased susceptibility
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  易感性
     Glutathione S-transferase M1 and T1 Gene Deletion Associated with Increased Susceptibility to Nasopharyngeal Carcinoma
     谷胱甘肽硫转移酶M1与T1基因缺失增加鼻咽癌易感性(英文)
短句来源
     In addition,CD11a + T cell decrease 8h later might lead to the increased susceptibility to infections. Mild change was found in CD11b + subset,the mechanism is now unclear.
     CD11a+ 亚群的降低 ( 8h后 )表明机体对感染的易感性增加 ,而CD11b+ 亚群的变化轻微 ;
短句来源
     In this study,HLA allele B * 4901 may be associated with increased susceptibility to HIV-1 infection, whereas the B * 40 allele may be associated with resistance to H HIV-1 infection.
     由此可见,B* 4901等位基因可能与HIV-1感染的易感性有关,而B*40等位基因可能与与HIV-1感染的抵抗性有关。
短句来源
     Conclusion The Fcγ RIIA-R/R131 genotype may be one of the contributors for the increased susceptibility to severe CP in Chinese Han nationality.
     结论 FcγRⅡA_R R131基因型与慢性牙周炎的严重程度相关 ,提示其可能与汉族人群慢性牙周炎的易感性有关。
短句来源
     The polymorphisms of p21 WAF1 gene might be associated with advanced cellular proliferation and increased susceptibility for carcinoma.
     p2 1WAF1基因多态性可能与促进细胞增殖和增强对癌的易感性有关。
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  易感性有关
     Conclusion The Fcγ RIIA-R/R131 genotype may be one of the contributors for the increased susceptibility to severe CP in Chinese Han nationality.
     结论 FcγRⅡA_R R131基因型与慢性牙周炎的严重程度相关 ,提示其可能与汉族人群慢性牙周炎的易感性有关
短句来源
     In this study,HLA allele B * 4901 may be associated with increased susceptibility to HIV-1 infection, whereas the B * 40 allele may be associated with resistance to H HIV-1 infection.
     由此可见,B* 4901等位基因可能与HIV-1感染的易感性有关,而B*40等位基因可能与与HIV-1感染的抵抗性有关。
短句来源
     These findings seemed to imply that patients with cervix cancer might possess characteristics of chromosomal instability reflecting possibly the hereditary trait inherent to the patient, thus leading to an increased susceptibility of the individual to malignancy.
     结果表明宫颈癌患者具有染色体不稳定性,可能反映个体所固有的特征,与肿瘤的遗传易感性有关
短句来源
     The polymorphisms of p21 WAF1 gene might be associated with advanced cellular proliferation and increased susceptibility for carcinoma.
     p2 1WAF1基因多态性可能与促进细胞增殖和增强对癌的易感性有关
短句来源
  “increased susceptibility”译为未确定词的双语例句
     The NQO1 T/T genotype significantly increased the risk for developing ESCC, compared to the combination of C/C and C/T genotypes, with the adjusted odds ratio (OR) of 1.81 (95%CI:1.04-3.15). This increased susceptibility exhibited pronouncedly in patients with family history of upper gastrointestinal cancers (adjusted OR=2.22, 95%CI:1.18-4.17).
     与 NQO1C/ C及 C/ T基因型相比 ,T/ T基因型可明显增加患 ESCC的风险性 (校正 OR=1.81,95 % CI:1.0 4~ 3.15 ) ,且在有上消化道肿瘤家族史的患者中尤为明显 (校正 OR=2 .2 2 ,95 % CI:1.18~4 .17)。
短句来源
     Stratified analysis between ACE and AT1R gene polymorphisms was shown that individuals carrying both ACE-DD homozygotes and AT1R-AC+CC genotypes increased susceptibility to DN(OR=8.569,95%CI:1.025~71.665).
     ACE和AT1R基因多态与DN的分层分析显示,同时携带ACE纯合子缺失基因型(DD)和AT1R突变基因型(AC+CC)者发生DN的危险较大,OR值为8.569。
短句来源
     An increased susceptibility to lysis in autologous tumor cells (AuTc) was observed when pre-incubating of tumor cells with TNF(100U/ml)or IFN (100U/ml) for 24 hours (P<0.05), especially when pre-incubated with both of them together (P<0.01).
     结果显示经TNF(100U/ml)或IFN(100U/ml)培养过的人肝癌细胞对人肝癌TIL的敏感性明显增强(P<0.05),两者合用,结果更显著(P<0.01);
短句来源
     Intracellular expression of the intrabody did not obviously affect p210~(BCR/ABL) expression levels, but inhibited tyrosine kinase activity of c-ABL and p210~(BCR/ABL) protein by 76% followed by a 48% down-regulation of the whole cell PTK activity in K562 cells and increased susceptibility of K562 cells to apoptosis-inducing stimulus.
     2.研究胞内抗体在K562细胞内表达后,细胞总蛋白、p210~(BCR/ABL)蛋白、c-ABL(p145~(ABL))蛋白酪氨酸激酶活性的变化,细胞凋亡特性的改变以及对细胞增殖、细胞内周期蛋白cyclin D2表达量、细胞周期时相分布的影响。
短句来源
     Thus, NSCLC patients with the 5A/5A genotype have higher risk of lymphatic metastasis than NSCLC patients with the 6A/6A genotype (OR=12.38, 95% CI=0.76-202.13). CONCLUSIONS: The 5A allele of MMP-3 might be associated with the increased susceptibility to NSCLC among smokers. The 5A homozygote might increase the risk of lymphatic metastasis in NSCLC patients.
     根据吸烟状况及病理类型分层分析发现,吸烟患者组5A等位基因频率(21.0%)显著高于健康吸烟组(12.9%)(χ2=4.81,P=0.03),携带5A/5A或5A/6A基因型可显著增高吸烟者的NSCLC发病风险(经性别、年龄校正的OR
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  increased susceptibility
After 2-3 days, the resistance disappeared or even gave way to an increased susceptibility to the infection; subsequently, the resistance increased again.
      
LAK plus EPI combined treatment increased susceptibility of H1299 WT and H1299 EPI(R) (300-fold EPI resistant) cells to LAK cell cytotoxicity.
      
This latter state manifests as systemic immune dysfunction, anergy and causes increased susceptibility to infections.
      
Whereas the plasma and LDL antioxidant status do not appear to be affected by fish oil supplementation, an increased susceptibility of LDL to oxidation was observed in these healthy volunteers.
      
Left ventricular hypertrophy (LVH) secondary to chronic pressure overload is associated with increased susceptibility to myocardial hypoperfusion and ischemia during increased cardiac work.
      
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Sister cliromatid exchanges (SCE) and chromosome aberrations in 30 patients and relative lengths of C-band of chromosomes in 20 patients with cervix cancer of lymphocytes in peripheral blood were studied. Very significant increase in SCE, hypodiploidies and relative lengths of C-band of chromosome 9 were observed, and significant increase in polyploidies, structural aberrations and relative lengths of C-band of chromosome 1 were also found in cancer paients as compared with controls, with all in non-randomized...

Sister cliromatid exchanges (SCE) and chromosome aberrations in 30 patients and relative lengths of C-band of chromosomes in 20 patients with cervix cancer of lymphocytes in peripheral blood were studied. Very significant increase in SCE, hypodiploidies and relative lengths of C-band of chromosome 9 were observed, and significant increase in polyploidies, structural aberrations and relative lengths of C-band of chromosome 1 were also found in cancer paients as compared with controls, with all in non-randomized distribution, No difference was noted in alterations between stages II and III cancers. These findings seemed to imply that patients with cervix cancer might possess characteristics of chromosomal instability reflecting possibly the hereditary trait inherent to the patient, thus leading to an increased susceptibility of the individual to malignancy.

作者报告30例宫颈癌患者外周血淋巴细胞染色体的变化其姐妹染色单体互换率、染色体畸变率及C带相对长度均较对照组显著增加,并呈非随机性变化;Ⅱ期和Ⅲ期癌间未见到差异。结果表明宫颈癌患者具有染色体不稳定性,可能反映个体所固有的特征,与肿瘤的遗传易感性有关。

Our interest in Down syndrome (DS) is due to the neuropathological features of Alzheimer disease (AD) which developed in all DS patients and to the increased susceptibility to leukemia in DS. We studied the ability of the lymphoblastoid cell lines from DS and AD patients to survive after treatment with x-ray. Both DS and AD lines were significantly more sensitive to x-ray than the normal lines (p<0.0001 and p=0.004). In other primary neuronal degenerations, including xeroderma pigmentosum, ataxia telangiectasia...

Our interest in Down syndrome (DS) is due to the neuropathological features of Alzheimer disease (AD) which developed in all DS patients and to the increased susceptibility to leukemia in DS. We studied the ability of the lymphoblastoid cell lines from DS and AD patients to survive after treatment with x-ray. Both DS and AD lines were significantly more sensitive to x-ray than the normal lines (p<0.0001 and p=0.004). In other primary neuronal degenerations, including xeroderma pigmentosum, ataxia telangiectasia and Cockayne syndrome, all their cultured cells were hypersensitive to DNAdamaging agents. These phenomena may reflect defective repair of induced DNA damage in DS patients, which could be the cause of their increased susceptibility to leukemia and premature death of their neurons.

作者注意到Down综合征(DS)患者均有Alzheimer病(AD)的神经病理学特征,且白血病的发病率显著增高:通过对DS和AD患者淋巴细胞株经X射线处理后生存能力的研究,发现两者均对X线有异常敏感(P<0.0001和0.004),对其它某些原发性神经元变性性疾病如着色性干皮病(XP)、毛细血管扩张性共济失调症和Cockayne综合征等作了比较,这些细胞均显示对DNA损伤因子异常敏感。在XP病人中这些现象可能反映着对诱发性DNA损伤的修复缺陷。因此,本病也可能是对损伤的DNA存在着修复的缺陷而导致白血病的发病率增高以及象AD那样的神经细胞的过早死亡。

Injury from ionizing radiation can cause increasing susceptibility of the body to infection. In the experiment, adherence and colonization of com-pylobacter jejuni (strain CJ-Sl3l) to irradiated mice were dynamically observed by the colony forming-units (CFU) method in vivo for the purpose to study the mechanisms of the effects of irradiation on susceptibility to infection. Results of the method of CFU in vivo showed, (l) Increases of adherence and colonization in the mice appeared when they...

Injury from ionizing radiation can cause increasing susceptibility of the body to infection. In the experiment, adherence and colonization of com-pylobacter jejuni (strain CJ-Sl3l) to irradiated mice were dynamically observed by the colony forming-units (CFU) method in vivo for the purpose to study the mechanisms of the effects of irradiation on susceptibility to infection. Results of the method of CFU in vivo showed, (l) Increases of adherence and colonization in the mice appeared when they were irradiated with "Co in different doses. (2) If mice were irradiated with dose lower than lOGy, AI (adhesive index) was significantly higher than that of unirradiated mice only at the peak of adherence, with 15Gy, AI markedly increased from 6 to 48 hours post inoculation, and with 20Gy, AI had obviously increased within 30 minutes and lasted over the whole course of the experiment. (3) The higher radiation dose the mice received, the larger the AI was increased. (4) The analysis of variance revealed, the increased AI due to radiation had no significant differences among inoculating times and segments of the gut. The increasing susceptibility of the whole-body irradiated mice to infection in the study expressed as increasing of adherence and colonization of campylobacter jejuni to mucosa occourred with no difference on every segments of the gut, and raised with the radiation dose.The changes of mice intestinal local micro-environment and its structure of intestinal mucosal surface due to radiation may play a promoting role on adherence and colonization of the bacteria.

电离辐射造成的损伤可引起机体对感染易感性的增高。本实验用体内菌落形成单位法(colony forming-units method in vivo,体内CFU法)对空肠弯曲菌CJ-S131株在受照小鼠体内的粘附、定居进行了动态观察,旨在研究辐射对感染易感性影响的机理。实验结果提示:(1)小鼠受不同剂量~(60)Coγ射线全身照射后均出现空弯菌在体内的粘附、定居增加。(2)小鼠受低于10Gy照射时,仅在粘附高峰时粘附指数(adhesive index,Al)显著高于对照组;在15Gy时,从感染后6~48h均可见AI的显著增加;而20Gy照射组,30min时AI即明显增加,并持续整个实验过程。(3)小鼠受照剂量越大,增加的AI亦越大。(4)方差分析提示,增加的AI在各肠段及各感染时间段间均无差别。小鼠受全身照射后对感染的易感性增加,表现为空弯菌在整个肠道粘膜的粘附增加,而无肠段间的区别,并随照射剂量的增大而增加。受照射后肠道局部微环境及肠粘膜表面结构的改变可能对细菌的粘附,定居起促进作用。

 
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