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induced rat paw edema
相关语句
  所致大鼠足跖肿胀
     Methods: Orally administration of Fengtong'an 50,25, 12.5 g/kg for one week, its pharmacodynamics were observed on dimethylbenzene induced mice ear edema, carrageenan induced rat paw edema and acetic acid induced mice writhing.
     方法 :风痛安胶囊 5 0、2 5、12 .5 g/ kg,口服给药 1周 ,考察二甲苯所致小鼠耳肿胀、对角叉菜所致大鼠足跖肿胀及醋酸引起的小鼠扭体反应。
短句来源
  所致大鼠足肿胀作用
     significantly inhibited carrageenin induced rat paw edema of 33.6% and 25.4% at 6 h;
     显著抑制角叉菜所致大鼠足肿胀作用 ,第 6小时抑制率分别为 33.6 %和 2 5 .4% ;
短句来源
  “induced rat paw edema”译为未确定词的双语例句
     Thirteen compounds (II 1,3,5,8 13,15,18,19,23 ) exhibited marked anti inflammatory activity comparable to diclofenac sodium (DC) and rofecoxib (RC) in xylene induced mice ear swelling model, and twelve compounds (II 1,3,5,7,8,10 12,17,18,20,23 ) showed remarkable anti inflammatory activity comparable to DC and RC in carrageenan induced rat paw edema.
     角叉菜胶致大鼠足跖肿胀模型试验结果显示 ,12个化合物 (II1 ,3,5,7,8,1 0 1 2 ,1 7,1 8,2 0 ,2 3)的抗炎活性与双氯芬酸钠 (DC)和罗非昔布 (RC)相当 (P >0 0 5 )。
短句来源
     In this paper, ten new derivatives of 2 (4 methoxybenzylidene) 5 aminomethyl cyclopentanone were designed and synthesized The structures of all these ten title compounds have been confirmed by IR, 1 H NMR and elemental analysis The compounds have been examined for the antiinflammatory activity on carrageenin induced rat paw edema test Through chemical synthesis, we have confirmed that the amino exchange reaction proceeds by an elimination addition mechanism
     本文设计合成了10个未见文献报道的2—对甲氧基苯亚甲基5取代胺甲基环戊酮衍生物,均经红外光谱、核磁共振谱及元素分析,证实其化学结构。 采用角叉菜胶诱发的大鼠足爪肿胀模型进行抗炎活性的初步筛选。
短句来源
     METHOD Models of acute inflammatory reactions of xylene induced mouse ear edema,albumin induced rat paw edema and the chronic inflammatory reaction of paper induced rat granuloma were performed to study the anti inflammatory effects.
     方法 用二甲苯致小鼠耳肿胀、鸡蛋清致大鼠足爪肿胀及大鼠肉芽肿炎症模型 (纸片法 ) ,考察绿舒筋多糖的抗炎作用 ;
短句来源
  相似匹配句对
     The rat model was induced by alloxan.
     动物模型用四氧嘧啶塑造。
短句来源
     Rat
     鼠(美国电影故事)
短句来源
     Induced into E.
     将表达载体转化E.
短句来源
     SHEAR INDUCED NEUROPEPTlDE Y IN RAT PLATELETS
     等剪切场中剪切诱导血小板释放神经肽Y
短句来源
     Between Fish and Bear’s Paw
     在鱼和熊掌之间
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  induced rat paw edema
Human recombinant platelet phospholipase A2 exacerbates poly-l-arginine induced rat paw edema
      
In addition, NCX-530 inhibited PGE2 generation in both the intact and ulcerated gastric mucosa and showed antiinflammatory action on carrageenan-induced rat paw edema, as effectively as indomethacin.
      
In carrageenan induced rat paw edema, ML3000 and indomethacin completely blocked the formation of PGE2 in the inflamed tissue.
      
Orally administered JTE-522 dose-dependently inhibited carrageenin-induced rat paw edema (ED30: 4.7?mg/kg).
      
Comparative effects of two potentiating peptides (KPP and BPP9a) on kinin-induced rat paw edema
      
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71 rats, weighing 180-250 g each, were used in this investigation. The results showed that Dan-Shen Injection could inhibit carrageenin-induced rat paw edema, zymosan stimulated β-g release from PMNs and neutrophil chemotaxis.The authors suggest that inhibition of lysosomal enzyme release and chemotaxis may be involved in the antiinflammatory effect of Dan-Shen injection.

丹参注射液对角叉菜胶所致大鼠足跖部炎症有明显抑制作用,肿胀抑制率达51%;丹参注射液对中性粒细胞趋化性及吞噬酵母多糖时溶酶体酶的释放有明显抑制作用。

Effects of anisodamine (654-2) on inflammatory reaction were investigated. Results showed that anisodamine could inhibit SO2-induced acute bronchitis in rats, carrageenen-induced rat paw edema, oleic acid-induced rat lung injury, and bleomycin A5-induced mouse lung fibrosis. It is suggested that inhibition of histamine pharmacological effect and lysosomal enzyme release may be responsible for antiinflammatory effect of anisodamine.

山莨菪碱(654-2)对二氧化硫吸入所致大鼠急性气管炎,角叉菜胶所致大鼠脚爪水肿,油酸所致大鼠急性肺损伤及博莱霉素A5所致肺纤维化均有保护作用。阻断组胺作用及抑制溶酶体酶的释放,可能是654-2抗炎症作用的部分环节。

It has been known that non-steroidal antiinflammatory drugs (NSAIDs) act by preventing cyclooxygenase products of arachidonic acid. In recent years, research on non-steroid dual inhibitors of cyclooxygenase (CO) and 5-lipoxygenase (5-LO), which should represent a novel class of antiinflammatory drugs with a wider spectrum of activity than classical NSAIDs, hasbeencarriedout. Inthepresent paper, a total of 29 compounds including 18 compounds of 2-(E)-(un) substituted benzylidene cyclopentanone (Ⅰ) derivatives...

It has been known that non-steroidal antiinflammatory drugs (NSAIDs) act by preventing cyclooxygenase products of arachidonic acid. In recent years, research on non-steroid dual inhibitors of cyclooxygenase (CO) and 5-lipoxygenase (5-LO), which should represent a novel class of antiinflammatory drugs with a wider spectrum of activity than classical NSAIDs, hasbeencarriedout. Inthepresent paper, a total of 29 compounds including 18 compounds of 2-(E)-(un) substituted benzylidene cyclopentanone (Ⅰ) derivatives and 11 compounds of 2-(E)-(un)substituted benzylidene-5-dimethylaminomethyl cyclopentanone (Ⅱ) derivatives were synthesized as dual inhibitors of CO/5-LO. Preliminary pharmacological test showed that Ⅰ_4, Ⅱ_(12) and Ⅰ_(13) given orally have significant inhibiting effect on carrageenan induced rat paw edema and most compounds of type Ⅱ exhibited potent effect when given subcutaneously. In particular, Ⅱ_3, which inhibited by 95.8%, 70.34%, and 44.2% at 50, 25, and 12.5 mg/kg respectivily, was similar to Ibuprofen.Some compounds of type Ⅱ exhibited anticancer activity both in vitro (IC_(50) ranging from 2.93 to 18.06/μmol/L on L1210)and in vivo (maximum increase of life span was 97.5% on EAC in mice).

本文设计,合成了2-(E)-取代苯亚甲基环戊酮(Ⅰ)类化合物18个及其Mannich碱盐酸盐(Ⅱ)类化合物11个,其中22个为新化合物。初步药理结果显示:对于角叉菜胶诱发的大鼠足趾水肿,Ⅰ_4,Ⅰ_(12)及Ⅰ_(13)口服有较显著的抑制作用,水溶性Ⅱ类化合物皮下注射有极强的抑制作用,其中Ⅱ_3于50,25和12.5 mg/kg剂量下抑制率分别为95.8%,70.3%和44.2%,它与布洛芬效力(25 mg/bg抑制率72.9%)相当.Ⅱ类化合物体外对L1210细胞及体内对荷艾氏腹水癌小鼠均有一定抗癌活性。

 
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